OA10880A - Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs - Google Patents

Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs Download PDF

Info

Publication number: OA10880A
Authority: OA; OAPI
Prior art keywords: tpgs; vitamin; compound; water soluble; hiv protease
Prior art date: 1996-03-22

Application number

OA9800171A

Other languages

English (en)

Inventor

Arup K Roy

Lioyd Gary Tillman

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-22

Filing date

1998-09-18

Publication date

2001-10-11

1996-03-26 Priority claimed from GBGB9606372.2A external-priority patent/GB9606372D0/en

1998-09-18 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2001-10-11 Publication of OA10880A publication Critical patent/OA10880A/en

Links

239000004030 hiv protease inhibitor Substances 0.000 title claims abstract description 27
239000000203 mixture Substances 0.000 title claims description 49
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 28
AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 title claims description 27
229940122440 HIV protease inhibitor Drugs 0.000 title claims description 18
150000001875 compounds Chemical class 0.000 title description 48
229940088594 vitamin Drugs 0.000 title description 4
229930003231 vitamin Natural products 0.000 title description 4
239000011782 vitamin Substances 0.000 title description 4
235000013343 vitamin Nutrition 0.000 title description 4
150000003722 vitamin derivatives Chemical class 0.000 title description 4
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 23
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 23
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UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims abstract description 5
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 5
KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims abstract description 5
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229960000311 ritonavir Drugs 0.000 description 2
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA9800171A 1996-03-22 1998-09-18 Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs OA10880A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1389396P	1996-03-22	1996-03-22
GBGB9606372.2A GB9606372D0 (en)	1996-03-26	1996-03-26	Pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
OA10880A true OA10880A (en)	2001-10-11

Family

ID=26308992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9800171A OA10880A (en)	1996-03-22	1998-09-18	Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs

Country Status (12)

Country	Link
JP (1)	JP3117726B2 (id)
AR (1)	AR006345A1 (id)
BG (1)	BG64457B1 (id)
CO (1)	CO4790151A1 (id)
HU (1)	HU228026B1 (id)
ID (1)	ID16781A (id)
IL (1)	IL126185A (id)
MY (1)	MY126358A (id)
OA (1)	OA10880A (id)
PL (1)	PL187919B1 (id)
TW (1)	TW455491B (id)
WO (1)	WO1997035587A1 (id)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001523221A (ja) *	1996-09-01	2001-11-20	ファーモスコーポレイション	親油性物質の促進された生物学的利用能のための固形共沈物
AU8145198A (en) *	1997-06-16	1999-01-04	Vertex Pharmaceuticals Incorporated	Methods of increasing the bioavailability of stable crystal polymorphs of a compound
US5891845A (en) *	1997-11-21	1999-04-06	Fuisz Technologies Ltd.	Drug delivery systems utilizing liquid crystal structures
ES2140329B1 (es) *	1997-12-04	2000-10-16	Univ Granada	Utilizacion de acido maslinico como inhibidor de proteasas para el tratamiento de la enfermedad causada por los virus de la inmunodeficiencia adquirida.
GB9812189D0 (en) *	1998-06-05	1998-08-05	Glaxo Group Ltd	Methods and compositions for increasing penetration of HIV protease inhibitors
EP1354587A1 (en) *	2000-12-22	2003-10-22	Takeda Chemical Industries, Ltd.	Medicinal compositions for oral use
AU2002350719A1 (en) *	2002-11-29	2004-06-23	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
JP2006518380A (ja)	2003-01-31	2006-08-10	スミスクライン・ビーチャム・コーポレイション	固体分散体組成物
WO2006036614A2 (en) *	2004-09-24	2006-04-06	Boehringer Ingelheim Pharmaceuticals, Inc.	A new class of surfactant-like materials comprising vitamin e tpgs and a water soluble polymer
CN101031284A (zh) *	2004-09-30	2007-09-05	伊斯曼化学公司	使亲脂性药物增溶而无显著外排抑制作用的含有维生素e tpgs分子的药物制剂和该制剂的用途
EP1880715A1 (en)	2006-07-19	2008-01-23	Abbott GmbH & Co. KG	Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
SA109300195B1 (ar)	2008-03-28	2013-04-20	Astrazeneca Ab	تركيبة صيدلانية جديدة مضادة للسرطان
ITRM20120331A1 (it)	2012-07-12	2014-01-13	Guidotti & C Spa Labor	Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992016501A1 (en) *	1991-03-20	1992-10-01	Vertex Pharmaceuticals Incorporated	Tetrahydroxyalkane derivatives as inhibitors of hiv aspartyl protease
DK0541168T3 (da) *	1991-11-08	1998-05-11	Merck & Co Inc	HIV-proteaseinhibitorer, som er egnede til behandling af AIDS
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
WO1994013629A1 (en) *	1992-12-11	1994-06-23	Vertex Pharmaceuticals Incorporated	Mannitol derivatives and their use as inhibitors of aspartyl protease
US5484926A (en) *	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
DE69334250D1 (de) *	1992-12-29	2009-01-29	Abbott Lab	Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern
ATE179164T1 (de) *	1993-01-15	1999-05-15	Agouron Pharma	Hiv-proteaseinhibitoren
AU1046895A (en) *	1993-11-05	1995-05-23	Merck & Co., Inc.	New quinazolines as inhibitors of hiv reverse transcriptase
IL111584A0 (en) *	1993-11-18	1995-01-24	Merck & Co Inc	Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
ES2174921T3 (es) *	1993-12-15	2002-11-16	Merck & Co Inc	Inhibidores de la proteasa del vih.
MX9603909A (es) *	1994-03-07	1997-03-29	Vertex Pharma	Derivados de sulfonamida como inhibidores de proteasa aspartilo.
GB9409778D0 (en) *	1994-05-16	1994-07-06	Dumex Ltd As	Compositions
US5527829A (en) *	1994-05-23	1996-06-18	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
EP0825849A1 (en) *	1995-05-19	1998-03-04	Abbott Laboratories	Self-emulsifying formulations of lipophilic drugs

1997
- 1997-03-20 MY MYPI97001186A patent/MY126358A/en unknown
- 1997-03-21 HU HU9901887A patent/HU228026B1/hu unknown
- 1997-03-21 WO PCT/EP1997/001438 patent/WO1997035587A1/en not_active Ceased
- 1997-03-21 AR ARP970101146A patent/AR006345A1/es active IP Right Grant
- 1997-03-21 TW TW086103607A patent/TW455491B/zh not_active IP Right Cessation
- 1997-03-21 CO CO97015457A patent/CO4790151A1/es unknown
- 1997-03-21 IL IL12618597A patent/IL126185A/xx not_active IP Right Cessation
- 1997-03-21 ID IDP970927A patent/ID16781A/id unknown
- 1997-03-21 PL PL32891697A patent/PL187919B1/pl unknown
- 1997-03-21 JP JP09534017A patent/JP3117726B2/ja not_active Expired - Lifetime
1998
- 1998-09-18 OA OA9800171A patent/OA10880A/en unknown
- 1998-10-12 BG BG102838A patent/BG64457B1/bg unknown

Also Published As

Publication number	Publication date
HU228026B1 (en)	2012-08-28
IL126185A (en)	2003-05-29
HUP9901887A3 (en)	2000-02-28
IL126185A0 (en)	1999-05-09
PL187919B1 (pl)	2004-11-30
CO4790151A1 (es)	1999-05-31
JP3117726B2 (ja)	2000-12-18
MY126358A (en)	2006-09-29
PL328916A1 (en)	1999-03-01
AR006345A1 (es)	1999-08-25
BG102838A (en)	1999-09-30
WO1997035587A1 (en)	1997-10-02
BG64457B1 (bg)	2005-03-31
ID16781A (id)	1997-11-13
TW455491B (en)	2001-09-21
HUP9901887A2 (hu)	1999-12-28
JP2000500504A (ja)	2000-01-18

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EP0315960B1 (en)	1994-02-16	Instant oral-release capsule containing nifedipine
US20110020440A1 (en)	2011-01-27	Stable solutions of sparingly soluble actives
US6730679B1 (en)	2004-05-04	Pharmaceutical formulations
US6551615B1 (en)	2003-04-22	Dexibuprofen-containing soft gelatin capsules and process for preparing the same
JP3117726B2 (ja)	2000-12-18	Ｖｘ４７８のようなｈｉｖプロテアーゼ阻害剤およびビタミンｅ―ｔｐｇｓのような水溶性ビタミンｅを含む組成物
WO1998005308A2 (en)	1998-02-12	Terazosin capsules
AU2002356421A1 (en)	2003-07-03	Dexibuprofen-containing soft gelatin capsules and process for preparing the same
RU2363462C2 (ru)	2009-08-10	Фармацевтическая композиция, содержащая 5-метил-2-(2′-хлор-6′-фторанилин)фенилуксусную кислоту
AP1150A (en)	2003-03-14	Compositions comprising an HIV protease inhibitor such as Vx 478 and a water soluble vitamin E compound such as vitamin E-TPGS.
KR100472581B1 (ko)	2005-06-16	Vx478과같은hiv프로테아제억제제및비타민e-tpgs와같은수용성비타민e화합물을포함하는조성물
US7632853B2 (en)	2009-12-15	Soluble, stable and concentrated pharmaceutical composition compromising ritonavir and process for preparing thereof
HK1016896B (en)	2003-07-11	Compositions comprising vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs
AU2010338249B2 (en)	2016-03-31	Oral liquid pharmaceutical composition of nifedipine
US20060141028A1 (en)	2006-06-29	Cyclosporin formulations
UA67723C2 (en)	2004-07-15	Pharmaceutical formulations for peroral administration and method for its preparation
US20060217320A1 (en)	2006-09-28	Soft gel formulations for saquinavir