OA11566A - Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone. - Google Patents

Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone. Download PDF

Info

Publication number: OA11566A
Authority: OA; OAPI
Prior art keywords: phenyl; compound; bone; ethoxy; pyrrolidin
Prior art date: 1998-06-16

Application number

OA1200000340A

Other languages

English (en)

Inventor

Hua Zhu Ke

David Duane Thompson

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-16

Filing date

1999-05-26

Publication date

2004-05-26

1999-05-26 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-05-26 Publication of OA11566A publication Critical patent/OA11566A/en

Links

102000003982 Parathyroid hormone Human genes 0.000 title claims abstract description 42
108090000445 Parathyroid hormone Proteins 0.000 title claims abstract description 42
239000000199 parathyroid hormone Substances 0.000 title claims abstract description 42
229960001319 parathyroid hormone Drugs 0.000 title claims abstract description 42
230000001225 therapeutic effect Effects 0.000 title description 3
229940095743 selective estrogen receptor modulator Drugs 0.000 title description 2
239000000333 selective estrogen receptor modulator Substances 0.000 title description 2
210000000988 bone and bone Anatomy 0.000 claims abstract description 55
208000001132 Osteoporosis Diseases 0.000 claims abstract description 23
208000036119 Frailty Diseases 0.000 claims abstract description 15
206010003549 asthenia Diseases 0.000 claims abstract description 15
239000000203 mixture Substances 0.000 claims abstract description 14
239000012634 fragment Substances 0.000 claims abstract description 13
GXESHMAMLJKROZ-IAPPQJPRSA-N lasofoxifene Chemical compound C1([C@@H]2[C@@H](C3=CC=C(C=C3CC2)O)C=2C=CC(OCCN3CCCC3)=CC=2)=CC=CC=C1 GXESHMAMLJKROZ-IAPPQJPRSA-N 0.000 claims abstract description 11
150000001875 compounds Chemical class 0.000 claims description 51
241000124008 Mammalia Species 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 15
239000002552 dosage form Substances 0.000 claims description 14
FEWJPZIEWOKRBE-LWMBPPNESA-L D-tartrate(2-) Chemical compound [O-]C(=O)[C@@H](O)[C@H](O)C([O-])=O FEWJPZIEWOKRBE-LWMBPPNESA-L 0.000 claims description 11
208000010392 Bone Fractures Diseases 0.000 claims description 10
206010065687 Bone loss Diseases 0.000 claims description 10
239000003085 diluting agent Substances 0.000 claims description 9
230000035876 healing Effects 0.000 claims description 5
230000001815 facial effect Effects 0.000 claims description 3
201000001245 periodontitis Diseases 0.000 claims description 3
JWQYZECMEPOAPF-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-2-ol Chemical compound C1=CC=C2CC(O)CCC2=C1 JWQYZECMEPOAPF-UHFFFAOYSA-N 0.000 claims description 2
201000010814 Synostosis Diseases 0.000 claims description 2
230000000849 parathyroid Effects 0.000 claims description 2
WRASVFOICVIUGY-UHFFFAOYSA-N 1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol Chemical compound OC1=CC=C2CCCCC2=C1C(C=C1)=CC=C1OCCN1CCCC1 WRASVFOICVIUGY-UHFFFAOYSA-N 0.000 claims 1
238000000034 method Methods 0.000 abstract description 37
150000003839 salts Chemical class 0.000 abstract description 7
208000001164 Osteoporotic Fractures Diseases 0.000 abstract description 4
230000000694 effects Effects 0.000 description 17
238000011282 treatment Methods 0.000 description 16
241000700159 Rattus Species 0.000 description 14
229940011871 estrogen Drugs 0.000 description 13
239000000262 estrogen Substances 0.000 description 13
239000002775 capsule Substances 0.000 description 12
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
239000003795 chemical substances by application Substances 0.000 description 8
230000011164 ossification Effects 0.000 description 8
206010017076 Fracture Diseases 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
201000010099 disease Diseases 0.000 description 6
241000282412 Homo Species 0.000 description 5
239000011888 foil Substances 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 4
230000003247 decreasing effect Effects 0.000 description 4
230000001965 increasing effect Effects 0.000 description 4
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 4
239000000243 solution Substances 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
206010028980 Neoplasm Diseases 0.000 description 3
239000003263 anabolic agent Substances 0.000 description 3
229940124325 anabolic agent Drugs 0.000 description 3
238000003556 assay Methods 0.000 description 3
201000011510 cancer Diseases 0.000 description 3
230000007423 decrease Effects 0.000 description 3
208000035475 disorder Diseases 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
239000003937 drug carrier Substances 0.000 description 3
230000036541 health Effects 0.000 description 3
150000004677 hydrates Chemical class 0.000 description 3
239000000463 material Substances 0.000 description 3
210000003205 muscle Anatomy 0.000 description 3
229920003023 plastic Polymers 0.000 description 3
208000001685 postmenopausal osteoporosis Diseases 0.000 description 3
229960004622 raloxifene Drugs 0.000 description 3
241000283690 Bos taurus Species 0.000 description 2
206010006187 Breast cancer Diseases 0.000 description 2
208000026310 Breast neoplasm Diseases 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
241000282472 Canis lupus familiaris Species 0.000 description 2
241000282326 Felis catus Species 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
102000015779 HDL Lipoproteins Human genes 0.000 description 2
108010010234 HDL Lipoproteins Proteins 0.000 description 2
102000007330 LDL Lipoproteins Human genes 0.000 description 2
108010007622 LDL Lipoproteins Proteins 0.000 description 2
241000218657 Picea Species 0.000 description 2
IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 description 2
230000008901 benefit Effects 0.000 description 2
229960002986 dinoprostone Drugs 0.000 description 2
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 2
239000002834 estrogen receptor modulator Substances 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
239000005556 hormone Substances 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
210000002997 osteoclast Anatomy 0.000 description 2
238000004806 packaging method and process Methods 0.000 description 2
239000006187 pill Substances 0.000 description 2
239000004033 plastic Substances 0.000 description 2
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 2
229940089617 risedronate Drugs 0.000 description 2
230000004936 stimulating effect Effects 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
238000010254 subcutaneous injection Methods 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 description 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
JWAZRIHNYRIHIV-UHFFFAOYSA-N 2-naphthol Chemical compound C1=CC=CC2=CC(O)=CC=C21 JWAZRIHNYRIHIV-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
208000007848 Alcoholism Diseases 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
208000020084 Bone disease Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000283707 Capra Species 0.000 description 1
ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 description 1
101100114828 Drosophila melanogaster Orai gene Proteins 0.000 description 1
241000283086 Equidae Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
240000003183 Manihot esculenta Species 0.000 description 1
235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
241000282339 Mustela Species 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
241001494479 Pecora Species 0.000 description 1
208000023146 Pre-existing disease Diseases 0.000 description 1
244000000231 Sesamum indicum Species 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
241000282898 Sus scrofa Species 0.000 description 1
208000002495 Uterine Neoplasms Diseases 0.000 description 1
206010046782 Uterine enlargement Diseases 0.000 description 1
206010048049 Wrist fracture Diseases 0.000 description 1
230000009471 action Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
239000000556 agonist Substances 0.000 description 1
206010001584 alcohol abuse Diseases 0.000 description 1
208000025746 alcohol use disease Diseases 0.000 description 1
230000001195 anabolic effect Effects 0.000 description 1
238000010171 animal model Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000002617 bone density conservation agent Substances 0.000 description 1
230000037118 bone strength Effects 0.000 description 1
230000008416 bone turnover Effects 0.000 description 1
DEGAKNSWVGKMLS-UHFFFAOYSA-N calcein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(O)=O)CC(O)=O)=C(O)C=C1OC1=C2C=C(CN(CC(O)=O)CC(=O)O)C(O)=C1 DEGAKNSWVGKMLS-UHFFFAOYSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229940125758 compound 15 Drugs 0.000 description 1
230000001054 cortical effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
229950004203 droloxifene Drugs 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
210000004696 endometrium Anatomy 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
229930182833 estradiol Natural products 0.000 description 1
230000001076 estrogenic effect Effects 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
230000006870 function Effects 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000007373 indentation Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000004973 liquid crystal related substance Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229960002378 oftasceine Drugs 0.000 description 1
238000003305 oral gavage Methods 0.000 description 1
238000012858 packaging process Methods 0.000 description 1
238000002638 palliative care Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
208000028169 periodontal disease Diseases 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
244000144977 poultry Species 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
BKXVVCILCIUCLG-UHFFFAOYSA-N raloxifene hydrochloride Chemical compound [H+].[Cl-].C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 BKXVVCILCIUCLG-UHFFFAOYSA-N 0.000 description 1
238000011160 research Methods 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000000276 sedentary effect Effects 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
210000002303 tibia Anatomy 0.000 description 1
238000004448 titration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000006211 transdermal dosage form Substances 0.000 description 1
206010046766 uterine cancer Diseases 0.000 description 1
-1 éthanol Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Steroid Compounds (AREA)

OA1200000340A 1998-06-16 1999-05-26 Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone. OA11566A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8947998P	1998-06-16	1998-06-16

Publications (1)

Publication Number	Publication Date
OA11566A true OA11566A (en)	2004-05-26

Family

ID=22217879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200000340A OA11566A (en)	1998-06-16	1999-05-26	Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone.

Country Status (34)

Country	Link
US (1)	US6132774A (id)
EP (1)	EP1094808A1 (id)
JP (1)	JP2002518323A (id)
KR (1)	KR20010052818A (id)
CN (1)	CN1305373A (id)
AP (1)	AP9901580A0 (id)
AR (1)	AR018867A1 (id)
AU (1)	AU3725999A (id)
BG (1)	BG105125A (id)
BR (1)	BR9911228A (id)
CA (1)	CA2335078A1 (id)
CO (1)	CO5070584A1 (id)
EA (1)	EA200001199A1 (id)
GT (1)	GT199900066A (id)
HN (1)	HN1999000063A (id)
HR (1)	HRP20000858A2 (id)
HU (1)	HUP0102759A3 (id)
ID (1)	ID26873A (id)
IL (1)	IL139588A0 (id)
IS (1)	IS5719A (id)
MA (1)	MA26649A1 (id)
NO (1)	NO20006313D0 (id)
NZ (1)	NZ508039A (id)
OA (1)	OA11566A (id)
PA (1)	PA8471201A1 (id)
PE (1)	PE20000644A1 (id)
PL (1)	PL344982A1 (id)
SK (1)	SK18922000A3 (id)
TN (1)	TNSN99119A1 (id)
TR (1)	TR200003567T2 (id)
UA (1)	UA60367C2 (id)
WO (1)	WO1999065482A1 (id)
YU (1)	YU75800A (id)
ZA (1)	ZA993972B (id)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HN1996000101A (es) *	1996-02-28	1997-06-26	Inc Pfizer	Terapia combinada para la osteoporosis
US20020107230A1 (en) *	2000-12-22	2002-08-08	Waldon R. Forrest	Methods and formulations for the treatment of female sexual dysfunction
US20030191096A1 (en) *	2002-04-03	2003-10-09	Leonard Thomas W.	Method of hormonal therapy
EP2428516A1 (en)	2003-11-19	2012-03-14	Metabasis Therapeutics, Inc.	Novel phosphorus-containing thyromimetics
ES2328384T3 (es) *	2004-11-23	2009-11-12	Warner-Lambert Company Llc	Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
US7790745B2 (en)	2005-10-21	2010-09-07	Bristol-Myers Squibb Company	Tetrahydroisoquinoline LXR Modulators
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2010093601A1 (en)	2009-02-10	2010-08-19	Metabasis Therapeutics, Inc.	Novel sulfonic acid-containing thyromimetics, and methods for their use
TW201043595A (en) *	2009-03-13	2010-12-16	Organon Nv	Tetrahydronaphthalen-2-ol derivatives
DE102010027016A1 (de)	2010-07-09	2012-01-12	Universitätsklinikum Jena	Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen
CN111067907A (zh) *	2018-10-18	2020-04-28	常州大学	孕激素在抑制血管内皮生长因子表达中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5254595A (en) *	1988-12-23	1993-10-19	Elf Sanofi	Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
US5552412A (en) *	1995-01-09	1996-09-03	Pfizer Inc	5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
TW432073B (en) *	1995-12-28	2001-05-01	Pfizer	Pyrazolopyridine compounds
HN1996000101A (es) *	1996-02-28	1997-06-26	Inc Pfizer	Terapia combinada para la osteoporosis

1999
- 1999-04-29 PA PA19998471201A patent/PA8471201A1/es unknown
- 1999-05-03 HN HN1999000063A patent/HN1999000063A/es unknown
- 1999-05-10 GT GT199900066A patent/GT199900066A/es unknown
- 1999-05-26 KR KR1020007014141A patent/KR20010052818A/ko not_active Ceased
- 1999-05-26 EA EA200001199A patent/EA200001199A1/ru unknown
- 1999-05-26 SK SK1892-2000A patent/SK18922000A3/sk unknown
- 1999-05-26 YU YU75800A patent/YU75800A/sh unknown
- 1999-05-26 OA OA1200000340A patent/OA11566A/en unknown
- 1999-05-26 PL PL99344982A patent/PL344982A1/xx unknown
- 1999-05-26 BR BR9911228-0A patent/BR9911228A/pt not_active IP Right Cessation
- 1999-05-26 CN CN99807345A patent/CN1305373A/zh active Pending
- 1999-05-26 ID IDW20002626A patent/ID26873A/id unknown
- 1999-05-26 IL IL13958899A patent/IL139588A0/xx unknown
- 1999-05-26 WO PCT/IB1999/000949 patent/WO1999065482A1/en not_active Ceased
- 1999-05-26 EP EP99919491A patent/EP1094808A1/en not_active Withdrawn
- 1999-05-26 HU HU0102759A patent/HUP0102759A3/hu unknown
- 1999-05-26 US US09/424,010 patent/US6132774A/en not_active Expired - Fee Related
- 1999-05-26 AU AU37259/99A patent/AU3725999A/en not_active Abandoned
- 1999-05-26 HR HR20000858A patent/HRP20000858A2/hr not_active Application Discontinuation
- 1999-05-26 TR TR2000/03567T patent/TR200003567T2/xx unknown
- 1999-05-26 UA UA2000127244A patent/UA60367C2/uk unknown
- 1999-05-26 NZ NZ508039A patent/NZ508039A/xx unknown
- 1999-05-26 CA CA002335078A patent/CA2335078A1/en not_active Abandoned
- 1999-05-26 JP JP2000554362A patent/JP2002518323A/ja active Pending
- 1999-06-10 AP APAP/P/1999/001580A patent/AP9901580A0/en unknown
- 1999-06-14 PE PE1999000526A patent/PE20000644A1/es not_active Application Discontinuation
- 1999-06-15 TN TNTNSN99119A patent/TNSN99119A1/fr unknown
- 1999-06-15 AR ARP990102846A patent/AR018867A1/es not_active Application Discontinuation
- 1999-06-15 ZA ZA9903972A patent/ZA993972B/xx unknown
- 1999-06-15 MA MA25623A patent/MA26649A1/fr unknown
- 1999-06-16 CO CO99037623A patent/CO5070584A1/es unknown
2000
- 2000-11-21 IS IS5719A patent/IS5719A/is unknown
- 2000-12-12 NO NO20006313A patent/NO20006313D0/no not_active Application Discontinuation
2001
- 2001-01-08 BG BG105125A patent/BG105125A/xx unknown

Also Published As

Publication number	Publication date
NZ508039A (en)	2003-03-28
AR018867A1 (es)	2001-12-12
IS5719A (is)	2000-11-21
CO5070584A1 (es)	2001-08-28
IL139588A0 (en)	2002-02-10
PA8471201A1 (es)	2000-09-29
CN1305373A (zh)	2001-07-25
BG105125A (en)	2001-11-30
EA200001199A1 (ru)	2001-04-23
PE20000644A1 (es)	2000-08-02
PL344982A1 (en)	2001-11-19
HRP20000858A2 (en)	2001-10-31
UA60367C2 (uk)	2003-10-15
WO1999065482A1 (en)	1999-12-23
US6132774A (en)	2000-10-17
CA2335078A1 (en)	1999-12-23
BR9911228A (pt)	2001-02-13
GT199900066A (es)	2000-10-31
ZA993972B (en)	2000-12-15
AU3725999A (en)	2000-01-05
SK18922000A3 (sk)	2001-09-11
KR20010052818A (ko)	2001-06-25
YU75800A (sh)	2003-12-31
JP2002518323A (ja)	2002-06-25
TR200003567T2 (tr)	2001-06-21
TNSN99119A1 (fr)	2005-11-10
HUP0102759A2 (hu)	2002-03-28
ID26873A (id)	2001-02-15
NO20006313L (no)	2000-12-12
HN1999000063A (es)	2000-01-12
AP9901580A0 (en)	1999-06-30
HUP0102759A3 (en)	2002-12-28
NO20006313D0 (no)	2000-12-12
EP1094808A1 (en)	2001-05-02
MA26649A1 (fr)	2004-12-20

Publication	Publication Date	Title
CA2262269C (en)	2003-07-15	Treatment of skeletal disorders
US6132774A (en)	2000-10-17	Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone
JP2001220357A (ja)	2001-08-14	Ｅｐ２／ｅｐ４レセプター選択アゴニストによる骨粗鬆症の治療
ZA200601214B (en)	2007-04-25	Composition and method for facilitating bone healing
US6284773B1 (en)	2001-09-04	Therapeutic combinations comprising a selective estrogen receptor modulator and prostaglandin E2
SK18912000A3 (sk)	2001-10-08	Terapeutické kombinácie obsahujúce selektívny modulátor receptorov estrogénu (serm) a sekretagogum rastového hormónu (ghs) nanie muskuloskeletárnej slabosti
EP1085867A1 (en)	2001-03-28	Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty
MXPA00012728A (en)	2001-07-31	Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone
HK1035666A (en)	2001-12-07	Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone
CZ20004679A3 (cs)	2001-05-16	Terapeutické kombinace (selektivních) modulátorů estrogenního receptoru (ŠERM) a prostředků podporujících sekreci růstového hormonu (GHS) pro léčbu muskuloskeletární fragility
MXPA99005564A (en)	2000-11-01	Therapeutic combinations comprising a selective estrogen receptor modulator and prostaglandin e2
CZ20004678A3 (cs)	2001-05-16	Terapeutické kombinace obsahující selektivní modulátor receptorů estrogenů a hormon příštítných tělísek
MXPA00012727A (en)	2001-07-31	Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty
HK1036414A (en)	2002-01-04	Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty
CZ20004680A3 (cs)	2001-06-13	Terapeutické kombinace (selektivních) modulátorů estrogenního receptorů (ŠERM) a prostředků podporujících sekreci růstového hormonu (GHS) pro léčbu muskuloskeletární fragility
McCoy	2001	Pharmacologic management of osteoporosis