OA11585A - Heterocyclic compounds as inhibitors of rotamase enzymes. - Google Patents

Heterocyclic compounds as inhibitors of rotamase enzymes. Download PDF

Info

Publication number: OA11585A
Authority: OA; OAPI
Prior art keywords: compound; alkyl; formula; benzoxazol; aryl
Prior art date: 1998-07-21

Application number

OA1200100023A

Other languages

English (en)

Inventor

Mark Ian Kemp

Michael John Palmer

Mark Allen Sanner

Martin James Wythes

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-21

Filing date

1999-06-28

Publication date

2004-07-26

1999-06-28 Application filed by Pfizer filed Critical Pfizer

2004-07-26 Publication of OA11585A publication Critical patent/OA11585A/en

Links

101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 title abstract description 11
102000004190 Enzymes Human genes 0.000 title abstract description 10
108090000790 Enzymes Proteins 0.000 title abstract description 10
239000003112 inhibitor Substances 0.000 title abstract description 7
101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 title abstract description 6
101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 title abstract description 6
101710103508 FK506-binding protein Proteins 0.000 title abstract description 5
101710104425 FK506-binding protein 2 Proteins 0.000 title abstract description 5
101710104423 FK506-binding protein 3 Proteins 0.000 title abstract description 5
101710104333 FK506-binding protein 4 Proteins 0.000 title abstract description 5
101710104342 FK506-binding protein 5 Proteins 0.000 title abstract description 5
101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 title abstract description 5
101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710114693 Outer membrane protein MIP Proteins 0.000 title abstract description 5
101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 title abstract description 5
101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 title abstract description 5
101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 title abstract description 5
101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 title abstract description 5
101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 title abstract description 5
101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 title abstract description 5
101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 title abstract description 5
101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 title abstract description 5
101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 title abstract description 5
101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 title abstract description 5
101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 title abstract description 5
101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 title abstract description 5
101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 title abstract description 5
101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 title abstract description 5
101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 title abstract description 5
101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 title abstract description 5
101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 5
102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 title 1
150000002391 heterocyclic compounds Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 204
125000003118 aryl group Chemical group 0.000 claims abstract description 47
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125000001424 substituent group Chemical group 0.000 claims abstract description 28
125000000217 alkyl group Chemical group 0.000 claims abstract description 26
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 20
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125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 17
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125000000623 heterocyclic group Chemical group 0.000 claims abstract description 8
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125000003342 alkenyl group Chemical group 0.000 claims abstract description 5
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238000000034 method Methods 0.000 claims description 70
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125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 35
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210000003169 central nervous system Anatomy 0.000 claims description 17
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238000006243 chemical reaction Methods 0.000 claims description 16
238000011282 treatment Methods 0.000 claims description 15
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
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125000001309 chloro group Chemical group Cl* 0.000 claims description 8
230000008569 process Effects 0.000 claims description 7
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 6
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MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 claims description 6
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208000005801 spondylosis Diseases 0.000 claims description 6
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125000000719 pyrrolidinyl group Chemical group 0.000 claims description 5
125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 claims description 5
125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 claims description 5
125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 4
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DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims description 4
125000001246 bromo group Chemical group Br* 0.000 claims description 4
230000008878 coupling Effects 0.000 claims description 4
238000010168 coupling process Methods 0.000 claims description 4
238000005859 coupling reaction Methods 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 4
125000001153 fluoro group Chemical group F* 0.000 claims description 4
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HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims description 4
201000000585 muscular atrophy Diseases 0.000 claims description 4
201000006938 muscular dystrophy Diseases 0.000 claims description 4
125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 4
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125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims description 4
238000006467 substitution reaction Methods 0.000 claims description 4
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 claims description 3
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125000002950 monocyclic group Chemical group 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
125000004076 pyridyl group Chemical group 0.000 claims description 3
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 3
125000001425 triazolyl group Chemical group 0.000 claims description 3
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101100258328 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) crc-2 gene Proteins 0.000 claims description 2
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238000005904 alkaline hydrolysis reaction Methods 0.000 claims 1
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Classifications

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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Chemical & Material Sciences (AREA)
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Engineering & Computer Science (AREA)
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Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
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Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
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Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

OA1200100023A 1998-07-21 1999-06-28 Heterocyclic compounds as inhibitors of rotamase enzymes. OA11585A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9815880.1A GB9815880D0 (en)	1998-07-21	1998-07-21	Heterocycles

Publications (1)

Publication Number	Publication Date
OA11585A true OA11585A (en)	2004-07-26

Family

ID=10835920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100023A OA11585A (en)	1998-07-21	1999-06-28	Heterocyclic compounds as inhibitors of rotamase enzymes.

Country Status (45)

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US (2)	US6372736B1 (is)
EP (1)	EP1100797B1 (is)
JP (2)	JP3795329B2 (is)
KR (2)	KR100468185B1 (is)
CN (3)	CN1511837A (is)
AP (1)	AP2001002046A0 (is)
AR (1)	AR019427A1 (is)
AT (1)	ATE233261T1 (is)
AU (1)	AU765925B2 (is)
BG (1)	BG105254A (is)
BR (1)	BR9912330A (is)
CA (1)	CA2338214C (is)
CO (1)	CO5080782A1 (is)
CR (1)	CR6073A (is)
DE (1)	DE69905582T2 (is)
DK (1)	DK1100797T3 (is)
DZ (1)	DZ2851A1 (is)
EA (1)	EA003513B1 (is)
EE (1)	EE200100044A (is)
ES (1)	ES2191484T3 (is)
GB (1)	GB9815880D0 (is)
GE (1)	GEP20033028B (is)
GT (1)	GT199900115A (is)
HK (1)	HK1039779A1 (is)
HN (1)	HN1999000106A (is)
HR (1)	HRP20010052A2 (is)
HU (1)	HUP0103413A3 (is)
ID (1)	ID26991A (is)
IL (1)	IL140244A0 (is)
IS (1)	IS5790A (is)
MA (1)	MA24936A1 (is)
MY (1)	MY118222A (is)
NO (1)	NO20010322L (is)
NZ (2)	NZ522270A (is)
OA (1)	OA11585A (is)
PA (1)	PA8478501A1 (is)
PE (1)	PE20001037A1 (is)
PL (1)	PL345734A1 (is)
SI (1)	SI1100797T1 (is)
SK (1)	SK772001A3 (is)
SV (1)	SV1999000102A (is)
TN (1)	TNSN99147A1 (is)
TR (1)	TR200100135T2 (is)
TW (1)	TWI229672B (is)
WO (1)	WO2000005232A1 (is)

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DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2010083199A1 (en) *	2009-01-19	2010-07-22	Abbott Laboratories	Benzthiazole inhibitors of poly(adp-ribose)polymerase
GB0905664D0 (en) *	2009-04-02	2009-05-13	Summit Corp Plc	Compounds for treatment of duchenne muscular dystrophy
JP6527851B2 (ja)	2013-03-12	2019-06-05	セルタクシス，インコーポレイテッド	ロイコトリエンａ４加水分解酵素を阻害する方法
EP2968264A4 (en)	2013-03-14	2016-11-02	Celtaxsys Inc	INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
AU2014239585B2 (en)	2013-03-14	2019-04-04	Celtaxsys, Inc.	Inhibitors of leukotriene A4 hydrolase
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1998
- 1998-07-21 GB GBGB9815880.1A patent/GB9815880D0/en not_active Ceased
1999
- 1999-06-28 CN CNA2003101239079A patent/CN1511837A/zh active Pending
- 1999-06-28 NZ NZ522270A patent/NZ522270A/en unknown
- 1999-06-28 HK HK02100933.8A patent/HK1039779A1/zh unknown
- 1999-06-28 SI SI9930246T patent/SI1100797T1/xx unknown
- 1999-06-28 OA OA1200100023A patent/OA11585A/en unknown
- 1999-06-28 CN CNA2004100399747A patent/CN1611499A/zh active Pending
- 1999-06-28 ID IDW20010155A patent/ID26991A/id unknown
- 1999-06-28 EP EP99963123A patent/EP1100797B1/en not_active Expired - Lifetime
- 1999-06-28 GE GEAP19995715A patent/GEP20033028B/en unknown
- 1999-06-28 KR KR10-2004-7007852A patent/KR100468185B1/ko not_active Expired - Fee Related
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- 1999-06-28 IL IL14024499A patent/IL140244A0/xx unknown
- 1999-06-28 NZ NZ508838A patent/NZ508838A/xx unknown
- 1999-06-28 CN CNB998089974A patent/CN1174978C/zh not_active Expired - Fee Related
- 1999-06-28 PL PL99345734A patent/PL345734A1/xx not_active Application Discontinuation
- 1999-06-28 EA EA200100052A patent/EA003513B1/ru not_active IP Right Cessation
- 1999-06-28 HR HR20010052A patent/HRP20010052A2/hr not_active Application Discontinuation
- 1999-06-28 HU HU0103413A patent/HUP0103413A3/hu unknown
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- 1999-06-28 AU AU42858/99A patent/AU765925B2/en not_active Ceased
- 1999-06-28 AT AT99963123T patent/ATE233261T1/de not_active IP Right Cessation
- 1999-06-28 TR TR2001/00135T patent/TR200100135T2/xx unknown
- 1999-06-28 CA CA002338214A patent/CA2338214C/en not_active Expired - Fee Related
- 1999-06-28 DE DE69905582T patent/DE69905582T2/de not_active Expired - Fee Related
- 1999-06-28 EE EEP200100044A patent/EE200100044A/xx unknown
- 1999-06-28 BR BR9912330-4A patent/BR9912330A/pt not_active Application Discontinuation
- 1999-06-28 JP JP2000561188A patent/JP3795329B2/ja not_active Expired - Fee Related
- 1999-06-28 KR KR10-2001-7000927A patent/KR100450008B1/ko not_active Expired - Fee Related
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- 1999-06-28 SK SK77-2001A patent/SK772001A3/sk unknown
- 1999-07-07 HN HN1999000106A patent/HN1999000106A/es unknown
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- 1999-07-19 AR ARP990103544A patent/AR019427A1/es unknown
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- 1999-07-20 MY MYPI99003048A patent/MY118222A/en unknown
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- 1999-07-20 PE PE1999000727A patent/PE20001037A1/es not_active Application Discontinuation
- 1999-07-20 PA PA19998478501A patent/PA8478501A1/es unknown
- 1999-07-20 MA MA25691A patent/MA24936A1/fr unknown
- 1999-07-21 US US09/358,107 patent/US6372736B1/en not_active Expired - Fee Related
2000
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2001
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- 2001-02-14 BG BG105254A patent/BG105254A/xx unknown
2002
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2003
- 2003-04-09 JP JP2003105099A patent/JP2004002374A/ja active Pending

Also Published As

Publication number	Publication date
HN1999000106A (es)	1999-11-11
EA003513B1 (ru)	2003-06-26
TNSN99147A1 (fr)	2005-11-10
TR200100135T2 (tr)	2001-06-21
PA8478501A1 (es)	2000-05-24
DK1100797T3 (da)	2003-04-22
HUP0103413A3 (en)	2002-10-28
JP3795329B2 (ja)	2006-07-12
EA200100052A1 (ru)	2001-06-25
BG105254A (en)	2001-10-31
IS5790A (is)	2000-12-22
CN1611499A (zh)	2005-05-04
EE200100044A (et)	2002-06-17
SK772001A3 (en)	2001-12-03
NO20010322L (no)	2001-03-15
GEP20033028B (en)	2003-07-25
NO20010322D0 (no)	2001-01-19
NZ508838A (en)	2002-12-20
KR100468185B1 (ko)	2005-01-26
KR20010071013A (ko)	2001-07-28
AR019427A1 (es)	2002-02-20
KR20040062640A (ko)	2004-07-07
HK1039779A1 (zh)	2002-05-10
PL345734A1 (en)	2002-01-02
CA2338214C (en)	2006-08-01
SI1100797T1 (en)	2003-06-30
DE69905582T2 (de)	2003-09-04
DZ2851A1 (fr)	2004-02-04
GT199900115A (es)	2001-01-10
GB9815880D0 (en)	1998-09-16
CO5080782A1 (es)	2001-09-25
CR6073A (es)	2004-04-29
US6372736B1 (en)	2002-04-16
KR100450008B1 (ko)	2004-09-24
US6562964B1 (en)	2003-05-13
CN1310718A (zh)	2001-08-29
HUP0103413A2 (hu)	2002-05-29
AU4285899A (en)	2000-02-14
HRP20010052A2 (en)	2001-12-31
BR9912330A (pt)	2001-04-17
ATE233261T1 (de)	2003-03-15
CN1174978C (zh)	2004-11-10
IL140244A0 (en)	2002-02-10
ID26991A (id)	2001-02-22
JP2002521382A (ja)	2002-07-16
CN1511837A (zh)	2004-07-14
AU765925B2 (en)	2003-10-02
MA24936A1 (fr)	2000-04-01
SV1999000102A (es)	2000-07-06
CA2338214A1 (en)	2000-02-03
AP2001002046A0 (en)	2001-03-31
EP1100797B1 (en)	2003-02-26
DE69905582D1 (de)	2003-04-03
EP1100797A1 (en)	2001-05-23
JP2004002374A (ja)	2004-01-08
NZ522270A (en)	2004-03-26
WO2000005232A1 (en)	2000-02-03
PE20001037A1 (es)	2000-10-11
ES2191484T3 (es)	2003-09-01
TWI229672B (en)	2005-03-21
MY118222A (en)	2004-09-30

Publication	Publication Date	Title
OA11585A (en)	2004-07-26	Heterocyclic compounds as inhibitors of rotamase enzymes.
EP0783500B1 (en)	1998-07-22	Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
EP0976732B1 (en)	2004-11-24	1,4-substituted cyclic amine derivatives
US5948793A (en)	1999-09-07	3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release
CA2873850C (en)	2016-10-04	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
US5914328A (en)	1999-06-22	Heterocyclic ether compounds useful in controlling neurotransmitter release
KR20070052693A (ko)	2007-05-22	폴리헤테로시클릭 화합물 및 대사성 글루타메이트 수용체길항제로서 이들의 용도
WO2002006234A1 (en)	2002-01-24	Sulfone derivatives, process for their production and use thereof
JPWO2004069824A1 (ja)	2006-05-25	ピラゾール誘導体
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