OA11675A - 2,4-Disubstituted triazine derivatives. - Google Patents

2,4-Disubstituted triazine derivatives. Download PDF

Info

Publication number: OA11675A
Authority: OA; OAPI
Prior art keywords: cyano; formula; substituted; compound; phenyl
Prior art date: 1998-11-10

Application number

OA1200100114A

Other languages

English (en)

Inventor

Bart De Corte

Marc Rene De Jonge

Jan Heeres

Paul Adriaan Jan Janssen

Robert W Kavash

Lucien Maria Henricus Koymans

Michael Joseph Kukla

Donald William Ludovici

Koen Jeanne Alfons Van Aken

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-10

Filing date

1999-11-04

Publication date

2005-01-12

1999-11-04 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-01-12 Publication of OA11675A publication Critical patent/OA11675A/en

Links

-1 2,4-Disubstituted triazine Chemical class 0.000 title claims abstract description 83
150000001875 compounds Chemical class 0.000 claims abstract description 97
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 34
241000725303 Human immunodeficiency virus Species 0.000 claims abstract description 22
150000001412 amines Chemical group 0.000 claims abstract description 17
238000011282 treatment Methods 0.000 claims abstract description 15
125000003118 aryl group Chemical group 0.000 claims abstract description 14
125000003373 pyrazinyl group Chemical group 0.000 claims abstract description 14
125000002098 pyridazinyl group Chemical group 0.000 claims abstract description 14
125000004076 pyridyl group Chemical group 0.000 claims abstract description 14
125000000714 pyrimidinyl group Chemical group 0.000 claims abstract description 14
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 13
239000003814 drug Substances 0.000 claims abstract description 12
208000015181 infectious disease Diseases 0.000 claims abstract description 11
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract description 10
125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract description 10
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 10
239000001257 hydrogen Substances 0.000 claims abstract description 10
125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 10
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 7
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims abstract description 7
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract description 6
238000004519 manufacturing process Methods 0.000 claims abstract description 6
125000004093 cyano group Chemical group *C#N 0.000 claims description 42
125000001424 substituent group Chemical group 0.000 claims description 28
125000005843 halogen group Chemical group 0.000 claims description 27
239000000203 mixture Substances 0.000 claims description 27
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 26
239000000543 intermediate Substances 0.000 claims description 24
239000002253 acid Substances 0.000 claims description 18
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 14
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
229910052799 carbon Inorganic materials 0.000 claims description 11
239000002585 base Substances 0.000 claims description 10
125000004429 atom Chemical group 0.000 claims description 7
239000003937 drug carrier Substances 0.000 claims description 7
239000012442 inert solvent Substances 0.000 claims description 7
229910052717 sulfur Inorganic materials 0.000 claims description 7
125000001931 aliphatic group Chemical group 0.000 claims description 6
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 6
125000001041 indolyl group Chemical group 0.000 claims description 6
125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims description 6
229910052760 oxygen Inorganic materials 0.000 claims description 5
125000000217 alkyl group Chemical group 0.000 claims description 4
231100000252 nontoxic Toxicity 0.000 claims description 4
230000003000 nontoxic effect Effects 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 4
125000001246 bromo group Chemical group Br* 0.000 claims description 3
125000001309 chloro group Chemical group Cl* 0.000 claims description 3
239000012458 free base Substances 0.000 claims description 2
SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 1
150000003839 salts Chemical class 0.000 abstract description 20
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 3
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-diisopropylethylamine Substances CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
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239000003513 alkali Substances 0.000 description 3
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239000003480 eluent Substances 0.000 description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
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125000000524 functional group Chemical group 0.000 description 3
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HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 3
FIDRAVVQGKNYQK-UHFFFAOYSA-N 1,2,3,4-tetrahydrotriazine Chemical compound C1NNNC=C1 FIDRAVVQGKNYQK-UHFFFAOYSA-N 0.000 description 2
JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 2
NAFOOGOADMAIJN-UHFFFAOYSA-N 2-anilino-2-phenylacetamide Chemical compound C=1C=CC=CC=1C(C(=O)N)NC1=CC=CC=C1 NAFOOGOADMAIJN-UHFFFAOYSA-N 0.000 description 2
208000030507 AIDS Diseases 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
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- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
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- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

OA1200100114A 1998-11-10 1999-11-04 2,4-Disubstituted triazine derivatives. OA11675A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10779998P	1998-11-10	1998-11-10
EP99203128		1999-09-24

Publications (1)

Publication Number	Publication Date
OA11675A true OA11675A (en)	2005-01-12

Family

ID=26153374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100114A OA11675A (en)	1998-11-10	1999-11-04	2,4-Disubstituted triazine derivatives.

Country Status (34)

Country	Link
US (2)	US6638932B1 (id)
EP (1)	EP1129079B1 (id)
JP (1)	JP2002529457A (id)
KR (1)	KR100620402B1 (id)
CN (1)	CN1207290C (id)
AP (1)	AP1636A (id)
AR (1)	AR021137A1 (id)
AT (1)	ATE315031T1 (id)
AU (1)	AU764472B2 (id)
BG (1)	BG65160B1 (id)
BR (1)	BR9915176A (id)
CA (1)	CA2351203C (id)
CY (1)	CY1105596T1 (id)
CZ (1)	CZ20011532A3 (id)
DE (1)	DE69929354T2 (id)
DK (1)	DK1129079T3 (id)
EA (1)	EA004501B1 (id)
EE (1)	EE200100253A (id)
ES (1)	ES2257081T3 (id)
HR (1)	HRP20010310A2 (id)
HU (1)	HUP0104395A3 (id)
ID (1)	ID28545A (id)
IL (2)	IL143024A0 (id)
MY (1)	MY126781A (id)
NO (1)	NO319788B1 (id)
NZ (1)	NZ510919A (id)
OA (1)	OA11675A (id)
PL (1)	PL196523B1 (id)
PT (1)	PT1129079E (id)
SI (1)	SI1129079T1 (id)
SK (1)	SK6022001A3 (id)
TR (1)	TR200101319T2 (id)
TW (1)	TW541305B (id)
WO (1)	WO2000027828A2 (id)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP1636A (en) *	1998-11-10	2006-07-17	Janssen Pharmaceutica Nv	2.4-disubstituted triazine derivatives.
DE19945982A1 (de)	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US7276510B2 (en)	2000-05-08	2007-10-02	Janssen Pharmaceutica, Inc.	HIV replication inhibitors
AR039540A1 (es) *	2002-05-13	2005-02-23	Tibotec Pharm Ltd	Compuestos microbicidas con contenido de pirimidina o triazina
CN102503903A (zh) *	2003-02-07	2012-06-20	詹森药业有限公司	抑制hiv的1,2,4-三嗪
RU2401833C2 (ru)	2004-08-10	2010-10-20	Янссен Фармацевтика Н.В.	Производные 1, 2, 4-триазин-6-она, ингибирующие вич
GB201204756D0 (en) *	2012-03-19	2012-05-02	Lewi Paulus J	Triazines with suitable spacers for treatment and/or prevention of HIV infections

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Publication number	Priority date	Publication date	Assignee	Title
JPS4927592B1 (id) *	1970-05-13	1974-07-18
BE754242A (fr)	1970-07-15	1971-02-01	Geigy Ag J R	Diamino-s-triazines et dinitro-s-triazines
US4650867A (en) *	1985-03-26	1987-03-17	Ciba-Geigy Corporation	Process for the preparation of 2,4,6-tris(aminophenylamino)triazines
JPH02308248A (ja) *	1989-05-24	1990-12-21	Fuji Photo Film Co Ltd	アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
CA2174080A1 (en)	1993-10-12	1995-04-20	Paul Edward Aldrich	1n-alkyl-n-arylpyrimidinamines and derivatives thereof
US5691364A (en) *	1995-03-10	1997-11-25	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
NO311614B1 (no)	1996-10-01	2001-12-17	Janssen Pharmaceutica Nv	Substituerte diamino-1,3,5-triazinderivater
JP2002503662A (ja) *	1998-02-17	2002-02-05	テュラリクインコーポレイテッド	抗ウイルス性ピリミジン誘導体
AP1636A (en) *	1998-11-10	2006-07-17	Janssen Pharmaceutica Nv	2.4-disubstituted triazine derivatives.

1999
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- 1999-11-04 IL IL14302499A patent/IL143024A0/xx active IP Right Grant
- 1999-11-04 CZ CZ20011532A patent/CZ20011532A3/cs unknown
- 1999-11-04 HR HR20010310A patent/HRP20010310A2/hr not_active Application Discontinuation
- 1999-11-04 KR KR1020017003574A patent/KR100620402B1/ko not_active Expired - Fee Related
- 1999-11-04 AT AT99953980T patent/ATE315031T1/de not_active IP Right Cessation
- 1999-11-04 TR TR2001/01319T patent/TR200101319T2/xx unknown
- 1999-11-04 DE DE69929354T patent/DE69929354T2/de not_active Expired - Fee Related
- 1999-11-04 US US09/831,808 patent/US6638932B1/en not_active Expired - Fee Related
- 1999-11-04 HU HU0104395A patent/HUP0104395A3/hu unknown
- 1999-11-04 CN CNB998130478A patent/CN1207290C/zh not_active Expired - Fee Related
- 1999-11-04 BR BR9915176-6A patent/BR9915176A/pt not_active IP Right Cessation
- 1999-11-04 OA OA1200100114A patent/OA11675A/en unknown
- 1999-11-04 EE EEP200100253A patent/EE200100253A/xx unknown
- 1999-11-04 CA CA002351203A patent/CA2351203C/en not_active Expired - Fee Related
- 1999-11-04 NZ NZ510919A patent/NZ510919A/en unknown
- 1999-11-04 WO PCT/EP1999/008688 patent/WO2000027828A2/en not_active Ceased
- 1999-11-04 AU AU10462/00A patent/AU764472B2/en not_active Ceased
- 1999-11-04 EP EP99953980A patent/EP1129079B1/en not_active Expired - Lifetime
- 1999-11-04 ES ES99953980T patent/ES2257081T3/es not_active Expired - Lifetime
- 1999-11-04 DK DK99953980T patent/DK1129079T3/da active
- 1999-11-04 PT PT99953980T patent/PT1129079E/pt unknown
- 1999-11-04 SI SI9930886T patent/SI1129079T1/sl unknown
- 1999-11-04 ID IDW00200101017A patent/ID28545A/id unknown
- 1999-11-04 JP JP2000581008A patent/JP2002529457A/ja active Pending
- 1999-11-04 PL PL348145A patent/PL196523B1/pl not_active IP Right Cessation
- 1999-11-04 EA EA200100534A patent/EA004501B1/ru not_active IP Right Cessation
- 1999-11-04 SK SK602-2001A patent/SK6022001A3/sk unknown
- 1999-11-05 MY MYPI99004801A patent/MY126781A/en unknown
- 1999-11-09 AR ARP990105681A patent/AR021137A1/es active IP Right Grant
- 1999-12-23 TW TW088119615A patent/TW541305B/zh not_active IP Right Cessation
2001
- 2001-04-06 BG BG105419A patent/BG65160B1/bg unknown
- 2001-04-19 NO NO20011934A patent/NO319788B1/no unknown
- 2001-05-07 IL IL143024A patent/IL143024A/en not_active IP Right Cessation
2003
- 2003-08-27 US US10/649,017 patent/US7015221B2/en not_active Expired - Fee Related
2006
- 2006-03-31 CY CY20061100457T patent/CY1105596T1/el unknown

Also Published As

Publication number	Publication date
EE200100253A (et)	2002-12-16
DK1129079T3 (da)	2006-05-15
EA004501B1 (ru)	2004-04-29
AP1636A (en)	2006-07-17
ATE315031T1 (de)	2006-02-15
CN1325387A (zh)	2001-12-05
MY126781A (en)	2006-10-31
ES2257081T3 (es)	2006-07-16
WO2000027828A3 (en)	2000-09-21
NO20011934D0 (no)	2001-04-19
CA2351203C (en)	2009-03-24
KR100620402B1 (ko)	2006-09-13
TR200101319T2 (tr)	2001-10-22
HUP0104395A3 (en)	2003-02-28
CY1105596T1 (el)	2010-07-28
US7015221B2 (en)	2006-03-21
BR9915176A (pt)	2001-08-14
TW541305B (en)	2003-07-11
EP1129079B1 (en)	2006-01-04
AR021137A1 (es)	2002-06-12
US20050277641A1 (en)	2005-12-15
NZ510919A (en)	2003-11-28
US6638932B1 (en)	2003-10-28
AU1046200A (en)	2000-05-29
SI1129079T1 (sl)	2006-06-30
PL196523B1 (pl)	2008-01-31
NO319788B1 (no)	2005-09-12
NO20011934L (no)	2001-04-19
HK1038232A1 (en)	2002-03-08
DE69929354T2 (de)	2006-09-14
CA2351203A1 (en)	2000-05-18
CZ20011532A3 (cs)	2001-10-17
HUP0104395A2 (hu)	2002-04-29
ID28545A (id)	2001-05-31
EA200100534A1 (ru)	2001-10-22
BG65160B1 (bg)	2007-04-30
IL143024A (en)	2006-06-11
HRP20010310A2 (en)	2002-06-30
PT1129079E (pt)	2006-05-31
JP2002529457A (ja)	2002-09-10
SK6022001A3 (en)	2002-01-07
EP1129079A2 (en)	2001-09-05
CN1207290C (zh)	2005-06-22
WO2000027828A2 (en)	2000-05-18
KR20010075234A (ko)	2001-08-09
DE69929354D1 (de)	2006-03-30
BG105419A (en)	2001-11-30
PL348145A1 (en)	2002-05-06
IL143024A0 (en)	2002-04-21
AU764472B2 (en)	2003-08-21

Publication	Publication Date	Title
EP1270560B1 (en)	2010-01-13	Hiv replication inhibiting pyrimidines
OA12029A (en)	2006-04-28	Antiviral compositions.
AU764472B2 (en)	2003-08-21	2,4-disubstituted triazine derivatives
HK1038232B (en)	2006-03-24	2,4-disubstituted triazine derivatives with anti hiv activity
MXPA01003644A (en)	2002-06-05	2,4-disubstituted triazine derivatives
ZA200103768B (en)	2002-06-10	2,4-Disubstituted triazine derivatives.
HK1025330B (en)	2003-06-13	Hiv replication inhibiting pyrimidines