OA11722A - Methods and compositions for restoring conformational stability of a protein of the p53 family. - Google Patents
Methods and compositions for restoring conformational stability of a protein of the p53 family. Download PDFInfo
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- OA11722A OA11722A OA1200100136A OA1200100136A OA11722A OA 11722 A OA11722 A OA 11722A OA 1200100136 A OA1200100136 A OA 1200100136A OA 1200100136 A OA1200100136 A OA 1200100136A OA 11722 A OA11722 A OA 11722A
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- OAPI
- Prior art keywords
- alkyl
- hydroxy
- protein
- aryl
- phenyl
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
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| WO2004034013A2 (en) * | 2002-05-06 | 2004-04-22 | Colorado State University Research Foundation | Genotoxicity analysis |
| AU2003258662A1 (en) * | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4-amino-quinazolines as anti cancer agents |
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| US6970791B1 (en) * | 2003-05-23 | 2005-11-29 | Verachem, Llc | Tailored user interfaces for molecular modeling |
| WO2005003100A2 (en) * | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| EP1687275A4 (en) * | 2003-11-21 | 2009-01-14 | Merck & Co Inc | PYRIDINE-4-YLAMINE COMPOUNDS SUITABLE FOR THE TREATMENT OF NEUROPATHIC PAIN |
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| KR100809890B1 (ko) * | 2003-12-24 | 2008-03-06 | 가부시키가이샤 로코모젠 | 암 억제 방법 |
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| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| US7790474B1 (en) | 2005-07-15 | 2010-09-07 | Schering Corporation | p53 modulators |
| MX2008000744A (es) * | 2005-07-15 | 2008-03-10 | Schering Corp | Derivados de quinazolina utiles en el tratamiento del cancer. |
| US8232298B2 (en) | 2006-03-22 | 2012-07-31 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between MDM2 and P53 |
| ATE470665T1 (de) | 2006-03-22 | 2010-06-15 | Janssen Pharmaceutica Nv | Cycloalkylaminderivate als inhibitoren der wechselwirkung zwischen mdm2 und p53 |
| NZ546477A (en) * | 2006-04-07 | 2009-04-30 | Auckland Uniservices Ltd | 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy |
| CA2657246C (en) | 2006-07-10 | 2017-10-31 | Donald Landry | Anti-cocaine compositions and treatment |
| WO2008155441A1 (en) * | 2007-06-20 | 2008-12-24 | Marikki Laiho | Activators and therapeutic applications thereof |
| CN101903038A (zh) | 2007-07-10 | 2010-12-01 | 纽约市哥伦比亚大学信托人 | 蛋白的热稳定化 |
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| MX2011008195A (es) | 2009-02-04 | 2011-09-06 | Janssen Pharmaceutica Nv | Derivados de indol como agentes anticancer. |
| US20130102627A1 (en) * | 2010-04-09 | 2013-04-25 | The Brigham And Women's Hospital, Inc. | Acridines As Inhibitors Of Haspin And DYRK Kinases |
| US9221760B2 (en) | 2011-05-09 | 2015-12-29 | Van Andel Research Institute | Autophagy inhibitors |
| US9187439B2 (en) | 2011-09-21 | 2015-11-17 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
| CN102660257B (zh) * | 2012-05-22 | 2013-11-27 | 南京邮电大学 | 吩噻嗪基喹唑啉类荧光离子探针及其应用 |
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| CN105399670B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 一种苯并(c)吖啶酰胺基硫脲衍生物及其制备方法和用途 |
| CN105418501B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 7‑对甲氧苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途 |
| CN105399671B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 7‑对甲苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途 |
| AU2017214733B2 (en) * | 2016-02-04 | 2022-09-29 | Yeda Research And Development Co. Ltd. | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53 |
| IL286839B (en) * | 2016-02-19 | 2022-08-01 | Pmv Pharmaceuticals Inc | Propyne-indole compounds |
| CN109694358B (zh) * | 2019-01-23 | 2022-02-08 | 广西师范大学 | 2-对硝苯乙烯基-4-取代氨基喹唑啉衍生物及其制备方法和应用 |
| SMT202500339T1 (it) | 2019-09-23 | 2025-11-10 | Pmv Pharmaceuticals Inc | Metodi e composti per ripristinare la funzione di p53 mutante |
| US12570645B2 (en) | 2020-06-22 | 2026-03-10 | Pmv Pharmaceuticals, Inc. | Uses of p53 x-ray co-crystal structures |
| US20210405056A1 (en) * | 2020-06-24 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | Methods for detecting mutant p53 function |
| WO2021262484A1 (en) | 2020-06-24 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | Combination therapy for treatment of cancer |
| GB202111035D0 (en) * | 2021-07-30 | 2021-09-15 | Vestlandets Innovasjonsselskap As | Therapy |
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| GB9224784D0 (en) * | 1992-11-26 | 1993-01-13 | Univ Dundee | Cellular protein |
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| US6270954B1 (en) * | 1996-04-10 | 2001-08-07 | The Regents Of The University Of California | Correction of genetic defects using chemical chaperones |
| US5900360A (en) * | 1996-04-10 | 1999-05-04 | Welch; William J. | Correction of genetic defects using chemical chaperones |
| DE19624154A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ringannelierte Dihydropyrane, Verfahren zur Herstellung sowie deren Verwendung |
| US5932613A (en) * | 1996-07-03 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Anticancer agents |
| US5958892A (en) * | 1996-07-30 | 1999-09-28 | Board Of Regents, The University Of Texas System | 2-methoxyestradiol-induced apoptosis in cancer cells |
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| US6387673B1 (en) * | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
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| US6380395B1 (en) * | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
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| US5981564A (en) * | 1998-07-01 | 1999-11-09 | Universite Laval | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof |
| DE69921151T2 (de) * | 1998-08-12 | 2005-06-02 | Daiichi Pure Chemicals Co. Ltd. | Fluorszierende marker |
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| US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| FR2788696B1 (fr) * | 1999-01-26 | 2004-03-05 | Synthelabo | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
| AU4564200A (en) * | 1999-04-29 | 2000-11-17 | Aventis Pharma S.A. | Method for treating cancer using camptothecin derivatives and 5-fluorouracil |
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| WO2001028550A1 (en) * | 1999-10-15 | 2001-04-26 | Mayo Foundation For Medical Education And Research | Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia |
| US6372785B1 (en) * | 2000-05-04 | 2002-04-16 | Keith Chan, President Globoasia, Llc | Synthesis of 1,8-dichloro-anthracene analogues and pharmaceutical compositions based thereon |
| US6384049B1 (en) * | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
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| US6391916B1 (en) * | 2000-07-21 | 2002-05-21 | The Hong Kong University Of Science And Technology | Enediyne derivatives |
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Also Published As
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| ZA200104210B (en) | 2003-02-24 |
| TR200101549T2 (tr) | 2001-11-21 |
| ID29061A (id) | 2001-07-26 |
| YU35401A (sh) | 2005-07-19 |
| EA003326B1 (ru) | 2003-04-24 |
| NO20012737D0 (no) | 2001-06-01 |
| HK1041644A1 (zh) | 2002-07-19 |
| BG105599A (en) | 2002-02-28 |
| NO20012737L (no) | 2001-07-09 |
| AU1290700A (en) | 2000-06-19 |
| US20020048271A1 (en) | 2002-04-25 |
| AP2001002153A0 (en) | 2001-06-30 |
| KR20010086073A (ko) | 2001-09-07 |
| WO2000032175A3 (en) | 2000-08-03 |
| JP2002531396A (ja) | 2002-09-24 |
| EA200100502A1 (ru) | 2001-12-24 |
| PL348310A1 (en) | 2002-05-20 |
| HUP0201215A2 (en) | 2002-08-28 |
| WO2000032175A2 (en) | 2000-06-08 |
| BR9915940A (pt) | 2001-09-11 |
| IL143094A0 (en) | 2002-04-21 |
| JP2006166920A (ja) | 2006-06-29 |
| CN1329493A (zh) | 2002-01-02 |
| HRP20010414A2 (en) | 2002-06-30 |
| IS5943A (is) | 2001-05-15 |
| EP1137418A2 (en) | 2001-10-04 |
| CA2350597A1 (en) | 2000-06-08 |
| EE200100302A (et) | 2002-08-15 |
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