OA11875A - 1-Amino triazolo Ä4,3-aÜquinazoline-5-ones et/ou- 5-thiones inhibitrices de phosphodiesterases IV. - Google Patents

1-Amino triazolo Ä4,3-aÜquinazoline-5-ones et/ou- 5-thiones inhibitrices de phosphodiesterases IV. Download PDF

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Publication number: OA11875A
Authority: OA; OAPI
Prior art keywords: triazolo; quinazolin; bromo; pyrrolidin; azepan
Prior art date: 1999-04-28

Application number

OA1200100282A

Other languages

English (en)

French (fr)

Inventor

Charles Andrianjara

Francine Breuzard

Bernard Gaudilliere

Remi Lavalette

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-28

Filing date

2000-04-28

Publication date

2006-03-29

2000-04-28 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-03-29 Publication of OA11875A publication Critical patent/OA11875A/fr

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108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title claims description 19
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title claims description 19
150000001875 compounds Chemical class 0.000 claims abstract description 279
238000000034 method Methods 0.000 claims abstract description 63
239000000203 mixture Substances 0.000 claims abstract description 45
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 41
150000003839 salts Chemical class 0.000 claims abstract description 9
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125000000217 alkyl group Chemical group 0.000 claims description 131
ATQUABCIJINPMX-UHFFFAOYSA-N quinazolin-5-ol Chemical compound C1=NC=C2C(O)=CC=CC2=N1 ATQUABCIJINPMX-UHFFFAOYSA-N 0.000 claims description 104
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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 54
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RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 45
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives

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OA1200100282A 1999-04-28 2000-04-28 1-Amino triazolo Ä4,3-aÜquinazoline-5-ones et/ou- 5-thiones inhibitrices de phosphodiesterases IV. OA11875A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9905398A FR2792938B1 (fr)	1999-04-28	1999-04-28	NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV

Publications (1)

Publication Number	Publication Date
OA11875A true OA11875A (en)	2006-03-29

Family

ID=9544983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100282A OA11875A (en)	1999-04-28	2000-04-28	1-Amino triazolo Ä4,3-aÜquinazoline-5-ones et/ou- 5-thiones inhibitrices de phosphodiesterases IV.

Country Status (34)

Country	Link
US (1)	US6828315B1 (de)
EP (1)	EP1177195B1 (de)
JP (1)	JP2002543199A (de)
KR (1)	KR20020008166A (de)
CN (1)	CN1352644A (de)
AP (1)	AP2001002309A0 (de)
AT (1)	ATE234840T1 (de)
AU (1)	AU4411500A (de)
BG (1)	BG106026A (de)
BR (1)	BR0010072A (de)
CA (1)	CA2388658A1 (de)
DE (1)	DE60001735T2 (de)
DK (1)	DK1177195T3 (de)
DZ (1)	DZ3154A1 (de)
EA (1)	EA004373B1 (de)
EE (1)	EE200100566A (de)
ES (1)	ES2194779T3 (de)
FR (1)	FR2792938B1 (de)
HK (1)	HK1044938B (de)
HR (1)	HRP20010794B1 (de)
HU (1)	HUP0202656A3 (de)
IL (1)	IL146178A0 (de)
IS (1)	IS6114A (de)
MA (1)	MA27343A1 (de)
MX (1)	MXPA01010888A (de)
NO (1)	NO20015235L (de)
OA (1)	OA11875A (de)
PL (1)	PL351951A1 (de)
PT (1)	PT1177195E (de)
SK (1)	SK15322001A3 (de)
TR (1)	TR200103099T2 (de)
WO (1)	WO2000066584A1 (de)
YU (1)	YU76401A (de)
ZA (1)	ZA200108847B (de)

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EP1188438A1 (de) *	2000-09-15	2002-03-20	Warner-Lambert Company	Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
PA8539501A1 (es) *	2001-02-14	2002-09-30	Warner Lambert Co	Compuestos triazolo como inhibidores de mmp
JP4510384B2 (ja) *	2001-05-23	2010-07-21	田辺三菱製薬株式会社	骨折治癒促進用組成物
EP1285922A1 (de)	2001-08-13	2003-02-26	Warner-Lambert Company	1-alkyl oder 1-cycloalkyltriazolo[4,3-a]chinazolin-5-one als phosphodiesterase Inhibitoren
FR2832711B1 (fr) *	2001-11-26	2004-01-30	Warner Lambert Co	Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
DE10229778A1 (de) *	2002-07-03	2004-01-29	Bayer Ag	Neue Verwendung von Imidazotriazinonen
AU2003277562B2 (en) *	2002-11-06	2009-03-26	Aska Pharmaceutical Co., Ltd.	Pyrazolonaphthyridine derivative
KR101026819B1 (ko) *	2003-01-09	2011-04-04	아스테라스 세이야쿠 가부시키가이샤	피롤로피리다진 유도체
BRPI0510166A (pt) *	2004-04-23	2007-10-02	Celgene Corp	método para tratar, prevenir ou controlar hipertensão pulmonar, e, composição farmacêutica
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
JP2010505811A (ja)	2006-10-04	2010-02-25	ファイザー・プロダクツ・インク	カルシウム受容体アンタゴニストとしてのピリド［４，３−ｄ］ピリミジン−４（３Ｈ）−オン誘導体
WO2009013286A1 (en) *	2007-07-24	2009-01-29	Novartis Ag	Organic compounds
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
CN103224498B (zh) *	2013-05-07	2015-10-28	陈定奔	两种唑并喹唑啉酮稠杂环的新合成方法

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US3865824A (en) *	1972-03-07	1975-02-11	Icn Pharmaceuticals	2-Aryl-7-substituted pyrazolo {8 1,5{i a{b {9 1,3,5-triazines
US3850932A (en) *	1973-06-28	1974-11-26	Sandoz Ag	5-(2-carboxy and 2-carboalkoxy-phenylamino)-1,2,4-triazolo-quinazolines
IL66835A (en) *	1981-09-24	1988-05-31	Roussel Uclaf	1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them
JPS6028979A (ja) *	1983-07-14	1985-02-14	Dai Ichi Seiyaku Co Ltd	イミダゾキナゾリン類化合物
DE69525978T2 (de) *	1995-06-06	2002-12-19	Pfizer	Trizyclische 5,6-dihydro-9h-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-alpha)pyridine
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1999
- 1999-04-28 FR FR9905398A patent/FR2792938B1/fr not_active Expired - Lifetime
2000
- 2000-04-28 US US09/980,540 patent/US6828315B1/en not_active Expired - Fee Related
- 2000-04-28 PT PT00967407T patent/PT1177195E/pt unknown
- 2000-04-28 AU AU44115/00A patent/AU4411500A/en not_active Abandoned
- 2000-04-28 TR TR2001/03099T patent/TR200103099T2/xx unknown
- 2000-04-28 EA EA200100994A patent/EA004373B1/ru not_active IP Right Cessation
- 2000-04-28 DE DE60001735T patent/DE60001735T2/de not_active Expired - Fee Related
- 2000-04-28 HU HU0202656A patent/HUP0202656A3/hu unknown
- 2000-04-28 AT AT00967407T patent/ATE234840T1/de not_active IP Right Cessation
- 2000-04-28 OA OA1200100282A patent/OA11875A/fr unknown
- 2000-04-28 YU YU76401A patent/YU76401A/sh unknown
- 2000-04-28 JP JP2000615614A patent/JP2002543199A/ja active Pending
- 2000-04-28 HK HK02105712.4A patent/HK1044938B/zh not_active IP Right Cessation
- 2000-04-28 ES ES00967407T patent/ES2194779T3/es not_active Expired - Lifetime
- 2000-04-28 KR KR1020017013825A patent/KR20020008166A/ko not_active Withdrawn
- 2000-04-28 EE EEP200100566A patent/EE200100566A/xx unknown
- 2000-04-28 AP APAP/P/2001/002309A patent/AP2001002309A0/en unknown
- 2000-04-28 WO PCT/FR2000/001174 patent/WO2000066584A1/fr not_active Ceased
- 2000-04-28 IL IL14617800A patent/IL146178A0/xx unknown
- 2000-04-28 HR HR20010794A patent/HRP20010794B1/xx not_active IP Right Cessation
- 2000-04-28 CN CN00808153A patent/CN1352644A/zh active Pending
- 2000-04-28 EP EP00967407A patent/EP1177195B1/de not_active Expired - Lifetime
- 2000-04-28 MX MXPA01010888A patent/MXPA01010888A/es active IP Right Grant
- 2000-04-28 PL PL00351951A patent/PL351951A1/xx not_active Application Discontinuation
- 2000-04-28 SK SK1532-2001A patent/SK15322001A3/sk unknown
- 2000-04-28 DK DK00967407T patent/DK1177195T3/da active
- 2000-04-28 CA CA002388658A patent/CA2388658A1/en not_active Abandoned
- 2000-04-28 BR BR0010072-2A patent/BR0010072A/pt not_active IP Right Cessation
- 2000-04-28 DZ DZ003154A patent/DZ3154A1/xx active
2001
- 2001-10-18 BG BG106026A patent/BG106026A/bg unknown
- 2001-10-19 IS IS6114A patent/IS6114A/is unknown
- 2001-10-23 MA MA26381A patent/MA27343A1/fr unknown
- 2001-10-26 NO NO20015235A patent/NO20015235L/no not_active Application Discontinuation
- 2001-10-26 ZA ZA200108847A patent/ZA200108847B/xx unknown

Also Published As

Publication number	Publication date
BG106026A (bg)	2002-05-31
CN1352644A (zh)	2002-06-05
HUP0202656A3 (en)	2004-12-28
ES2194779T3 (es)	2003-12-01
HRP20010794A2 (en)	2003-04-30
ATE234840T1 (de)	2003-04-15
HK1044938A1 (en)	2002-11-08
EA004373B1 (ru)	2004-04-29
EP1177195B1 (de)	2003-03-19
WO2000066584B1 (fr)	2001-02-15
EE200100566A (et)	2003-02-17
EP1177195A1 (de)	2002-02-06
WO2000066584A1 (fr)	2000-11-09
HUP0202656A2 (hu)	2002-12-28
DE60001735D1 (de)	2003-04-24
IS6114A (is)	2001-10-19
NO20015235D0 (no)	2001-10-26
PT1177195E (pt)	2003-07-31
ZA200108847B (en)	2002-11-27
FR2792938A1 (fr)	2000-11-03
KR20020008166A (ko)	2002-01-29
YU76401A (sh)	2004-07-15
CA2388658A1 (en)	2000-11-09
JP2002543199A (ja)	2002-12-17
EA200100994A1 (ru)	2002-06-27
HRP20010794B1 (en)	2004-06-30
DE60001735T2 (de)	2004-02-05
BR0010072A (pt)	2002-02-05
HK1044938B (zh)	2003-12-24
MXPA01010888A (es)	2003-06-24
FR2792938B1 (fr)	2001-07-06
IL146178A0 (en)	2002-07-25
DK1177195T3 (da)	2003-07-14
AU4411500A (en)	2000-11-17
NO20015235L (no)	2001-12-21
DZ3154A1 (fr)	2000-11-09
SK15322001A3 (sk)	2002-11-06
AP2001002309A0 (en)	2001-12-31
PL351951A1 (en)	2003-07-14
MA27343A1 (fr)	2005-06-01
US6828315B1 (en)	2004-12-07
TR200103099T2 (tr)	2002-12-23

Publication	Publication Date	Title
EP1177195B1 (de)	2003-03-19	1-aminotriazolo 4,3-a chinazolin-5-one und/oder -thione inhibitoren von phosphodiesterasen iv
US6747035B2 (en)	2004-06-08	1-alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
EP1086105B1 (de)	2006-03-01	Annellierte azepinone als inhibitoren cyclin-abhängiger kinasen
JP2005529843A (ja)	2005-10-06	トリアゾロ［４，３−ａ］ピリド［２，３−ｄ］ピリミジン−５−オン、それらを含有する組成物、その製造方法及び使用
EP1556382B1 (de)	2008-05-28	3-phenylpyridoindolderivate, ihre herstellung und verwendung
TW201300390A (zh)	2013-01-01	喹□啉化合物
EP1590355A1 (de)	2005-11-02	Neue tricyclische azepinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
EP1092715B1 (de)	2005-03-23	Cyanoindol-Derivate als Inhibitoren der Wiederaufnahme von Serotonin, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
CZ20022222A3 (cs)	2003-05-14	Nové substituované pyrazolo [4,3-e] diazepiny, farmaceutické kompozice obsahující tyto diazepiny, jejich použití jako léčiva a způsoby jejich přípravy
HUT63423A (en)	1993-08-30	Process for producing tetracyclic diimidazo- and imidazopyrimido quinazoline derivatives and pharmaceutical compositions comprising same
JP2001512124A (ja)	2001-08-21	新規な２，３−ベンゾジアゼピン誘導体
KR100845749B1 (ko)	2008-07-11	트리시클, 이의 제조 및 약학적 제제로서의 용도
US6962912B2 (en)	2005-11-08	Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them
LU84775A1 (fr)	1983-11-17	Nouveaux derives cycloaliphatiques condenses de pyrido(1,2-a)pyrimidines substituees
HK1083844A1 (en)	2006-07-14	N- [3-(3-substituted-pyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-sulfonamides, and compositions, and methods related thereto
HK1083844B (en)	2009-06-19	N- [3-(3-substituted-pyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-sulfonamides, and compositions, and methods related thereto