OA12245A - Benzoamide piperidine compounds as substance P antagonists. - Google Patents

Info

Publication number

OA12245A

OA12245A OA1200200312A OA1200200312A OA12245A OA 12245 A OA12245 A OA 12245A OA 1200200312 A OA1200200312 A OA 1200200312A OA 1200200312 A OA1200200312 A OA 1200200312A OA 12245 A OA12245 A OA 12245A

Authority

OA

OAPI

Prior art keywords

methyl

phenyl

methoxy

piperidin

ylamino

Prior art date

2000-04-10

Links

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• NXUSCSCBRVCRCN-UHFFFAOYSA-N benzamide;piperidine Chemical class C1CCNCC1.NC(=O)C1=CC=CC=C1 NXUSCSCBRVCRCN-UHFFFAOYSA-N 0.000 title abstract description 3
• 239000003890 substance P antagonist Substances 0.000 title description 3
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• -1 2-phenyl-piperidin-3-ylamino Chemical group 0.000 claims description 183
• 125000001153 fluoro group Chemical group F* 0.000 claims description 138
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 95
• 125000001424 substituent group Chemical group 0.000 claims description 93
• 125000000217 alkyl group Chemical group 0.000 claims description 92
• 239000000203 mixture Substances 0.000 claims description 83
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 80
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• 239000001257 hydrogen Substances 0.000 claims description 61
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• 125000005843 halogen group Chemical group 0.000 claims description 55
• 125000000623 heterocyclic group Chemical group 0.000 claims description 50
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 48
• 229910052799 carbon Inorganic materials 0.000 claims description 45
• 125000003545 alkoxy group Chemical group 0.000 claims description 42
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 37
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• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
• 125000004429 atom Chemical group 0.000 claims description 16
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