OA12252A - Antihypertensive agents and use. - Google Patents

Antihypertensive agents and use. Download PDF

Info

Publication number: OA12252A
Authority: OA; OAPI
Prior art keywords: antihypertensive; sait; pharmaceutically acceptable; pharmaceutical composition; quinapril
Prior art date: 2000-04-26

Application number

OA1200200325A

Other languages

English (en)

Inventor

Bruce Jeffrey Auerbach

Karen Diane Hitchcock

Michael John Ryan

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-26

Filing date

2001-03-22

Publication date

2006-05-11

2001-03-22 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-05-11 Publication of OA12252A publication Critical patent/OA12252A/en

Links

239000002220 antihypertensive agent Substances 0.000 title claims abstract description 63
229940030600 antihypertensive agent Drugs 0.000 title claims abstract description 62
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 25
206010020772 Hypertension Diseases 0.000 claims abstract description 22
150000003839 salts Chemical class 0.000 claims abstract description 20
239000000203 mixture Substances 0.000 claims abstract description 19
125000000217 alkyl group Chemical group 0.000 claims abstract description 11
125000003342 alkenyl group Chemical group 0.000 claims abstract description 8
125000000304 alkynyl group Chemical group 0.000 claims abstract description 5
125000000896 monocarboxylic acid group Chemical group 0.000 claims abstract description 4
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150000003536 tetrazoles Chemical class 0.000 claims abstract description 3
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229960005141 piperazine Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229960005483 polythiazide Drugs 0.000 description 1
229920000046 polythiazide Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
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HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
238000009790 rate-determining step (RDS) Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000029865 regulation of blood pressure Effects 0.000 description 1
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229920006395 saturated elastomer Polymers 0.000 description 1
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150000004760 silicates Chemical class 0.000 description 1
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RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
229960002909 spirapril Drugs 0.000 description 1
108700035424 spirapril Proteins 0.000 description 1
HRWCVUIFMSZDJS-SZMVWBNQSA-N spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 description 1
229950006297 spiraprilat Drugs 0.000 description 1
108700006892 spiraprilat Proteins 0.000 description 1
FMMDBLMCSDRUPA-BPUTZDHNSA-N spiraprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)C(O)=O)CC1=CC=CC=C1 FMMDBLMCSDRUPA-BPUTZDHNSA-N 0.000 description 1
238000011699 spontaneously hypertensive rat Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
230000035488 systolic blood pressure Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229960004084 temocapril Drugs 0.000 description 1
FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
JQSHEDRVRBSFCZ-YWZLYKJASA-N tinofedrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC=CC=1)CC=C(C1=CSC=C1)C=1C=CSC=1 JQSHEDRVRBSFCZ-YWZLYKJASA-N 0.000 description 1
229950006638 tinofedrine Drugs 0.000 description 1
238000004448 titration Methods 0.000 description 1
JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 description 1
229960002312 tolazoline Drugs 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000003325 tomography Methods 0.000 description 1
235000021076 total caloric intake Nutrition 0.000 description 1
229960002051 trandolapril Drugs 0.000 description 1
239000006211 transdermal dosage form Substances 0.000 description 1
229960002906 trimazosin Drugs 0.000 description 1
YNZXWQJZEDLQEG-UHFFFAOYSA-N trimazosin Chemical compound N1=C2C(OC)=C(OC)C(OC)=CC2=C(N)N=C1N1CCN(C(=O)OCC(C)(C)O)CC1 YNZXWQJZEDLQEG-UHFFFAOYSA-N 0.000 description 1
235000021081 unsaturated fats Nutrition 0.000 description 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
229960004699 valsartan Drugs 0.000 description 1
229960000744 vinpocetine Drugs 0.000 description 1
229960002769 zofenopril Drugs 0.000 description 1
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
UQWLOWFDKAFKAP-WXHSDQCUSA-N zofenoprilat Chemical compound C1[C@@H](C(O)=O)N(C(=O)[C@@H](CS)C)C[C@H]1SC1=CC=CC=C1 UQWLOWFDKAFKAP-WXHSDQCUSA-N 0.000 description 1
229950001300 zofenoprilat Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

OA1200200325A 2000-04-26 2001-03-22 Antihypertensive agents and use. OA12252A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19985500P	2000-04-26	2000-04-26
US24228000P	2000-10-20	2000-10-20

Publications (1)

Publication Number	Publication Date
OA12252A true OA12252A (en)	2006-05-11

Family

ID=26895229

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200325A OA12252A (en)	2000-04-26	2001-03-22	Antihypertensive agents and use.

Country Status (34)

Country	Link
EP (1)	EP1280522B1 (is)
JP (1)	JP2003531170A (is)
KR (1)	KR20020091245A (is)
CN (1)	CN1426299A (is)
AP (1)	AP2002002665A0 (is)
AR (1)	AR031104A1 (is)
AT (1)	ATE283691T1 (is)
AU (1)	AU2001247658A1 (is)
BG (1)	BG107264A (is)
BR (1)	BR0110234A (is)
CA (1)	CA2405559A1 (is)
CZ (1)	CZ20023459A3 (is)
DE (1)	DE60107559T2 (is)
DO (1)	DOP2001000150A (is)
EA (1)	EA005245B1 (is)
EE (1)	EE200200611A (is)
ES (1)	ES2231470T3 (is)
HR (1)	HRP20020936A2 (is)
HU (1)	HUP0300403A3 (is)
IL (1)	IL152474A0 (is)
IS (1)	IS6570A (is)
MA (1)	MA26894A1 (is)
MX (1)	MXPA02009662A (is)
NO (1)	NO20025135L (is)
NZ (1)	NZ521713A (is)
OA (1)	OA12252A (is)
PA (1)	PA8516001A1 (is)
PE (1)	PE20011308A1 (is)
PL (1)	PL357906A1 (is)
PT (1)	PT1280522E (is)
SK (1)	SK15132002A3 (is)
SV (1)	SV2002000367A (is)
TN (1)	TNSN01061A1 (is)
WO (1)	WO2001080847A2 (is)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1045691T1 (en) *	1997-12-12	2005-04-30	Warner-Lambert Company Llc	Statin-carboxyalkylether combinations
US8278310B2 (en) *	2007-06-21	2012-10-02	Actimis Pharmaceuticals, Inc.	Amine salts of a CRTH2 antagonist
DE102008026033B4 (de) *	2008-05-30	2017-08-24	Voith Patent Gmbh	Antriebsstrang mit einer hydrodynamischen Maschine
SI23149A (sl) *	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5298497A (en) *	1990-05-15	1994-03-29	E. R. Squibb & Sons, Inc.	Method for preventing onset of hypertension employing a cholesterol lowering drug
US5648387A (en) *	1995-03-24	1997-07-15	Warner-Lambert Company	Carboxyalkylethers, formulations, and treatment of vascular diseases
NZ503982A (en) *	1997-12-12	2002-03-28	Warner Lambert Co	Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus

2001
- 2001-03-22 CZ CZ20023459A patent/CZ20023459A3/cs unknown
- 2001-03-22 EP EP01920625A patent/EP1280522B1/en not_active Expired - Lifetime
- 2001-03-22 SK SK1513-2002A patent/SK15132002A3/sk not_active Application Discontinuation
- 2001-03-22 AT AT01920625T patent/ATE283691T1/de not_active IP Right Cessation
- 2001-03-22 BR BR0110234-6A patent/BR0110234A/pt not_active IP Right Cessation
- 2001-03-22 PT PT01920625T patent/PT1280522E/pt unknown
- 2001-03-22 MX MXPA02009662A patent/MXPA02009662A/es unknown
- 2001-03-22 DE DE60107559T patent/DE60107559T2/de not_active Expired - Fee Related
- 2001-03-22 EA EA200200953A patent/EA005245B1/ru not_active IP Right Cessation
- 2001-03-22 NZ NZ521713A patent/NZ521713A/en unknown
- 2001-03-22 AP APAP/P/2002/002665A patent/AP2002002665A0/en unknown
- 2001-03-22 KR KR1020027014357A patent/KR20020091245A/ko not_active Withdrawn
- 2001-03-22 HU HU0300403A patent/HUP0300403A3/hu unknown
- 2001-03-22 PL PL01357906A patent/PL357906A1/xx not_active Application Discontinuation
- 2001-03-22 IL IL15247401A patent/IL152474A0/xx unknown
- 2001-03-22 EE EEP200200611A patent/EE200200611A/xx unknown
- 2001-03-22 OA OA1200200325A patent/OA12252A/en unknown
- 2001-03-22 CN CN01808632A patent/CN1426299A/zh active Pending
- 2001-03-22 JP JP2001577946A patent/JP2003531170A/ja active Pending
- 2001-03-22 ES ES01920625T patent/ES2231470T3/es not_active Expired - Lifetime
- 2001-03-22 CA CA002405559A patent/CA2405559A1/en not_active Abandoned
- 2001-03-22 WO PCT/US2001/009088 patent/WO2001080847A2/en not_active Ceased
- 2001-03-22 HR HRP20020936 patent/HRP20020936A2/hr not_active Application Discontinuation
- 2001-03-22 AU AU2001247658A patent/AU2001247658A1/en not_active Abandoned
- 2001-04-05 SV SV2001000367A patent/SV2002000367A/es not_active Application Discontinuation
- 2001-04-19 TN TNTNSN01061A patent/TNSN01061A1/en unknown
- 2001-04-23 PA PA20018516001A patent/PA8516001A1/es unknown
- 2001-04-24 DO DO2001000150A patent/DOP2001000150A/es unknown
- 2001-04-24 PE PE2001000363A patent/PE20011308A1/es not_active Application Discontinuation
- 2001-04-25 AR ARP010101902A patent/AR031104A1/es unknown
2002
- 2002-09-27 IS IS6570A patent/IS6570A/is unknown
- 2002-10-17 MA MA26872A patent/MA26894A1/fr unknown
- 2002-10-25 NO NO20025135A patent/NO20025135L/no not_active Application Discontinuation
- 2002-11-12 BG BG107264A patent/BG107264A/xx unknown

Also Published As

Publication number	Publication date
PT1280522E (pt)	2005-02-28
MXPA02009662A (es)	2003-03-10
ES2231470T3 (es)	2005-05-16
JP2003531170A (ja)	2003-10-21
DE60107559D1 (de)	2005-01-05
EP1280522B1 (en)	2004-12-01
AP2002002665A0 (en)	2002-12-31
EP1280522A2 (en)	2003-02-05
AU2001247658A1 (en)	2001-11-07
SK15132002A3 (sk)	2003-08-05
IS6570A (is)	2002-09-27
AR031104A1 (es)	2003-09-10
WO2001080847A2 (en)	2001-11-01
DOP2001000150A (es)	2002-08-15
PL357906A1 (en)	2004-08-09
MA26894A1 (fr)	2004-12-20
IL152474A0 (en)	2003-05-29
WO2001080847A3 (en)	2002-07-18
BG107264A (en)	2003-07-31
KR20020091245A (ko)	2002-12-05
BR0110234A (pt)	2003-03-05
EA005245B1 (ru)	2004-12-30
PE20011308A1 (es)	2002-01-18
PA8516001A1 (es)	2002-09-17
NZ521713A (en)	2004-09-24
DE60107559T2 (de)	2005-04-14
NO20025135L (no)	2002-11-27
HUP0300403A2 (hu)	2003-06-28
EE200200611A (et)	2004-06-15
SV2002000367A (es)	2002-08-26
ATE283691T1 (de)	2004-12-15
NO20025135D0 (no)	2002-10-25
EA200200953A1 (ru)	2003-04-24
CZ20023459A3 (cs)	2003-05-14
TNSN01061A1 (en)	2005-11-10
HRP20020936A2 (en)	2004-12-31
CA2405559A1 (en)	2001-11-01
HUP0300403A3 (en)	2005-03-29
CN1426299A (zh)	2003-06-25

Publication	Publication Date	Title
EP1009400B1 (en)	2004-12-29	Combination therapy comprising atorvastatin and an antihypertensive agent
HUP0003103A2 (hu)	2001-01-29	Az amlodipin és egy sztatin vegyület felhasználása kombinált terápiában
HRP980473A2 (en)	1999-06-30	Therapeutic combinations
EP1045691B1 (en)	2004-12-29	Statin-carboxyalkylether combinations
US8557835B2 (en)	2013-10-15	Statin-carboxyalkylether combinations
EP1280522B1 (en)	2004-12-01	Combination of carboxyalkylethers with antihypertensives and pharmaceutical use
US20020103252A1 (en)	2002-08-01	Statin-carboxyalkylether combinations
US20030225123A1 (en)	2003-12-04	Antihypertensive agents and use
EP1037623A1 (en)	2000-09-27	Antihyperlipidemic statin-lp(a) inhibitor combinations
ZA200208131B (en)	2004-01-22	Antihypertensive agents and use.
US20050261275A1 (en)	2005-11-24	Therapeutic combination
US20040092574A1 (en)	2004-05-13	Statin-Lp(a) inhibitor combinations
EP1481962A1 (en)	2004-12-01	New cholesterolemia-lowering carboxyalkylether compound
EP1514543A1 (en)	2005-03-16	Combination therapy comprising atorvastatin and an antihypertensive agent
MXPA00002085A (en)	2001-03-05	Combination therapy comprising amlodipine and a statin compound