OA12362A - Substituted imidazoles as tafia inhibitors. - Google Patents

Substituted imidazoles as tafia inhibitors. Download PDF

Info

Publication number: OA12362A
Authority: OA; OAPI
Prior art keywords: formula; compound; preparation; hydrogen; compounds
Prior art date: 2000-08-17

Application number

OA1200300039A

Other languages

English (en)

French (fr)

Inventor

Charlotte Moira Norfo Allerton

Julian Blagg

Mark Edward Bunnage

John Steele

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-17

Filing date

2001-08-08

Publication date

2004-04-07

2000-08-17 Priority claimed from GB0020346A external-priority patent/GB0020346D0/en

2000-11-09 Priority claimed from GB0027409A external-priority patent/GB0027409D0/en

2000-12-04 Priority claimed from GB0029556A external-priority patent/GB0029556D0/en

2001-08-08 Application filed by Pfizer filed Critical Pfizer

2004-04-07 Publication of OA12362A publication Critical patent/OA12362A/fr

Links

239000003112 inhibitor Substances 0.000 title claims abstract description 86
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QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims abstract description 8
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims abstract description 8
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OA1200300039A 2000-08-17 2001-08-08 Substituted imidazoles as tafia inhibitors. OA12362A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0020346A GB0020346D0 (en)	2000-08-17	2000-08-17	Pharmaceuticals
GB0027409A GB0027409D0 (en)	2000-11-09	2000-11-09	Pharmaceuticals
GB0029556A GB0029556D0 (en)	2000-12-04	2000-12-04	Pharmaceuticals

Publications (1)

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OA12362A true OA12362A (en)	2004-04-07

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OA1200300039A OA12362A (en)	2000-08-17	2001-08-08	Substituted imidazoles as tafia inhibitors.

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EP (1)	EP1311488B1 (pl)
JP (2)	JP4119746B2 (pl)
KR (1)	KR20030022412A (pl)
CN (1)	CN1443173A (pl)
AP (1)	AP1375A (pl)
AR (1)	AR035580A1 (pl)
AT (1)	ATE447557T1 (pl)
AU (1)	AU2001276605A1 (pl)
BG (1)	BG107330A (pl)
BR (1)	BR0113289A (pl)
CA (1)	CA2419633C (pl)
CY (1)	CY1109693T1 (pl)
CZ (1)	CZ2003388A3 (pl)
DE (1)	DE60140368D1 (pl)
DK (1)	DK1311488T3 (pl)
DO (1)	DOP2001000233A (pl)
EA (1)	EA005532B1 (pl)
EE (1)	EE200300070A (pl)
ES (1)	ES2334101T3 (pl)
HR (1)	HRP20030103A2 (pl)
HU (1)	HUP0303763A3 (pl)
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IS (1)	IS6638A (pl)
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MX (1)	MXPA03001425A (pl)
NO (1)	NO20030706L (pl)
NZ (1)	NZ522823A (pl)
OA (1)	OA12362A (pl)
PA (1)	PA8525401A1 (pl)
PE (1)	PE20020352A1 (pl)
PL (1)	PL361054A1 (pl)
PT (1)	PT1311488E (pl)
SI (1)	SI1311488T1 (pl)
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SV (1)	SV2002000602A (pl)
TN (1)	TNSN01126A1 (pl)
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SE0103272D0 (sv)	2001-09-28	2001-09-28	Astrazeneca Ab	Chemical compounds
US6713496B2 (en)	2002-01-22	2004-03-30	Pfizer Inc	3-(imidazolyl)-2-alkoxypropanoic acids
EP1467731A1 (en) *	2002-01-22	2004-10-20	Pfizer Limited	3-(imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors
CA2472239A1 (en)	2002-01-22	2003-07-31	Pfizer Inc.	3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases
WO2004097406A2 (en) *	2003-04-29	2004-11-11	Universität Zürich	Nϵ AND/OR Nα DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH [M(OH2)3(CO)3]+ BY FAC COORDINATION
SE0302853D0 (sv) *	2003-10-29	2003-10-29	Astrazeneca Ab	Chemical compounds
AU2004290499C1 (en) *	2003-11-03	2011-02-24	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
WO2005051384A1 (en) *	2003-11-25	2005-06-09	Pfizer Limited	Stabilised pharmaceutical compositions
CA2604912A1 (en) *	2005-04-18	2006-10-26	Bayer Schering Pharma Aktiengesellschaft	Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci
DE102005049385A1 (de) *	2005-10-15	2007-04-19	Sanofi-Aventis Deutschland Gmbh	Imidazolderivate als Inhibitoren von TAFIa
NZ577312A (en) *	2006-12-06	2012-02-24	Sanofi Aventis	Urea and sulfamide derivatives as tafia inhibitors
EP2262783A2 (en) *	2008-02-21	2010-12-22	Sanofi-Aventis	Covalently binding imaging probes
AU2009310841A1 (en)	2008-10-29	2010-05-06	Taisho Pharmaceutical Co., Ltd.	Compounds having TAFIa inhibitory activity
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2001
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- 2001-08-08 CN CN01813131A patent/CN1443173A/zh active Pending
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2002
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Also Published As

Publication number	Publication date
WO2002014285A1 (en)	2002-02-21
MXPA03001425A (es)	2003-06-06
ES2334101T3 (es)	2010-03-05
DE60140368D1 (de)	2009-12-17
EP1311488B1 (en)	2009-11-04
MA26940A1 (fr)	2004-12-20
IL153225A0 (en)	2003-07-06
CA2419633C (en)	2011-05-10
JP4119746B2 (ja)	2008-07-16
PT1311488E (pt)	2009-12-30
DK1311488T3 (da)	2010-01-04
UY26889A1 (es)	2002-03-22
PL361054A1 (pl)	2004-09-20
IS6638A (is)	2002-11-28
NZ522823A (en)	2004-11-26
EE200300070A (et)	2005-02-15
HUP0303763A3 (en)	2004-06-28
PA8525401A1 (es)	2002-04-25
SV2002000602A (es)	2002-10-24
HUP0303763A2 (hu)	2004-04-28
CN1443173A (zh)	2003-09-17
AP1375A (en)	2005-03-03
JP2008169224A (ja)	2008-07-24
AR035580A1 (es)	2004-06-16
NO20030706D0 (no)	2003-02-14
TNSN01126A1 (fr)	2005-11-10
JP2004506044A (ja)	2004-02-26
ATE447557T1 (de)	2009-11-15
HRP20030103A2 (en)	2003-04-30
EA200201239A1 (ru)	2003-08-28
AP2001002250A0 (en)	2001-09-30
PE20020352A1 (es)	2002-05-11
AU2001276605A1 (en)	2002-02-25
EP1311488A1 (en)	2003-05-21
CY1109693T1 (el)	2014-08-13
KR20030022412A (ko)	2003-03-15
BG107330A (en)	2003-06-30
CZ2003388A3 (cs)	2004-03-17
DOP2001000233A (es)	2002-05-15
BR0113289A (pt)	2003-06-17
JP4778531B2 (ja)	2011-09-21
SK1732003A3 (en)	2004-08-03
EA005532B1 (ru)	2005-04-28
CA2419633A1 (en)	2002-02-21
SI1311488T1 (sl)	2010-01-29
NO20030706L (no)	2003-04-15

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