OA12533A - Ep4 receptor selective agonists in the treatment of osteoporosis. - Google Patents

Ep4 receptor selective agonists in the treatment of osteoporosis. Download PDF

Info

Publication number: OA12533A
Authority: OA; OAPI
Prior art keywords: oxo; pyrrolidin; compound; phenyl; prodrug
Prior art date: 2000-11-27

Application number

OA1200300141A

Other languages

English (en)

Inventor

Kimberly O'keefe Cameron

Bruce Allen Lefker

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-27

Filing date

2001-11-05

Publication date

2006-06-05

2001-11-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-06-05 Publication of OA12533A publication Critical patent/OA12533A/en

Links

208000001132 Osteoporosis Diseases 0.000 title claims abstract description 40
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208000010392 Bone Fractures Diseases 0.000 claims abstract description 41
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206010065687 Bone loss Diseases 0.000 claims abstract description 16
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
230000007547 defect Effects 0.000 claims abstract description 6
208000002679 Alveolar Bone Loss Diseases 0.000 claims abstract description 5
208000036119 Frailty Diseases 0.000 claims abstract description 4
206010003549 asthenia Diseases 0.000 claims abstract description 4
239000000651 prodrug Substances 0.000 claims description 140
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GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
229960004276 zoledronic acid Drugs 0.000 description 1
XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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OA1200300141A 2000-11-27 2001-11-05 Ep4 receptor selective agonists in the treatment of osteoporosis. OA12533A (en)

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Also Published As

Publication number	Publication date
DE60130675T2 (de)	2008-01-24
NZ525164A (en)	2005-04-29
PT1339678E (pt)	2007-11-30
US6552067B2 (en)	2003-04-22
PL362030A1 (pl)	2004-10-18
US20020065308A1 (en)	2002-05-30
ATE374182T1 (de)	2007-10-15
US20040259921A1 (en)	2004-12-23
HN2001000266A (es)	2002-01-30
GT200100238AA (es)	2004-05-12
AR035074A1 (es)	2004-04-14
CY1106976T1 (el)	2012-09-26
EA200300379A1 (ru)	2003-08-28
JP2007197467A (ja)	2007-08-09
WO2002042268A3 (en)	2002-07-25
WO2002042268A2 (en)	2002-05-30
UY27038A1 (es)	2002-07-31
SV2003000746A (es)	2003-01-13
CZ20031257A3 (cs)	2004-04-14
EP1339678A2 (en)	2003-09-03
PE20020637A1 (es)	2002-07-18
SK5562003A3 (en)	2004-08-03
TNSN01166A1 (fr)	2005-11-10
TW200424170A (en)	2004-11-16
PA8533901A1 (es)	2002-11-28
EP1339678B1 (en)	2007-09-26
ES2291361T3 (es)	2008-03-01
KR20030053063A (ko)	2003-06-27
BR0115687A (pt)	2003-09-09
US6747054B2 (en)	2004-06-08
DE60130675D1 (de)	2007-11-08
DK1339678T3 (da)	2008-02-04
ZA200302803B (en)	2004-04-13
JP2004521869A (ja)	2004-07-22
MA26961A1 (fr)	2004-12-20
JP3984164B2 (ja)	2007-10-03
NO20032360D0 (no)	2003-05-26
GT200100238A (es)	2002-06-26
MXPA03004623A (es)	2003-09-05
CN1476429A (zh)	2004-02-18
BG107697A (en)	2004-01-30
SI1339678T1 (sl)	2007-12-31
US20030149086A1 (en)	2003-08-07
IS6775A (is)	2003-04-10
ECSP034623A (es)	2003-07-25
HUP0400807A2 (hu)	2004-07-28
NO20032360L (no)	2003-07-23
CA2429850C (en)	2008-12-30
AU2002210848A1 (en)	2002-06-03
US7192979B2 (en)	2007-03-20
EE200300246A (et)	2003-10-15
CA2429850A1 (en)	2002-05-30
IL155368A0 (en)	2003-11-23

Publication	Publication Date	Title
US6747054B2 (en)	2004-06-08	EP4 receptor selective agonists in the treatment of osteoporosis
DE69736007T2 (de)	2006-12-28	Vorbeugung des verlustes und wiederherstellung von knochenmasse unter verwendung von prostaglandin-analogen
US6376502B1 (en)	2002-04-23	Osteoporosis compounds
US6531485B2 (en)	2003-03-11	Prostaglandin agonists
SK286136B6 (sk)	2008-04-07	Agonisty prostaglandínu, ich použitie samotných alebo v kombináciách a farmaceutické kompozície a kity s ich obsahom
CA2697950A1 (en)	2009-03-05	Polymorphs of prostaglandin agonists and methods for making the same
HK1059433A (en)	2004-07-02	Ep4 receptor selective agonists in the treatment of osteoporosis