OA12729A - 3-Beta-D ribofuranosylthiazoloÄ4,5-dÜpyridimine nucleosides and uses thereof. - Google Patents

3-Beta-D ribofuranosylthiazoloÄ4,5-dÜpyridimine nucleosides and uses thereof. Download PDF

Info

Publication number: OA12729A
Authority: OA; OAPI
Prior art keywords: substituted; groups; alkyl; compound; amino acid
Prior art date: 2001-11-27

Application number

OA1200400146A

Other languages

English (en)

Inventor

Devron R Averett

Joseph R Lennox

Erik J Rueden

Stephen E Webber

Original Assignee

Anadys Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-27

Filing date

2002-11-27

Publication date

2006-06-28

2002-11-27 Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc

2006-06-28 Publication of OA12729A publication Critical patent/OA12729A/en

Links

239000002777 nucleoside Substances 0.000 title abstract description 12
125000003835 nucleoside group Chemical group 0.000 title abstract description 5
150000001875 compounds Chemical class 0.000 claims abstract description 106
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 18
125000000217 alkyl group Chemical group 0.000 claims description 33
125000000753 cycloalkyl group Chemical group 0.000 claims description 9
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 9
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
125000000547 substituted alkyl group Chemical group 0.000 claims description 4
150000008574 D-amino acids Chemical group 0.000 claims description 3
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235000015424 sodium Nutrition 0.000 description 1
238000003797 solvolysis reaction Methods 0.000 description 1
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235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
210000004989 spleen cell Anatomy 0.000 description 1
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230000000087 stabilizing effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical class OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 1
239000000758 substrate Substances 0.000 description 1
150000003890 succinate salts Chemical class 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
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125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
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230000001988 toxicity Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000000844 transformation Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
238000001665 trituration Methods 0.000 description 1
230000010245 tubular reabsorption Effects 0.000 description 1
230000005951 type IV hypersensitivity Effects 0.000 description 1
208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
210000003932 urinary bladder Anatomy 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
239000004474 valine Substances 0.000 description 1
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GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical group C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1
229940051021 yellow-fever virus Drugs 0.000 description 1
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239000011701 zinc Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/22—Pteridine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Joints Allowing Movement (AREA)

OA1200400146A 2001-11-27 2002-11-27 3-Beta-D ribofuranosylthiazoloÄ4,5-dÜpyridimine nucleosides and uses thereof. OA12729A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33346001P	2001-11-27	2001-11-27

Publications (1)

Publication Number	Publication Date
OA12729A true OA12729A (en)	2006-06-28

Family

ID=23302891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400146A OA12729A (en)	2001-11-27	2002-11-27	3-Beta-D ribofuranosylthiazoloÄ4,5-dÜpyridimine nucleosides and uses thereof.

Country Status (28)

Country	Link
US (3)	US6924271B2 (de)
EP (1)	EP1451203B1 (de)
JP (1)	JP4493337B2 (de)
KR (1)	KR100718371B1 (de)
CN (2)	CN101033242A (de)
AP (1)	AP2004003069A0 (de)
AT (1)	ATE448238T1 (de)
AU (1)	AU2002365412B2 (de)
BR (1)	BR0214407A (de)
CA (1)	CA2468552C (de)
CO (1)	CO5590931A2 (de)
DE (1)	DE60234376D1 (de)
EA (1)	EA008380B1 (de)
EC (1)	ECSP045167A (de)
ES (1)	ES2333945T3 (de)
GE (1)	GEP20074099B (de)
HR (1)	HRP20040541A2 (de)
IL (1)	IL162137A0 (de)
IS (1)	IS7283A (de)
MA (1)	MA27156A1 (de)
MX (1)	MXPA04004966A (de)
NO (1)	NO20042676L (de)
NZ (1)	NZ533628A (de)
OA (1)	OA12729A (de)
TN (1)	TNSN04113A1 (de)
UA (1)	UA79764C2 (de)
WO (1)	WO2003045968A1 (de)
YU (1)	YU45204A (de)

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2002
- 2002-11-27 KR KR1020047008062A patent/KR100718371B1/ko not_active Expired - Fee Related
- 2002-11-27 UA UA20040604959A patent/UA79764C2/uk unknown
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- 2002-11-27 CN CNA2006101728401A patent/CN101033242A/zh active Pending
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Publication number	Publication date
EA008380B1 (ru)	2007-04-27
EP1451203B1 (de)	2009-11-11
CN101033242A (zh)	2007-09-12
IL162137A0 (en)	2005-11-20
TNSN04113A1 (en)	2006-06-01
KR100718371B1 (ko)	2007-05-14
UA79764C2 (en)	2007-07-25
KR20040065230A (ko)	2004-07-21
CA2468552C (en)	2011-09-20
IS7283A (is)	2004-05-21
MXPA04004966A (es)	2006-03-21
ATE448238T1 (de)	2009-11-15
US6924271B2 (en)	2005-08-02
AP2004003069A0 (en)	2004-06-30
CN1612889A (zh)	2005-05-04
ECSP045167A (es)	2004-10-26
US20030199461A1 (en)	2003-10-23
EA200400735A1 (ru)	2004-12-30
CN1300165C (zh)	2007-02-14
US20080090844A1 (en)	2008-04-17
HRP20040541A2 (en)	2004-10-31
NZ533628A (en)	2006-07-28
AU2002365412A1 (en)	2003-06-10
AU2002365412B2 (en)	2008-10-09
US20050182001A1 (en)	2005-08-18
ES2333945T3 (es)	2010-03-03
YU45204A (sh)	2006-08-17
CO5590931A2 (es)	2005-12-30
JP4493337B2 (ja)	2010-06-30
DE60234376D1 (de)	2009-12-24
GEP20074099B (en)	2007-05-10
CA2468552A1 (en)	2003-06-05
JP2005515196A (ja)	2005-05-26
BR0214407A (pt)	2004-10-19
WO2003045968A1 (en)	2003-06-05
EP1451203A1 (de)	2004-09-01
NO20042676L (no)	2004-08-24
MA27156A1 (fr)	2005-01-03

Publication	Publication Date	Title
US6924271B2 (en)	2005-08-02	3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
US7321033B2 (en)	2008-01-22	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
AU2004271972B2 (en)	2010-06-03	TLR7 ligands for the treatment of hepatitis C
US6509320B1 (en)	2003-01-21	Purine L-nucleosides, analogs and uses thereof
JP2002105096A (ja)	2002-04-10	プリンｌ−ヌクレオシド類およびその用途
BRPI0518861B1 (pt)	2021-03-09	compostos, sais ou hidratos farmaceuticamente aceitos, composição farmacêutica e uso de quantidade terapeutica ou profilaticamente eficaz de composto ou de composição farmacêutica
ES2399891T3 (es)	2013-04-04	Nucleosidos de 3-?-D-ribofuranosiltiazolo[4,5-d]pirimidina y usos de los mismos
NZ544582A (en)	2007-10-26	3-Beta-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and uses thereof
KR20070015642A (ko)	2007-02-05	３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리디민누클레오시드 및 이의 용도
KR100880298B1 (ko)	2009-01-28	３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리미딘뉴클레오시드 및 이의 용도
JP2009518393A (ja)	2009-05-07	がん治療用ジオキソラン誘導体