OA12756A - 3-(Imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors. - Google Patents

3-(Imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors. Download PDF

Info

Publication number: OA12756A
Authority: OA; OAPI
Prior art keywords: préparation; hydrogen; compound according; nmr; 400mhz
Prior art date: 2002-01-22

Application number

OA1200400190A

Other languages

English (en)

Inventor

Charlotte Moira Norfo Allerton

David John Bull

Mark Edward Bunnage

Robert John Maguire

John Steele

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-22

Filing date

2003-01-10

Publication date

2006-07-03

2002-01-22 Priority claimed from GB0201389A external-priority patent/GB0201389D0/en

2002-01-29 Priority claimed from GB0202027A external-priority patent/GB0202027D0/en

2003-01-10 Application filed by Pfizer filed Critical Pfizer

2006-07-03 Publication of OA12756A publication Critical patent/OA12756A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Surgery (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

OA1200400190A 2002-01-22 2003-01-10 3-(Imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors. OA12756A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0201389A GB0201389D0 (en)	2002-01-22	2002-01-22	3-(imidazolyl)-2-alkoxypropanoic acids
GB0202027A GB0202027D0 (en)	2002-01-29	2002-01-29	3-(imidazolyl)-2-alkoxypropanoic acids

Publications (1)

Publication Number	Publication Date
OA12756A true OA12756A (en)	2006-07-03

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ID=27614792

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400190A OA12756A (en)	2002-01-22	2003-01-10	3-(Imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors.

Country Status (24)

Country	Link
EP (1)	EP1467731A1 (pl)
JP (1)	JP2005520811A (pl)
KR (1)	KR20040077775A (pl)
CN (1)	CN1620291A (pl)
AP (1)	AP2004003084A0 (pl)
AR (1)	AR038197A1 (pl)
BR (1)	BR0307016A (pl)
CA (1)	CA2472238A1 (pl)
EA (1)	EA200400716A1 (pl)
EC (1)	ECSP045200A (pl)
HR (1)	HRP20040659A2 (pl)
IL (1)	IL162677A0 (pl)
IS (1)	IS7310A (pl)
MA (1)	MA27167A1 (pl)
MX (1)	MXPA04006573A (pl)
NO (1)	NO20043457L (pl)
OA (1)	OA12756A (pl)
PA (1)	PA8563501A1 (pl)
PE (1)	PE20030929A1 (pl)
PL (1)	PL371487A1 (pl)
TN (1)	TNSN04121A1 (pl)
TW (1)	TW200302094A (pl)
UY (1)	UY27615A1 (pl)
WO (1)	WO2003061652A1 (pl)

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WO2005051384A1 (en) *	2003-11-25	2005-06-09	Pfizer Limited	Stabilised pharmaceutical compositions
JP2008536923A (ja) *	2005-04-18	2008-09-11	バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト	心筋の再灌流の増強およびｐｃｉの容易化のためのｔａｆｉ阻害剤の使用
WO2010050525A1 (ja)	2008-10-29	2010-05-06	大正製薬株式会社	ＴＡＦＩａ阻害活性を有する化合物
US8987242B2 (en)	2008-12-05	2015-03-24	Merck Sharp & Dohme Corp.	Morpholinone compounds as factor IXA inhibitors
JP2012511008A (ja) *	2008-12-05	2012-05-17	持田製薬株式会社	ＩＸａ因子阻害薬としてのモルホリノン化合物
BR112012023412A2 (pt)	2010-03-18	2018-05-08	Daiichi Sankyo Company, Limited	composto, drogra farmacêutica, inibidor de tafia, promotor de fibrinólise, droga preventiva ou terapêutica, composição farmacêutica, e, uso de um composto.
EP2548871B1 (en) *	2010-03-18	2017-07-19	Daiichi Sankyo Company, Limited	Cycloalkyl-substituted imidazole derivative
KR20160018557A (ko)	2013-06-10	2016-02-17	사노피	TAFIa의 저해제로서의 마크로사이클릭 우레아 유도체, 이의 제법 및 의약품으로서의 이의 용도
US20190117624A1 (en)	2016-03-29	2019-04-25	Daiichi Sankyo Company, Limited	Therapeutic agent for inflammatory bowel diseases
MY202326A (en)	2017-09-14	2024-04-24	Daiichi Sankyo Co Ltd	Compound having cyclic structure

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SE9901572D0 (sv) *	1999-05-03	1999-05-03	Astra Ab	New compounds
ATE447557T1 (de) *	2000-08-17	2009-11-15	Pfizer Ltd	Substitutuierte imidazole als tafia inhibitoren

2003
- 2003-01-10 EA EA200400716A patent/EA200400716A1/ru unknown
- 2003-01-10 BR BR0307016-6A patent/BR0307016A/pt not_active IP Right Cessation
- 2003-01-10 KR KR10-2004-7011370A patent/KR20040077775A/ko not_active Ceased
- 2003-01-10 HR HR20040659A patent/HRP20040659A2/hr not_active Application Discontinuation
- 2003-01-10 IL IL16267703A patent/IL162677A0/xx unknown
- 2003-01-10 JP JP2003561596A patent/JP2005520811A/ja active Pending
- 2003-01-10 WO PCT/IB2003/000060 patent/WO2003061652A1/en not_active Ceased
- 2003-01-10 PL PL03371487A patent/PL371487A1/pl unknown
- 2003-01-10 AP APAP/P/2004/003084A patent/AP2004003084A0/en unknown
- 2003-01-10 EP EP03700059A patent/EP1467731A1/en not_active Withdrawn
- 2003-01-10 CN CNA03802599XA patent/CN1620291A/zh active Pending
- 2003-01-10 OA OA1200400190A patent/OA12756A/en unknown
- 2003-01-10 MX MXPA04006573A patent/MXPA04006573A/es unknown
- 2003-01-10 CA CA002472238A patent/CA2472238A1/en not_active Abandoned
- 2003-01-16 TW TW092100889A patent/TW200302094A/zh unknown
- 2003-01-17 PE PE2003000058A patent/PE20030929A1/es not_active Application Discontinuation
- 2003-01-20 UY UY27615A patent/UY27615A1/es not_active Application Discontinuation
- 2003-01-21 AR ARP030100165A patent/AR038197A1/es unknown
- 2003-01-22 PA PA20038563501A patent/PA8563501A1/es unknown
2004
- 2004-06-14 IS IS7310A patent/IS7310A/is unknown
- 2004-06-30 TN TNP2004000121A patent/TNSN04121A1/en unknown
- 2004-07-15 MA MA27786A patent/MA27167A1/fr unknown
- 2004-07-22 EC EC2004005200A patent/ECSP045200A/es unknown
- 2004-08-19 NO NO20043457A patent/NO20043457L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AR038197A1 (es)	2005-01-05
AP2004003084A0 (en)	2004-09-30
CN1620291A (zh)	2005-05-25
UY27615A1 (es)	2003-08-29
IL162677A0 (en)	2005-11-20
ECSP045200A (es)	2004-08-27
PE20030929A1 (es)	2003-11-05
BR0307016A (pt)	2004-11-03
TNSN04121A1 (en)	2006-06-01
CA2472238A1 (en)	2003-07-31
PA8563501A1 (es)	2004-08-31
EP1467731A1 (en)	2004-10-20
PL371487A1 (pl)	2005-06-13
IS7310A (is)	2004-06-14
JP2005520811A (ja)	2005-07-14
WO2003061652A1 (en)	2003-07-31
NO20043457L (no)	2004-08-19
MA27167A1 (fr)	2005-01-03
TW200302094A (en)	2003-08-01
KR20040077775A (ko)	2004-09-06
EA200400716A1 (ru)	2004-12-30
MXPA04006573A (es)	2004-10-04
HRP20040659A2 (en)	2004-10-31
WO2003061652A8 (en)	2004-09-10

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