OA13111A - Anti-microbially active diamine-based guanine derivatives. - Google Patents

Anti-microbially active diamine-based guanine derivatives. Download PDF

Info

Publication number: OA13111A
Authority: OA; OAPI
Prior art keywords: diamine; guanidine; mic; use according; molecular mass
Prior art date: 2003-03-20

Application number

OA1200500264A

Other languages

English (en)

Inventor

Apostolos Georgopoulos

Original Assignee

Geopharma Produktions Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-20

Filing date

2004-03-17

Publication date

2006-11-10

2004-03-17 Application filed by Geopharma Produktions Gmbh filed Critical Geopharma Produktions Gmbh

2006-11-10 Publication of OA13111A publication Critical patent/OA13111A/en

Links

150000004985 diamines Chemical class 0.000 title claims abstract description 11
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title description 3
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 13
239000003814 drug Substances 0.000 claims abstract description 10
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 6
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 6
125000003277 amino group Chemical group 0.000 claims abstract description 5
239000002253 acid Substances 0.000 claims abstract description 3
238000004519 manufacturing process Methods 0.000 claims abstract description 3
238000006068 polycondensation reaction Methods 0.000 claims abstract description 3
230000000845 anti-microbial effect Effects 0.000 claims description 8
229940079593 drug Drugs 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
-1 triethylene glycol diamine Chemical class 0.000 claims description 7
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 5
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
150000002357 guanidines Chemical class 0.000 claims description 2
229920001451 polypropylene glycol Polymers 0.000 claims description 2
125000005702 oxyalkylene group Chemical group 0.000 abstract description 2
150000003839 salts Chemical class 0.000 abstract description 2
WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical compound NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 abstract 2
229920000642 polymer Polymers 0.000 abstract 1
239000008186 active pharmaceutical agent Substances 0.000 description 20
229940088679 drug related substance Drugs 0.000 description 20
238000012360 testing method Methods 0.000 description 11
239000000243 solution Substances 0.000 description 9
244000052616 bacterial pathogen Species 0.000 description 8
230000000694 effects Effects 0.000 description 8
241000588724 Escherichia coli Species 0.000 description 7
230000001580 bacterial effect Effects 0.000 description 7
244000005700 microbiome Species 0.000 description 7
239000003242 anti bacterial agent Substances 0.000 description 6
229940088710 antibiotic agent Drugs 0.000 description 6
230000006378 damage Effects 0.000 description 6
241000894006 Bacteria Species 0.000 description 5
241000589517 Pseudomonas aeruginosa Species 0.000 description 5
241000233866 Fungi Species 0.000 description 4
241000191967 Staphylococcus aureus Species 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
208000015181 infectious disease Diseases 0.000 description 4
241000894007 species Species 0.000 description 4
241001480043 Arthrodermataceae Species 0.000 description 3
241000335423 Blastomyces Species 0.000 description 3
206010017533 Fungal infection Diseases 0.000 description 3
206010061218 Inflammation Diseases 0.000 description 3
241000588748 Klebsiella Species 0.000 description 3
241000589516 Pseudomonas Species 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
230000001419 dependent effect Effects 0.000 description 3
230000037304 dermatophytes Effects 0.000 description 3
208000024386 fungal infectious disease Diseases 0.000 description 3
230000004054 inflammatory process Effects 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
230000005722 itchiness Effects 0.000 description 3
239000002674 ointment Substances 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
241000589291 Acinetobacter Species 0.000 description 2
241000588914 Enterobacter Species 0.000 description 2
241000194032 Enterococcus faecalis Species 0.000 description 2
208000007882 Gastritis Diseases 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
241000607142 Salmonella Species 0.000 description 2
241000295644 Staphylococcaceae Species 0.000 description 2
206010041925 Staphylococcal infections Diseases 0.000 description 2
241000191963 Staphylococcus epidermidis Species 0.000 description 2
241000700605 Viruses Species 0.000 description 2
241000607447 Yersinia enterocolitica Species 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000000740 bleeding effect Effects 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
230000037396 body weight Effects 0.000 description 2
208000037976 chronic inflammation Diseases 0.000 description 2
230000006020 chronic inflammation Effects 0.000 description 2
229940032049 enterococcus faecalis Drugs 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 2
230000003641 microbiacidal effect Effects 0.000 description 2
210000004877 mucosa Anatomy 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
229940098232 yersinia enterocolitica Drugs 0.000 description 2
241000588625 Acinetobacter sp. Species 0.000 description 1
241000222120 Candida <Saccharomycetales> Species 0.000 description 1
241000222122 Candida albicans Species 0.000 description 1
206010011409 Cross infection Diseases 0.000 description 1
206010011985 Decubitus ulcer Diseases 0.000 description 1
241000194033 Enterococcus Species 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
208000009889 Herpes Simplex Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
241000588749 Klebsiella oxytoca Species 0.000 description 1
241000588747 Klebsiella pneumoniae Species 0.000 description 1
241000219470 Mirabilis Species 0.000 description 1
241000186359 Mycobacterium Species 0.000 description 1
241001502334 Mycobacterium avium complex bacterium Species 0.000 description 1
241000187484 Mycobacterium gordonae Species 0.000 description 1
241000186363 Mycobacterium kansasii Species 0.000 description 1
241000187479 Mycobacterium tuberculosis Species 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
241000588769 Proteus <enterobacteria> Species 0.000 description 1
241000607768 Shigella Species 0.000 description 1
241000223238 Trichophyton Species 0.000 description 1
241001045770 Trichophyton mentagrophytes Species 0.000 description 1
108010059993 Vancomycin Proteins 0.000 description 1
206010048038 Wound infection Diseases 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
239000012080 ambient air Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000001857 anti-mycotic effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000012620 biological material Substances 0.000 description 1
229940095731 candida albicans Drugs 0.000 description 1
208000023652 chronic gastritis Diseases 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
210000004195 gingiva Anatomy 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000011005 laboratory method Methods 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
238000000034 method Methods 0.000 description 1
239000002068 microbial inoculum Substances 0.000 description 1
210000002200 mouth mucosa Anatomy 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
230000008693 nausea Effects 0.000 description 1
239000002547 new drug Substances 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
230000002747 voluntary effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

OA1200500264A 2003-03-20 2004-03-17 Anti-microbially active diamine-based guanine derivatives. OA13111A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0045303A AT500998B1 (de)	2003-03-20	2003-03-20	Antimikrobiell wirkendes arzneimittel

Publications (1)

Publication Number	Publication Date
OA13111A true OA13111A (en)	2006-11-10

Family

ID=32996821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200500264A OA13111A (en)	2003-03-20	2004-03-17	Anti-microbially active diamine-based guanine derivatives.

Country Status (25)

Country	Link
US (1)	US20060093573A1 (xx)
EP (1)	EP1605927B1 (xx)
JP (1)	JP4970931B2 (xx)
KR (1)	KR20060003331A (xx)
CN (1)	CN1767821A (xx)
AP (1)	AP2189A (xx)
AT (2)	AT500998B1 (xx)
AU (1)	AU2004222664B2 (xx)
BR (1)	BRPI0408541A (xx)
CA (1)	CA2518968A1 (xx)
CY (1)	CY1107251T1 (xx)
DE (1)	DE502004005903D1 (xx)
DK (1)	DK1605927T3 (xx)
EA (1)	EA012620B1 (xx)
ES (1)	ES2299828T3 (xx)
HR (1)	HRP20050819A2 (xx)
IL (1)	IL170994A (xx)
MX (1)	MXPA05009983A (xx)
OA (1)	OA13111A (xx)
PL (1)	PL1605927T3 (xx)
PT (1)	PT1605927E (xx)
SI (1)	SI1605927T1 (xx)
UA (1)	UA84418C2 (xx)
WO (1)	WO2004082671A1 (xx)
ZA (1)	ZA200507282B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008031105A1 (en) *	2006-09-08	2008-03-13	Delaval Holdings Ab	Polymeric guanidine salt-based germicides
DE102008009591A1 (de) *	2008-02-15	2009-08-20	Galinski, Erwin A., Prof. Dr.	Zwitterionische Guanidiniumverbindungen als selektive antimikrobielle Wirkstoffe
WO2010126376A1 (en) *	2009-04-30	2010-11-04	Bakteriefritt As	Composition for sterilizing surfaces
DE102009029010A1 (de) *	2009-08-31	2011-03-03	Evonik Goldschmidt Gmbh	Antimikrobielle Etherguanidine
DE102009052721A1 (de)	2009-11-12	2011-05-26	B. Braun Melsungen Ag	Verwendung polymerer oder oligomerer Wirkstoffe für medizinische Artikel
WO2012055568A1 (en)	2010-10-29	2012-05-03	Mindinvest Holdings Ltd.	Liposomal drug composition containing a polymeric guanidine derivative
AT516070B1 (de) *	2014-07-31	2016-08-15	Sealife Pharma Gmbh	Verfahren zur Herstellung von Polyguanidinen
EP3524055A1 (de) *	2018-02-08	2019-08-14	BCSK Biocid GmbH	Antibakterielles und spermizides gleitmittel
AT521124A1 (de) *	2018-03-23	2019-10-15	Bcsk Biocid Gmbh	Verfahren und Zusammensetzung zur Bekämpfung von Viren der Familie Picornaviridae

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2336605A (en) *	1941-12-29	1943-12-14	Du Pont	Pesticide
DE4002403A1 (de) *	1990-01-27	1991-08-01	Degussa	Verfahren zur herstellung von biozid wirksamen polymeren guanidinsalzen
DE4002404A1 (de) *	1990-01-27	1991-08-01	Degussa	Loesungen polymerer guanidinsalze mit erhoehter biozidwirksamkeit, verfahren zu ihrer herstellung und verwendung
BR0111163A (pt) *	2000-05-11	2003-04-08	P O C Oil Industry Technology	Polìmeros biocidas à base de sais de guanidina
US6955806B2 (en) *	2001-01-18	2005-10-18	Genzyme Corporation	Ionene polymers and their use as antimicrobial agents
AT501983B1 (de) *	2003-02-04	2007-03-15	Geopharma Produktionsgmbh	Zytostatisches arzneimittel enthaltend ein polymeres guanidinderivat

2003
- 2003-03-20 AT AT0045303A patent/AT500998B1/de not_active IP Right Cessation
2004
- 2004-03-17 EA EA200501485A patent/EA012620B1/ru not_active IP Right Cessation
- 2004-03-17 MX MXPA05009983A patent/MXPA05009983A/es active IP Right Grant
- 2004-03-17 HR HR20050819A patent/HRP20050819A2/xx not_active Application Discontinuation
- 2004-03-17 CA CA002518968A patent/CA2518968A1/en not_active Abandoned
- 2004-03-17 KR KR1020057017591A patent/KR20060003331A/ko not_active Ceased
- 2004-03-17 ES ES04721079T patent/ES2299828T3/es not_active Expired - Lifetime
- 2004-03-17 SI SI200430664T patent/SI1605927T1/sl unknown
- 2004-03-17 AU AU2004222664A patent/AU2004222664B2/en not_active Ceased
- 2004-03-17 JP JP2006503945A patent/JP4970931B2/ja not_active Expired - Fee Related
- 2004-03-17 CN CNA2004800074828A patent/CN1767821A/zh active Pending
- 2004-03-17 AT AT04721079T patent/ATE383152T1/de not_active IP Right Cessation
- 2004-03-17 DE DE502004005903T patent/DE502004005903D1/de not_active Expired - Lifetime
- 2004-03-17 UA UAA200509898A patent/UA84418C2/ru unknown
- 2004-03-17 PT PT04721079T patent/PT1605927E/pt unknown
- 2004-03-17 OA OA1200500264A patent/OA13111A/en unknown
- 2004-03-17 AP AP2005003404A patent/AP2189A/xx active
- 2004-03-17 EP EP04721079A patent/EP1605927B1/de not_active Expired - Lifetime
- 2004-03-17 PL PL04721079T patent/PL1605927T3/pl unknown
- 2004-03-17 BR BRPI0408541-8A patent/BRPI0408541A/pt not_active IP Right Cessation
- 2004-03-17 WO PCT/AT2004/000097 patent/WO2004082671A1/de not_active Ceased
- 2004-03-17 DK DK04721079T patent/DK1605927T3/da active
2005
- 2005-09-09 ZA ZA200507282A patent/ZA200507282B/en unknown
- 2005-09-19 US US11/230,141 patent/US20060093573A1/en not_active Abandoned
- 2005-09-20 IL IL170994A patent/IL170994A/en not_active IP Right Cessation
2008
- 2008-03-19 CY CY20081100307T patent/CY1107251T1/el unknown

Also Published As

Publication number	Publication date
EP1605927A1 (de)	2005-12-21
BRPI0408541A (pt)	2006-03-07
JP4970931B2 (ja)	2012-07-11
WO2004082671A1 (de)	2004-09-30
PT1605927E (pt)	2008-04-07
EA200501485A1 (ru)	2006-04-28
AT500998B1 (de)	2008-10-15
CY1107251T1 (el)	2012-11-21
AU2004222664A1 (en)	2004-09-30
HRP20050819A2 (en)	2006-02-28
KR20060003331A (ko)	2006-01-10
AP2189A (en)	2010-12-24
EP1605927B1 (de)	2008-01-09
PL1605927T3 (pl)	2008-06-30
AU2004222664B2 (en)	2009-12-03
MXPA05009983A (es)	2006-03-09
ATE383152T1 (de)	2008-01-15
ZA200507282B (en)	2006-12-27
CA2518968A1 (en)	2004-09-30
CN1767821A (zh)	2006-05-03
JP2006520329A (ja)	2006-09-07
ES2299828T3 (es)	2008-06-01
SI1605927T1 (sl)	2008-06-30
IL170994A (en)	2010-06-30
DE502004005903D1 (de)	2008-02-21
DK1605927T3 (da)	2008-05-13
AT500998A1 (de)	2006-05-15
UA84418C2 (ru)	2008-10-27
EA012620B1 (ru)	2009-10-30
US20060093573A1 (en)	2006-05-04
AP2005003404A0 (en)	2005-12-31

Publication	Publication Date	Title
US9173972B2 (en)	2015-11-03	Methods and compositions for promoting wound healing
JP6023425B2 (ja)	2016-11-09	グラム陽性菌感染症の治療のための抗菌組合せ療法
JP2005511642A5 (xx)	2006-01-12
JPH0780774B2 (ja)	1995-08-30	薬剤組成物
KR20070040332A (ko)	2007-04-16	다중양이온성 항균 치료
CN105492005A (zh)	2016-04-13	治疗包括乳房炎的微生物感染的方法
US6017912A (en)	2000-01-25	Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle
WO2002094179A2 (en)	2002-11-28	Novel topical microbicidal compositions
AU2004222664B2 (en)	2009-12-03	Anti-microbially active diamine-based guanine derivatives
US9248159B2 (en)	2016-02-02	MRSA bactericidal topical gel
JP2010534199A (ja)	2010-11-04	抗菌複合治療
US20220386621A1 (en)	2022-12-08	Disinfectants with iodine and copper complexes for use against coronavirus
CN108605976A (zh)	2018-10-02	一种用于抑制和杀灭病菌的抗菌剂
RU2292919C1 (ru)	2007-02-10	Средство для дезинфекции кожного покрова
US20250375453A1 (en)	2025-12-11	High-efficiency antimicrobial composition
US20230389553A1 (en)	2023-12-07	Disinfectants with iodine and copper complexes for biofilm eradication and prevention
HK1091405A (en)	2007-01-19	Anti-microbially active diamine-based guanine derivatives
Postlethwait et al.	1964	Iodophor for Presurgical Skin Antisepsis: An Evaluation
KR20260053375A (ko)	2026-04-21	신규한 고효율 항미생물 조성물
US20070185202A1 (en)	2007-08-09	Methods and compositions for ophthalmic treatment of fungal and bacterial infections
JP2006117587A (ja)	2006-05-11	殺菌消毒剤組成物