OA13258A - Amino acids with affinity for the alpha2delta-protein. - Google Patents

Amino acids with affinity for the alpha2delta-protein. Download PDF

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Publication number
OA13258A
OA13258A OA1200600094A OA1200600094A OA13258A OA 13258 A OA13258 A OA 13258A OA 1200600094 A OA1200600094 A OA 1200600094A OA 1200600094 A OA1200600094 A OA 1200600094A OA 13258 A OA13258 A OA 13258A
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OA
OAPI
Prior art keywords
acid
phenyl
amino
aminomethyl
methyl
Prior art date
Application number
OA1200600094A
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English (en)
Inventor
Christopher James Deur
Christine Nylund Kolz
Augustine Tobi Osuma
Mark Stephen Plummer
Jacob Bradley Schwarz
Andrew John Thorpe
David Juergen Wustrow
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Warner Lambert Co
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34396281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA13258(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of OA13258A publication Critical patent/OA13258A/en

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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • C07D263/18—Oxygen atoms
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OA1200600094A 2003-09-25 2004-09-13 Amino acids with affinity for the alpha2delta-protein. OA13258A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50595303P 2003-09-25 2003-09-25
US50744303P 2003-09-30 2003-09-30

Publications (1)

Publication Number Publication Date
OA13258A true OA13258A (en) 2007-01-31

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OA1200600094A OA13258A (en) 2003-09-25 2004-09-13 Amino acids with affinity for the alpha2delta-protein.

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US (3) US7179934B2 (es)
EP (1) EP1667957A2 (es)
JP (2) JP4001349B2 (es)
KR (2) KR100768974B1 (es)
AP (1) AP2006003544A0 (es)
AR (1) AR046022A1 (es)
AU (1) AU2004276072A1 (es)
BR (1) BRPI0414781A (es)
CA (1) CA2540208A1 (es)
CO (1) CO5680413A2 (es)
CR (1) CR8290A (es)
EA (1) EA200600467A1 (es)
EC (1) ECSP066450A (es)
IL (1) IL173764A0 (es)
IS (1) IS8308A (es)
MA (1) MA28048A1 (es)
MX (1) MXPA06003395A (es)
NL (2) NL1027115C2 (es)
NO (1) NO20061812L (es)
OA (1) OA13258A (es)
PA (1) PA8613101A1 (es)
PE (1) PE20050434A1 (es)
RS (1) RS20060210A (es)
TN (1) TNSN06095A1 (es)
TW (1) TW200528420A (es)
UY (1) UY28533A1 (es)
WO (1) WO2005030700A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2573128A1 (en) * 2004-07-09 2006-01-26 Warner-Lambert Company Llc Preparation of beta-amino acids having affinity for the alpha-2-delta protein
KR20070107147A (ko) * 2005-03-24 2007-11-06 파마시아 앤드 업존 캄파니 엘엘씨 알파-2-델타 단백질에 친화성을 갖는 광학적으로 순수한베타-아미노산의 제조
WO2007057756A2 (en) * 2005-11-17 2007-05-24 Pfizer Limited Isocystene derivatives for the treatment of pain
KR20080100284A (ko) * 2006-03-06 2008-11-14 화이자 프로덕츠 인코포레이티드 비-회복성 수면을 위한 알파-2-델타 리간드
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
US20110124705A1 (en) * 2009-11-24 2011-05-26 Xenoport, Inc. Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof
US20110130454A1 (en) * 2009-11-24 2011-06-02 Xenoport, Inc. Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof
WO2014069626A1 (ja) * 2012-11-01 2014-05-08 協和発酵キリン株式会社 ピリミドジアゼピノン化合物の製造方法
AU2015280412B2 (en) 2014-06-26 2018-07-26 Island Breeze Systems Ca, Llc MDI related products and methods of use
CN116351339B (zh) * 2022-06-07 2026-01-23 北京先通国际医药科技股份有限公司 一种液体组合物的生产设备及其制备方法和用途
CN121969603A (zh) * 2023-10-12 2026-05-01 美国西门子医学诊断股份有限公司 普瑞巴林半抗原、免疫原和蛋白质结合物及其生产和使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US195251A (en) * 1877-09-18 Improvement in coffee-roasters
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5578606A (en) * 1992-10-30 1996-11-26 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
NZ334898A (en) * 1996-10-23 2000-09-29 Warner Lambert Co Substituted gamma aminobutyric acids as pharamceutical agents
US6306909B1 (en) * 1997-03-12 2001-10-23 Queen's University At Kingston Anti-epileptogenic agents
CA2374755C (en) * 1999-06-10 2010-03-30 Warner-Lambert Company Mono- and disubstituted 3-propyl gamma-aminobutyric acids
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US7419981B2 (en) * 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0219024D0 (en) * 2002-08-15 2002-09-25 Pfizer Ltd Synergistic combinations
US20050043406A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
GB0322140D0 (en) * 2003-09-22 2003-10-22 Pfizer Ltd Combinations

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