PA8564401A1 - Polimorfismos geneticos en el gen de la preprotaquikinina - Google Patents

Polimorfismos geneticos en el gen de la preprotaquikinina

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Publication number
PA8564401A1
PA8564401A1 PA20038564401A PA8564401A PA8564401A1 PA 8564401 A1 PA8564401 A1 PA 8564401A1 PA 20038564401 A PA20038564401 A PA 20038564401A PA 8564401 A PA8564401 A PA 8564401A PA 8564401 A1 PA8564401 A1 PA 8564401A1
Authority
PA
Panama
Prior art keywords
gene
nkna
compatibility
effectiveness
determination
Prior art date
Application number
PA20038564401A
Other languages
English (en)
Inventor
Pierre Vankan
Andrew Sleight
Dorothee Foernzler
Lara Hashimoto
Jia Li
Luedin Eric Eric
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8564401A1 publication Critical patent/PA8564401A1/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Zoology (AREA)
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  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
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  • Rheumatology (AREA)
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  • Physical Education & Sports Medicine (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN METODO PARA CORRELACIONAR POLIMORFISMOS DE UN UNICO NUCLEOTIDO EN EL GEN DE LA PREPROTAQUIKININA (NKNA) CON LA EFICACIA Y COMPATIBILIDAD DE UN COMPUESTO FARMACOLOGICAMENTE ACTIVO ADMINISTRADO A UN SER HUMANO. LA INVENCION SE REFIERE ADEMAS A UN METODO PARA DETERMINAR LA EFICACIA Y COMPATIBILIDAD DE UN COMPUESTO FARMACOLOGICAMENTE ACTIVO ADMINISTRADO A UN SER HUMANO, METODO QUE COMPRENDE LA DETERMINACION DE AL MENOS UN POLIMORFISMO DE UN UNICO NUCLEOTIDO EN EL GEN NKNA. LOS METODOS ANTERIORMENTE MENCIONADOS SE BASAN EN LA DETERMINACION DE POLIMORFISMOS DE UN UNICO NUCLEOTIDO ESPECIFICO EN EL GEN NKNA Y EN LA DETERMINACION DE LA EFICACIA Y COMPATIBILIDAD DE UN COMPUESTO FARMACOLOGICAMENTE ACTIVO EN HUMANOS EN REFERENCIA AL POLIMORFISMO DE NKNA. LA INVENCION SE REFIERE ADEMAS A ACIDOS NUCLEICOS AISLADOS QUE CONTENGAN DENTRO DE SU SECUENCIA LOS POLOMORFISMOS COMO SE HA DEFINIDO AQUI DENTRO, A CEBADORES DE ACIDO NUCLEICO Y SONDAS DE OLIGONUCLEOTIDOS CAPACES DE HIBRIDAR CON ESTE TIPO DE ACIDO NUCLEICOS Y PARA KITS DE DIAGNOSTICO QUE INCLUYAN UNO O MAS DE ESTOS CEBADORES Y SONDAS PARA LA DETECCION DE UN POLIMORFISMO EN EL GEN NKNA, A UN ENVASE FARMACEUTICO QUE INCLUYA ANTAGONISTAS DEL RECEPTOR NK-1 Y INSTRUCCIONES PARA LA ADMINISTRACION DEL FARMACO A SERES HUMANOS EVALUADO PARA LOS POLIMORFISMOS ASI COMO PARA UN MEDIO LEGIBLE POR UN ORDENADOR CON INFORMACION DE LA SECUENCIA PARA LOS POLIMORFISMOS DEL GEN NKNA ALMACENADA.
PA20038564401A 2002-01-31 2003-01-29 Polimorfismos geneticos en el gen de la preprotaquikinina PA8564401A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02001937 2002-01-31

Publications (1)

Publication Number Publication Date
PA8564401A1 true PA8564401A1 (es) 2004-03-26

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ID=27635778

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PA20038564401A PA8564401A1 (es) 2002-01-31 2003-01-29 Polimorfismos geneticos en el gen de la preprotaquikinina

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US (2) US20030158187A1 (es)
EP (1) EP1472377A2 (es)
JP (1) JP2005515788A (es)
KR (1) KR20040077910A (es)
CN (1) CN1625603A (es)
AR (1) AR038334A1 (es)
BR (1) BR0307257A (es)
CA (1) CA2473128A1 (es)
GT (1) GT200300020A (es)
HR (1) HRP20040669A2 (es)
IL (1) IL162733A0 (es)
MX (1) MXPA04007353A (es)
NO (1) NO20043613L (es)
PA (1) PA8564401A1 (es)
PE (1) PE20030816A1 (es)
PL (1) PL371731A1 (es)
RU (1) RU2004126440A (es)
TW (1) TW200302729A (es)
UY (1) UY27634A1 (es)
WO (1) WO2003064685A2 (es)
ZA (1) ZA200405516B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1984891B (zh) 2004-07-06 2012-08-08 弗·哈夫曼-拉罗切有限公司 用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法
CN102449166B (zh) * 2009-05-26 2013-12-04 厦门大学 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法
JP6317763B2 (ja) * 2013-01-08 2018-04-25 シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 対象における癌となる危険性を予測し又は癌と診断する方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613431D0 (en) * 1986-06-03 1986-07-09 Medical Res Council Human tachykinins
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
AU5052599A (en) * 1998-07-25 2000-02-21 Astrazeneca Ab Genetic polymorphisms in the human neurokinin 2 receptor gene and their use in diagnosis and treatment of diseases
SI1103545T1 (en) * 1999-11-29 2004-02-29 F. Hoffmann-La Roche Ag 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof

Also Published As

Publication number Publication date
AR038334A1 (es) 2005-01-12
CA2473128A1 (en) 2003-08-07
UY27634A1 (es) 2003-07-31
EP1472377A2 (en) 2004-11-03
WO2003064685A2 (en) 2003-08-07
US20030158187A1 (en) 2003-08-21
WO2003064685A3 (en) 2003-12-24
RU2004126440A (ru) 2005-08-10
KR20040077910A (ko) 2004-09-07
IL162733A0 (en) 2005-11-20
PE20030816A1 (es) 2003-10-28
US20060228752A1 (en) 2006-10-12
MXPA04007353A (es) 2004-11-26
ZA200405516B (en) 2005-07-01
TW200302729A (en) 2003-08-16
PL371731A1 (en) 2005-06-27
GT200300020A (es) 2003-12-23
JP2005515788A (ja) 2005-06-02
NO20043613L (no) 2004-08-30
HRP20040669A2 (en) 2005-06-30
BR0307257A (pt) 2004-12-14
CN1625603A (zh) 2005-06-08

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