PE20021060A1 - Empleo de amidas de acidos antranilicos como medicamento para el tratamiento de arritmias, asi como preparados farmaceuticos que las contienen - Google Patents
Empleo de amidas de acidos antranilicos como medicamento para el tratamiento de arritmias, asi como preparados farmaceuticos que las contienenInfo
- Publication number
- PE20021060A1 PE20021060A1 PE2002000355A PE2002000355A PE20021060A1 PE 20021060 A1 PE20021060 A1 PE 20021060A1 PE 2002000355 A PE2002000355 A PE 2002000355A PE 2002000355 A PE2002000355 A PE 2002000355A PE 20021060 A1 PE20021060 A1 PE 20021060A1
- Authority
- PE
- Peru
- Prior art keywords
- arrhythmias
- treatment
- alkyl
- amides
- medicinal
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- -1 COMe Chemical group 0.000 abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- 206010042600 Supraventricular arrhythmias Diseases 0.000 abstract 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001746 atrial effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- JFSPBVWPKOEZCB-UHFFFAOYSA-N fenfuram Chemical compound O1C=CC(C(=O)NC=2C=CC=CC=2)=C1C JFSPBVWPKOEZCB-UHFFFAOYSA-N 0.000 abstract 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE AL EMPLEO DE AMIDAS DE ACIDO ANTRANILICO DE FORMULA I DONDE R1 ES (CH2)x-R8; x ES 0-5; R8 ES FENILO, TIENILO, FURANILO OPCIONALMENTE SUSTITUIDOS CON F, Cl, Br, I, CF3, OCF3, NO2, ENTRE OTROS; R2 Y R3 SON H, ALQUILO C1-C3; R4 ES ALQUILO C3-C7; CICLOALQUILO C3-C7, FENILO, NAFTILO, HETEROARILO; R5, R6, R7 SON F, Cl, Br; I, CF3, OCF3, NO2, CN, COOMe, COMe, CONH2, OH, ALQUILO C1-C4, ALCOXI C1-C4, DIMETILAMINO, SULFAMOILO, METILSULFONILO, METILSULFONILAMINO, ENTRE OTROS; PARA EL TRATAMIENTO DE TRASTORNOS DEL RITMO CARDIACO, ARRITMIAS DE REENTRADA, ARRITMIAS SUPRAVENTRICULARES, FIBRILACION ATRIAL, TREMULACION ATRIAL, AL SER LOS COMPUESTOS BLOQUEADORES DEL COMPONENTE DE ACTIVACION LENTA DEL CANAL DE K (Kv1.5), BLOQUEAN EN LA AURICULA UNA CORRIENTE DE POTASIO DENOMINADA "RECTIFICADOR RETARDADO DE ACTIVACION ULTRARAPIDA"
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10121002A DE10121002A1 (de) | 2001-04-28 | 2001-04-28 | Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021060A1 true PE20021060A1 (es) | 2003-01-15 |
Family
ID=7683151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000355A PE20021060A1 (es) | 2001-04-28 | 2002-04-26 | Empleo de amidas de acidos antranilicos como medicamento para el tratamiento de arritmias, asi como preparados farmaceuticos que las contienen |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20020193422A1 (es) |
| DE (1) | DE10121002A1 (es) |
| PE (1) | PE20021060A1 (es) |
| WO (1) | WO2002087568A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10312061A1 (de) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| EA200600203A1 (ru) | 2003-08-08 | 2006-08-25 | Янссен Фармацевтика, Н. В. | Производные 2-(хиноксалин-5-илсульфониламино)бензамида в качестве модуляторов сск2 |
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| JP2008514608A (ja) | 2004-09-24 | 2008-05-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | スルホンアミド化合物 |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| RU2436577C2 (ru) * | 2006-04-27 | 2011-12-20 | Санофи-Авентис Дойчланд Гмбх | Ингибиторы ионных task-1 и task-3 каналов |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| US8664425B2 (en) | 2010-02-02 | 2014-03-04 | Honeywell International Inc. | Bluegreen fluorescent compounds |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
| NZ627942A (en) | 2012-01-27 | 2016-03-31 | Gilead Sciences Inc | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| WO2019232384A1 (en) * | 2018-06-01 | 2019-12-05 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6300368B1 (en) * | 1998-06-30 | 2001-10-09 | Mitsui Chemicals, Inc. | Anilide derivatives and antiarrhythmic agents containing the same |
| BR0011571A (pt) * | 1999-06-24 | 2002-03-05 | Smithkline Beecham Corp | Antagonistas do receptor de limpeza de macrófago |
| DE19929076A1 (de) * | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| JP2001151742A (ja) * | 1999-11-26 | 2001-06-05 | Mitsui Chemicals Inc | アニリド誘導体及びそれを含有する抗不整脈剤 |
-
2001
- 2001-04-28 DE DE10121002A patent/DE10121002A1/de not_active Withdrawn
-
2002
- 2002-04-13 WO PCT/EP2002/004137 patent/WO2002087568A1/de not_active Ceased
- 2002-04-26 PE PE2002000355A patent/PE20021060A1/es not_active Application Discontinuation
- 2002-04-26 US US10/132,184 patent/US20020193422A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002087568A1 (de) | 2002-11-07 |
| DE10121002A1 (de) | 2002-11-14 |
| US20020193422A1 (en) | 2002-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |