PE20021068A1 - Proceso para preparar un epoxido de bencilo - Google Patents
Proceso para preparar un epoxido de benciloInfo
- Publication number
- PE20021068A1 PE20021068A1 PE2002000343A PE2002000343A PE20021068A1 PE 20021068 A1 PE20021068 A1 PE 20021068A1 PE 2002000343 A PE2002000343 A PE 2002000343A PE 2002000343 A PE2002000343 A PE 2002000343A PE 20021068 A1 PE20021068 A1 PE 20021068A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally substituted
- methyl
- alkyl
- halogen
- prot
- Prior art date
Links
- -1 BENZYL EPOXIDE Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- 101100448208 Human herpesvirus 6B (strain Z29) U69 gene Proteins 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- OIRDBPQYVWXNSJ-UHFFFAOYSA-N methyl trifluoromethansulfonate Chemical compound COS(=O)(=O)C(F)(F)F OIRDBPQYVWXNSJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000001012 protector Effects 0.000 abstract 1
- CPDCSUDWYWFWOW-NSHDSACASA-N tert-butyl n-[(2s)-1-chloro-3-(3,5-difluorophenyl)-1-oxopropan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H](C(Cl)=O)CC1=CC(F)=CC(F)=C1 CPDCSUDWYWFWOW-NSHDSACASA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
- C07D301/26—Y being hydrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REFIERE A COMPUESTOS INTERMEDIARIOS PARA LA PREPARACION DE EPOXIDOS N-PROTEGIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDAD DE ALZHEIMER DE FORMULA PROT-N(H)-C(H)(CH2R)-COO-R1; DONDE R ES FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C3, ALQUENILO C2-C6, ALQUINILO C2-C6, HALOGENO, HIDROXI, CIANO, ALCOXI C1-C6, NR12R13, CICLOALQUILO C3-C8; R12 Y R13 SON H, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON OH, NH2, ALQUILO C1-C8, CICLOALQUILO C3-C8; R1 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALOGENO, CH2-CH=CH2, FENILO OPCIONALMENTE SUSTITUIDO CON NITRO, HALOGENO, CIANO, BENCILO; PROT ES PROTECTOR DE NITROGENO t-BUTOXICARBONILO, BENCILOXICARBONILO. SON COMPUESTOS PREFERIDOS METIL ESTER DEL ACIDO (2S)-2-[(TER-BUTOXICARBONIL)AMINO]-3-(3,5-DIFLUROFENILPROPANOICO; (2S)-2-[[(BENCILOXI)CARBONIL]-AMINO]-3-(3,5-DIFLUROFENIL)-3-PROPANOATO DE METILO; (2S,3S)-3-AMINO-1-CLORO-4-(3,5-DIFLUROFENIL)BUTAN-2-OL, t-BUTIL-(1S)-2-CLORO-1-[3,5-DIFLUOROBENCIL]-2-OXOETILCARBAMATO; (2Z)-2-[(BENCILOXI)CARBONIL]-3-(3,5-DIFLUOROFENIL)-3-PROPENOATO DE METILO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DEL ESTER QUE COMPRENDE ESTERIFICACION DE UN AMINOACIDO PROTEGIDO PROT-N(H)-C(H)(CH2R)-COOH CON UN AGENTE DE ALQUILACION TAL COMO DIMETILSULFATO, YODURO DE METILO, TRIFLATO DE METILO, EN PRESENCIA DE UNA BASE COMO HIDROXIDO, CARBONATO, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28577201P | 2001-04-23 | 2001-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021068A1 true PE20021068A1 (es) | 2002-12-11 |
Family
ID=23095626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000343A PE20021068A1 (es) | 2001-04-23 | 2002-04-23 | Proceso para preparar un epoxido de bencilo |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6849750B2 (es) |
| EP (1) | EP1381597B1 (es) |
| JP (1) | JP2004529152A (es) |
| KR (1) | KR20040047750A (es) |
| CN (1) | CN1612871A (es) |
| AP (1) | AP2003002897A0 (es) |
| AR (1) | AR035960A1 (es) |
| AT (1) | ATE401299T1 (es) |
| BR (1) | BR0209163A (es) |
| CA (1) | CA2445163A1 (es) |
| CO (1) | CO5650163A2 (es) |
| DE (1) | DE60227652D1 (es) |
| EA (1) | EA007535B1 (es) |
| ES (1) | ES2309170T3 (es) |
| IL (2) | IL158585A0 (es) |
| MX (1) | MXPA03009723A (es) |
| NO (1) | NO20034738L (es) |
| NZ (1) | NZ529169A (es) |
| OA (1) | OA12597A (es) |
| PE (1) | PE20021068A1 (es) |
| PL (1) | PL365058A1 (es) |
| WO (1) | WO2002085877A2 (es) |
| ZA (1) | ZA200308261B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| CA2558034A1 (en) | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamine aspartyl protease inhibitors |
| US7385085B2 (en) | 2004-07-09 | 2008-06-10 | Elan Pharmaceuticals, Inc. | Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors |
| WO2007047305A1 (en) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors |
| US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2788044B2 (ja) * | 1989-02-06 | 1998-08-20 | サントリー株式会社 | マレイミド誘導体およびそれを有効成分として含有する農園芸用殺菌剤 |
| US5482947A (en) | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
| US5583238A (en) | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| US5521219A (en) | 1992-08-25 | 1996-05-28 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US5481011A (en) * | 1994-12-13 | 1996-01-02 | Bristol-Myers Squibb Company | Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters |
| US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
| EP0958293B1 (en) | 1997-02-04 | 2005-01-19 | The Regents Of The University Of California | Nanomolar, non-peptide inhibitors of cathepsin d |
| CA2273643A1 (en) | 1998-06-09 | 1999-12-09 | F. Hoffmann-La Roche Ag | Stereoselective reduction of carbonyl compounds |
| JP2003528071A (ja) | 2000-03-23 | 2003-09-24 | エラン ファーマスーティカルズ インコーポレイテッド | アルツハイマー病治療用組成物および方法 |
| JP2004502665A (ja) | 2000-06-30 | 2004-01-29 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病を治療する化合物 |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US20030096864A1 (en) | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| MXPA04005428A (es) | 2001-12-06 | 2004-12-06 | Elan Pharm Inc | Hidroxietilaminas substituidas. |
-
2002
- 2002-04-19 AR ARP020101444A patent/AR035960A1/es unknown
- 2002-04-23 AT AT02728882T patent/ATE401299T1/de not_active IP Right Cessation
- 2002-04-23 JP JP2002583404A patent/JP2004529152A/ja active Pending
- 2002-04-23 IL IL15858502A patent/IL158585A0/xx unknown
- 2002-04-23 EA EA200301133A patent/EA007535B1/ru not_active IP Right Cessation
- 2002-04-23 WO PCT/US2002/012591 patent/WO2002085877A2/en not_active Ceased
- 2002-04-23 CA CA002445163A patent/CA2445163A1/en not_active Abandoned
- 2002-04-23 MX MXPA03009723A patent/MXPA03009723A/es active IP Right Grant
- 2002-04-23 ES ES02728882T patent/ES2309170T3/es not_active Expired - Lifetime
- 2002-04-23 BR BR0209163-1A patent/BR0209163A/pt not_active IP Right Cessation
- 2002-04-23 NZ NZ529169A patent/NZ529169A/en unknown
- 2002-04-23 KR KR10-2003-7013902A patent/KR20040047750A/ko not_active Ceased
- 2002-04-23 US US10/128,122 patent/US6849750B2/en not_active Expired - Fee Related
- 2002-04-23 PE PE2002000343A patent/PE20021068A1/es not_active Application Discontinuation
- 2002-04-23 OA OA1200300276A patent/OA12597A/en unknown
- 2002-04-23 EP EP02728882A patent/EP1381597B1/en not_active Expired - Lifetime
- 2002-04-23 AP APAP/P/2003/002897A patent/AP2003002897A0/en unknown
- 2002-04-23 PL PL02365058A patent/PL365058A1/xx not_active Application Discontinuation
- 2002-04-23 CN CNA02812636XA patent/CN1612871A/zh active Pending
- 2002-04-23 DE DE60227652T patent/DE60227652D1/de not_active Expired - Fee Related
-
2003
- 2003-10-23 NO NO20034738A patent/NO20034738L/no not_active Application Discontinuation
- 2003-10-23 IL IL158585A patent/IL158585A/en not_active IP Right Cessation
- 2003-10-23 ZA ZA200308261A patent/ZA200308261B/en unknown
- 2003-11-20 CO CO03102567A patent/CO5650163A2/es not_active Application Discontinuation
-
2005
- 2005-02-01 US US11/048,389 patent/US7638646B2/en not_active Expired - Fee Related
-
2009
- 2009-12-23 US US12/646,526 patent/US20100099898A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20034738L (no) | 2003-12-04 |
| CA2445163A1 (en) | 2002-10-31 |
| IL158585A (en) | 2009-06-15 |
| AR035960A1 (es) | 2004-07-28 |
| US6849750B2 (en) | 2005-02-01 |
| US7638646B2 (en) | 2009-12-29 |
| ES2309170T3 (es) | 2008-12-16 |
| EP1381597A2 (en) | 2004-01-21 |
| WO2002085877A2 (en) | 2002-10-31 |
| DE60227652D1 (de) | 2008-08-28 |
| PL365058A1 (en) | 2004-12-27 |
| MXPA03009723A (es) | 2004-03-16 |
| US20050130936A1 (en) | 2005-06-16 |
| OA12597A (en) | 2006-06-08 |
| EP1381597B1 (en) | 2008-07-16 |
| KR20040047750A (ko) | 2004-06-05 |
| EA200301133A1 (ru) | 2004-04-29 |
| ZA200308261B (en) | 2004-05-24 |
| BR0209163A (pt) | 2004-08-24 |
| NO20034738D0 (no) | 2003-10-23 |
| AP2003002897A0 (en) | 2003-12-31 |
| EA007535B1 (ru) | 2006-10-27 |
| WO2002085877A3 (en) | 2003-03-06 |
| CO5650163A2 (es) | 2006-06-30 |
| JP2004529152A (ja) | 2004-09-24 |
| US20030004360A1 (en) | 2003-01-02 |
| NZ529169A (en) | 2005-06-24 |
| CN1612871A (zh) | 2005-05-04 |
| ATE401299T1 (de) | 2008-08-15 |
| IL158585A0 (en) | 2004-05-12 |
| US20100099898A1 (en) | 2010-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |