PE20031002A1 - Procedimiento para la sintesis de cloroadenosina y metiltioadenosina - Google Patents
Procedimiento para la sintesis de cloroadenosina y metiltioadenosinaInfo
- Publication number
- PE20031002A1 PE20031002A1 PE2003000193A PE2003000193A PE20031002A1 PE 20031002 A1 PE20031002 A1 PE 20031002A1 PE 2003000193 A PE2003000193 A PE 2003000193A PE 2003000193 A PE2003000193 A PE 2003000193A PE 20031002 A1 PE20031002 A1 PE 20031002A1
- Authority
- PE
- Peru
- Prior art keywords
- chloroadenosine
- methylthioadenosine
- synthesis
- filter
- aqueous solvent
- Prior art date
Links
- PLDLXZBHSVQZNN-CRKDRTNXSA-N (2s,3r,4s,5r)-2-(6-aminopurin-9-yl)-2-chloro-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@]1(Cl)O[C@H](CO)[C@@H](O)[C@H]1O PLDLXZBHSVQZNN-CRKDRTNXSA-N 0.000 title abstract 4
- WUUGFSXJNOTRMR-IOSLPCCCSA-N 5'-S-methyl-5'-thioadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-IOSLPCCCSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 239000003125 aqueous solvent Substances 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229960005305 adenosine Drugs 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 239000012267 brine Substances 0.000 abstract 1
- 159000000011 group IA salts Chemical class 0.000 abstract 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/08—Alloys with open or closed pores
- C22C1/083—Foaming process in molten metal other than by powder metallurgy
- C22C1/086—Gas foaming process
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Metallurgy (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
QUE COMPRENDE, PARA LA SINTESIS DE CLOROADENOSINA: a) HACER REACCIONAR ADENOSINA EN UN DISOLVENTE NO ACUOSO CON UN CLORURO DE TIONILO Y UNA PIRIDINA PARA FORMAR UNA SOLUCION DE REACCION; b) CAMBIAR EL DISOLVENTE NO ACUOSO POR UN ALCOHOL INFERIOR Y ANADIR UNA BASE A LA SOLUCION DE REACCION; Y, c) FILTRAR, LAVAR, SECAR LA CLOROADENOSINA RESULTANTE, SIENDO EL RENDIMIENTO MAYOR A 70%. PARA LA SINTESIS DE METILTIOADENOSINA: i) ANADIR DIMETILFORMAMIDA Y UN TIOMETOXIDO ALCALINO A LA CLOROADENOSINA PARA FORMAR UNA SEGUNDA SOLUCION DE REACCION; ii) ANADIR SALMUERA A LA SEGUNDA SOLUCION; iii) AJUSTAR ENTRE 6,8 Y 7,2 EL pH DE LA SEGUNDA SOLUCION PARA FORMAR UNA SUSPENSION, Y FILTRARLA PARA FORMAR UN RESIDUO; iv) TRITURAR EL RESIDUO CON AGUA; Y, v) FILTRAR Y SECAR EL RESIDUO PARA DAR METILTIOADENOSINA. EL DISOLVENTE NO ACUOSO ES TETRAHIDROFURANO, ACETONITRILO, PIRIDINA O COMBINACION DE LOS MISMOS. LA BASE ES UN CARBONATO O BICARBONATO DE UN METAL ALCALINO, UNA SAL ALCALINA O HIDROXIDO DE AMONIO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36128402P | 2002-03-04 | 2002-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20031002A1 true PE20031002A1 (es) | 2003-11-29 |
Family
ID=27789105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000193A PE20031002A1 (es) | 2002-03-04 | 2003-02-27 | Procedimiento para la sintesis de cloroadenosina y metiltioadenosina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20030181713A1 (es) |
| EP (1) | EP1483279A1 (es) |
| KR (1) | KR20040094761A (es) |
| CN (1) | CN1639182A (es) |
| AR (1) | AR038716A1 (es) |
| AU (1) | AU2003206011A1 (es) |
| BR (1) | BR0308091A (es) |
| CA (1) | CA2477729A1 (es) |
| GT (1) | GT200300047A (es) |
| HN (1) | HN2003000082A (es) |
| IL (1) | IL163778A0 (es) |
| MX (1) | MXPA04008550A (es) |
| PA (1) | PA8567901A1 (es) |
| PE (1) | PE20031002A1 (es) |
| PL (1) | PL370863A1 (es) |
| RU (1) | RU2004126699A (es) |
| SV (1) | SV2004001491A (es) |
| TW (1) | TW200304826A (es) |
| UY (1) | UY27693A1 (es) |
| WO (1) | WO2003074541A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102245628B1 (ko) * | 2013-04-05 | 2021-04-28 | 라이온 가부시키가이샤 | 내복 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4373122A (en) * | 1981-01-26 | 1983-02-08 | W. H. Brady Co. | Capacitance switch |
| US4454122A (en) * | 1981-04-27 | 1984-06-12 | Bioresearch S.R.L. | Adenosine derivatives of anti-inflammatory and analgesic activity, and therapeutic compositions which contain them as their active principle |
| US4373097A (en) * | 1981-04-27 | 1983-02-08 | Bioresearch S.R.L. | Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity |
| JPS61171423A (ja) * | 1985-01-24 | 1986-08-02 | Advance Res & Dev Co Ltd | 抗う蝕乃至抗歯周症剤 |
| US6492349B1 (en) * | 1993-03-31 | 2002-12-10 | Nutramax Laboratories, Inc. | Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue |
| US5872104A (en) * | 1994-12-27 | 1999-02-16 | Oridigm Corporation | Combinations and methods for reducing antimicrobial resistance |
-
2003
- 2003-02-14 US US10/367,361 patent/US20030181713A1/en not_active Abandoned
- 2003-02-17 EP EP03702894A patent/EP1483279A1/en not_active Withdrawn
- 2003-02-17 RU RU2004126699/04A patent/RU2004126699A/ru not_active Application Discontinuation
- 2003-02-17 CA CA002477729A patent/CA2477729A1/en not_active Abandoned
- 2003-02-17 KR KR10-2004-7013733A patent/KR20040094761A/ko not_active Ceased
- 2003-02-17 MX MXPA04008550A patent/MXPA04008550A/es not_active Application Discontinuation
- 2003-02-17 IL IL16377803A patent/IL163778A0/xx unknown
- 2003-02-17 PL PL03370863A patent/PL370863A1/xx not_active Application Discontinuation
- 2003-02-17 CN CNA03805177XA patent/CN1639182A/zh active Pending
- 2003-02-17 WO PCT/IB2003/000595 patent/WO2003074541A1/en not_active Ceased
- 2003-02-17 AU AU2003206011A patent/AU2003206011A1/en not_active Abandoned
- 2003-02-17 BR BR0308091-9A patent/BR0308091A/pt not_active Application Discontinuation
- 2003-02-27 PA PA20038567901A patent/PA8567901A1/es unknown
- 2003-02-27 PE PE2003000193A patent/PE20031002A1/es not_active Application Discontinuation
- 2003-02-28 UY UY27693A patent/UY27693A1/es not_active Application Discontinuation
- 2003-03-03 SV SV2003001491A patent/SV2004001491A/es not_active Application Discontinuation
- 2003-03-03 AR ARP030100701A patent/AR038716A1/es not_active Application Discontinuation
- 2003-03-03 TW TW092104403A patent/TW200304826A/zh unknown
- 2003-03-03 HN HN2003000082A patent/HN2003000082A/es unknown
- 2003-03-04 GT GT200300047A patent/GT200300047A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040094761A (ko) | 2004-11-10 |
| BR0308091A (pt) | 2004-12-21 |
| RU2004126699A (ru) | 2005-04-10 |
| WO2003074541A1 (en) | 2003-09-12 |
| GT200300047A (es) | 2003-10-10 |
| US20030181713A1 (en) | 2003-09-25 |
| AU2003206011A1 (en) | 2003-09-16 |
| PL370863A1 (en) | 2005-05-30 |
| IL163778A0 (en) | 2005-12-18 |
| EP1483279A1 (en) | 2004-12-08 |
| UY27693A1 (es) | 2003-10-31 |
| SV2004001491A (es) | 2004-05-07 |
| TW200304826A (en) | 2003-10-16 |
| PA8567901A1 (es) | 2003-11-12 |
| CN1639182A (zh) | 2005-07-13 |
| MXPA04008550A (es) | 2004-12-06 |
| CA2477729A1 (en) | 2003-09-12 |
| AR038716A1 (es) | 2005-01-26 |
| HN2003000082A (es) | 2004-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |