PE20031052A1 - Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la cicloxigenasa-2 - Google Patents
Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la cicloxigenasa-2Info
- Publication number
- PE20031052A1 PE20031052A1 PE2003000166A PE2003000166A PE20031052A1 PE 20031052 A1 PE20031052 A1 PE 20031052A1 PE 2003000166 A PE2003000166 A PE 2003000166A PE 2003000166 A PE2003000166 A PE 2003000166A PE 20031052 A1 PE20031052 A1 PE 20031052A1
- Authority
- PE
- Peru
- Prior art keywords
- alpha
- cycloxygenase
- combinations
- selective inhibitor
- delta ligand
- Prior art date
Links
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229960002870 gabapentin Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 abstract 1
- 229960002004 valdecoxib Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE: a) VALDECOXIB O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES Y b) UN LIGANDO ALFA-2-DELTA SELECCIONADO DE GABAPENTINA, PREGABALINA, HIDROCLORURO DE 3-(1-AMINOMETIL-CICLOHEXILMETIL)-4H-[1,2,4]-OXADIAZOL-5-ONA, (3S,4S)-(1-AMINOMETIL-3,4-DIMETIL-CICLOPENTIL)-ACETICO. LA COMPOSICION COMPRENDE ADEMAS UN VEHICULO, DILUYENTE FARMACEUTICAMENTE ACEPTABLE Y ES UTIL PARA EL TRATAMIENTO DE INFLAMACION, OSTEOARTRITIS, ARTRITIS REUMATOIDE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35929502P | 2002-02-22 | 2002-02-22 | |
| US40436502P | 2002-08-19 | 2002-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20031052A1 true PE20031052A1 (es) | 2003-12-24 |
Family
ID=27760521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000166A PE20031052A1 (es) | 2002-02-22 | 2003-02-17 | Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la cicloxigenasa-2 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030199567A1 (es) |
| EP (1) | EP1480639A1 (es) |
| JP (1) | JP2005523281A (es) |
| KR (1) | KR20040085216A (es) |
| CN (1) | CN1635887A (es) |
| AR (1) | AR038531A1 (es) |
| AU (1) | AU2003246864A1 (es) |
| BR (1) | BR0307906A (es) |
| CA (1) | CA2476438A1 (es) |
| CO (1) | CO5611109A2 (es) |
| HN (1) | HN2003000071A (es) |
| IL (1) | IL162932A0 (es) |
| MX (1) | MXPA04008175A (es) |
| NO (1) | NO20043947L (es) |
| PA (1) | PA8567201A1 (es) |
| PE (1) | PE20031052A1 (es) |
| PL (1) | PL372210A1 (es) |
| RU (1) | RU2286151C2 (es) |
| TW (1) | TW200303214A (es) |
| UY (1) | UY27675A1 (es) |
| WO (1) | WO2003070237A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60332387D1 (de) * | 2002-12-13 | 2010-06-10 | Warner Lambert Co | Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege |
| WO2004084880A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND α2δ SUBUNIT CALCIUM CHANNEL MODULATORS |
| EP1492519B1 (en) * | 2003-03-21 | 2006-11-15 | Dynogen Pharmaceuticals, Inc. | Methods for treating lower urinary tract disorders using antimuscarinics and alpha-2-delta subunit calcium channel modulators |
| WO2004084881A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING FUNCTIONAL BOWEL DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS |
| US7169812B2 (en) * | 2003-07-01 | 2007-01-30 | Medtronic, Inc. | Process for producing injectable gabapentin compositions |
| DE602004024317D1 (de) * | 2003-09-12 | 2010-01-07 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| WO2005041976A2 (en) * | 2003-10-23 | 2005-05-12 | Medtronic, Inc. | Injectable gabapentin compositions |
| MX2008013137A (es) * | 2006-04-11 | 2008-10-21 | Novartis Ag | Compuestos organicos. |
| JP2010513357A (ja) * | 2006-12-22 | 2010-04-30 | ノバルティス アーゲー | Ｄｐｐ−ｉｖ阻害剤としての１−アミノメチル−１−フェニル−シクロヘキサン誘導体 |
| EP2286224A4 (en) * | 2008-05-05 | 2012-04-25 | Univ Winthrop Hospital | METHOD FOR IMPROVING THE CARDIOVASCULAR RISK PROFILE OF COX-INHIBITORS |
| KR101730924B1 (ko) * | 2008-09-05 | 2017-04-27 | 그뤼넨탈 게엠베하 | 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물 |
| KR102631399B1 (ko) | 2018-03-30 | 2024-02-01 | 씨지인바이츠 주식회사 | 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물 |
| CN116782897A (zh) * | 2020-10-28 | 2023-09-19 | 特默罗制药股份有限公司 | 水不溶性的cox-2抑制剂的水性制剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234929A (en) * | 1992-07-20 | 1993-08-10 | William Chelen | Method of treating motion sickness with anticonvulsants and antitussive agents |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| US5420270A (en) * | 1993-10-07 | 1995-05-30 | G. D. Searle & Co. | Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5352638A (en) * | 1994-02-22 | 1994-10-04 | Corning Incorporated | Nickel aluminosilicate glass-ceramics |
| CZ291757B6 (cs) * | 1994-07-27 | 2003-05-14 | Warner-Lambert Company | Léčivo pro léčení úzkosti a panického strachu |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| AU8668598A (en) * | 1997-08-20 | 1999-03-08 | University Of Oklahoma, The | Gaba analogs to prevent and treat gastrointestinal damage |
| EP1011658B1 (en) * | 1997-09-08 | 2005-12-07 | Warner-Lambert Company Llc | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| KR20010033153A (ko) * | 1997-12-16 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도 |
| JP2002538221A (ja) * | 1999-03-10 | 2002-11-12 | ワーナー−ランバート・カンパニー | 抗てんかん作用を有する化合物を包含する鎮痛組成物およびその使用方法 |
| HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| GB9927844D0 (en) * | 1999-11-26 | 2000-01-26 | Glaxo Group Ltd | Chemical compounds |
| CA2362816C (en) * | 1999-12-08 | 2007-02-06 | Pharmacia Corporation | Valdecoxib compositions |
-
2003
- 2003-02-12 PL PL03372210A patent/PL372210A1/xx not_active Application Discontinuation
- 2003-02-12 WO PCT/IB2003/000534 patent/WO2003070237A1/en not_active Ceased
- 2003-02-12 EP EP03742460A patent/EP1480639A1/en not_active Withdrawn
- 2003-02-12 IL IL16293203A patent/IL162932A0/xx unknown
- 2003-02-12 AU AU2003246864A patent/AU2003246864A1/en not_active Abandoned
- 2003-02-12 CN CNA038043564A patent/CN1635887A/zh active Pending
- 2003-02-12 CA CA002476438A patent/CA2476438A1/en not_active Abandoned
- 2003-02-12 MX MXPA04008175A patent/MXPA04008175A/es unknown
- 2003-02-12 RU RU2004125609/15A patent/RU2286151C2/ru not_active IP Right Cessation
- 2003-02-12 BR BR0307906-6A patent/BR0307906A/pt not_active IP Right Cessation
- 2003-02-12 JP JP2003569193A patent/JP2005523281A/ja not_active Abandoned
- 2003-02-12 KR KR10-2004-7013032A patent/KR20040085216A/ko not_active Ceased
- 2003-02-14 US US10/366,798 patent/US20030199567A1/en not_active Abandoned
- 2003-02-17 PE PE2003000166A patent/PE20031052A1/es not_active Application Discontinuation
- 2003-02-19 UY UY27675A patent/UY27675A1/es not_active Application Discontinuation
- 2003-02-20 AR ARP030100547A patent/AR038531A1/es unknown
- 2003-02-21 TW TW092103596A patent/TW200303214A/zh unknown
- 2003-02-21 PA PA20038567201A patent/PA8567201A1/es unknown
- 2003-02-21 HN HN2003000071A patent/HN2003000071A/es unknown
-
2004
- 2004-08-13 CO CO04079024A patent/CO5611109A2/es not_active Application Discontinuation
- 2004-09-21 NO NO20043947A patent/NO20043947L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2286151C2 (ru) | 2006-10-27 |
| US20030199567A1 (en) | 2003-10-23 |
| HN2003000071A (es) | 2003-11-24 |
| PL372210A1 (en) | 2005-07-11 |
| EP1480639A1 (en) | 2004-12-01 |
| JP2005523281A (ja) | 2005-08-04 |
| WO2003070237A1 (en) | 2003-08-28 |
| KR20040085216A (ko) | 2004-10-07 |
| RU2004125609A (ru) | 2006-01-27 |
| BR0307906A (pt) | 2004-12-21 |
| CN1635887A (zh) | 2005-07-06 |
| NO20043947L (no) | 2004-09-21 |
| IL162932A0 (en) | 2005-11-20 |
| AU2003246864A1 (en) | 2003-09-09 |
| CO5611109A2 (es) | 2006-02-28 |
| AR038531A1 (es) | 2005-01-19 |
| CA2476438A1 (en) | 2003-08-28 |
| UY27675A1 (es) | 2003-09-30 |
| PA8567201A1 (es) | 2003-11-12 |
| TW200303214A (en) | 2003-09-01 |
| MXPA04008175A (es) | 2004-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |