PE20071035A1 - DERIVADOS DE ESTER O ACIDO ACETICO COMO MODULADORES DEL RECEPTOR CRTh2 - Google Patents
DERIVADOS DE ESTER O ACIDO ACETICO COMO MODULADORES DEL RECEPTOR CRTh2Info
- Publication number
- PE20071035A1 PE20071035A1 PE2006001570A PE2006001570A PE20071035A1 PE 20071035 A1 PE20071035 A1 PE 20071035A1 PE 2006001570 A PE2006001570 A PE 2006001570A PE 2006001570 A PE2006001570 A PE 2006001570A PE 20071035 A1 PE20071035 A1 PE 20071035A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- carbon atoms
- group
- modulators
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title 3
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 CYANE Chemical class 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003979 eosinophil Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE A SE SELECCIONA INDEPENDIENTEMENTE DE CH Y NITROGENO; D ES CR3 O NITROGENO; R1 Y R2 ES HIDROGENO, HALOGENO O ALQUILO C1-C8; R3 ES ALQUILO C1-C8, HALOGENO, CIANO, HIDROXILO, ENTRE OTROS; R4 ES HALOGENO, ALQUILO C1-C8, HALOALQUILO C1-C8, UN GRUPO CARBOXICLICO DE 3 A 15 ATOMOS DE CARBONO, ENTRE OTROS; R5 ES HALOGENO, ALQUILO C1-C8, HALOALQUILO C1-C8, ENTRE OTROS; R6 ES HIDROGENO O ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO POR UN GRUPO CARBOCICLICO DE 3 A 15 ATOMOS DE CARBONO; W ES UN GRUPO CARBOCICLICO AROMATICO DE 6 A 15 ATOMOS DE CARBONO O UN GRUPO HETEROCICLICO DE 4 A 14 MIEMBROS; X ES UN ENLACE, ALQUILENO DE 2 A 8 ATOMOS DE CARBONO OPCIONALMENTE SUBSTITUIDO POR UNO O MAS GRUPOS SELECCIONADOS DE ALQUILO C1-C8, HALOGENO, HIDROXILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN ACTIVIDAD MODULADORA DEL RECEPTOR QUIMIOATRAYENTE ACOPLADO A LA PROTEINA G, CRTh2, EXPRESADO EN CELULAS Th2, EOSINOFILOS Y BASOFILOS Y SON UTILES EN EL TRATAMIENTO DE CONDICIONES ALERGICAS Y ANTIINFLAMATORIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0525144.2A GB0525144D0 (en) | 2005-12-09 | 2005-12-09 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071035A1 true PE20071035A1 (es) | 2007-10-30 |
Family
ID=35735863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001570A PE20071035A1 (es) | 2005-12-09 | 2006-12-06 | DERIVADOS DE ESTER O ACIDO ACETICO COMO MODULADORES DEL RECEPTOR CRTh2 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080312229A1 (es) |
| EP (1) | EP1960398B1 (es) |
| JP (1) | JP2009518343A (es) |
| KR (1) | KR20080065699A (es) |
| CN (1) | CN101326185A (es) |
| AR (1) | AR056887A1 (es) |
| AT (1) | ATE482957T1 (es) |
| AU (1) | AU2006322206B2 (es) |
| BR (1) | BRPI0619529A2 (es) |
| CA (1) | CA2630611A1 (es) |
| DE (1) | DE602006017256D1 (es) |
| GB (1) | GB0525144D0 (es) |
| PE (1) | PE20071035A1 (es) |
| PT (1) | PT1960398E (es) |
| RU (1) | RU2008127439A (es) |
| TW (1) | TW200732337A (es) |
| WO (1) | WO2007065683A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY144903A (en) | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
| GB0525143D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
| BRPI0715179A2 (pt) | 2006-08-07 | 2013-06-11 | Actelion Pharmaceuticals Ltd | composto, composiÇço farmacÊutica e uso de um composto |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| JP2011509991A (ja) * | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Ｃｒｔｈ２アンタゴニスト活性を有する化合物 |
| HRP20150898T1 (hr) * | 2010-01-27 | 2015-10-09 | Boehringer Ingelheim International Gmbh | Spojevi pirazola kao antagonisti crth2 |
| PT2558447E (pt) | 2010-03-22 | 2014-11-25 | Actelion Pharmaceuticals Ltd | Derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9hcarbazol e o seu uso como moduladores do receptor de prostaglandina d2 |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| MX353408B (es) | 2010-04-22 | 2018-01-11 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| DK2697223T3 (en) | 2011-04-14 | 2016-09-05 | Actelion Pharmaceuticals Ltd | 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor |
| PT2781508T (pt) * | 2011-11-17 | 2019-03-20 | Kbp Biosciences Co Ltd | Compostos de anel fundido contendo azoto para utilização como antagonistas de crth2 |
| AR099767A1 (es) | 2014-03-17 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados del ácido acético azaindol y su uso como moduladores del receptor de prostaglandina d2 |
| KR20160133536A (ko) | 2014-03-18 | 2016-11-22 | 액테리온 파마슈티칼 리미티드 | 아자인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 이의 용도 |
| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| AU2016323262B2 (en) | 2015-09-15 | 2020-11-19 | Idorsia Pharmaceuticals Ltd | Crystalline forms |
| RU2020118594A (ru) | 2017-11-06 | 2021-12-09 | Рапт Терапьютикс, Инк. | Противораковые агенты |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3320268A (en) * | 1964-08-14 | 1967-05-16 | Merck & Co Inc | 1-aroyl or heteroaroyl-7-azaindole-3-carboxylates and derivatives |
| RU2356887C2 (ru) * | 2003-02-06 | 2009-05-27 | ДОМПЕ ФА.Р.МА.С.п.А. | 2-арилуксусные кислоты, их производные и содержащие их фармацевтические композиции |
| MY144903A (en) * | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
-
2005
- 2005-12-09 GB GBGB0525144.2A patent/GB0525144D0/en not_active Ceased
-
2006
- 2006-12-06 PE PE2006001570A patent/PE20071035A1/es not_active Application Discontinuation
- 2006-12-07 DE DE602006017256T patent/DE602006017256D1/de active Active
- 2006-12-07 WO PCT/EP2006/011770 patent/WO2007065683A1/en not_active Ceased
- 2006-12-07 AU AU2006322206A patent/AU2006322206B2/en not_active Ceased
- 2006-12-07 PT PT06819000T patent/PT1960398E/pt unknown
- 2006-12-07 RU RU2008127439/04A patent/RU2008127439A/ru unknown
- 2006-12-07 AT AT06819000T patent/ATE482957T1/de not_active IP Right Cessation
- 2006-12-07 AR ARP060105412A patent/AR056887A1/es unknown
- 2006-12-07 BR BRPI0619529-6A patent/BRPI0619529A2/pt not_active IP Right Cessation
- 2006-12-07 CA CA002630611A patent/CA2630611A1/en not_active Abandoned
- 2006-12-07 US US12/096,453 patent/US20080312229A1/en not_active Abandoned
- 2006-12-07 JP JP2008543732A patent/JP2009518343A/ja active Pending
- 2006-12-07 KR KR1020087013721A patent/KR20080065699A/ko not_active Abandoned
- 2006-12-07 CN CNA2006800462767A patent/CN101326185A/zh active Pending
- 2006-12-07 EP EP06819000A patent/EP1960398B1/en not_active Not-in-force
- 2006-12-08 TW TW095146173A patent/TW200732337A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006017256D1 (de) | 2010-11-11 |
| BRPI0619529A2 (pt) | 2011-10-04 |
| KR20080065699A (ko) | 2008-07-14 |
| AU2006322206A1 (en) | 2007-06-14 |
| US20080312229A1 (en) | 2008-12-18 |
| ATE482957T1 (de) | 2010-10-15 |
| EP1960398A1 (en) | 2008-08-27 |
| AU2006322206B2 (en) | 2010-08-19 |
| GB0525144D0 (en) | 2006-01-18 |
| CN101326185A (zh) | 2008-12-17 |
| TW200732337A (en) | 2007-09-01 |
| WO2007065683A1 (en) | 2007-06-14 |
| JP2009518343A (ja) | 2009-05-07 |
| CA2630611A1 (en) | 2007-06-14 |
| RU2008127439A (ru) | 2010-01-20 |
| AR056887A1 (es) | 2007-10-31 |
| EP1960398B1 (en) | 2010-09-29 |
| PT1960398E (pt) | 2010-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |