PE20090045A1 - Docetaxel cristalino anhidro estable y metodo para la preparacion del mismo - Google Patents
Docetaxel cristalino anhidro estable y metodo para la preparacion del mismoInfo
- Publication number
- PE20090045A1 PE20090045A1 PE2008000630A PE2008000630A PE20090045A1 PE 20090045 A1 PE20090045 A1 PE 20090045A1 PE 2008000630 A PE2008000630 A PE 2008000630A PE 2008000630 A PE2008000630 A PE 2008000630A PE 20090045 A1 PE20090045 A1 PE 20090045A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- docetaxel
- crystalline
- anhydro
- stable
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 3
- 229960003668 docetaxel Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 abstract 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
SE REFIERE A UNA FORMA CRISTALINA ANHIDRA DE DOCETAXEL DE FORMULA (I) DONDE Ph ES FENILO; Ac ES ACETILO; Bz ES BENZOILO; Boc ES T-BUTOXICARBONILO, EN DONDE LA FORMA CRISTALINA TIENE UN ESPECTRO DE DIFRACCION DE RAYOS X QUE MUESTRA PICOS EXPRESADOS EN GRADOS 2 DE 4.88, 9.22, 9.72, 10.38, 11.30, 11.88, 13.34, 14.56, 15.14, 16.62, 17.28, 17.66, 19.02, 19.62, 19.86, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE LA FORMA CRISTALINA QUE COMPRENDE: i) DISOLVER DOCETAXEL EN UN SOLVENTE ORGANICO TAL COMO CETONA, MEZCLA DE DICLOROMETANO-METANOL, ENTRE OTROS; ii) ANADIR UN ANTISOLVENTE TAL COMO PENTANO, HEXANO Y HEPTANO A LA SOLUCION RESULTANTE; Y iii) RECUPERAR LOS CRISTALES RESULTANTES MEDIANTE FILTRACION. DICHA FORMA CRISTALINA ANHIDRA ES UN ANTITUMORAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020070035065A KR100878455B1 (ko) | 2007-04-10 | 2007-04-10 | 안정한 무수결정형 도세탁셀 및 이의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090045A1 true PE20090045A1 (es) | 2009-03-22 |
Family
ID=39831157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000630A PE20090045A1 (es) | 2007-04-10 | 2008-04-09 | Docetaxel cristalino anhidro estable y metodo para la preparacion del mismo |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100099897A1 (es) |
| EP (1) | EP2155709A4 (es) |
| JP (1) | JP2010523647A (es) |
| KR (1) | KR100878455B1 (es) |
| CN (1) | CN101652356A (es) |
| AR (1) | AR065928A1 (es) |
| CL (1) | CL2008000980A1 (es) |
| PE (1) | PE20090045A1 (es) |
| TW (1) | TW200906813A (es) |
| WO (1) | WO2008123751A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006130978A1 (en) | 2005-06-06 | 2006-12-14 | The University Of British Columbia | Polymer-based serum albumin substitute |
| KR101149600B1 (ko) * | 2009-12-31 | 2012-05-29 | 주식회사 삼양제넥스바이오 | 고순도 무수결정형 도세탁셀 제조방법 |
| BR112012021991A2 (pt) | 2010-03-01 | 2020-09-01 | The University Of British Columbia | policlicerol hiperramificado uso de um poliglicerol hipermanificado, método de adiministração de uma força biologicamente ativa a um tecido biológico, composição farmacêutica e método de síntese de um poliglicerol hiperrramificado. |
| US10842770B2 (en) | 2010-05-03 | 2020-11-24 | Teikoku Pharma Usa, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
| US8842114B1 (en) | 2011-04-29 | 2014-09-23 | Nvidia Corporation | System, method, and computer program product for adjusting a depth of displayed objects within a region of a display |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| EP3294286A4 (en) | 2015-05-15 | 2019-01-02 | Albuvex LLC | Docetaxel and human serum albumin complexes |
| US11419842B2 (en) | 2016-10-27 | 2022-08-23 | Zhuhai Beihai Biotech Co., Ltd. | Neutral pH compositions of Docetaxel and human serum albumin |
| ES3037830T3 (en) | 2020-02-04 | 2025-10-07 | Zhuhai Beihai Biotech Co Ltd | Formulations of docetaxel |
| AU2022443487A1 (en) | 2022-02-25 | 2024-09-05 | Zhuhai Beihai Biotech Co., Ltd. | Taxotere composition and method |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2722191B1 (fr) | 1994-07-08 | 1996-08-23 | Rhone Poulenc Rorer Sa | Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle |
| US7176325B2 (en) * | 2002-04-05 | 2007-02-13 | Natural Pharmaceuticals, Inc. | Selective acylation of secondary hydroxyl groups |
| US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
| EP1947094A3 (en) * | 2003-12-12 | 2009-02-18 | Quiral Quimica Do Brasil | Process for the preparation of taxane derivatives |
| FR2864340B1 (fr) * | 2003-12-19 | 2006-03-24 | Commissariat Energie Atomique | Microcomposant comportant une microcavite hermetique et procede de fabrication d'un tel microcomposant |
| CN100420681C (zh) | 2005-04-29 | 2008-09-24 | 上海奥锐特国际贸易有限公司 | 多烯紫杉醇三水物的制备方法 |
| JP2008523111A (ja) * | 2005-10-12 | 2008-07-03 | シコール インコーポレイティド | ドセタキセルの結晶形及びそれらの調製方法 |
| KR100995390B1 (ko) * | 2006-01-02 | 2010-11-19 | 주식회사 삼양제넥스 | 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법 |
| BRPI0600194A (pt) * | 2006-01-30 | 2007-10-23 | Quiral Quimica Do Brasil S A | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
| EP2094084A4 (en) * | 2006-10-20 | 2010-01-13 | Scinopharm Singapore Pte Ltd | PROCESS FOR PREPARING CRYSTALLINE WATER-FREE DOCETAXEL |
-
2007
- 2007-04-10 KR KR1020070035065A patent/KR100878455B1/ko not_active Expired - Fee Related
-
2008
- 2008-04-03 AR ARP080101384A patent/AR065928A1/es not_active Application Discontinuation
- 2008-04-04 CL CL200800980A patent/CL2008000980A1/es unknown
- 2008-04-09 TW TW097112817A patent/TW200906813A/zh unknown
- 2008-04-09 PE PE2008000630A patent/PE20090045A1/es not_active Application Discontinuation
- 2008-04-10 CN CN200880011306A patent/CN101652356A/zh active Pending
- 2008-04-10 EP EP08741259A patent/EP2155709A4/en not_active Withdrawn
- 2008-04-10 WO PCT/KR2008/002014 patent/WO2008123751A1/en not_active Ceased
- 2008-04-10 JP JP2010502936A patent/JP2010523647A/ja not_active Withdrawn
- 2008-04-10 US US12/532,887 patent/US20100099897A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100099897A1 (en) | 2010-04-22 |
| TW200906813A (en) | 2009-02-16 |
| KR20080091945A (ko) | 2008-10-15 |
| AR065928A1 (es) | 2009-07-08 |
| EP2155709A4 (en) | 2010-09-15 |
| EP2155709A1 (en) | 2010-02-24 |
| KR100878455B1 (ko) | 2009-01-13 |
| JP2010523647A (ja) | 2010-07-15 |
| CL2008000980A1 (es) | 2008-08-22 |
| CN101652356A (zh) | 2010-02-17 |
| WO2008123751A1 (en) | 2008-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |