PE20090902A1 - Combinacion de un antimitotico e inhibidor de aurora quinasa como agentes anticancerigenos - Google Patents

Combinacion de un antimitotico e inhibidor de aurora quinasa como agentes anticancerigenos

Info

Publication number
PE20090902A1
PE20090902A1 PE2008001275A PE2008001275A PE20090902A1 PE 20090902 A1 PE20090902 A1 PE 20090902A1 PE 2008001275 A PE2008001275 A PE 2008001275A PE 2008001275 A PE2008001275 A PE 2008001275A PE 20090902 A1 PE20090902 A1 PE 20090902A1
Authority
PE
Peru
Prior art keywords
antimittic
combination
halo
alkyl
kinase inhibitor
Prior art date
Application number
PE2008001275A
Other languages
English (en)
Inventor
Andrea Dawn Basso
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40305124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090902(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20090902A1 publication Critical patent/PE20090902A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

REFERIDO A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN AGENTE ANTIMITOTICO SELECCIONADO DEL GRUPO QUE CONSISTE DE: TAXANO, PACLITAXEL, UN COMPUESTO DE FORMULA (A) ENTRE OTROS. DONDE EL ANILLO Y ES ARILO DE 5 A 6 MIEMBROS O UN HETEROARILO DE 5 O 6 MIEMBROS FUSIONADO COMO SE INDICA EN LA FORMULA A; W ES N O C(R12), DONDE R12 ES H, HALO, ALQUILO, ENTRE OTROS; X ES N O N-OXIDO; Z ES S, S(=O) O S(=O)2; R1 ES H, ALQUILO, HALO, ENTRE OTROS; R2 ES H, HALO, ARILO, ENTRE OTROS; R3 ES ALQUILO, CICLOALQUILO, HETEROCICLILO, ENTRE OTROS; Y B) UN INHIBIDOR DE AURORA QUINASA.TAL COMO (E), DONDE R ES H, CN, CICLOALQUILO, ENTRE OTROS; R1, R2 Y R3 SON H, ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (i), (ii), (iii), ENTRE OTROS. TAMBIEN SE REFIERE A UN METODO DE PREPARACION. DICHO COMPUESTO ES INHIBIDOR DEL CRECIMIENTO CELULAR Y ES UTIL EN EL TRATAMIENTO DEL CANCER
PE2008001275A 2007-07-31 2008-07-30 Combinacion de un antimitotico e inhibidor de aurora quinasa como agentes anticancerigenos PE20090902A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95308707P 2007-07-31 2007-07-31
US2398508P 2008-01-28 2008-01-28

Publications (1)

Publication Number Publication Date
PE20090902A1 true PE20090902A1 (es) 2009-07-25

Family

ID=40305124

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001275A PE20090902A1 (es) 2007-07-31 2008-07-30 Combinacion de un antimitotico e inhibidor de aurora quinasa como agentes anticancerigenos

Country Status (17)

Country Link
US (1) US20100249030A1 (es)
EP (1) EP2182986A2 (es)
JP (1) JP2010535201A (es)
KR (1) KR20100042287A (es)
CN (1) CN101808666A (es)
AR (1) AR068048A1 (es)
AU (1) AU2008282885A1 (es)
BR (1) BRPI0814874A2 (es)
CA (1) CA2694218A1 (es)
CL (1) CL2008002224A1 (es)
CO (1) CO6331446A2 (es)
EC (1) ECSP109918A (es)
MX (1) MX2010001340A (es)
PE (1) PE20090902A1 (es)
RU (1) RU2010106878A (es)
TW (1) TW200911241A (es)
WO (1) WO2009017701A2 (es)

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US8669259B2 (en) * 2009-08-26 2014-03-11 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
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Also Published As

Publication number Publication date
JP2010535201A (ja) 2010-11-18
CO6331446A2 (es) 2011-10-20
WO2009017701A2 (en) 2009-02-05
TW200911241A (en) 2009-03-16
EP2182986A2 (en) 2010-05-12
AU2008282885A1 (en) 2009-02-05
CN101808666A (zh) 2010-08-18
ECSP109918A (es) 2010-02-26
CL2008002224A1 (es) 2009-07-17
CA2694218A1 (en) 2009-02-05
AR068048A1 (es) 2009-11-04
BRPI0814874A2 (pt) 2019-09-24
RU2010106878A (ru) 2011-09-10
WO2009017701A3 (en) 2009-05-07
US20100249030A1 (en) 2010-09-30
KR20100042287A (ko) 2010-04-23
MX2010001340A (es) 2010-06-02

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