PE20121049A1 - Derivados de pirazinooxazepina - Google Patents

Derivados de pirazinooxazepina

Info

Publication number
PE20121049A1
PE20121049A1 PE2011002104A PE2011002104A PE20121049A1 PE 20121049 A1 PE20121049 A1 PE 20121049A1 PE 2011002104 A PE2011002104 A PE 2011002104A PE 2011002104 A PE2011002104 A PE 2011002104A PE 20121049 A1 PE20121049 A1 PE 20121049A1
Authority
PE
Peru
Prior art keywords
alkyl
oxazepine
tetrahydropirazino
methyl
substituted
Prior art date
Application number
PE2011002104A
Other languages
English (en)
Inventor
Shigekazu Sasaki
Tomokazu Kusumoto
Izumi Nomura
Hironobu Maezaki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20121049A1 publication Critical patent/PE20121049A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1' ES MORFOLINILO SUSTITUIDO CON ALQUILO C1-C6, PIPERIDILO SUSTITUIDO CON ALQUILO C1-C6, PIRROLILO, IMIDAZOLILO, ENTRE OTROS; R2' ESH, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON GRUPOS ALCOXI C1-C6; R3 ES H, UN ATOMO DE HALOGENO O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: 3-(1-METILETOXI)-6,7,8,9-TETRAHIDROPIRAZINO[2,3-f][1,4]OXAZEPINA; N-METIL-N-(1-METIL)-6,7,8,9-TETRAHIDROPIRAZINO[2,3-f][1,4]OXAZEPINA; 3-CICLOPROPIL-6,7,8,9-TETRAHIDROPIRAZINO[2,3-f][1,4]OXAZEPINA; ENTRE OTROS. DICHOS COMPUESTOS SON ACTIVADORES DEL RECEPTOR DE SEROTONINA 5-HT2C UTIL EN EL TRATAMIENTO DE UN SINTOMA URINARIO INFERIOR, OBESIDAD Y/O PROLAPSO DE ORGANOS
PE2011002104A 2009-06-15 2010-06-14 Derivados de pirazinooxazepina PE20121049A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009142673 2009-06-15

Publications (1)

Publication Number Publication Date
PE20121049A1 true PE20121049A1 (es) 2012-08-22

Family

ID=42561089

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011002104A PE20121049A1 (es) 2009-06-15 2010-06-14 Derivados de pirazinooxazepina

Country Status (40)

Country Link
US (4) US9115139B2 (es)
EP (1) EP2442870B1 (es)
JP (2) JP5579262B2 (es)
KR (1) KR101768234B1 (es)
CN (1) CN102458579B (es)
AR (1) AR077094A1 (es)
AU (1) AU2010260847B2 (es)
BR (1) BRPI1011502A2 (es)
CA (1) CA2765239C (es)
CL (1) CL2011003154A1 (es)
CO (1) CO6491037A2 (es)
CR (1) CR20120021A (es)
CY (1) CY1115483T1 (es)
DK (1) DK2442870T3 (es)
DO (1) DOP2011000393A (es)
EA (1) EA021079B1 (es)
EC (1) ECSP12011603A (es)
ES (1) ES2480275T3 (es)
GE (1) GEP20146168B (es)
HR (1) HRP20140589T1 (es)
IL (1) IL216761A (es)
JO (1) JO3087B1 (es)
MA (1) MA33430B1 (es)
ME (1) ME01835B (es)
MX (1) MX2011013081A (es)
MY (1) MY157497A (es)
NZ (1) NZ597507A (es)
PE (1) PE20121049A1 (es)
PL (1) PL2442870T3 (es)
PT (1) PT2442870E (es)
RS (1) RS53414B (es)
SG (1) SG176696A1 (es)
SI (1) SI2442870T1 (es)
SM (1) SMT201400080B (es)
TN (1) TN2011000630A1 (es)
TW (2) TW201529584A (es)
UA (1) UA108357C2 (es)
UY (1) UY32707A (es)
WO (1) WO2010147226A1 (es)
ZA (1) ZA201109370B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2727585A1 (en) 2006-05-16 2014-05-07 Takeda Pharmaceutical Company Limited In-vivo screening method
JP5579262B2 (ja) * 2009-06-15 2014-08-27 武田薬品工業株式会社 ピラジノオキサゼピン誘導体
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
JP2014201578A (ja) * 2013-04-09 2014-10-27 武田薬品工業株式会社 線維筋痛症治療剤
JP2014214132A (ja) * 2013-04-26 2014-11-17 武田薬品工業株式会社 ニコチン依存症の予防・治療剤
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
WO2017026538A1 (en) 2015-08-07 2017-02-16 Takeda Pharmaceutical Company Limited Production method of pyrazine
WO2017111178A1 (en) 2015-12-24 2017-06-29 Takeda Pharmaceutical Company Limited Solid preparation
US9985579B2 (en) 2016-04-12 2018-05-29 Preformed Line Products Co. Mounting assembly for mounting a solar panel
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
SE0002754D0 (sv) 2000-07-21 2000-07-21 Pharmacia & Upjohn Ab New pharmaceutical combination formulation and method of treatment with the combination
CA2428905A1 (en) 2000-11-20 2002-05-23 Biovitrum Ab PIPERAZINYLPYRAZINE COMPOUNDS FOR USE AS ANTAGONISTS OF THE SEROTONIN 5-HT2 RECEPTOR
WO2002083863A2 (en) 2001-04-17 2002-10-24 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
SE0201544D0 (sv) 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
ES2307102T3 (es) 2002-06-19 2008-11-16 Biovitrum Ab (Publ) Piperazinilpirazinas como moduladores del receptor de la serotonina 5-ht2c.
AU2003243089B2 (en) 2002-06-19 2010-01-07 Biovitrum Ab (Publ) Novel compounds, their use and preparation
CA2514547A1 (en) 2003-01-28 2004-08-12 Takeda Pharmaceutical Company Limited Receptor agonists
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
MXPA05013364A (es) 2003-06-17 2006-03-17 Arena Pharm Inc Procedimiento para preparar 3-benzazepinas.
JP2006056881A (ja) 2004-07-21 2006-03-02 Takeda Chem Ind Ltd 縮合環化合物
JP5237810B2 (ja) 2005-09-01 2013-07-17 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
FR2895259B1 (fr) 2005-12-22 2008-02-22 Urosphere Sas Methodes de traitement des incontinences urinaires
EP2727585A1 (en) * 2006-05-16 2014-05-07 Takeda Pharmaceutical Company Limited In-vivo screening method
US8247403B2 (en) 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
US20090062253A1 (en) 2007-08-31 2009-03-05 Kalypsys, Inc. Heterocyclodiazepine cannabinoid receptor modulators for treatment of disease
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND ITS USE
WO2009063993A1 (ja) * 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
EP2213675B1 (en) * 2007-11-15 2013-08-14 Takeda Pharmaceutical Company Limited Pyridooxazepine derivative and use thereof
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
JP5579262B2 (ja) * 2009-06-15 2014-08-27 武田薬品工業株式会社 ピラジノオキサゼピン誘導体

Also Published As

Publication number Publication date
AR077094A1 (es) 2011-08-03
TWI542592B (zh) 2016-07-21
JP2012530051A (ja) 2012-11-29
PT2442870E (pt) 2014-07-16
UA108357C2 (xx) 2015-04-27
MY157497A (en) 2016-06-15
US20100317651A1 (en) 2010-12-16
JO3087B1 (ar) 2017-03-15
NZ597507A (en) 2013-09-27
CO6491037A2 (es) 2012-07-31
TW201529584A (zh) 2015-08-01
EP2442870B1 (en) 2014-04-16
US20120135979A1 (en) 2012-05-31
TW201109338A (en) 2011-03-16
US8324201B2 (en) 2012-12-04
AU2010260847A1 (en) 2012-01-19
US9115139B2 (en) 2015-08-25
CN102458579A (zh) 2012-05-16
IL216761A (en) 2016-03-31
JP5579203B2 (ja) 2014-08-27
CN102458579B (zh) 2014-11-05
US8314088B2 (en) 2012-11-20
MA33430B1 (fr) 2012-07-03
WO2010147226A1 (en) 2010-12-23
CA2765239C (en) 2018-08-07
DK2442870T3 (da) 2014-06-30
CR20120021A (es) 2012-03-06
ES2480275T3 (es) 2014-07-25
BRPI1011502A2 (pt) 2016-03-22
MX2011013081A (es) 2012-01-20
EA201270017A1 (ru) 2012-07-30
HK1169623A1 (en) 2013-02-01
US20110288291A1 (en) 2011-11-24
EA021079B1 (ru) 2015-03-31
ME01835B (me) 2014-12-20
SG176696A1 (en) 2012-01-30
CL2011003154A1 (es) 2012-06-15
CY1115483T1 (el) 2017-01-04
ZA201109370B (en) 2012-10-31
GEP20146168B (en) 2014-09-25
TN2011000630A1 (en) 2013-05-24
KR101768234B1 (ko) 2017-08-14
US20110282054A1 (en) 2011-11-17
US8318722B2 (en) 2012-11-27
SMT201400080B (it) 2014-09-08
DOP2011000393A (es) 2012-02-15
RS53414B (sr) 2014-12-31
ECSP12011603A (es) 2012-03-30
IL216761A0 (en) 2012-02-29
CA2765239A1 (en) 2010-12-23
HRP20140589T1 (hr) 2014-08-01
PL2442870T3 (pl) 2014-12-31
SI2442870T1 (sl) 2014-07-31
JP2012107032A (ja) 2012-06-07
AU2010260847B2 (en) 2016-11-24
JP5579262B2 (ja) 2014-08-27
KR20120034734A (ko) 2012-04-12
UY32707A (es) 2011-01-31
EP2442870A1 (en) 2012-04-25

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