PE20121086A1 - Compuestos de azetidinona y uso medico de los mismos - Google Patents
Compuestos de azetidinona y uso medico de los mismosInfo
- Publication number
- PE20121086A1 PE20121086A1 PE2012000185A PE2012000185A PE20121086A1 PE 20121086 A1 PE20121086 A1 PE 20121086A1 PE 2012000185 A PE2012000185 A PE 2012000185A PE 2012000185 A PE2012000185 A PE 2012000185A PE 20121086 A1 PE20121086 A1 PE 20121086A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- fluorophenyl
- halogen
- cyane
- trifluoromethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I, R1 ES 1-3 SUSTITUYENTES DE H, HALOGENO, TRIFLUOROMETILO, CIANO, ALQUILO C1-C6, ENTRE OTROS; R2 ES 1-3 SUSTITUYENTES DE H, HALOGENO, TRIFLUOROMETILO, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R3 ES 1-3 SUSTITUYENTES DE H, HALOGENO, BENCILOXILO, ALCOXILO C1-C6, CIANO, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ALQUENILO C2-C6, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C6; R6 ES H, -COR7; R7 ES ALQUILO C1-C10, FENILO SUSTITUIDO O NO CON HALOGENO, TRIFLUOROMETILO, CIANO, ENTRE OTROS; m ES 0-3; n ES 1-3. SON COMPUESTOS PREFERIDOS: (3R,4S)-1-(4-FLUOROFENIL)-3-[(Z)-3-(4-FLUOROFENIL)-4-HIDROXI-BUT-2-ENIL]-4-(4-HIDROXIFENIL)AZETIDIN-2-ONA; (4R,4S)-1-(4-FLUOROFENIL)-3-[(E)-3-(4-FLUOROFENIL)-4-HIDROXI-BUT-2-ENIL]-4-(4-FENOXIFENIL)AZETIDIN-2-ONA; ENTRE OTROS. DICHOS COMPUESTOS PUEDEN REDUCIR LOS NIVELES DE COLESTEROL TOTAL Y COLESTEROL DE LIPOPROTEINAS DE BAJA DENSIDAD EN PLASMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101628888A CN101993403B (zh) | 2009-08-11 | 2009-08-11 | 氮杂环丁酮类化合物及医药应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121086A1 true PE20121086A1 (es) | 2012-08-17 |
Family
ID=43585888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000185A PE20121086A1 (es) | 2009-08-11 | 2010-08-09 | Compuestos de azetidinona y uso medico de los mismos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8623855B2 (es) |
| EP (1) | EP2465847B1 (es) |
| JP (1) | JP5706896B2 (es) |
| KR (1) | KR101394993B1 (es) |
| CN (2) | CN101993403B (es) |
| CA (1) | CA2770793C (es) |
| CL (1) | CL2012000351A1 (es) |
| EA (1) | EA021484B1 (es) |
| IL (1) | IL218045A (es) |
| IN (1) | IN2012DN01132A (es) |
| MX (1) | MX2012001829A (es) |
| MY (1) | MY157237A (es) |
| NZ (1) | NZ598050A (es) |
| PE (1) | PE20121086A1 (es) |
| SG (1) | SG178313A1 (es) |
| UA (1) | UA105053C2 (es) |
| WO (1) | WO2011017907A1 (es) |
| ZA (1) | ZA201201676B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| HK1210143A1 (en) * | 2012-09-05 | 2016-04-15 | 浙江海正药业股份有限公司 | Crystal forms of azetidinone compounds and preparing methods thereof |
| CN104780918B (zh) * | 2013-03-01 | 2017-03-08 | 浙江海正药业股份有限公司 | 用于预防和/或治疗丙型肝炎的氮杂环丁酮化合物及其组合物 |
| CN105294426B (zh) * | 2014-06-09 | 2019-05-14 | 浙江海正药业股份有限公司 | 氮杂环丁酮化合物制备方法及其中间体 |
| WO2019101150A1 (zh) * | 2017-11-23 | 2019-05-31 | 浙江海正药业股份有限公司 | 一种海泽麦布片剂及其制备方法 |
| WO2019101151A1 (zh) * | 2017-11-23 | 2019-05-31 | 浙江海正药业股份有限公司 | 一种海泽麦布和HMG-CoA还原酶抑制剂的药物组合物 |
| WO2022262768A1 (zh) * | 2021-06-17 | 2022-12-22 | 浙江海正药业股份有限公司 | 海泽麦布中间体及其制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2525125B2 (ja) | 1991-07-23 | 1996-08-14 | シェリング・コーポレーション | 血清コレステロ―ル低下薬として有用な置換β−ラクタム化合物およびそれらの製法 |
| LT3595B (en) | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5627176A (en) | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| CA2191455A1 (en) | 1994-06-20 | 1995-12-28 | Wayne Vaccaro | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5633246A (en) | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| EP0877750B1 (en) | 1995-10-31 | 2002-06-19 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic a gents |
| US5756470A (en) | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| ES2287826T3 (es) | 2000-12-20 | 2007-12-16 | Schering Corp | 2-azetidinonas sustituidas con hidroxi utiles como agentes hipocolesterolemicos. |
| IL156552A0 (en) | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
| EP1345895B1 (de) | 2000-12-21 | 2006-12-27 | Sanofi-Aventis Deutschland GmbH | Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen |
| MXPA03005019A (es) | 2000-12-21 | 2003-09-25 | Avantis Pharma Deutschland Gmb | Derivados de difenilazetidinonas, metodo para su produccion farmacos que contienen estos compuestos y su uso. |
| TWI291957B (en) * | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
| DE10227507A1 (de) | 2002-06-19 | 2004-01-08 | Aventis Pharma Deutschland Gmbh | Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE10227506A1 (de) | 2002-06-19 | 2004-01-08 | Aventis Pharma Deutschland Gmbh | Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE10227508A1 (de) | 2002-06-19 | 2004-01-08 | Aventis Pharma Deutschland Gmbh | Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| TW200726746A (en) * | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
| US7696177B2 (en) * | 2005-06-15 | 2010-04-13 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
| CN101134739A (zh) * | 2006-09-01 | 2008-03-05 | 长春吉大天元化学技术股份有限公司 | 新的β-内酰胺类化合物及其制备方法及其药物用途 |
| WO2008057948A2 (en) * | 2006-11-01 | 2008-05-15 | Ironwood Pharmaceuticals, Inc. | Processes for production of diphenylylazetidin-2-ones and related compounds |
| US20080280836A1 (en) * | 2007-05-08 | 2008-11-13 | Morriello Gregori J | Anti-hypercholesterolemic biaryl azetidinone compounds |
| CN101423511A (zh) * | 2007-11-05 | 2009-05-06 | 中山奕安泰医药科技有限公司 | 依泽替米贝中间体及依泽替米贝的合成方法 |
| CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
-
2009
- 2009-08-11 CN CN2009101628888A patent/CN101993403B/zh active Active
-
2010
- 2010-08-09 IN IN1132DEN2012 patent/IN2012DN01132A/en unknown
- 2010-08-09 KR KR1020127004728A patent/KR101394993B1/ko active Active
- 2010-08-09 CN CN201080035472.0A patent/CN102448932B/zh active Active
- 2010-08-09 JP JP2012524081A patent/JP5706896B2/ja active Active
- 2010-08-09 US US13/389,932 patent/US8623855B2/en active Active
- 2010-08-09 UA UAA201202735A patent/UA105053C2/uk unknown
- 2010-08-09 WO PCT/CN2010/001206 patent/WO2011017907A1/zh not_active Ceased
- 2010-08-09 SG SG2012008660A patent/SG178313A1/en unknown
- 2010-08-09 EP EP10807852.8A patent/EP2465847B1/en active Active
- 2010-08-09 EA EA201270248A patent/EA021484B1/ru not_active IP Right Cessation
- 2010-08-09 PE PE2012000185A patent/PE20121086A1/es active IP Right Grant
- 2010-08-09 CA CA2770793A patent/CA2770793C/en active Active
- 2010-08-09 MX MX2012001829A patent/MX2012001829A/es active IP Right Grant
- 2010-08-09 NZ NZ598050A patent/NZ598050A/xx not_active IP Right Cessation
- 2010-08-09 MY MYPI2012000578A patent/MY157237A/en unknown
-
2012
- 2012-02-09 IL IL218045A patent/IL218045A/en not_active IP Right Cessation
- 2012-02-10 CL CL2012000351A patent/CL2012000351A1/es unknown
- 2012-03-07 ZA ZA2012/01676A patent/ZA201201676B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY157237A (en) | 2016-05-13 |
| US20120208994A1 (en) | 2012-08-16 |
| EP2465847A4 (en) | 2013-04-17 |
| WO2011017907A1 (zh) | 2011-02-17 |
| IL218045A (en) | 2017-05-29 |
| KR101394993B1 (ko) | 2014-05-15 |
| AU2010282097A1 (en) | 2012-04-05 |
| JP5706896B2 (ja) | 2015-04-22 |
| EA201270248A1 (ru) | 2012-07-30 |
| CA2770793C (en) | 2017-06-13 |
| ZA201201676B (en) | 2012-11-28 |
| CN101993403B (zh) | 2012-07-11 |
| CA2770793A1 (en) | 2011-02-17 |
| US8623855B2 (en) | 2014-01-07 |
| EA021484B1 (ru) | 2015-06-30 |
| IL218045A0 (en) | 2012-04-30 |
| EP2465847A1 (en) | 2012-06-20 |
| CL2012000351A1 (es) | 2012-08-10 |
| SG178313A1 (en) | 2012-03-29 |
| MX2012001829A (es) | 2012-07-23 |
| UA105053C2 (uk) | 2014-04-10 |
| CN101993403A (zh) | 2011-03-30 |
| CN102448932B (zh) | 2014-08-13 |
| NZ598050A (en) | 2013-03-28 |
| IN2012DN01132A (es) | 2015-04-10 |
| CN102448932A (zh) | 2012-05-09 |
| JP2013501734A (ja) | 2013-01-17 |
| KR20120047969A (ko) | 2012-05-14 |
| EP2465847B1 (en) | 2016-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |