PE20121473A1 - Uso de 4-[etil(dimetil)amonio]butanoato en el tratamiento de enfermedades cardiovasculares - Google Patents

Uso de 4-[etil(dimetil)amonio]butanoato en el tratamiento de enfermedades cardiovasculares

Info

Publication number
PE20121473A1
PE20121473A1 PE2012000523A PE2012000523A PE20121473A1 PE 20121473 A1 PE20121473 A1 PE 20121473A1 PE 2012000523 A PE2012000523 A PE 2012000523A PE 2012000523 A PE2012000523 A PE 2012000523A PE 20121473 A1 PE20121473 A1 PE 20121473A1
Authority
PE
Peru
Prior art keywords
ethyl
dimethyl
butanoate
ammonium
treatment
Prior art date
Application number
PE2012000523A
Other languages
English (en)
Inventor
Ivars Kalvins
Maija Dambrova
Edgars Liepins
Osvalds Pugovis
Reinis Vilskersts
Janis Kuka
Solveiga Grinberga
Einars Loza
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of PE20121473A1 publication Critical patent/PE20121473A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN PROCESO DE PREPARACION DEL COMPUESTO 4-[ETIL(DIMETIL)AMONIO]BUTANOATO, QUE COMPRENDE: (A) ANADIR BROMURO DE ETILO A 4-(DIMETILAMONIO)BUTANOATO EN ACETONA PARA LA OBTENCION DEL BROMURO DE N-ETIL-4-METOXI-N,N-DIMETIL-4-OXO-1-BUTANAMINIO Y (B) TRATAR BROMURO DE N-ETIL-4-METOXI-N,N-DIMETIL-4-OXO-1-BUTANAMINIO CON SOLUCION DE HIDROXIDO POTASICO EN ETANOL. DICHO COMPUESTO TIENE UN EFECTO CARDIOPROTECTOR SIENDO UTIL PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES
PE2012000523A 2009-10-22 2010-10-22 Uso de 4-[etil(dimetil)amonio]butanoato en el tratamiento de enfermedades cardiovasculares PE20121473A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-09-181A LV14345B (lv) 2009-10-22 2009-10-22 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai

Publications (1)

Publication Number Publication Date
PE20121473A1 true PE20121473A1 (es) 2012-11-18

Family

ID=43530044

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000523A PE20121473A1 (es) 2009-10-22 2010-10-22 Uso de 4-[etil(dimetil)amonio]butanoato en el tratamiento de enfermedades cardiovasculares

Country Status (32)

Country Link
US (2) US9278907B2 (es)
EP (1) EP2491005B1 (es)
JP (1) JP5552169B2 (es)
KR (1) KR101355417B1 (es)
CN (1) CN102666476B (es)
AR (1) AR081514A1 (es)
AU (1) AU2010309756B2 (es)
BR (1) BR112012009162B8 (es)
CA (1) CA2781499C (es)
CL (1) CL2012001010A1 (es)
CO (1) CO6531459A2 (es)
CU (1) CU20120065A7 (es)
DK (1) DK2491005T3 (es)
EA (1) EA020303B1 (es)
ES (1) ES2508117T3 (es)
GE (1) GEP20146123B (es)
HR (1) HRP20140964T1 (es)
IL (1) IL219217A0 (es)
LV (1) LV14345B (es)
ME (1) ME01917B (es)
MX (1) MX2012004630A (es)
NZ (1) NZ599521A (es)
PE (1) PE20121473A1 (es)
PL (1) PL2491005T3 (es)
PT (1) PT2491005E (es)
RS (1) RS53620B1 (es)
SI (1) SI2491005T1 (es)
SM (1) SMT201400176B (es)
TN (1) TN2012000174A1 (es)
UA (1) UA107201C2 (es)
WO (1) WO2011048201A1 (es)
ZA (1) ZA201202916B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8565150B2 (en) * 2009-03-11 2013-10-22 At&T Mobility Ii Llc Architectural model for LTE (long term evolution) EPC (evolved packet core) deployment
GEP20156373B (en) * 2011-04-27 2015-09-25 Grindeks Jsc Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease
DE102012109911A1 (de) 2011-10-19 2013-04-25 Electronics And Telecommunications Research Institute Energy harvesting device using electromagnetic interference signal and sensor system including the same
JO3117B1 (ar) * 2012-12-20 2017-09-20 Grindeks Jsc استعمال 3- كربوكسي- ن-إيثيل- ن، ن- ثاني ميثيل بروبان-1– أمينيوم أو ملح منه مقبول صيدلانياً في معالجة تصلب الشرايين
JO3333B1 (ar) 2013-09-26 2019-03-13 Grindeks Jsc استعمال 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium أو ملح مقبول دوائيا منه للوقاية من السكري وعلاجه
CN107879944B (zh) * 2017-10-30 2020-05-22 杭州海尔希畜牧科技有限公司 一种制备丁基甜菜碱的方法

Family Cites Families (17)

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GB1238868A (es) 1967-08-08 1971-07-14
SU997646A1 (ru) 1978-11-27 1983-02-23 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Кормова добавка
IT1210935B (it) 1981-09-17 1989-09-29 Inst Orch Sinteza Akademi Nauk Composizione farmaceutica per il trattamento di malattie cardiovascolari.
IT1190280B (it) * 1986-04-24 1988-02-16 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di gamma-butirrobetaina
US4933103A (en) * 1987-03-23 1990-06-12 Kao Corporation Bleaching composition
SU1680693A1 (ru) * 1987-03-25 1991-09-30 Институт Органического Синтеза Ан Латвсср Этил-3-(2,2-диметил-2-этилгидразиний)пропионат иодистый, про вл ющий антиаритмическую активность
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
JP3119430B2 (ja) * 1995-07-25 2000-12-18 大鵬薬品工業株式会社 水酸基ラジカル消去剤
LV11728B (en) 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition
US5973026A (en) 1998-02-02 1999-10-26 Xerox Corporation Ink jet inks
JP2000239239A (ja) * 1999-02-22 2000-09-05 Kankyo Meneki Gijutsu Kenkyusho:Kk クロルメコート類縁化合物のハプテン化合物、抗体及び測定方法
CA2508094A1 (en) 2005-05-20 2006-11-20 Vivier Canada Inc. Composition for accelerating collagen synthesis
US7863274B2 (en) 2005-07-29 2011-01-04 Concert Pharmaceuticals Inc. Deuterium enriched analogues of tadalafil as PDE5 inhibitors
LV13705B (en) 2006-11-06 2008-07-20 Ivars Kalvins Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide
JP4761265B2 (ja) 2007-10-17 2011-08-31 学校法人甲南学園 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法
CN101538214A (zh) * 2009-04-24 2009-09-23 潍坊祥维斯化学品有限公司 生产γ-丁基甜菜碱及其盐酸盐的方法
EP2702037A1 (en) * 2011-04-27 2014-03-05 Grindeks, A Joint Stock Company 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease

Also Published As

Publication number Publication date
CU24114B1 (es) 2015-08-27
NZ599521A (en) 2013-11-29
US9278907B2 (en) 2016-03-08
TN2012000174A1 (en) 2013-12-12
BR112012009162B1 (pt) 2021-02-02
PT2491005E (pt) 2014-10-29
CL2012001010A1 (es) 2012-08-31
UA107201C2 (uk) 2014-12-10
US20160137589A1 (en) 2016-05-19
EP2491005B1 (en) 2014-07-23
ME01917B (me) 2015-05-20
RS53620B1 (sr) 2015-04-30
LV14345A (lv) 2011-05-20
MX2012004630A (es) 2013-07-29
KR20120101634A (ko) 2012-09-14
AU2010309756B2 (en) 2013-10-17
HK1169824A1 (en) 2013-02-08
LV14345B (lv) 2011-07-20
EA020303B1 (ru) 2014-10-30
CO6531459A2 (es) 2012-09-28
US9573882B2 (en) 2017-02-21
PL2491005T3 (pl) 2015-03-31
CU20120065A7 (es) 2012-06-29
AR081514A1 (es) 2012-10-03
IL219217A0 (en) 2012-06-28
JP5552169B2 (ja) 2014-07-16
JP2013508342A (ja) 2013-03-07
US20120220656A1 (en) 2012-08-30
EA201200514A1 (ru) 2012-09-28
AU2010309756A1 (en) 2012-05-17
CN102666476A (zh) 2012-09-12
WO2011048201A1 (en) 2011-04-28
CA2781499A1 (en) 2011-04-28
KR101355417B1 (ko) 2014-01-27
SMT201400176B (it) 2015-01-15
HRP20140964T1 (hr) 2014-12-05
EP2491005A1 (en) 2012-08-29
BR112012009162A2 (pt) 2020-08-18
ES2508117T3 (es) 2014-10-16
DK2491005T3 (da) 2014-10-27
CN102666476B (zh) 2014-07-09
BR112012009162B8 (pt) 2021-07-27
GEP20146123B (en) 2014-07-25
SI2491005T1 (sl) 2014-12-31
CA2781499C (en) 2015-03-24
ZA201202916B (en) 2013-05-29

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