PE20121804A1 - Derivados de 8-hidroxiquinolina-7-carboxamida como antifungicos - Google Patents
Derivados de 8-hidroxiquinolina-7-carboxamida como antifungicosInfo
- Publication number
- PE20121804A1 PE20121804A1 PE2012000846A PE2012000846A PE20121804A1 PE 20121804 A1 PE20121804 A1 PE 20121804A1 PE 2012000846 A PE2012000846 A PE 2012000846A PE 2012000846 A PE2012000846 A PE 2012000846A PE 20121804 A1 PE20121804 A1 PE 20121804A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxamide
- antifungic
- hydroxyquinoline
- derivatives
- quinoline
- Prior art date
Links
- FOXMISVOVQTSGS-UHFFFAOYSA-N 8-hydroxyquinoline-7-carboxamide Chemical class C1=CC=NC2=C(O)C(C(=O)N)=CC=C21 FOXMISVOVQTSGS-UHFFFAOYSA-N 0.000 title 1
- 230000001716 anti-fugal effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- MMCIXNVRVDTQSG-UHFFFAOYSA-N quinoline-7-carboxamide Chemical compound C1=CC=NC2=CC(C(=O)N)=CC=C21 MMCIXNVRVDTQSG-UHFFFAOYSA-N 0.000 abstract 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I, DONDE A ES -(CH2)n-X; n ES 0-1; X ES HETEROCICLO MONOCICLO, 2,3-DIHIDROBENZO[b][1,4]DIOXINA, ARILO SUSTITUIDO EN POSICION para. SON COMPUESTOS PREFERIDOS: 8-HIDROXI-N-(1,1-DIOXIDOTETRAHIDROTIEN-3-IL)QUINOLINA-7-CARBOXAMIDA; 8-HIDROXI-N-((1-METIL-1H-IMIDAZOL-2-IL)METIL)QUINOLINA-7-CARBOXAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES COMO AGENTES ANTIMICOTICOS TENIENDO ADEMAS ACTIVIDAD CONTRA ESPECIES DE CANDIDA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09180895A EP2345641A1 (en) | 2009-12-29 | 2009-12-29 | New secondary 8-hydroxyquinoline-7-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121804A1 true PE20121804A1 (es) | 2013-01-17 |
Family
ID=42025709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000846A PE20121804A1 (es) | 2009-12-29 | 2010-12-28 | Derivados de 8-hidroxiquinolina-7-carboxamida como antifungicos |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US8729076B2 (es) |
| EP (2) | EP2345641A1 (es) |
| JP (1) | JP5755245B2 (es) |
| KR (1) | KR20120097407A (es) |
| CN (1) | CN102712596B (es) |
| AU (1) | AU2010338269B2 (es) |
| BR (1) | BR112012015732A2 (es) |
| CA (1) | CA2783230A1 (es) |
| CL (1) | CL2012001759A1 (es) |
| CO (1) | CO6561775A2 (es) |
| CY (1) | CY1115060T1 (es) |
| DK (1) | DK2519504T3 (es) |
| DO (1) | DOP2012000185A (es) |
| EA (1) | EA020487B1 (es) |
| EC (1) | ECSP12012008A (es) |
| ES (1) | ES2460626T3 (es) |
| GE (1) | GEP20156269B (es) |
| GT (1) | GT201200214A (es) |
| HR (1) | HRP20140348T1 (es) |
| IL (1) | IL220307A (es) |
| MA (1) | MA33830B1 (es) |
| ME (1) | ME01748B (es) |
| MX (1) | MX2012007746A (es) |
| MY (1) | MY162548A (es) |
| NI (1) | NI201200115A (es) |
| NZ (1) | NZ600782A (es) |
| PE (1) | PE20121804A1 (es) |
| PH (1) | PH12012501325A1 (es) |
| PL (1) | PL2519504T3 (es) |
| PT (1) | PT2519504E (es) |
| RS (1) | RS53303B (es) |
| SG (1) | SG181588A1 (es) |
| SI (1) | SI2519504T1 (es) |
| SM (1) | SMT201400059B (es) |
| TN (1) | TN2012000319A1 (es) |
| UA (1) | UA109422C2 (es) |
| WO (1) | WO2011080266A1 (es) |
| ZA (1) | ZA201204349B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2345643A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof |
| EP2345642A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents |
| CN104805147B (zh) * | 2014-01-26 | 2018-01-05 | 上海医药工业研究院 | 一种二噁英类化合物的制备方法、纯化方法及应用 |
| KR20220148881A (ko) | 2020-03-04 | 2022-11-07 | 앰플릭스 파마슈티컬스, 인크. | 진균 감염 치료에서의 화합물의 용도 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US326328A (en) | 1885-09-15 | Broiler | ||
| US326330A (en) | 1885-09-15 | Harness-support | ||
| DE540842C (de) | 1930-08-06 | 1931-12-28 | Chinosol Fabrik Akt Ges | Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure |
| FR2160718A1 (en) * | 1971-11-23 | 1973-07-06 | Roussel Uclaf | 7-benzyl aminomethyl-8-hydroxy quinolines - bacteriostats and fungistats |
| DE3426995A1 (de) | 1984-07-21 | 1986-01-30 | Dr.Ing.H.C. F. Porsche Ag, 7000 Stuttgart | Halterung einer scheibe, vorzugsweise einer windschutzscheibe |
| WO1996032015A1 (de) | 1995-04-08 | 1996-10-17 | Basf Aktiengesellschaft | Synergistische fungizide zusammensetzungen aus chinolinderivaten und cytochrom b/c-inhibitors |
| EP0927164A1 (en) | 1996-09-10 | 1999-07-07 | PHARMACIA & UPJOHN COMPANY | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| US6919351B2 (en) | 2000-10-12 | 2005-07-19 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors |
| CA2425440C (en) | 2000-10-12 | 2010-04-13 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| JP3616628B2 (ja) | 2001-03-01 | 2005-02-02 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
| EP1541558B1 (en) | 2002-08-13 | 2008-08-13 | Shionogi & Co., Ltd. | Heterocyclic compounds having hiv integrase inhibitory activity |
| WO2005033079A1 (ja) * | 2003-09-30 | 2005-04-14 | Eisai Co., Ltd. | ヘテロ環化合物を含有する新規な抗真菌剤 |
| FR2889192A1 (fr) * | 2005-07-27 | 2007-02-02 | Cytomics Systems Sa | Composes antifongiques, compositions contenant ces composes et leurs utilisations |
| RU2009106461A (ru) * | 2006-07-25 | 2010-08-27 | Энвиво Фармасьютикалз, Инк. (Us) | Хинолиновые производные |
| EP2345642A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents |
| EP2345643A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof |
-
2009
- 2009-12-29 EP EP09180895A patent/EP2345641A1/en not_active Withdrawn
-
2010
- 2010-12-28 PL PL10798129T patent/PL2519504T3/pl unknown
- 2010-12-28 JP JP2012546434A patent/JP5755245B2/ja not_active Expired - Fee Related
- 2010-12-28 CA CA2783230A patent/CA2783230A1/en not_active Abandoned
- 2010-12-28 HR HRP20140348AT patent/HRP20140348T1/hr unknown
- 2010-12-28 US US13/519,686 patent/US8729076B2/en not_active Expired - Fee Related
- 2010-12-28 NZ NZ600782A patent/NZ600782A/xx not_active IP Right Cessation
- 2010-12-28 BR BR112012015732A patent/BR112012015732A2/pt not_active IP Right Cessation
- 2010-12-28 WO PCT/EP2010/070793 patent/WO2011080266A1/en not_active Ceased
- 2010-12-28 ME MEP-2014-36A patent/ME01748B/me unknown
- 2010-12-28 PE PE2012000846A patent/PE20121804A1/es not_active Application Discontinuation
- 2010-12-28 MX MX2012007746A patent/MX2012007746A/es active IP Right Grant
- 2010-12-28 EP EP10798129.2A patent/EP2519504B1/en active Active
- 2010-12-28 DK DK10798129.2T patent/DK2519504T3/da active
- 2010-12-28 SG SG2012042305A patent/SG181588A1/en unknown
- 2010-12-28 PH PH1/2012/501325A patent/PH12012501325A1/en unknown
- 2010-12-28 UA UAA201207792A patent/UA109422C2/uk unknown
- 2010-12-28 PT PT107981292T patent/PT2519504E/pt unknown
- 2010-12-28 SI SI201030586T patent/SI2519504T1/sl unknown
- 2010-12-28 CN CN201080059735.1A patent/CN102712596B/zh not_active Expired - Fee Related
- 2010-12-28 MY MYPI2012002954A patent/MY162548A/en unknown
- 2010-12-28 ES ES10798129.2T patent/ES2460626T3/es active Active
- 2010-12-28 RS RS20140238A patent/RS53303B/sr unknown
- 2010-12-28 GE GEAP201012811A patent/GEP20156269B/en unknown
- 2010-12-28 KR KR1020127019423A patent/KR20120097407A/ko not_active Ceased
- 2010-12-28 AU AU2010338269A patent/AU2010338269B2/en not_active Ceased
- 2010-12-28 EA EA201270672A patent/EA020487B1/ru not_active IP Right Cessation
-
2012
- 2012-06-11 IL IL220307A patent/IL220307A/en not_active IP Right Cessation
- 2012-06-13 ZA ZA2012/04349A patent/ZA201204349B/en unknown
- 2012-06-15 MA MA34973A patent/MA33830B1/fr unknown
- 2012-06-22 TN TNP2012000319A patent/TN2012000319A1/en unknown
- 2012-06-25 GT GT201200214A patent/GT201200214A/es unknown
- 2012-06-26 CO CO12106820A patent/CO6561775A2/es unknown
- 2012-06-26 CL CL2012001759A patent/CL2012001759A1/es unknown
- 2012-06-27 DO DO2012000185A patent/DOP2012000185A/es unknown
- 2012-06-28 NI NI201200115A patent/NI201200115A/es unknown
- 2012-06-28 EC ECSP12012008 patent/ECSP12012008A/es unknown
-
2014
- 2014-05-13 CY CY20141100340T patent/CY1115060T1/el unknown
- 2014-05-21 SM SM201400059T patent/SMT201400059B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |