PE20171061A1 - Composiciones farmaceuticas de accion prolongada para hepatitis c - Google Patents

Composiciones farmaceuticas de accion prolongada para hepatitis c

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Publication number
PE20171061A1
PE20171061A1 PE2017000834A PE2017000834A PE20171061A1 PE 20171061 A1 PE20171061 A1 PE 20171061A1 PE 2017000834 A PE2017000834 A PE 2017000834A PE 2017000834 A PE2017000834 A PE 2017000834A PE 20171061 A1 PE20171061 A1 PE 20171061A1
Authority
PE
Peru
Prior art keywords
months
hepatitis
long
pharmaceutical compositions
formula
Prior art date
Application number
PE2017000834A
Other languages
English (en)
Inventor
Zhi Hong
Martin R Leivers
Original Assignee
Glaxosmithkline Intellectual Property (No 2) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54478190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20171061(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Intellectual Property (No 2) Ltd filed Critical Glaxosmithkline Intellectual Property (No 2) Ltd
Publication of PE20171061A1 publication Critical patent/PE20171061A1/es

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    • A61K31/69—Boron compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se refiere a una composicion farmaceutica parenteral de accion prolongada (LAP) que comprende un agentes antivirico inhibidor del virus de la hepatitis C (VHC) derivado de benzofurano de formula 6-(N-(7-cloro-1-hidroxi-1,3-dihidrobenzo[c][1,2]oxaborol-5-il)metilsulfonamido)-5-ciclopropil-2-(4-fluorofenil)-N-metilbenxofuran-3-carboxamida (Formula I). Dicha composicion tambien comprende un sistema tensioactivo que comprende un tensioactivo tal como polisorbato 80, un estabilizador tal como polietilenglicol, una sal tamponadora tal como acetato. Estas formulaciones se emplean en el tratamiento de la hepatitis C y son adecuadas para administrarse una vez al mes, cada 2 meses, cada 3 meses, cada 6 meses o cada 12 meses, lo cual favorece el cumplimiento del tratamiento y el aumento de comodidad del paciente
PE2017000834A 2014-11-10 2015-10-30 Composiciones farmaceuticas de accion prolongada para hepatitis c PE20171061A1 (es)

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