PE20171180A1 - Anticuerpos anti-pd-1 y sus metodos de uso - Google Patents

Anticuerpos anti-pd-1 y sus metodos de uso

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Publication number
PE20171180A1
PE20171180A1 PE2017000975A PE2017000975A PE20171180A1 PE 20171180 A1 PE20171180 A1 PE 20171180A1 PE 2017000975 A PE2017000975 A PE 2017000975A PE 2017000975 A PE2017000975 A PE 2017000975A PE 20171180 A1 PE20171180 A1 PE 20171180A1
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PE
Peru
Prior art keywords
seq
cdr1
cdr2
cdr3
refers
Prior art date
Application number
PE2017000975A
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English (en)
Inventor
Yasmina Noubia Abdiche
Helen Kim Cho
Weihsien Ho
Karin Ute Jooss
Arvind Rajpal
Sawsan Youssef
Original Assignee
Rinat Neuroscience Corp
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Publication date
Application filed by Rinat Neuroscience Corp filed Critical Rinat Neuroscience Corp
Publication of PE20171180A1 publication Critical patent/PE20171180A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K2039/53—DNA (RNA) vaccination
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se refiere a un anticuerpo antagonista aislado que se fija especificamente a PD-1 (proteina de muerte celular programada 1) caracterizado porque comprende: una region variable de cadena pesada (VH) que comprende una CDR1, CDR2 y CDR3 que tienen una secuencia seleccionada de SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 y SEQ ID NO: 6 y una region de variable de cadena liviana (VL) que comprende una CDR1, CDR2 y CDR3 que tienen una secuencia seleccionada de SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NO:8 y SEQ ID NO: 9. Tambien se refiere a una composicion farmaceutica que lo comprende; siendo util en el tratamiento del cancer
PE2017000975A 2014-12-09 2015-12-02 Anticuerpos anti-pd-1 y sus metodos de uso PE20171180A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462089658P 2014-12-09 2014-12-09
US201562242750P 2015-10-16 2015-10-16
US201562251973P 2015-11-06 2015-11-06

Publications (1)

Publication Number Publication Date
PE20171180A1 true PE20171180A1 (es) 2017-08-22

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ID=54849669

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PE2017000975A PE20171180A1 (es) 2014-12-09 2015-12-02 Anticuerpos anti-pd-1 y sus metodos de uso

Country Status (26)

Country Link
US (4) US10155037B2 (es)
EP (2) EP4166572A1 (es)
JP (1) JP6552621B2 (es)
KR (1) KR102012113B1 (es)
CN (1) CN107207593B (es)
AU (2) AU2015359003B2 (es)
CA (1) CA2914087C (es)
CO (1) CO2017005738A2 (es)
DK (1) DK3230319T3 (es)
ES (1) ES2929721T3 (es)
HR (1) HRP20221226T1 (es)
HU (1) HUE060165T2 (es)
IL (1) IL252280B2 (es)
MX (1) MX389945B (es)
MY (1) MY193404A (es)
NZ (1) NZ731735A (es)
PE (1) PE20171180A1 (es)
PH (1) PH12017500994A1 (es)
PL (1) PL3230319T3 (es)
PT (1) PT3230319T (es)
RU (1) RU2701797C2 (es)
SA (1) SA517381676B1 (es)
SG (1) SG11201703950PA (es)
TW (1) TWI595006B (es)
WO (1) WO2016092419A1 (es)
ZA (1) ZA201703438B (es)

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