PE37199A1 - Agente reductor para alquilacion reductiva de antibioticos glicopeptidos - Google Patents

Agente reductor para alquilacion reductiva de antibioticos glicopeptidos

Info

Publication number: PE37199A1
Authority: PE; Peru
Prior art keywords: reducing agent; rental; reductive; reuble; glycopeptide
Prior art date: 1996-11-21

Application number

PE1997001053A

Other languages

English (en)

Spanish (es)

Inventor

Richard Alan Berglund

Hua Zheng

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-21

Filing date

1997-11-19

Publication date

1999-04-14

1997-11-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1999-04-14 Publication of PE37199A1 publication Critical patent/PE37199A1/es

Links

239000003638 chemical reducing agent Substances 0.000 title abstract 4
102000002068 Glycopeptides Human genes 0.000 title abstract 2
108010015899 Glycopeptides Proteins 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title 1
229940088710 antibiotic agent Drugs 0.000 title 1
230000002829 reductive effect Effects 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
150000001299 aldehydes Chemical class 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
229910000085 borane Inorganic materials 0.000 abstract 1
NNTOJPXOCKCMKR-UHFFFAOYSA-N boron;pyridine Chemical compound [B].C1=CC=NC=C1 NNTOJPXOCKCMKR-UHFFFAOYSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
UORVGPXVDQYIDP-UHFFFAOYSA-N trihydridoboron Substances B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PE1997001053A 1996-11-21 1997-11-19 Agente reductor para alquilacion reductiva de antibioticos glicopeptidos PE37199A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3159596P	1996-11-21	1996-11-21

Publications (1)

Publication Number	Publication Date
PE37199A1 true PE37199A1 (es)	1999-04-14

Family

ID=21860365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE1997001053A PE37199A1 (es)	1996-11-21	1997-11-19	Agente reductor para alquilacion reductiva de antibioticos glicopeptidos

Country Status (14)

Country	Link
US (1)	US5939382A (de)
EP (1)	EP0845477B1 (de)
JP (1)	JP2001503784A (de)
AR (1)	AR010622A1 (de)
AT (1)	ATE296834T1 (de)
AU (1)	AU5358598A (de)
CA (1)	CA2272261C (de)
CO (1)	CO4930279A1 (de)
DE (1)	DE69733401T2 (de)
ID (1)	ID19281A (de)
MY (1)	MY122001A (de)
PE (1)	PE37199A1 (de)
WO (1)	WO1998021952A1 (de)
ZA (1)	ZA9710427B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6518242B1 (en)	1998-02-20	2003-02-11	Theravance, Inc.	Derivatives of glycopeptide antibacterial agents
US6392012B1 (en)	1998-12-23	2002-05-21	Advanced Medicine, Inc.	Glycopeptide derivatives and pharmaceutical compositions containing the same
EP1276759B1 (de)	2000-05-02	2008-07-30	Theravance, Inc.	Verfahren zur reduktiven alkylierung von glykopeptiden
TWI275594B (en)	2001-08-24	2007-03-11	Theravance Inc	Process for preparing vancomycin phosphonate derivatives
TWI312785B (en)	2001-08-24	2009-08-01	Theravance Inc	Process for preparing vancomycin derivatives
WO2014152332A1 (en)	2013-03-15	2014-09-25	Melinta Therapeutics, Inc.	Methods of treating infections in overweight and obese patients using antibiotics
MX385925B (es)	2014-07-17	2025-03-18	The Medicines Co	Oritavancina de alta pureza y método para producir la misma.
CN106188243B (zh) *	2015-05-05	2020-06-26	博瑞生物医药（苏州）股份有限公司	一种奥利万星的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4698327A (en) *	1985-04-25	1987-10-06	Eli Lilly And Company	Novel glycopeptide derivatives
US4877450A (en) *	1989-02-23	1989-10-31	Learonal, Inc.	Formaldehyde-free electroless copper plating solutions
ZA909847B (en) *	1989-12-13	1992-08-26	Lilly Co Eli	Glycopeptide derivatives
JPH05310772A (ja) *	1992-05-07	1993-11-22	Microbial Chem Res Found	アントラサイクリン抗生物質の製造方法
NZ270387A (en) *	1994-01-28	1996-11-26	Lilly Co Eli	Glycopeptide antibiotic, its production and compositions thereof

1997
- 1997-11-12 US US08/968,320 patent/US5939382A/en not_active Expired - Fee Related
- 1997-11-19 MY MYPI97005547A patent/MY122001A/en unknown
- 1997-11-19 CO CO97067570A patent/CO4930279A1/es unknown
- 1997-11-19 ZA ZA9710427A patent/ZA9710427B/xx unknown
- 1997-11-19 AR ARP970105412A patent/AR010622A1/es active IP Right Grant
- 1997-11-19 AT AT97309297T patent/ATE296834T1/de not_active IP Right Cessation
- 1997-11-19 DE DE69733401T patent/DE69733401T2/de not_active Expired - Fee Related
- 1997-11-19 PE PE1997001053A patent/PE37199A1/es not_active Application Discontinuation
- 1997-11-19 EP EP97309297A patent/EP0845477B1/de not_active Expired - Lifetime
- 1997-11-20 WO PCT/US1997/021126 patent/WO1998021952A1/en not_active Ceased
- 1997-11-20 AU AU53585/98A patent/AU5358598A/en not_active Abandoned
- 1997-11-20 ID IDP973720A patent/ID19281A/id unknown
- 1997-11-20 CA CA002272261A patent/CA2272261C/en not_active Expired - Fee Related
- 1997-11-20 JP JP52383898A patent/JP2001503784A/ja not_active Ceased

Also Published As

Publication number	Publication date
CA2272261C (en)	2008-01-08
WO1998021952A1 (en)	1998-05-28
ID19281A (id)	1998-06-28
EP0845477B1 (de)	2005-06-01
HK1011543A1 (en)	1999-07-16
CO4930279A1 (es)	2000-06-27
CA2272261A1 (en)	1998-05-28
MY122001A (en)	2006-03-31
AU5358598A (en)	1998-06-10
EP0845477A1 (de)	1998-06-03
US5939382A (en)	1999-08-17
ZA9710427B (en)	1999-05-19
AR010622A1 (es)	2000-06-28
DE69733401D1 (de)	2005-07-07
DE69733401T2 (de)	2006-04-27
JP2001503784A (ja)	2001-03-21
ATE296834T1 (de)	2005-06-15

Similar Documents

Publication	Publication Date	Title
AR005010A1 (es)	1999-04-07	Metodo para convertir metanol a olefinas
TR199801629A2 (xx)	1999-10-21	Fungisidal 2 -metoksibenzofenonlar.
ES2079063T3 (es)	1996-01-01	Utilizacion de analogos de vitamina d en el tratamiento del acne.
ES2063256T3 (es)	1995-01-01	Derivados avermectin cetales utiles como agentes antiparasitarios.
AR030947A1 (es)	2003-09-03	Guanidinas de acido cinamico substituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico asi como un medicamento que las contiene
CL2004001128A1 (es)	2005-04-01	Compuestos derivados de halogenopirimidinas aril eter; composicion pesticida; procedimiento de preparacion; compuestos intermediarios; y uso del compuesto como agente pesticida.
PA8527001A1 (es)	2002-07-30	Poliarilcarboxamidas utiles como agentes reductores de lipidos
ES2079719T3 (es)	1996-01-16	Derivados de amidinofenilalanina, procedimiento para su preparacion, su utilizacion y agentes que los contienen en calidad de anticoagulantes.
ES2118992T3 (es)	1998-10-01	Derivados ciclicos, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES2166093T3 (es)	2002-04-01	Procedimiento para la preparacion de compuestos de pirimidina.
GT199900011A (es)	2000-07-20	Nuevos derivados del acido dihidroxihexanoico
ES2179476T3 (es)	2003-01-16	Procedimiento para preparar derivados de pirazol.
ES2110177T3 (es)	1998-02-01	Composicion fungicida para impedir el desarrollo de moho en los productos alimenticios y agricolas.
ES2162336T3 (es)	2001-12-16	Modulo de espectroscopia de correlacion de fluorescencia para un microscopio.
UY26133A1 (es)	2000-12-29	Derivado sustituido de pirazol.
AR006058A1 (es)	1999-07-21	Procedimientos para preparar compuestos de dicianoacetato y de 1,2-pirazol-5-amino-3-substituido
ES2143004T3 (es)	2000-05-01	Derivados de la milbemicina, su preparacion y uso.
ES2155621T3 (es)	2001-05-16	Derivados azo del acido 5-aminosalicilico para el tratamiento de la enfermedad inflamatoria intestinal.
ES2135722T3 (es)	1999-11-01	1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.
ES2140765T3 (es)	2000-03-01	Guanididas sustituidas del acido cinamico, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico cardiovascular, asi como medicamento que las contiene.
ES2107826T3 (es)	1997-12-01	Procedimiento de fabricacion de una pelicula biodegradable, hidrofoba y transparente y pelicula asi obtenida.
ES2192334T3 (es)	2003-10-01	Procedimiento mejorado para preparar un agente antiparasitario.
ES2168324T3 (es)	2002-06-16	Benzoilguanidinas sustituidas con heterociclos-n-oxidos, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamento que las contiene.
SE9604582D0 (sv)	1996-12-13	Novel compounds
ES2186191T3 (es)	2003-05-01	Productos de reaccion del acido fosfonico y su uso en composiciones de recubrimiento.

Legal Events

Date	Code	Title	Description
2001-08-20	FG	Grant, registration
2010-06-22	FD	Application declared void or lapsed