PE55596A1 - Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo - Google Patents

Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Info

Publication number
PE55596A1
PE55596A1 PE1995286554A PE28655495A PE55596A1 PE 55596 A1 PE55596 A1 PE 55596A1 PE 1995286554 A PE1995286554 A PE 1995286554A PE 28655495 A PE28655495 A PE 28655495A PE 55596 A1 PE55596 A1 PE 55596A1
Authority
PE
Peru
Prior art keywords
piperadinyl
piperazinyl
aids
alkyl
substituted
Prior art date
Application number
PE1995286554A
Other languages
English (en)
Inventor
Richard C Thomas
Toni-Jo Poel
Donna L Romero
Paul D May
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE55596(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE55596A1 publication Critical patent/PE55596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE AL COMPUESTO DE FORMULA I DONDE R1 PUEDE SER (A) o (B); SI ES (A): R1-1 ES H, F, Cl ENTRE OTROS; R1-2 ES H, F, Cl ENTRE OTROS; R1-3 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1-1, R1-2 y R1-3 SON -H; SI ES (B): R1-4 ES H o CH3, DE PREFERENCIA EL PRIMERO; R1-5 ES H, F, Cl ENTRE OTROS; R1-6 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1 ES (A); R2 ES -CO- o -CH2-; R3 ES (R3-I), (R3-II), (R3-III) ENTRE OTROS; R4 ES -N=, -CH=, -CF= ENTRE OTROS; R5 ES -N=, -CH=, -CF= ENTRE OTROS; R6 ES -N=, -CH=, -CF= ENTRE OTROS; R7 ES -N= o -CH=; R8 ES C1-C6 ALQUILO, C3-C5 CICLOALQUILO, -CH2-O-R8-1 EN DONDE R8-1 ES C1-C3 ALQUILO, -CH2-CH2-CF3 ENTRE OTROS
PE1995286554A 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo PE55596A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35492594A 1994-12-13 1994-12-13
US40009595A 1995-03-07 1995-03-07

Publications (1)

Publication Number Publication Date
PE55596A1 true PE55596A1 (es) 1996-12-11

Family

ID=26998606

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995286554A PE55596A1 (es) 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Country Status (10)

Country Link
US (1) US5866589A (es)
EP (1) EP0797576A1 (es)
JP (1) JPH10510530A (es)
AR (1) AR003106A1 (es)
AU (1) AU4151696A (es)
CO (1) CO4700295A1 (es)
IL (1) IL116310A (es)
PE (1) PE55596A1 (es)
TW (1) TW406075B (es)
WO (1) WO1996018628A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL133960A0 (en) * 1997-08-15 2001-04-30 Pfizer Prod Inc 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives
WO1999043658A1 (en) * 1998-02-27 1999-09-02 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
SE9803773D0 (sv) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
GB0016453D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
EP1363705B9 (en) * 2001-02-02 2012-11-07 Bristol-Myers Squibb Company Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
CN100567266C (zh) * 2001-11-14 2009-12-09 先灵公司 类大麻苷受体配体
WO2004035571A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
RS52518B (sr) 2007-04-23 2013-04-30 Janssen Pharmaceutica N.V. Derivati 4-alkoksipiridazina kao brzo disocirajući dopamin 2 receptorski antagonisti
US20100137368A1 (en) * 2007-04-23 2010-06-03 Janssen Pharmaceutica N.V. Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
MX2009011416A (es) * 2007-04-23 2009-11-05 Janssen Pharmaceutica Nv Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
AU2008312948C1 (en) * 2007-10-16 2012-08-09 Daiichi Sankyo Company, Limited Pyrimidyl indoline compound
CA2729313C (en) * 2008-07-03 2016-08-30 Janssen Pharmaceutica Nv Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists
ES2622161T3 (es) 2008-07-31 2017-07-05 Janssen Pharmaceutica, N.V. Piridinas sustituidas con piperazin-1-il-trifluorometilo como antagonistas del receptor de la dopamina 2 de disociación rápida
CN106573893B (zh) 2014-07-31 2020-06-09 巴斯夫欧洲公司 制备吡唑的方法
CA3187499A1 (en) * 2015-05-11 2016-11-17 Eric George KLAUBER Process for preparing 4-amino-pyridazines
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686188A (en) * 1970-06-30 1972-08-22 Ciba Geigy Corp N-benzofurylmethyl-arylalkyleneimines
DE69028552T2 (de) * 1989-12-28 1997-03-06 The Upjohn Co., Kalamazoo, Mich. Diaromatische substituierte verbindungen gegen den aids-virus
US5563142A (en) * 1989-12-28 1996-10-08 The Upjohn Company Diaromatic substituted compounds as anti-HIV-1 agents
WO1992018089A2 (en) * 1991-04-09 1992-10-29 The Upjohn Company Use of steroidal and non-steroidal amines to sensitize multidrug-resistant cells
EP0594702B1 (en) * 1991-07-03 1997-01-29 PHARMACIA & UPJOHN COMPANY Substituted indoles as anti-aids pharmaceuticals
DE4307883A1 (en) * 1992-03-12 1993-09-23 Westarp Martin Egon Dr Med Use of anti-retroviral substances - to treat motor-neuronal diseases
WO1994009781A1 (en) * 1992-10-28 1994-05-11 The Upjohn Company Use of bhap compounds in combination with other non-nucleoside reverse transcriptase inhibitors for the treatment of hiv infection
EP0757398A1 (de) * 1995-07-25 1997-02-05 DORNIER GmbH Anordnung von mehreren Brennstoffzellen-Stacks zu einem Modul

Also Published As

Publication number Publication date
AU4151696A (en) 1996-07-03
TW406075B (en) 2000-09-21
US5866589A (en) 1999-02-02
IL116310A (en) 2000-08-31
AR003106A1 (es) 1998-07-08
EP0797576A1 (en) 1997-10-01
JPH10510530A (ja) 1998-10-13
IL116310A0 (en) 1996-03-31
WO1996018628A1 (en) 1996-06-20
CO4700295A1 (es) 1998-12-29

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