PH14163A - Derivatives of 4-desacetyl vlb c-3 carboxhydrazide - Google Patents

Derivatives of 4-desacetyl vlb c-3 carboxhydrazide

Info

Publication number: PH14163A
Authority: PH; Philippines
Prior art keywords: carboxhydrazide; derivatives; desacetyl vlb; desacetyl; vlb
Prior art date: 1978-04-20

Application number

PH23391A

Other languages

English (en)

Inventor

Koert Gerzon

G Cullinan

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-17

Publication date

1981-03-19

1979-04-17 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1981-03-19 Publication of PH14163A publication Critical patent/PH14163A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PH23391A 1978-04-20 1979-04-17 Derivatives of 4-desacetyl vlb c-3 carboxhydrazide PH14163A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
PH14163A true PH14163A (en)	1981-03-19

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH23391A PH14163A (en)	1978-04-20	1979-04-17	Derivatives of 4-desacetyl vlb c-3 carboxhydrazide

Country Status (32)

Country	Link
US (1)	US4166810A (ro)
EP (1)	EP0005051B1 (ro)
JP (1)	JPS54141798A (ro)
AR (1)	AR228940A1 (ro)
AT (1)	AT369010B (ro)
AU (1)	AU527109B2 (ro)
BE (1)	BE875652A (ro)
BG (3)	BG33297A3 (ro)
CA (1)	CA1097629A (ro)
CH (1)	CH643269A5 (ro)
CS (3)	CS218583B2 (ro)
DD (1)	DD143075A5 (ro)
DE (1)	DE2964130D1 (ro)
DK (1)	DK147484C (ro)
EG (1)	EG14867A (ro)
ES (2)	ES479754A1 (ro)
FI (1)	FI791286A7 (ro)
FR (1)	FR2423495A1 (ro)
GB (1)	GB2019396B (ro)
GR (1)	GR69987B (ro)
HU (1)	HU181431B (ro)
IE (1)	IE48213B1 (ro)
IL (1)	IL57168A (ro)
LU (1)	LU81166A1 (ro)
NZ (1)	NZ190213A (ro)
PH (1)	PH14163A (ro)
PL (3)	PL215911A1 (ro)
PT (1)	PT69496A (ro)
RO (3)	RO81114A (ro)
SU (3)	SU1225490A3 (ro)
YU (1)	YU93179A (ro)
ZA (1)	ZA791856B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DE3483336D1 (de) *	1983-03-30	1990-11-08	Lilly Industries Ltd	Vincaleukoblastin-derivate.
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
ATE427948T1 (de)	2001-04-24	2009-04-15	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
CA2484640C (en) *	2002-05-15	2012-01-17	Endocyte, Inc.	Vitamin-mitomycin conjugates
WO2004069159A2 (en)	2003-01-27	2004-08-19	Endocyte, Inc.	Vitamin receptor binding drug delivery conjugates
CN101098854B (zh) *	2004-07-23	2012-12-05	恩多塞特公司	二价连接体及其轭合物
CN101175757B (zh) *	2005-03-16	2012-11-14	恩多塞特公司	蝶酸及其缀合物的合成和纯化
EP2382995A3 (en)	2005-08-19	2013-09-25	Endocyte, Inc.	Ligand conjugates of Vinca alkaloids, analogs and derivatives
BRPI0615354A2 (pt) *	2005-08-19	2011-05-17	Endocyte, Inc.	conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso
US20100087370A1 (en) *	2007-02-14	2010-04-08	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) *	2007-02-16	2010-04-29	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
AU2008224988A1 (en) *	2007-03-14	2008-09-18	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
CN101784565B (zh)	2007-06-25	2014-12-10	恩多塞特公司	含有亲水性间隔区接头的共轭物
CN101909441B (zh)	2007-10-25	2015-05-13	恩多塞特公司	微管蛋白抑制剂及其制备方法
EP2476414B1 (en) *	2009-09-07	2015-03-04	NIPRO Patch Co., Ltd.	Transdermally absorbable preparation
US10080805B2 (en)	2012-02-24	2018-09-25	Purdue Research Foundation	Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
BR112015008365A2 (pt)	2012-10-16	2017-07-04	Endocyte Inc	composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
IL48685A (en)	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 FI FI791286A patent/FI791286A7/fi not_active Application Discontinuation
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG056470A patent/BG33297A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 BG BG043323A patent/BG33294A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 BG BG056469A patent/BG33296A3/xx unknown
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
ZA791856B (en)	1980-11-26
PL119416B1 (en)	1981-12-31
CS218584B2 (en)	1983-02-25
AR228940A1 (es)	1983-05-13
DK147484B (da)	1984-08-27
NZ190213A (en)	1982-12-21
GB2019396B (en)	1982-09-15
GR69987B (ro)	1982-07-22
RO81037A (ro)	1983-02-01
BG33297A3 (bg)	1983-01-14
AU527109B2 (en)	1983-02-17
JPS54141798A (en)	1979-11-05
DK147484C (da)	1985-03-25
CS218583B2 (en)	1983-02-25
YU93179A (en)	1983-01-21
HU181431B (en)	1983-07-28
BG33294A3 (bg)	1983-01-14
CS218585B2 (en)	1983-02-25
PL215911A1 (ro)	1980-03-24
EP0005051B1 (en)	1982-12-01
FI791286A7 (fi)	1981-01-01
PT69496A (en)	1979-05-01
ES479753A1 (es)	1980-08-16
IE790795L (en)	1979-10-20
CA1097629A (en)	1981-03-17
SU893135A3 (ru)	1981-12-23
IL57168A (en)	1983-10-31
ATA291279A (de)	1982-04-15
PL125470B1 (en)	1983-05-31
IE48213B1 (en)	1984-10-31
SU1225490A3 (ru)	1986-04-15
ES479754A1 (es)	1980-08-16
BE875652A (fr)	1979-10-18
AT369010B (de)	1982-11-25
US4166810A (en)	1979-09-04
DE2964130D1 (en)	1983-01-05
IL57168A0 (en)	1979-07-25
SU1061698A3 (ru)	1983-12-15
EG14867A (en)	1986-09-30
LU81166A1 (fr)	1979-09-07
AU4609779A (en)	1979-10-25
EP0005051A1 (en)	1979-10-31
JPS6245873B2 (ro)	1987-09-29
FR2423495A1 (fr)	1979-11-16
RO81037B (ro)	1983-01-30
RO80084B (ro)	1983-01-30
GB2019396A (en)	1979-10-31
DK160679A (da)	1979-10-21
RO80084A (ro)	1983-02-01
DD143075A5 (de)	1980-07-30
CH643269A5 (fr)	1984-05-30
BG33296A3 (bg)	1983-01-14
RO81114A (ro)	1983-02-01
RO81114B (ro)	1983-01-30
FR2423495B1 (ro)	1983-02-11

Publication	Publication Date	Title
PH14163A (en)	1981-03-19	Derivatives of 4-desacetyl vlb c-3 carboxhydrazide
GB2017101B (en)	1982-12-22	Production of maytansinoids
GB2017681B (en)	1982-08-04	Derivatives of 3-phenyl-3-phenoxy-propanamine
ZA7830B (en)	1978-11-29	Derivatives of thio-methylcarbamates
GB2045756B (en)	1983-01-26	Hydroxy derivatives of 2-isopropylamino-prorimidine
JPS5540676A (en)	1980-03-22	Manufacture of proline derivative
JPS5513293A (en)	1980-01-30	Derivative of nntrifluoloacetyllnnphosphono methylglycinate
GB2034305B (en)	1982-12-22	Preparation of piperidine derivatives
GB2025417B (en)	1983-03-02	Derivatives of 1 - phenyl - 1 - propanol
GB2025422B (en)	1983-05-05	17-acetylene derivatives of androst-4-ene
GB2039892B (en)	1982-11-17	Production of narwedine-type derivatives
AU528337B2 (en)	1983-04-28	Derivatives of pyrrolidinecarboxaldehyde
JPS55145670A (en)	1980-11-13	Manufacture of hydroxy derivative of isopropylaminopyrimidine
CU35135A (en)	1982-08-24	Derivatives of dichlohexadiene
JPS5513298A (en)	1980-01-30	Imidazolylethoxy derivative of pyrazolopyridine methanol and its manufacture
JPS5655391A (en)	1981-05-15	Imidazolylethoxymethyl derivative of dioxoloquinoline
JPS54125661A (en)	1979-09-29	Manufacture of isooxazol derivative
IL56815A0 (en)	1979-05-31	Isomerisation of 3-vinyl-piperidine derivatives
GB2017088B (en)	1982-10-20	Derivatives of eburnamonine
JPS5573641A (en)	1980-06-03	Manufacture of nitroodiphenylamine derivative
IL54308A0 (en)	1978-06-15	Derivatives of 9-fluoroprednisolone
GB2028825B (en)	1983-02-02	Synthesis of steroid
JPS5531081A (en)	1980-03-05	Manufacture of 22aminobenzophenone derivative
JPS5526379A (en)	1980-02-25	Handraillinterlocked piece of
JPS5547972A (en)	1980-04-05	Bumper of autobicycle