PH18391A - Chemical process for the synthesis of macrolide antibiotics - Google Patents

Chemical process for the synthesis of macrolide antibiotics

Info

Publication number: PH18391A
Authority: PH; Philippines
Prior art keywords: synthesis; chemical process; macrolide antibiotics; fluoroerythomycins; anhydroerythromycin
Prior art date: 1981-11-27

Application number

PH28203A

Other languages

English (en)

Inventor

Luciano Toscano

Original Assignee

Pierrel Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-11-27

Filing date

1982-11-26

Publication date

1985-06-21

1982-11-26 Application filed by Pierrel Spa filed Critical Pierrel Spa

1985-06-21 Publication of PH18391A publication Critical patent/PH18391A/en

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000001311 chemical methods and process Methods 0.000 title 1
239000003120 macrolide antibiotic agent Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PH28203A 1981-11-27 1982-11-26 Chemical process for the synthesis of macrolide antibiotics PH18391A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT25345/81A IT1195299B (it)	1981-11-27	1981-11-27	Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici

Publications (1)

Publication Number	Publication Date
PH18391A true PH18391A (en)	1985-06-21

Family

ID=11216419

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH28203A PH18391A (en)	1981-11-27	1982-11-26	Chemical process for the synthesis of macrolide antibiotics

Country Status (13)

Country	Link
US (1)	US4514562A (cs)
EP (1)	EP0080763B1 (cs)
JP (1)	JPS58109496A (cs)
KR (1)	KR880001566B1 (cs)
AT (1)	ATE15805T1 (cs)
BE (1)	BE895155A (cs)
CA (1)	CA1209987A (cs)
CH (1)	CH660596A5 (cs)
DE (1)	DE3266578D1 (cs)
FI (1)	FI75835C (cs)
FR (1)	FR2517311B1 (cs)
IT (1)	IT1195299B (cs)
PH (1)	PH18391A (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1163796B (it) *	1983-07-18	1987-04-08	Pierrel Spa	Procedimento per la preparazione di (8s)-8-fluoroeritromicina
IT1196041B (it) *	1984-03-08	1988-11-10	Pierrel Spa	Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti
DE3424525A1 (de) *	1984-07-04	1986-01-16	Kernforschungsanlage Jülich GmbH, 5170 Jülich	Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
JPS6185378A (ja) *	1984-10-02	1986-04-30	Daikin Ind Ltd	８−フルオロエリスロノライド誘導体の製法
US4876245A (en) *	1986-12-22	1989-10-24	Daikin Industries Ltd.	Fluorine-containing macrolide compounds and their use
PE5591A1 (es) *	1988-12-19	1991-02-15	Lilly Co Eli	Un nuevo grupo de compuestos de macrolida
US5591606A (en) *	1992-11-06	1997-01-07	Dowelanco	Process for the production of A83543 compounds with Saccharopolyspora spinosa
CA2156194C (en) *	1993-03-12	2008-01-08	Jon S. Mynderse	New a83543 compounds and process for production thereof
US5393743A (en) *	1993-07-06	1995-02-28	Abbott Laboratories	Erythromycin derivatives
US5552533A (en) *	1994-09-14	1996-09-03	Alliedsignal Inc.	Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating agents
US6001981A (en) *	1996-06-13	1999-12-14	Dow Agrosciences Llc	Synthetic modification of Spinosyn compounds
KR20070012643A (ko) *	2004-02-24	2007-01-26	아르끄마 프랑스	삼블록 연속 공중합체를 포함하는 가교 조성물, 그의 제조방법 및 그의 용도
US20120316106A1 (en)	2009-12-29	2012-12-13	Yeda Research And Development Co. Ltd.	Synergistic antibiotic combinations and derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2812323A (en) *	1954-11-03	1957-11-05	Lilly Co Eli	Des-n-methyl erythromycin
US3674773A (en) *	1970-10-06	1972-07-04	Abbott Lab	Erythromycin derivatives
DE3268339D1 (en) *	1981-01-09	1986-02-20	Pierrel Spa	Novel semisynthetic macrolidic antibiotics, microbiological processes for their preparation and related microorganism, novel intermediate compounds for their preparation and related pharmaceutical compositions containing them

1981
- 1981-11-27 IT IT25345/81A patent/IT1195299B/it active
1982
- 1982-11-19 EP EP82201476A patent/EP0080763B1/en not_active Expired
- 1982-11-19 AT AT82201476T patent/ATE15805T1/de not_active IP Right Cessation
- 1982-11-19 DE DE8282201476T patent/DE3266578D1/de not_active Expired
- 1982-11-22 US US06/443,580 patent/US4514562A/en not_active Expired - Lifetime
- 1982-11-26 BE BE0/209580A patent/BE895155A/fr unknown
- 1982-11-26 CA CA000416447A patent/CA1209987A/en not_active Expired
- 1982-11-26 FR FR8219865A patent/FR2517311B1/fr not_active Expired
- 1982-11-26 CH CH6889/82A patent/CH660596A5/it not_active IP Right Cessation
- 1982-11-26 PH PH28203A patent/PH18391A/en unknown
- 1982-11-26 KR KR8205343A patent/KR880001566B1/ko not_active Expired
- 1982-11-26 FI FI824084A patent/FI75835C/fi not_active IP Right Cessation
- 1982-11-27 JP JP57208363A patent/JPS58109496A/ja active Granted

Also Published As

Publication number	Publication date
FI824084A0 (fi)	1982-11-26
IT1195299B (it)	1988-10-12
FR2517311A1 (fr)	1983-06-03
KR840002413A (ko)	1984-07-02
CA1209987A (en)	1986-08-19
BE895155A (fr)	1983-03-16
US4514562A (en)	1985-04-30
FI75835B (fi)	1988-04-29
EP0080763A1 (en)	1983-06-08
FR2517311B1 (fr)	1987-12-24
DE3266578D1 (en)	1985-10-31
IT8125345A0 (it)	1981-11-27
EP0080763B1 (en)	1985-09-25
KR880001566B1 (ko)	1988-08-22
ATE15805T1 (de)	1985-10-15
JPS58109496A (ja)	1983-06-29
CH660596A5 (it)	1987-05-15
JPH0312077B2 (cs)	1991-02-19
FI824084L (fi)	1983-05-28
FI75835C (fi)	1988-08-08

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