PH19214A - Process for the manufacture of beta-lactams - Google Patents
Process for the manufacture of beta-lactamsInfo
- Publication number
- PH19214A PH19214A PH30129A PH30129A PH19214A PH 19214 A PH19214 A PH 19214A PH 30129 A PH30129 A PH 30129A PH 30129 A PH30129 A PH 30129A PH 19214 A PH19214 A PH 19214A
- Authority
- PH
- Philippines
- Prior art keywords
- signifies
- general formula
- formula see
- see diagramm
- lactams
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003952 β-lactams Chemical class 0.000 title abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1. A process for the manufacture of optically uniform beta -lactams of the general formula see diagramm : EP0116854,P10,F1 wherein R**1 signifies lower alkanoyl, lower alkoxycarbonyl or benzoyl, R**2 signifies hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl or cyano, R**3 signifies hydrogen or lower alkyl, B signifies lower alkylidene, lower cycloalkylidene or carbonyl and Z signifies lower 2-alkenyl or 2,4-di(lower alkoxy)benzyl, whereby the residues denoted as lower have a maximum of 7 carbon atoms, and their corresponding optical antipodes, characterized by reacting a salt of a carboxylic acid of the general formula see diagramm : EP0116854,P10,F2 wherein R**1, R**3 have the above significance, in the presence of a reactive derivative of an organic sulphonic acid and a base with an optically uniform compound of the general formula see diagramm : EP0116854,P11,F3 wherein B and Z have the above significance, or the optical antipode thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH32083 | 1983-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH19214A true PH19214A (en) | 1986-02-04 |
Family
ID=4184333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH30129A PH19214A (en) | 1983-01-20 | 1984-01-19 | Process for the manufacture of beta-lactams |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0116854B1 (en) |
| JP (1) | JPS59137479A (en) |
| KR (1) | KR840007230A (en) |
| AT (1) | ATE37879T1 (en) |
| AU (1) | AU566914B2 (en) |
| CA (1) | CA1251454A (en) |
| DE (1) | DE3474549D1 (en) |
| DK (1) | DK24084A (en) |
| IE (1) | IE56572B1 (en) |
| IL (1) | IL70685A (en) |
| NZ (1) | NZ206831A (en) |
| PH (1) | PH19214A (en) |
| ZA (1) | ZA84292B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK36784A (en) * | 1983-02-25 | 1984-08-26 | Hoffmann La Roche | PROCEDURE FOR PREPARING CHIRAL ALDEHYDES |
| DK411384A (en) * | 1983-10-03 | 1985-04-04 | Hoffmann La Roche | PROCEDURE FOR THE PREPARATION OF AZETIDINE UNDIVERIVES |
| US5395931A (en) * | 1988-06-30 | 1995-03-07 | Merck & Co., Inc. | 6-amido-1-methyl-2-(substituted-thio)carbapenems |
| US5138050A (en) * | 1988-06-30 | 1992-08-11 | Merck & Co., Inc. | 6-amido-1-methyl carbapenems |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1262128A (en) * | 1981-08-27 | 1989-10-03 | Christian N. Hubschwerlen | .beta.-lactams |
| EP0096296B1 (en) * | 1982-06-03 | 1987-07-29 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 1-sulfo-2-oxoazetidine derivatives |
| CA1204746A (en) * | 1982-08-19 | 1986-05-20 | Hoffmann-La Roche Limited | .beta. LACTAMS |
| DK36784A (en) * | 1983-02-25 | 1984-08-26 | Hoffmann La Roche | PROCEDURE FOR PREPARING CHIRAL ALDEHYDES |
-
1984
- 1984-01-06 CA CA000444812A patent/CA1251454A/en not_active Expired
- 1984-01-13 NZ NZ206831A patent/NZ206831A/en unknown
- 1984-01-13 ZA ZA84292A patent/ZA84292B/en unknown
- 1984-01-13 IL IL70685A patent/IL70685A/en not_active IP Right Cessation
- 1984-01-16 AU AU23288/84A patent/AU566914B2/en not_active Ceased
- 1984-01-17 DE DE8484100452T patent/DE3474549D1/en not_active Expired
- 1984-01-17 AT AT84100452T patent/ATE37879T1/en active
- 1984-01-17 EP EP84100452A patent/EP0116854B1/en not_active Expired
- 1984-01-18 JP JP59005852A patent/JPS59137479A/en active Pending
- 1984-01-19 PH PH30129A patent/PH19214A/en unknown
- 1984-01-19 DK DK24084A patent/DK24084A/en not_active Application Discontinuation
- 1984-01-19 KR KR1019840000230A patent/KR840007230A/en not_active Ceased
- 1984-01-19 IE IE114/84A patent/IE56572B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE840114L (en) | 1984-07-20 |
| ZA84292B (en) | 1984-09-26 |
| DK24084D0 (en) | 1984-01-19 |
| ATE37879T1 (en) | 1988-10-15 |
| DK24084A (en) | 1984-07-21 |
| EP0116854A2 (en) | 1984-08-29 |
| AU2328884A (en) | 1984-07-26 |
| DE3474549D1 (en) | 1988-11-17 |
| AU566914B2 (en) | 1987-11-05 |
| JPS59137479A (en) | 1984-08-07 |
| NZ206831A (en) | 1987-04-30 |
| CA1251454A (en) | 1989-03-21 |
| IL70685A0 (en) | 1984-04-30 |
| IE56572B1 (en) | 1991-09-11 |
| EP0116854B1 (en) | 1988-10-12 |
| EP0116854A3 (en) | 1984-12-05 |
| IL70685A (en) | 1988-09-30 |
| KR840007230A (en) | 1984-12-06 |
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