PH19436A - Process for the isomerization of ergoline derivatives - Google Patents

Process for the isomerization of ergoline derivatives

Info

Publication number: PH19436A
Authority: PH; Philippines
Prior art keywords: isomerization; pct; ergoline derivatives; sec; date apr
Prior art date: 1980-09-23

Application number

PH26242A

Other languages

English (en)

Inventor

Zdenex Brich

Herbert Muhle

Original Assignee

Sandoz Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-23

Filing date

1981-09-22

Publication date

1986-04-15

1981-09-22 Application filed by Sandoz Ltd filed Critical Sandoz Ltd

1986-04-15 Publication of PH19436A publication Critical patent/PH19436A/en

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
238000006317 isomerization reaction Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000005588 protonation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PH26242A 1980-09-23 1981-09-22 Process for the isomerization of ergoline derivatives PH19436A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH712280A CH644606A5 (de)	1980-09-23	1980-09-23	Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.

Publications (1)

Publication Number	Publication Date
PH19436A true PH19436A (en)	1986-04-15

Family

ID=4320306

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH26242A PH19436A (en)	1980-09-23	1981-09-22	Process for the isomerization of ergoline derivatives

Country Status (27)

Country	Link
US (1)	US4515950A (fr)
EP (1)	EP0048695B1 (fr)
JP (1)	JPS5785385A (fr)
KR (1)	KR870001508B1 (fr)
AT (1)	ATE7916T1 (fr)
AU (1)	AU547647B2 (fr)
CA (1)	CA1178581A (fr)
CH (1)	CH644606A5 (fr)
CS (1)	CS228518B2 (fr)
DD (1)	DD201679A5 (fr)
DE (1)	DE3164195D1 (fr)
DK (1)	DK418781A (fr)
ES (1)	ES8301982A1 (fr)
FI (1)	FI70018C (fr)
GR (1)	GR75044B (fr)
HU (1)	HU185317B (fr)
IE (1)	IE51593B1 (fr)
IL (1)	IL63902A (fr)
MA (1)	MA19281A1 (fr)
NO (1)	NO155967C (fr)
NZ (1)	NZ198436A (fr)
PH (1)	PH19436A (fr)
PL (1)	PL134179B1 (fr)
PT (1)	PT73713B (fr)
SU (1)	SU1152521A3 (fr)
YU (1)	YU42426B (fr)
ZA (1)	ZA816617B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3309493A1 (de) *	1983-03-14	1984-09-20	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
NL193541C (nl) *	1984-01-12	2000-01-04	Novartis Ag	8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
DE3533672A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-substituierte ergolinderivate
DE3533675A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-brom-ergolinderivate
DE3708028A1 (de) *	1987-03-10	1988-09-22	Schering Ag	Verfahren zur herstellung von 2,3ss-dihydroergolinen, 2-substituierte 2,3ss-dihydroergoline und ihre verwendung als arzneimittel
MX2017009406A (es)	2015-01-20	2018-01-18	Xoc Pharmaceuticals Inc	Compuestos de tipo isoergolina y usos de estos.
JP6856532B2 (ja)	2015-01-20	2021-04-07	エックスオーシーファーマシューティカルズインコーポレイテッドＸｏｃＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ	エルゴリン化合物およびその使用
CA3064274A1 (fr)	2017-06-01	2018-12-06	Xoc Pharmaceuticals, Inc.	Derives d'ergoline destines a etre utilises en medecine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3817988A (en) *	1971-11-16	1974-06-18	Res Inst Medicine Chem	PROCESS FOR 11,12-ENOLISATION OF 9a-HALO-11-KETO-STEROIDS
CH585750A5 (en) *	1973-10-12	1977-03-15	Sandoz Ag	Prepn. of (8)-methyl-dihydro-lysergic acid derivs. - from (7)-ergolene-(8)-carboxylates by methylation and redn.
GB1517973A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3968111A (en) *	1974-12-06	1976-07-06	Eli Lilly And Company	8,8-Disubstituted-6-methylergolines and related compounds
DE2656344A1 (de) *	1975-12-23	1977-07-07	Sandoz Ag	Ergolinderivate, ihre verwendung und herstellung
EP0021206B1 (fr) *	1979-06-13	1983-06-22	Schering Aktiengesellschaft	Dérivés de l'(ergoline-yl)-N', N'-diéthylurée, leur préparation et médicaments les contenant
US4246265A (en) *	1979-10-01	1981-01-20	Eli Lilly And Company	6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
DE3001752A1 (de) *	1980-01-16	1981-07-30	Schering Ag Berlin Und Bergkamen, 1000 Berlin	Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen

1980
- 1980-09-23 CH CH712280A patent/CH644606A5/de not_active IP Right Cessation
1981
- 1981-09-16 FI FI812894A patent/FI70018C/fi not_active IP Right Cessation
- 1981-09-17 AT AT81810382T patent/ATE7916T1/de not_active IP Right Cessation
- 1981-09-17 EP EP81810382A patent/EP0048695B1/fr not_active Expired
- 1981-09-17 DE DE8181810382T patent/DE3164195D1/de not_active Expired
- 1981-09-21 ES ES505669A patent/ES8301982A1/es not_active Expired
- 1981-09-21 IL IL63902A patent/IL63902A/xx unknown
- 1981-09-21 PT PT73713A patent/PT73713B/pt unknown
- 1981-09-21 DK DK418781A patent/DK418781A/da not_active Application Discontinuation
- 1981-09-21 GR GR66104A patent/GR75044B/el unknown
- 1981-09-21 SU SU813338647A patent/SU1152521A3/ru active
- 1981-09-21 DD DD81233439A patent/DD201679A5/de not_active IP Right Cessation
- 1981-09-21 NO NO813196A patent/NO155967C/no unknown
- 1981-09-22 YU YU2275/81A patent/YU42426B/xx unknown
- 1981-09-22 IE IE2201/81A patent/IE51593B1/en unknown
- 1981-09-22 PH PH26242A patent/PH19436A/en unknown
- 1981-09-22 PL PL1981233129A patent/PL134179B1/pl unknown
- 1981-09-22 NZ NZ198436A patent/NZ198436A/en unknown
- 1981-09-22 JP JP56150516A patent/JPS5785385A/ja active Pending
- 1981-09-22 MA MA19482A patent/MA19281A1/fr unknown
- 1981-09-22 AU AU75556/81A patent/AU547647B2/en not_active Ceased
- 1981-09-22 KR KR1019810003538A patent/KR870001508B1/ko not_active Expired
- 1981-09-22 CA CA000386357A patent/CA1178581A/fr not_active Expired
- 1981-09-22 HU HU812740A patent/HU185317B/hu not_active IP Right Cessation
- 1981-09-23 CS CS817022A patent/CS228518B2/cs unknown
- 1981-09-23 ZA ZA816617A patent/ZA816617B/xx unknown
- 1981-09-23 US US06/375,290 patent/US4515950A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
YU227581A (en)	1983-10-31
AU7555681A (en)	1982-04-01
NO155967B (no)	1987-03-23
AU547647B2 (en)	1985-10-31
DE3164195D1 (en)	1984-07-19
PL233129A1 (fr)	1982-05-10
FI70018C (fi)	1986-09-12
KR830007641A (ko)	1983-11-04
KR870001508B1 (ko)	1987-08-20
IE51593B1 (en)	1987-01-21
YU42426B (en)	1988-08-31
SU1152521A3 (en)	1985-04-23
ES505669A0 (es)	1982-12-16
HU185317B (en)	1985-01-28
FI812894L (fi)	1982-03-24
DD201679A5 (de)	1983-08-03
GR75044B (fr)	1984-07-12
IE812201L (en)	1982-03-23
NZ198436A (en)	1985-07-12
IL63902A (en)	1986-07-31
MA19281A1 (fr)	1982-04-01
US4515950A (en)	1985-05-07
CH644606A5 (de)	1984-08-15
NO813196L (no)	1982-03-24
ATE7916T1 (de)	1984-06-15
CS228518B2 (en)	1984-05-14
JPS5785385A (en)	1982-05-28
CA1178581A (fr)	1984-11-27
EP0048695A1 (fr)	1982-03-31
IL63902A0 (en)	1981-12-31
PT73713A (en)	1981-10-01
PL134179B1 (en)	1985-07-31
ES8301982A1 (es)	1982-12-16
ZA816617B (en)	1983-04-27
DK418781A (da)	1982-03-24
PT73713B (en)	1983-05-11
EP0048695B1 (fr)	1984-06-13
NO155967C (no)	1987-07-01
FI70018B (fi)	1986-01-31

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