PH20831A - Aryloxy-n-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic - Google Patents
Aryloxy-n-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmicInfo
- Publication number
- PH20831A PH20831A PH30213A PH30213A PH20831A PH 20831 A PH20831 A PH 20831A PH 30213 A PH30213 A PH 30213A PH 30213 A PH30213 A PH 30213A PH 20831 A PH20831 A PH 20831A
- Authority
- PH
- Philippines
- Prior art keywords
- carbon atoms
- lower alkyl
- phenyl
- aminoalkyl
- pyrrolidine
- Prior art date
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title abstract 2
- 239000003416 antiarrhythmic agent Substances 0.000 title abstract 2
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical class NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- -1 2,3-dihydro1H-inden-4-yl Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/557,885 US4547514A (en) | 1983-12-05 | 1983-12-05 | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH20831A true PH20831A (en) | 1987-04-30 |
Family
ID=24227270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH30213A PH20831A (en) | 1983-12-05 | 1984-02-09 | Aryloxy-n-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4547514A (de) |
| EP (1) | EP0147909B1 (de) |
| JP (1) | JPS60123466A (de) |
| KR (1) | KR900005133B1 (de) |
| AT (1) | ATE48413T1 (de) |
| AU (1) | AU572747B2 (de) |
| CA (1) | CA1227797A (de) |
| DE (1) | DE3480651D1 (de) |
| DK (1) | DK52784A (de) |
| ES (4) | ES529364A0 (de) |
| HU (1) | HU193719B (de) |
| IL (1) | IL70823A (de) |
| PH (1) | PH20831A (de) |
| PT (1) | PT78090B (de) |
| ZA (1) | ZA84697B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810703A (en) * | 1984-10-19 | 1989-03-07 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US4812451A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha. |
| US4812452A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US5183902A (en) * | 1985-02-28 | 1993-02-02 | A. H. Robins Company, Incorporated | Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides |
| US5151418A (en) * | 1985-02-28 | 1992-09-29 | A. H. Robins Company, Incorporated | Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides |
| DE3800868A1 (de) * | 1988-01-14 | 1989-07-27 | Thomae Gmbh Dr K | Mittel zur behandlung von bradycardien und bradyarrhythmien |
| US5192776A (en) * | 1988-03-14 | 1993-03-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-subsituted-4-pentafluorophenoxypiperidines |
| US5212184A (en) * | 1988-03-14 | 1993-05-18 | Hoechst-Roussel Pharmaceuticals Inc. | 1-substituted-4-pentafluorophenoxypiperidines |
| EP2202223B1 (de) * | 2007-10-18 | 2017-01-25 | Takeda Pharmaceutical Company Limited | Heterocyclische verbindung als blut-rbp4 senkende agent |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2831862A (en) * | 1956-02-27 | 1958-04-22 | Lakeside Lab Inc | Ethers of n-alkyl-3-hydroxypiperidine and salts thereof |
| US3577432A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
| US3577415A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-substituted phenoxypyrrolidines |
| FR2315274A1 (fr) * | 1975-06-27 | 1977-01-21 | Parcor | Nouveaux derives de la thieno (2,3-c) pyridine, leur preparation et leurs applications |
| US4036957A (en) * | 1975-11-18 | 1977-07-19 | A. H. Robins Company, Inc. | Phenoxy compounds in combinations to suppress gastric bleeding in aspirin therapy |
| MX6634E (es) * | 1979-01-09 | 1985-09-12 | Robins Co Inc A H | Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas |
-
1983
- 1983-12-05 US US06/557,885 patent/US4547514A/en not_active Expired - Fee Related
-
1984
- 1984-01-30 IL IL70823A patent/IL70823A/xx unknown
- 1984-01-30 ZA ZA84697A patent/ZA84697B/xx unknown
- 1984-02-01 ES ES529364A patent/ES529364A0/es active Granted
- 1984-02-01 AU AU23976/84A patent/AU572747B2/en not_active Ceased
- 1984-02-06 DK DK52784A patent/DK52784A/da not_active Application Discontinuation
- 1984-02-09 PH PH30213A patent/PH20831A/en unknown
- 1984-02-10 PT PT78090A patent/PT78090B/pt not_active IP Right Cessation
- 1984-03-23 JP JP59055975A patent/JPS60123466A/ja active Pending
- 1984-05-10 KR KR1019840002526A patent/KR900005133B1/ko not_active Expired
- 1984-06-13 EP EP84303995A patent/EP0147909B1/de not_active Expired
- 1984-06-13 AT AT84303995T patent/ATE48413T1/de not_active IP Right Cessation
- 1984-06-13 DE DE8484303995T patent/DE3480651D1/de not_active Expired - Fee Related
- 1984-06-18 CA CA000456806A patent/CA1227797A/en not_active Expired
- 1984-12-04 HU HU844476A patent/HU193719B/hu not_active IP Right Cessation
-
1985
- 1985-06-14 ES ES544169A patent/ES8802021A1/es not_active Expired
-
1986
- 1986-06-02 ES ES555591A patent/ES8802572A1/es not_active Expired
- 1986-06-02 ES ES555590A patent/ES8802571A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8601876A1 (es) | 1985-11-16 |
| AU2397684A (en) | 1985-06-13 |
| IL70823A0 (en) | 1984-04-30 |
| US4547514A (en) | 1985-10-15 |
| JPS60123466A (ja) | 1985-07-02 |
| ES8802572A1 (es) | 1987-07-01 |
| ATE48413T1 (de) | 1989-12-15 |
| IL70823A (en) | 1987-10-20 |
| AU572747B2 (en) | 1988-05-12 |
| HU193719B (en) | 1987-11-30 |
| CA1227797A (en) | 1987-10-06 |
| KR850004959A (ko) | 1985-08-19 |
| ES8802021A1 (es) | 1987-01-16 |
| EP0147909A1 (de) | 1985-07-10 |
| ES529364A0 (es) | 1985-11-16 |
| EP0147909B1 (de) | 1989-12-06 |
| ES555590A0 (es) | 1987-07-01 |
| KR900005133B1 (ko) | 1990-07-20 |
| DK52784D0 (da) | 1984-02-06 |
| PT78090A (en) | 1984-03-01 |
| ES555591A0 (es) | 1987-07-01 |
| ES8802571A1 (es) | 1987-07-01 |
| HUT35648A (en) | 1985-07-29 |
| DE3480651D1 (de) | 1990-01-11 |
| ES544169A0 (es) | 1987-01-16 |
| PT78090B (en) | 1986-04-17 |
| ZA84697B (en) | 1984-09-26 |
| DK52784A (da) | 1985-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0251315A3 (en) | Naphthalene derivatives, process for their preparation and pharmaceutical compositions containing the same | |
| HUT52059A (en) | Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components | |
| PT82854A (en) | Process for the preparation of pyridonocarboxylic acid derivatives | |
| TW198030B (de) | ||
| MY107474A (en) | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents. | |
| HUT40101A (en) | Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents | |
| ES8501362A1 (es) | Un procedimiento para la preparacion de nuevos derivados arilfenolicos. | |
| PH20831A (en) | Aryloxy-n-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic | |
| IE780718L (en) | Pyrroloquinoxalines | |
| HUT54668A (en) | Process for producing acriloyl-piperazine derivatives and pharmaceutical compositions containing them | |
| IL74533A0 (en) | Pharmaceutical compositions comprising piperidine derivatives,some novel piperidine derivatives and method for the preparation thereof | |
| HUT47923A (en) | Process for production of new derivatives of naphtotiazephin and medical compositions containing these substances | |
| JPS5699473A (en) | Tetrahydrothiopyrane derivative | |
| MY101746A (en) | 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof. |