PH22522A - 3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds - Google Patents

3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds

Info

Publication number
PH22522A
PH22522A PH34204A PH34204A PH22522A PH 22522 A PH22522 A PH 22522A PH 34204 A PH34204 A PH 34204A PH 34204 A PH34204 A PH 34204A PH 22522 A PH22522 A PH 22522A
Authority
PH
Philippines
Prior art keywords
compounds
lower alkyl
denotes
aryl
sulphur
Prior art date
Application number
PH34204A
Inventor
Hutchison Alan Jeffrey
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PH22522A publication Critical patent/PH22522A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Dental Preparations (AREA)

Abstract

Compounds of the formula: <IMAGE> in which Z denotes oxygen or sulphur, R denotes hydrogen or lower alkyl, R1 denotes hydrogen, lower alkyl or aryl(lower alkyl), R2 denotes hydrogen, lower alkyl or aryl(lower alkyl) or R1 and R2 together denote alkylene having 4-6 C atoms, R3 denotes hydrogen, hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning sulphur for Z, R3 denotes hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning oxygen for Z and R3 is bonded in position 5 or 8 in compounds having the meaning oxygen for Z, and R4 and R5 independently of one another denote hydrogen, lower alkyl or halogen, and pharmaceutically acceptable salts thereof, or mono- or di-S-oxides of compounds of the formula I in which Z denotes sulphur. The compounds can be used as modulators for the receptors of the central nervous system, for example as serotonin receptor antagonists in the treatment of disorders of the central nervous system.
PH34204A 1985-09-03 1986-09-01 3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds PH22522A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77206885A 1985-09-03 1985-09-03

Publications (1)

Publication Number Publication Date
PH22522A true PH22522A (en) 1988-10-17

Family

ID=25093804

Family Applications (1)

Application Number Title Priority Date Filing Date
PH34204A PH22522A (en) 1985-09-03 1986-09-01 3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds

Country Status (18)

Country Link
EP (1) EP0222996B1 (en)
JP (1) JPS6259273A (en)
KR (1) KR900003883B1 (en)
AT (1) ATE63744T1 (en)
AU (1) AU596113B2 (en)
DD (1) DD249480A5 (en)
DE (1) DE3679378D1 (en)
DK (1) DK418486A (en)
ES (1) ES2001923A6 (en)
FI (1) FI86720C (en)
GR (1) GR862239B (en)
HU (1) HU202853B (en)
IL (1) IL79920A (en)
NO (1) NO863507L (en)
NZ (1) NZ217432A (en)
PH (1) PH22522A (en)
PT (1) PT83300B (en)
ZA (1) ZA866685B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957928A (en) * 1986-06-26 1990-09-18 Ciba-Geigy Corporation Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (en) * 1986-12-19 1986-12-19 Astra Laekemedel Ab NOVEL CHROMAN DERIVATIVES
EP0322361A3 (en) * 1987-12-23 1990-01-24 Ciba-Geigy Ag Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds
PT92669B (en) * 1988-12-23 1995-09-12 Beecham Group Ltd PROCESS FOR THE PREPARATION OF BICYCLIC COMPOUNDS, PREFERENCE DERIVED FROM DEBENZOPYRANE
CA2047236C (en) * 1989-04-27 1997-07-22 Bengt Ronny Andersson Substituted 3-amino chromans
SE8904127D0 (en) * 1989-12-07 1989-12-07 Astra Ab NEW BIOCYCLIC AMINO-SUBSTITUTED COMPOUNDS
SE8904361D0 (en) 1989-12-22 1989-12-22 Astra Ab NEW CHROMAN AND THIOCHROMAN DERIVATIVES
US5616610A (en) * 1989-12-22 1997-04-01 Astra Aktiebolag (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
US5273994A (en) * 1990-04-09 1993-12-28 Adir Et Compagnie 3-aminochroman compounds
FR2660657B1 (en) * 1990-04-09 1993-05-07 Adir NOVEL 3-AMINOCHROMANE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2678617B1 (en) * 1991-07-01 1995-01-20 Adir NEW PROCESS FOR THE SYNTHESIS OF ENANTIOMERS OF 3-AMINO CHROMAN DERIVATIVES.
FR2681325B1 (en) * 1991-09-16 1993-12-17 Fabre Medicament Pierre DERIVATIVES OF AMINOMETHYL-4 PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
FR2689509B1 (en) * 1992-04-01 1994-06-03 Adir NEW SPIRANIC DERIVATIVES OF 3-AMINO CHROMANE, THEIR PREPARATION METHODS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SK281507B6 (en) * 1992-11-30 2001-04-09 Smithkline Beecham Plc USE OF BENZOPYRAN ANALOGUE, BENZOPYRAN ANALOGUE, METHODS OF PREPARATION AND PHARMACEUTICAL COMPOSITION WITH THEIR CONTENT
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607886A (en) * 1969-04-24 1971-09-21 Parke Davis & Co Chromanamines
US3629289A (en) * 1969-04-24 1971-12-21 Parke Davis & Co Chromanamines
US4203895A (en) * 1978-04-14 1980-05-20 Warner-Lambert Company Process for the preparation of cis-(±)-3,4-dihydro-N,N,2-trimethyl-2H-1-benzopyran-3-amine and intermediates produced thereby

Also Published As

Publication number Publication date
GR862239B (en) 1986-12-31
HU202853B (en) 1991-04-29
FI86720C (en) 1992-10-12
DE3679378D1 (en) 1991-06-27
EP0222996A3 (en) 1987-12-02
EP0222996A2 (en) 1987-05-27
FI863558A7 (en) 1987-03-04
AU6231786A (en) 1987-03-05
NO863507D0 (en) 1986-09-02
KR900003883B1 (en) 1990-06-04
KR870003088A (en) 1987-04-15
DK418486A (en) 1987-03-04
DD249480A5 (en) 1987-09-09
IL79920A0 (en) 1986-12-31
DK418486D0 (en) 1986-09-02
PT83300A (en) 1986-10-01
ES2001923A6 (en) 1988-07-01
PT83300B (en) 1989-05-12
JPS6259273A (en) 1987-03-14
ATE63744T1 (en) 1991-06-15
IL79920A (en) 1991-07-18
FI86720B (en) 1992-06-30
HUT44771A (en) 1988-04-28
AU596113B2 (en) 1990-04-26
ZA866685B (en) 1987-04-29
NZ217432A (en) 1990-03-27
FI863558A0 (en) 1986-09-03
EP0222996B1 (en) 1991-05-22
NO863507L (en) 1987-03-04

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