PH25109A - Antibiotic solutions and the lyophilization thereof - Google Patents

Antibiotic solutions and the lyophilization thereof

Info

Publication number: PH25109A
Authority: PH; Philippines
Prior art keywords: gel; lyophilization; concentration; antibiotic solutions; vancomycin hydrochloride
Prior art date: 1987-10-15

Application number

PH37669A

Other languages

English (en)

Inventor

Robert Lee Robison

Original Assignee

Robert Lee Robison

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-15

Filing date

1988-10-12

Publication date

1991-02-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22330088&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH25109(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-10-12 Application filed by Robert Lee Robison filed Critical Robert Lee Robison

1991-02-19 Publication of PH25109A publication Critical patent/PH25109A/en

Links

230000003115 biocidal effect Effects 0.000 title abstract 2
238000004108 freeze drying Methods 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
108010059993 Vancomycin Proteins 0.000 abstract 2
229960001572 vancomycin hydrochloride Drugs 0.000 abstract 2
LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 abstract 2
239000013011 aqueous formulation Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1
-1 ethanol Chemical class 0.000 abstract 1
230000009969 flowable effect Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

PH37669A 1987-10-15 1988-10-12 Antibiotic solutions and the lyophilization thereof PH25109A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/109,885 US4885275A (en)	1987-10-15	1987-10-15	Vancomycin-HCL solutions and the lyophilization thereof

Publications (1)

Publication Number	Publication Date
PH25109A true PH25109A (en)	1991-02-19

Family

ID=22330088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH37669A PH25109A (en)	1987-10-15	1988-10-12	Antibiotic solutions and the lyophilization thereof

Country Status (17)

Country	Link
US (1)	US4885275A (es)
EP (1)	EP0318146B1 (es)
JP (2)	JP2883890B2 (es)
KR (1)	KR970007907B1 (es)
AT (1)	ATE74013T1 (es)
AU (1)	AU610936B2 (es)
CA (1)	CA1326211C (es)
DE (1)	DE3869563D1 (es)
DK (1)	DK167141B1 (es)
ES (1)	ES2036690T3 (es)
GR (1)	GR3004155T3 (es)
HU (1)	HU200558B (es)
IE (1)	IE61049B1 (es)
IL (1)	IL88024A (es)
NZ (1)	NZ226550A (es)
PH (1)	PH25109A (es)
ZA (1)	ZA887579B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03193735A (ja) *	1989-12-22	1991-08-23	Shionogi & Co Ltd	グリコペプチド系抗生物質の安定化組成物
WO1997019690A1 (en) *	1995-12-01	1997-06-05	Eli Lilly And Company	Stable vancomycin hydrochloride solutions
US5786022A (en) *	1996-10-31	1998-07-28	Ethicon, Inc.	Coating mixture for surgical articles
US6391851B1 (en) *	1997-03-10	2002-05-21	Fujisawa Pharmaceutical Co., Ltd.	Hydrochlorides of vancomycin antibiotics and process for producing the same
WO1999041012A1 (en) *	1998-02-13	1999-08-19	Korea Research Institute Of Chemical Technology	A solid catalyst with core-shell catalytic phase and a method of preparation thereof
UA75083C2 (uk) *	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів
US7262317B2 (en)	2000-07-23	2007-08-28	Ono Pharmaceuticals Co., Ltd.	Freeze-dried preparation of n[o-(p-pivaloyloxybenzenasulfonylamino) benzoyl] glycine monosodium salt tetrahydrate and process for producing same
US20060074014A1 (en)	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
TWI342312B (en) *	2003-10-22	2011-05-21	Theravance Inc	Hydrochloride salts of a glycopeptide phosphonate derivative
US8182461B2 (en)	2003-11-04	2012-05-22	Smiths Medical Asd, Inc.	Syringe pump rapid occlusion detection system
JP5280813B2 (ja) *	2007-11-28	2013-09-04	日医工株式会社	グリコペプチド類含有凍結乾燥組成物及びその製造方法
KR101101663B1 (ko) *	2009-01-13	2011-12-30	(주) 제노텍	반코마이신 습체의 정제방법
US9616098B2 (en)	2013-05-30	2017-04-11	Scidose, Llc	Formulations of vancomycin
CN108601730B (zh) *	2016-01-15	2021-10-26	赛多斯制药有限责任公司	万古霉素的制剂
MX388732B (es)	2016-05-09	2025-03-20	Xellia Pharmaceuticals Aps	Formulaciones de antibioticos glicopeptidicos estabilizados
US11433115B2 (en)	2020-10-30	2022-09-06	Somerset Therapeutics, Llc	Glycopeptide antibiotics liquid formulations and methods and uses thereof
CN112691083B (zh) *	2020-12-28	2022-05-06	瀚晖制药有限公司	盐酸万古霉素的冻干工艺
WO2024092091A1 (en) *	2022-10-26	2024-05-02	Thomas Jefferson University	Biodegradable pocket for drug delivery and associated methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3067099A (en) *	1955-09-16	1962-12-04	Lilly Co Eli	Vancomycin and method for its preparation
HU176215B (en) *	1978-01-27	1981-01-28	Chinoin Gyogyszer Es Vegyeszet	Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
US4378348A (en) *	1979-12-28	1983-03-29	Otsuka Pharmaceutical Co., Ltd.	OA-7653 Substance
JPS58177949A (ja) *	1982-04-12	1983-10-18	Takeda Chem Ind Ltd	ランカシジン群抗生物質包接化合物
US4670258A (en) *	1984-02-10	1987-06-02	Vanderbilt University	Storable prepackaged aqueous solutions of vancomycin
US4547488A (en) *	1984-04-16	1985-10-15	Eli Lilly And Company	Antibiotic M43D, pharmaceutical compositions and method of use
AU618517B2 (en) *	1986-12-23	1992-01-02	Eugene J. Van Scott	Additives enhancing topical actions of therapeutic agents

1987
- 1987-10-15 US US07/109,885 patent/US4885275A/en not_active Expired - Lifetime
1988
- 1988-10-11 CA CA000579735A patent/CA1326211C/en not_active Expired - Fee Related
- 1988-10-11 ZA ZA887579A patent/ZA887579B/xx unknown
- 1988-10-12 IL IL88024A patent/IL88024A/xx active Protection Beyond IP Right Term
- 1988-10-12 NZ NZ226550A patent/NZ226550A/en unknown
- 1988-10-12 PH PH37669A patent/PH25109A/en unknown
- 1988-10-13 ES ES198888309584T patent/ES2036690T3/es not_active Expired - Lifetime
- 1988-10-13 EP EP88309584A patent/EP0318146B1/en not_active Expired - Lifetime
- 1988-10-13 JP JP63260349A patent/JP2883890B2/ja not_active Expired - Lifetime
- 1988-10-13 AU AU23696/88A patent/AU610936B2/en not_active Expired
- 1988-10-13 AT AT88309584T patent/ATE74013T1/de not_active IP Right Cessation
- 1988-10-13 DK DK570588A patent/DK167141B1/da not_active IP Right Cessation
- 1988-10-13 DE DE8888309584T patent/DE3869563D1/de not_active Expired - Lifetime
- 1988-10-14 HU HU885303A patent/HU200558B/hu unknown
- 1988-10-14 IE IE312988A patent/IE61049B1/en not_active IP Right Cessation
- 1988-10-14 KR KR1019880013395A patent/KR970007907B1/ko not_active Expired - Fee Related
1992
- 1992-03-26 GR GR920400468T patent/GR3004155T3/el unknown
1997
- 1997-08-13 JP JP9218556A patent/JP2983934B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ZA887579B (en)	1990-06-27
KR970007907B1 (ko)	1997-05-17
DK570588A (da)	1989-04-16
DE3869563D1 (de)	1992-04-30
NZ226550A (en)	1990-04-26
JPH01146825A (ja)	1989-06-08
AU2369688A (en)	1989-06-08
HUT49285A (en)	1989-09-28
AU610936B2 (en)	1991-05-30
IL88024A0 (en)	1989-06-30
JP2983934B2 (ja)	1999-11-29
DK167141B1 (da)	1993-09-06
EP0318146A1 (en)	1989-05-31
EP0318146B1 (en)	1992-03-25
GR3004155T3 (es)	1993-03-31
HU200558B (en)	1990-07-28
JP2883890B2 (ja)	1999-04-19
IE883129L (en)	1989-04-15
IE61049B1 (en)	1994-09-21
KR890006243A (ko)	1989-06-12
IL88024A (en)	1993-04-04
JPH1081619A (ja)	1998-03-31
CA1326211C (en)	1994-01-18
ATE74013T1 (de)	1992-04-15
DK570588D0 (da)	1988-10-13
US4885275A (en)	1989-12-05
ES2036690T3 (es)	1993-06-01

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