PH25728A - Combined use of an antigestagen, a progesteron synthesis inhibitor of the trilostane, epostane type - Google Patents
Combined use of an antigestagen, a progesteron synthesis inhibitor of the trilostane, epostane typeInfo
- Publication number
- PH25728A PH25728A PH37078A PH37078A PH25728A PH 25728 A PH25728 A PH 25728A PH 37078 A PH37078 A PH 37078A PH 37078 A PH37078 A PH 37078A PH 25728 A PH25728 A PH 25728A
- Authority
- PH
- Philippines
- Prior art keywords
- antigestagen
- trilostane
- synthesis inhibitor
- progesteron
- combined use
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 4
- 239000003418 antiprogestin Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- CETKWEWBSMKADK-GSXVSZIWSA-N epostane Chemical compound C([C@]1(C)[C@@](C)(O)CC[C@H]1[C@@H]1CC2)C[C@@H]1[C@]1(C)[C@]32O[C@]3(C)C(O)=C(C#N)C1 CETKWEWBSMKADK-GSXVSZIWSA-N 0.000 title abstract 2
- 229950002674 epostane Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- KVJXBPDAXMEYOA-CXANFOAXSA-N trilostane Chemical compound OC1=C(C#N)C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@]32O[C@@H]31 KVJXBPDAXMEYOA-CXANFOAXSA-N 0.000 title abstract 2
- 229960001670 trilostane Drugs 0.000 title abstract 2
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The medicine contains a progesterone synthesis inhibitor (ProH) of the trilostane or epostane type and an antigestagen (AG) and is used for inducing labour at term in humans and animals and for terminating normal or pathological pregnancy. The combination according to the invention is also suitable for treating hormone-dependent tumours, endometriosis and dysmenorrhoea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873720420 DE3720420A1 (en) | 1987-06-16 | 1987-06-16 | PROGESTERONE SYNTHESIS INHIBITOR AND ANTI-STAGE TO BEGINNING BIRTH OR FOR PREGNANCY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH25728A true PH25728A (en) | 1991-10-18 |
Family
ID=6329981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH37078A PH25728A (en) | 1987-06-16 | 1988-06-15 | Combined use of an antigestagen, a progesteron synthesis inhibitor of the trilostane, epostane type |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0296097B1 (en) |
| JP (1) | JP2716461B2 (en) |
| AT (1) | ATE94391T1 (en) |
| AU (1) | AU611160B2 (en) |
| CA (1) | CA1318251C (en) |
| DE (2) | DE3720420A1 (en) |
| DK (1) | DK327288A (en) |
| ES (1) | ES2059556T3 (en) |
| IE (1) | IE63453B1 (en) |
| IL (1) | IL86731A (en) |
| PH (1) | PH25728A (en) |
| ZA (1) | ZA884315B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3522753B2 (en) * | 1992-09-25 | 2004-04-26 | バーンズ,クライブ | Prevention of deposition of pollutants in beer lines |
| GB2345851B (en) * | 2000-01-18 | 2004-05-26 | Gavin Paul Vinson | A combination of trilostane or keto-trilostane and an anti-oestrogen for the treatment of an oestrogen-dependent cancer or tumour |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4062954A (en) * | 1976-12-27 | 1977-12-13 | Sterling Drug Inc. | Process for using a steroid compound |
| IL68222A (en) * | 1983-03-24 | 1987-02-27 | Yeda Res & Dev | Contraceptive compositions comprising a progesterone antagonist and a blocker of progesterone activity |
-
1987
- 1987-06-16 DE DE19873720420 patent/DE3720420A1/en not_active Withdrawn
-
1988
- 1988-06-13 JP JP63143843A patent/JP2716461B2/en not_active Expired - Fee Related
- 1988-06-14 DE DE88730135T patent/DE3884067D1/en not_active Expired - Fee Related
- 1988-06-14 ES ES88730135T patent/ES2059556T3/en not_active Expired - Lifetime
- 1988-06-14 AT AT88730135T patent/ATE94391T1/en not_active IP Right Cessation
- 1988-06-14 EP EP88730135A patent/EP0296097B1/en not_active Expired - Lifetime
- 1988-06-14 IL IL86731A patent/IL86731A/en not_active IP Right Cessation
- 1988-06-15 CA CA000569576A patent/CA1318251C/en not_active Expired - Fee Related
- 1988-06-15 IE IE180488A patent/IE63453B1/en not_active IP Right Cessation
- 1988-06-15 PH PH37078A patent/PH25728A/en unknown
- 1988-06-15 DK DK327288A patent/DK327288A/en not_active Application Discontinuation
- 1988-06-16 AU AU17750/88A patent/AU611160B2/en not_active Ceased
- 1988-06-16 ZA ZA884315A patent/ZA884315B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU611160B2 (en) | 1991-06-06 |
| DK327288D0 (en) | 1988-06-15 |
| IL86731A (en) | 1992-11-15 |
| DE3884067D1 (en) | 1993-10-21 |
| DE3720420A1 (en) | 1988-12-29 |
| DK327288A (en) | 1988-12-17 |
| CA1318251C (en) | 1993-05-25 |
| EP0296097B1 (en) | 1993-09-15 |
| ES2059556T3 (en) | 1994-11-16 |
| IL86731A0 (en) | 1988-11-30 |
| ATE94391T1 (en) | 1993-10-15 |
| EP0296097A3 (en) | 1990-04-04 |
| JPS63316725A (en) | 1988-12-26 |
| IE63453B1 (en) | 1995-04-19 |
| ZA884315B (en) | 1989-06-28 |
| IE881804L (en) | 1988-12-16 |
| AU1775088A (en) | 1988-12-22 |
| EP0296097A2 (en) | 1988-12-21 |
| JP2716461B2 (en) | 1998-02-18 |
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