PH25933A - Cyclic peptolides - Google Patents

Cyclic peptolides

Info

Publication number
PH25933A
PH25933A PH37083A PH37083A PH25933A PH 25933 A PH25933 A PH 25933A PH 37083 A PH37083 A PH 37083A PH 37083 A PH37083 A PH 37083A PH 25933 A PH25933 A PH 25933A
Authority
PH
Philippines
Prior art keywords
peptolides
cyclic
cyclic peptolides
undecapeptide
cyclisation
Prior art date
Application number
PH37083A
Other languages
English (en)
Inventor
Michael Morris Dreyfuss
Max H Schreier
Hanz Tscherter
Roland Wenger
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of PH25933A publication Critical patent/PH25933A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PH37083A 1987-06-19 1988-06-17 Cyclic peptolides PH25933A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH231787 1987-06-19
CH251787 1987-07-02

Publications (1)

Publication Number Publication Date
PH25933A true PH25933A (en) 1991-12-19

Family

ID=25690129

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37083A PH25933A (en) 1987-06-19 1988-06-17 Cyclic peptolides

Country Status (17)

Country Link
US (1) US5116816A (de)
EP (1) EP0296123B1 (de)
JP (1) JP2641256B2 (de)
KR (1) KR970010928B1 (de)
AT (1) ATE110784T1 (de)
AU (1) AU623078B2 (de)
CA (1) CA1338183C (de)
DE (1) DE3851268T2 (de)
ES (1) ES2056954T3 (de)
FI (1) FI87928C (de)
HU (1) HU204101B (de)
IE (1) IE64008B1 (de)
IL (1) IL86789A (de)
MY (1) MY103735A (de)
NZ (1) NZ225071A (de)
PH (1) PH25933A (de)
PT (1) PT87763B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU213553B (en) * 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
JP3480848B2 (ja) * 1992-06-19 2003-12-22 タカラバイオ株式会社 環状ペプチドの合成方法
US5260215A (en) * 1992-07-20 1993-11-09 Merck & Co., Inc. Fungal microorganism ATCC 74167 capable of producing cholesterol lowering compounds
US6187547B1 (en) 1993-09-08 2001-02-13 Novartis Ag Assay kit
PL181990B1 (pl) * 1994-07-27 2001-10-31 Novartis Ag Cyklopeptolidy, szczep grzybny i srodek terapeutyczny stanowiacy inhibitor ekspresji czasteczek adhezyjnych PL PL PL PL
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ATE314388T1 (de) 1997-10-08 2006-01-15 Isotechnika Inc Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
EP1214293A1 (de) 1999-09-08 2002-06-19 Guilford Pharmaceuticals Inc. Nicht-peptidische cyclophilin bindende verbindungen und ihre verwendung
US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US6593362B2 (en) 2001-05-21 2003-07-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
US20040147433A1 (en) * 2001-06-14 2004-07-29 Marcus Keep Neuroimmunophilins for selective neuronal radioprotection
BRPI0213658A8 (pt) 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
JP2005506990A (ja) * 2001-10-19 2005-03-10 アイソテクニカ インコーポレーテッド 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
EP1603512A2 (de) * 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Neue cyclosporine
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
EP1814902B1 (de) * 2004-11-22 2008-10-22 Astellas Pharma Inc. Zyklosporinanalog
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US8642536B2 (en) 2008-10-17 2014-02-04 Wisconsin Alumni Research Foundation Method of making biologically active alpha-beta peptides
KR20110093858A (ko) * 2008-11-06 2011-08-18 데비오 레쉑쉐 빠르마슈띠끄 에스.아 시클로운데카뎁시펩티드 화합물 및 약제로서 상기 화합물의 용도
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2011141891A1 (en) 2010-05-12 2011-11-17 Debio Recherche Pharmaceutique S.A. Use of cycloundecadepsipeptide compounds
MY165152A (en) 2010-12-15 2018-02-28 Contravir Pharmaceuticals Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
EP2705856A1 (de) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
GB201217560D0 (en) * 2012-10-02 2012-11-14 Mitopharm Ltd Novel cyclic depsipeptide compounds and their uses
HUP1500502A2 (en) 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
JPS5665853A (en) * 1979-11-01 1981-06-03 Sankyo Co Ltd Mycoplanesin derivative and its preparation
US4384996A (en) * 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
IE60394B1 (en) * 1986-12-15 1994-07-13 Lilly Co Eli Antibiotic A10255 complex and factors, process, microorganisms for its production
GB8727807D0 (en) * 1987-11-27 1987-12-31 Lepetit Spa Novel antibiotic compounds named a/16686 factors a'1,a'2 and a'3

Also Published As

Publication number Publication date
NZ225071A (en) 1991-05-28
DE3851268T2 (de) 1995-01-26
EP0296123B1 (de) 1994-08-31
HU204101B (en) 1991-11-28
EP0296123A2 (de) 1988-12-21
IE64008B1 (en) 1995-06-28
IL86789A (en) 1993-02-21
IL86789A0 (en) 1988-11-30
FI87928C (fi) 1993-03-10
ES2056954T3 (es) 1994-10-16
JPS6425798A (en) 1989-01-27
AU623078B2 (en) 1992-05-07
ATE110784T1 (de) 1994-09-15
AU1812488A (en) 1988-12-22
FI87928B (fi) 1992-11-30
PT87763B (pt) 1992-10-30
FI882926A0 (fi) 1988-06-17
EP0296123A3 (en) 1990-06-20
FI882926L (fi) 1988-12-20
KR890000518A (ko) 1989-03-15
DE3851268D1 (de) 1994-10-06
IE881838L (en) 1988-12-19
HUT50220A (en) 1989-12-28
JP2641256B2 (ja) 1997-08-13
US5116816A (en) 1992-05-26
KR970010928B1 (ko) 1997-07-02
CA1338183C (en) 1996-03-26
PT87763A (pt) 1988-07-01
MY103735A (en) 1993-09-30

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