PH26017A - Aqueous antimicrobial ophthalmic solutions - Google Patents

Aqueous antimicrobial ophthalmic solutions Download PDF

Info

Publication number: PH26017A
Authority: PH; Philippines
Prior art keywords: composition; quaternary ammonium; lenses; compound; agent
Prior art date: 1988-09-15

Application number

PH39240A

Other languages

English (en)

Inventor

Masood A Chowhan

R Gregg Harris

Connie L Luthy

Danny O Helton

Original Assignee

Alcon Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-15

Filing date

1989-09-15

Publication date

1992-01-29

1989-09-15 Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc

1992-01-29 Publication of PH26017A publication Critical patent/PH26017A/en

Links

230000000845 anti-microbial effect Effects 0.000 title claims description 11
239000002997 ophthalmic solution Substances 0.000 title 1
239000000203 mixture Substances 0.000 claims description 47
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 15
125000000129 anionic group Chemical group 0.000 claims description 12
239000008139 complexing agent Substances 0.000 claims description 12
125000001453 quaternary ammonium group Chemical group 0.000 claims description 12
-1 citrate ions Chemical class 0.000 claims description 10
235000002639 sodium chloride Nutrition 0.000 claims description 10
239000003795 chemical substances by application Substances 0.000 claims description 9
230000000249 desinfective effect Effects 0.000 claims description 9
239000004599 antimicrobial Substances 0.000 claims description 8
150000001875 compounds Chemical class 0.000 claims description 8
238000000034 method Methods 0.000 claims description 8
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 7
150000001450 anions Chemical class 0.000 claims description 7
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 6
229960000999 sodium citrate dihydrate Drugs 0.000 claims description 3
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 2
OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims description 2
229910019142 PO4 Inorganic materials 0.000 claims description 2
229960002303 citric acid monohydrate Drugs 0.000 claims description 2
229940009662 edetate Drugs 0.000 claims description 2
229940124274 edetate disodium Drugs 0.000 claims description 2
230000006872 improvement Effects 0.000 claims description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
239000010452 phosphate Substances 0.000 claims description 2
229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 2
229960002796 polystyrene sulfonate Drugs 0.000 claims description 2
239000011970 polystyrene sulfonate Substances 0.000 claims description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
150000003868 ammonium compounds Chemical class 0.000 claims 2
239000000243 solution Substances 0.000 description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
239000003755 preservative agent Substances 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
150000002500 ions Chemical class 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
239000007983 Tris buffer Substances 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
230000009467 reduction Effects 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
229910001415 sodium ion Inorganic materials 0.000 description 3
239000000126 substance Substances 0.000 description 3
WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
239000003945 anionic surfactant Substances 0.000 description 2
229960000686 benzalkonium chloride Drugs 0.000 description 2
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
229960003260 chlorhexidine Drugs 0.000 description 2
239000007979 citrate buffer Substances 0.000 description 2
229960004106 citric acid Drugs 0.000 description 2
239000000645 desinfectant Substances 0.000 description 2
239000003889 eye drop Substances 0.000 description 2
244000005700 microbiome Species 0.000 description 2
238000004321 preservation Methods 0.000 description 2
239000008213 purified water Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229940075554 sorbate Drugs 0.000 description 2
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
229940123208 Biguanide Drugs 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
150000004283 biguanides Chemical class 0.000 description 1
150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
125000002843 carboxylic acid group Chemical group 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
150000003841 chloride salts Chemical class 0.000 description 1
150000001805 chlorine compounds Chemical group 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
239000006196 drop Substances 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
229920003145 methacrylic acid copolymer Polymers 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000000178 monomer Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000003760 tallow Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3723—Polyamines or polyalkyleneimines

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Wood Science & Technology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Emergency Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Apparatus For Disinfection Or Sterilisation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Eyeglasses (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PH39240A 1988-09-15 1989-09-15 Aqueous antimicrobial ophthalmic solutions PH26017A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/244,974 US5037647A (en)	1988-09-15	1988-09-15	Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride

Publications (1)

Publication Number	Publication Date
PH26017A true PH26017A (en)	1992-01-29

Family

ID=22924837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH39240A PH26017A (en)	1988-09-15	1989-09-15	Aqueous antimicrobial ophthalmic solutions

Country Status (17)

Country	Link
US (1)	US5037647A (de)
EP (1)	EP0359574B1 (de)
JP (1)	JPH0649060B2 (de)
AR (1)	AR247326A1 (de)
AT (1)	ATE182081T1 (de)
AU (1)	AU625099B2 (de)
CA (1)	CA1334573C (de)
DE (1)	DE68929031T2 (de)
DK (1)	DK175224B1 (de)
ES (1)	ES2136055T3 (de)
FI (1)	FI105321B (de)
GR (1)	GR3031328T3 (de)
MX (1)	MX168660B (de)
NZ (1)	NZ230663A (de)
PH (1)	PH26017A (de)
WO (1)	WO1990002555A1 (de)
ZA (1)	ZA897060B (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0349487A3 (de) *	1988-06-28	1990-07-04	Ciba-Geigy Ag	Antimikrobielle Augenlösung, die Dodecyl-dimethyl-(2-phenoxyethyl)-ammoniumbromid enthält und Verfahren zu deren Verwendung
US6051611A (en) *	1991-11-08	2000-04-18	Alcon Laboratories, Inc.	Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias
US5512597A (en) *	1991-11-08	1996-04-30	Alcon Laboratories, Inc.	Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials
US5547663A (en) *	1991-11-08	1996-08-20	Alcon Laboratories, Inc.	Absolute molecular weight polymers and methods for their use
EP0542686A1 (de) *	1991-11-13	1993-05-19	Ciba-Geigy Ag	Verfahren und Behälter für die Sterilisation und Desinfektion
US5256420A (en) *	1991-12-23	1993-10-26	Ciba-Geigy Corporation	Method of imparting antimicrobial acitivity to an ophthalmic composition
US5356555A (en) *	1992-09-14	1994-10-18	Allergan, Inc.	Non-oxidative method and composition for simultaneously cleaning and disinfecting contact lenses using a protease with a disinfectant
AU733386B2 (en) *	1993-08-27	2001-05-10	Alcon Laboratories, Inc.	Process for cleaning and disinfecting contact lenses
AU5417501A (en) *	1993-08-27	2001-09-20	Alcon Laboratories, Inc.	Process for cleaning and disinfecting contact lenses
US5370744B1 (en) *	1993-08-27	1999-11-09	Alcon Lab Inc	Process for cleaning and disinfecting contact lenses
US5382599A (en) *	1993-10-13	1995-01-17	Allergan, Inc.	Method of inhibiting protozoan growth in eye care products using a polyvalent cation chelating agent
US5536494A (en) *	1994-10-04	1996-07-16	Alcon Laboratories, Inc.	Polyethylene oxide-containing quaternary ammunium polymers and pharmaceutical compositions containing an antimicrobial amount of same
US5603929A (en) *	1994-11-16	1997-02-18	Alcon Laboratories, Inc.	Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
WO2000028998A1 (en) *	1998-11-16	2000-05-25	Rohto Pharmaceutical Co., Ltd.	Liquid ophthalmic preparations
US6790816B2 (en)	1999-09-24	2004-09-14	Bausch & Lomb Incorporated	High osmolyte cleaning and disinfection method and solution for contact lenses
US6375973B2 (en)	2000-01-25	2002-04-23	Alcon Universal Ltd.	Ophthalmic anti-allergy compositions suitable for use with contact lenses
US20030100465A1 (en) *	2000-12-14	2003-05-29	The Clorox Company, A Delaware Corporation	Cleaning composition
US7799751B2 (en) *	2000-12-14	2010-09-21	The Clorox Company	Cleaning composition
US20020183233A1 (en) *	2000-12-14	2002-12-05	The Clorox Company, Delaware Corporation	Bactericidal cleaning wipe
DE10137978A1 (de) *	2001-08-02	2003-02-13	Creavis Tech & Innovation Gmbh	Antimikrobielle Reinigungsmittel
JP4255656B2 (ja) *	2001-09-17	2009-04-15	株式会社メニコン	眼科用液剤及びコンタクトレンズ用液剤
US20040028645A1 (en) *	2001-12-13	2004-02-12	Masood Chowhan	Artificial tear composition adapted to be used with contact lenses
EP1474109B1 (de)	2001-12-21	2010-08-25	Alcon, Inc.	Verwendung von synthetischen anorganischen nanoteilchen als träger für augenmedikamente
EP1471925A2 (de) *	2001-12-21	2004-11-03	Alcon, Inc.	Anorganische nanopartikel zur modifizierung der viskosität und physikalischer eigenschaften von ophthalmischen und ohrenheilkundigen zusammensetzungen
EP1455804A4 (de) *	2001-12-21	2005-01-05	Alcon Inc	Verwendung von nanoteilchen als träger von bioziden in ophthalmischen zusammensetzungen
US7282178B2 (en) *	2005-06-03	2007-10-16	Bausch & Lomb Incorporated	Composition and method for cleaning lipid deposits on contact lenses
US20060276359A1 (en) *	2005-06-03	2006-12-07	Bausch & Lomb Incorporated	Composition and method for cleaning lipid deposits on contact lenses
US20060275173A1 (en) *	2005-06-03	2006-12-07	Bausch & Lomb Incorporated	Method for cleaning lipid deposits on silicone hydrogel contact lenses
JP5135526B2 (ja) *	2005-06-27	2013-02-06	株式会社メニコンネクト	コンタクトレンズ用液剤
US20070053948A1 (en) *	2005-09-08	2007-03-08	Bausch & Lomb Incorporated	Lens care solution demonstration kit
TWI434926B (zh) *	2006-12-11	2014-04-21	Alcon Res Ltd	眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用
US8227017B2 (en) *	2007-11-13	2012-07-24	Quick-Med Technologies, Inc.	System and method for enhancing the efficacy of antimicrobial contact lenses and other surfaces
TWI544927B (zh) *	2008-03-17	2016-08-11	愛爾康研究有限公司	具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
PT2254549E (pt)	2008-03-17	2014-01-30	Alcon Res Ltd	Composições farmacêuticas aquosas que contêm complexos de borato-poliol
CA2723954A1 (en) *	2008-05-19	2009-11-26	Alcon Research, Ltd.	Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer
TW201023912A (en) *	2008-12-05	2010-07-01	Alcon Res Ltd	Pharmaceutical suspension
US8431751B1 (en)	2008-12-24	2013-04-30	Alcon Research, Ltd.	Polymeric quaternary ammonium compounds with vicinal hydroxy groups
AU2010221438C1 (en) *	2009-03-03	2015-01-29	Alcon Research, Ltd.	Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
US8912236B2 (en) *	2009-03-03	2014-12-16	Alcon Research, Ltd.	Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
TW201038295A (en) *	2009-04-17	2010-11-01	Alcon Res Ltd	Aqueous ophthalmic compositions containing anionic therapeutic agents
TWI489997B (zh)	2009-06-19	2015-07-01	Alcon Res Ltd	含有硼酸－多元醇錯合物之水性藥學組成物
TWI547522B (zh) *	2009-07-07	2016-09-01	愛爾康研究有限公司	環氧乙烷環氧丁烷嵌段共聚物組成物
TWI478730B (zh)	2009-12-03	2015-04-01	Alcon Res Ltd	眼科乳劑
US8999312B2 (en)	2010-06-02	2015-04-07	Alcon Research, Ltd.	Use of PBO-PEO-PBO block copolymers in ophthalmic compositions
EP3045163A1 (de)	2011-04-22	2016-07-20	Alcon Research, Ltd.	Ophthalmische zusammensetzung mit einem viskositätsverstärkungssystem mit zwei unterschiedlichen viskositätsverstärkern
KR20140022900A (ko)	2011-04-22	2014-02-25	알콘 리서치, 리미티드	2종의 상이한 점도 증강제를 포함하는 점도 증강 시스템을 갖는 안과 조성물
TWI544922B (zh)	2011-05-19	2016-08-11	愛爾康研究有限公司	高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
TW201336527A (zh)	2012-02-10	2013-09-16	Alcon Res Ltd	具增強的穩定性之水性藥學組成物
WO2014058402A2 (en) *	2012-10-12	2014-04-17	Alke Saglik Urunleri Sanayi Ve Ticaret Anonim Sirketi	Liquid cip (clean-in-place) detergent combinations
US10174006B2 (en)	2013-06-06	2019-01-08	Novartis Ag	Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease
HUE038809T2 (hu)	2013-12-17	2018-11-28	Novartis Ag	Térhálósított hidrofíl bevonattal ellátott szilikon hidrogél lencse
CN107922887B (zh) *	2015-08-03	2020-08-07	花王株式会社	抗菌型衣物用液体洗涤剂组合物
JP2019513137A (ja)	2016-03-30	2019-05-23	アユヴィスリサーチインク．ＡｙｕｖｉｓＲｅｓｅａｒｃｈ，Ｉｎｃ．	新規組成物及び治療方法
TWI884130B (zh)	2018-02-21	2025-05-21	瑞士商愛爾康公司	基於脂質的眼用乳劑
KR20210027381A (ko)	2018-07-02	2021-03-10	아유비스 리서치, 인코포레이티드	신규 면역조절 소분자
EP4431497A1 (de)	2019-02-15	2024-09-18	Bausch + Lomb Ireland Limited	Kristalline formen von 4-(7-hydroxy-2-isopropyl-4-oxo-4h-chinazolin-3-yl)-benzonitril und deren formulierungen
JP6994061B2 (ja)	2019-02-15	2022-01-14	ノバルティスアーゲー	４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
WO2022029656A1 (en)	2020-08-06	2022-02-10	Novartis Ag	Crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile and formulations thereof
CN113088411A (zh) *	2021-04-08	2021-07-09	山西利普达医药科技有限公司	一种含聚季铵盐-1的眼用清洗灭活病毒组合物及其应用
JP2025531367A (ja)	2022-09-21	2025-09-19	ボシュ＋ロムアイルランドリミテッド	Ｔｒｐｖ１アンタゴニストの結晶多形形態およびその製剤

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US440771A (en) *		1890-11-18		Oil-cup
DE2930865A1 (de) *	1979-07-30	1981-02-12	Schuelke & Mayr Gmbh	Desinfektions- und konservierungsmittel
US4499077A (en) *	1981-02-03	1985-02-12	Stockel Richard F	Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects
US4407791A (en) *	1981-09-28	1983-10-04	Alcon Laboratories, Inc.	Ophthalmic solutions
US4525346A (en) *	1981-09-28	1985-06-25	Alcon Laboratories, Inc.	Aqueous antimicrobial ophthalmic solutions
EP0145710A1 (de) *	1983-05-25	1985-06-26	Alcon Laboratories, Inc.	Ophthalmische lösung
US4579960A (en) *	1984-05-07	1986-04-01	Schering Corporation	Stable solutions containing thimerosal
CA1259542A (en) *	1984-09-28	1989-09-19	Francis X. Smith	Disinfecting and preserving solutions for contact lenses and methods of use
US4599195A (en) *	1984-12-28	1986-07-08	Alcon Laboratories, Inc.	Solution and method for removing protein, lipid, and calcium deposits from contact lenses
DE3575672D1 (de) *	1985-07-22	1990-03-08	Bausch & Lomb	Verfahren und loesung zur desinfektion und konservierung von kontaktlinsen.
EP0252974B1 (de) *	1986-01-06	1992-12-09	Allergan, Inc	Erhöhung von enzymatischer wirksamkeit bei der reinigung von kontaktlinsen durch verwendung von hypotonischen lösungen
US4734222A (en) *	1986-04-03	1988-03-29	Ciba-Geigy Corporation	Composition and method for cleaning soft and hard contact lenses
GB8625103D0 (en) *	1986-10-20	1986-11-26	Unilever Plc	Disinfectant compositions
BR8707615A (pt) *	1986-12-24	1989-10-03	Alcon Lab Inc	Composicao para limpeza de lentes de contato e processo para sua utilizacao
ES2053161T3 (es) *	1989-09-21	1994-07-16	Ciba Vision Ag	Composiciones antimicrobianas.

1988
- 1988-09-15 US US07/244,974 patent/US5037647A/en not_active Expired - Lifetime
1989
- 1989-09-13 CA CA000611333A patent/CA1334573C/en not_active Expired - Lifetime
- 1989-09-14 NZ NZ230663A patent/NZ230663A/en unknown
- 1989-09-15 ES ES89309381T patent/ES2136055T3/es not_active Expired - Lifetime
- 1989-09-15 MX MX017572A patent/MX168660B/es unknown
- 1989-09-15 DE DE68929031T patent/DE68929031T2/de not_active Expired - Lifetime
- 1989-09-15 WO PCT/US1989/004002 patent/WO1990002555A1/en not_active Ceased
- 1989-09-15 AR AR89314940A patent/AR247326A1/es active
- 1989-09-15 PH PH39240A patent/PH26017A/en unknown
- 1989-09-15 AU AU43113/89A patent/AU625099B2/en not_active Expired
- 1989-09-15 AT AT89309381T patent/ATE182081T1/de not_active IP Right Cessation
- 1989-09-15 JP JP1509897A patent/JPH0649060B2/ja not_active Expired - Lifetime
- 1989-09-15 ZA ZA897060A patent/ZA897060B/xx unknown
- 1989-09-15 EP EP89309381A patent/EP0359574B1/de not_active Expired - Lifetime
1990
- 1990-05-02 FI FI902194A patent/FI105321B/fi active IP Right Grant
- 1990-05-09 DK DK199001156A patent/DK175224B1/da not_active IP Right Cessation
1999
- 1999-09-24 GR GR990402430T patent/GR3031328T3/el unknown

Also Published As

Publication number	Publication date
DE68929031T2 (de)	1999-11-11
AR247326A1 (es)	1994-12-29
MX168660B (es)	1993-06-02
JPH0649060B2 (ja)	1994-06-29
US5037647A (en)	1991-08-06
EP0359574A3 (de)	1990-08-29
NZ230663A (en)	1991-05-28
DE68929031D1 (de)	1999-08-19
GR3031328T3 (en)	1999-12-31
DK115690A (da)	1990-05-09
DK175224B1 (da)	2004-07-12
EP0359574B1 (de)	1999-07-14
FI105321B (fi)	2000-07-31
AU625099B2 (en)	1992-07-02
WO1990002555A1 (en)	1990-03-22
JPH02502733A (ja)	1990-08-30
ES2136055T3 (es)	1999-11-16
DK115690D0 (da)	1990-05-09
FI902194A0 (fi)	1990-05-02
HK1011941A1 (en)	1999-07-23
CA1334573C (en)	1995-02-28
AU4311389A (en)	1990-04-02
ZA897060B (en)	1991-05-29
EP0359574A2 (de)	1990-03-21
ATE182081T1 (de)	1999-07-15

Publication	Publication Date	Title
PH26017A (en)	1992-01-29	Aqueous antimicrobial ophthalmic solutions
EP0180309B1 (de)	1992-02-19	Desinfektions- und Aufbewahrungslösungen für Kontaktlinsen und Verfahren zur Verwendung
CA1158548A (en)	1983-12-13	Contact lens disinfecting and preserving solution (polymeric)
AU734735B2 (en)	2001-06-21	Compositions and methods for enhancing contact lens wearability
CN1240361A (zh)	2000-01-05	低分子量氨基醇在眼用组合物中的应用
EP0885019B1 (de)	2003-10-29	Zweistufiges system für die neutralisation von iod bei der behandlung von kontaktlinsen
EP0909808B1 (de)	2002-06-05	Verfahren zur Reinigung und Desinfektion von Kontaktlinsen
EP1734923A1 (de)	2006-12-27	Zink-konservierungszusammensetzung und anwendungsverfahren
WO2008082948A2 (en)	2008-07-10	Ophthalmic alginate composition related methods of manufacture and methods of use
AU627195B2 (en)	1992-08-20	Antimicrobial ophthalmic solutions containing dodecyl- dimethyl-(2-phenoxyethyl)-ammonium bromide and methods of using the same
HK1011941B (en)	2000-04-20	Aqueous antimicrobial solutions for contact lens care
JP2001242428A (ja)	2001-09-07	コンタクトレンズ用液剤およびソフトコンタクトレンズの洗浄、消毒、保存方法
US5290512A (en)	1994-03-01	Method of disinfecting a contact lens and preserving a contact lens care solution
AU2004201867C1 (en)	2010-02-25	Process for cleaning and disinfecting contact lenses
HK1016517B (en)	2004-10-15	Dual neutralization system for iodine treatment of contact lenses