PH26284A - Antiviral or antibacterial composition and method of use thereof - Google Patents

Antiviral or antibacterial composition and method of use thereof Download PDF

Info

Publication number: PH26284A
Authority: PH; Philippines
Prior art keywords: composition; dimer; lysozyme; treating; ribonuclease
Prior art date: 1988-05-26

Application number

PH38684A

Other languages

English (en)

Inventor

Witold Kiczka

Original Assignee

Nika Health Products Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-26

Filing date

1989-05-23

Publication date

1992-04-10

1989-05-23 Application filed by Nika Health Products Ltd filed Critical Nika Health Products Ltd

1992-04-10 Publication of PH26284A publication Critical patent/PH26284A/en

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

PH38684A 1988-05-26 1989-05-23 Antiviral or antibacterial composition and method of use thereof PH26284A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17858888A	1988-05-26	1988-05-26
PCT/US1988/001785 WO1989011294A1 (en)	1988-05-26	1988-05-26	Antiviral or antibacterial compound and method of use
OA59731A OA09785A (en)	1988-05-26	1990-01-26	Antiviral or antibacterial compound and method of use

Publications (1)

Publication Number	Publication Date
PH26284A true PH26284A (en)	1992-04-10

Family

ID=33162813

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH38684A PH26284A (en)	1988-05-26	1989-05-23	Antiviral or antibacterial composition and method of use thereof

Country Status (23)

Country	Link
US (3)	US5200182A (cs)
EP (1)	EP0380484B1 (cs)
JP (1)	JPH0649659B2 (cs)
AT (1)	ATE93143T1 (cs)
AU (1)	AU624331B2 (cs)
BG (1)	BG60544B1 (cs)
CA (1)	CA1335425C (cs)
CS (1)	CS277030B6 (cs)
DK (1)	DK173078B1 (cs)
ES (1)	ES2011577A6 (cs)
FI (1)	FI900412A7 (cs)
HK (1)	HK42394A (cs)
HU (1)	HU204710B (cs)
IL (1)	IL90092A (cs)
LV (1)	LV10054B (cs)
MA (1)	MA21560A1 (cs)
MW (1)	MW390A1 (cs)
OA (1)	OA09785A (cs)
PH (1)	PH26284A (cs)
RU (1)	RU2092183C1 (cs)
WO (1)	WO1989011294A1 (cs)
YU (1)	YU109289A (cs)
ZA (1)	ZA893382B (cs)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0649659B2 (ja) *	1988-05-26	1994-06-29	ニカヘルスプロダクツ，リミテッド	抗ウイルス及び抗菌組成物並びに使用方法
US5989880A (en)	1990-01-08	1999-11-23	Nika Health Products Ltd.	Method of preparing lysozyme dimers
BR9007970A (pt) *	1990-01-08	1992-11-17	Nika Health Products Ltd	Processo para preparacao de dimeros de ribonuclease
PL173978B1 (pl) *	1992-07-13	1998-05-29	Nika Health Products Ltd	Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej
CH682541A5 (de) *	1992-06-23	1993-10-15	Urs Viktor Dr Wirth	Biochemische Inaktivierung von RNA-Viren.
US6183742B1 (en)	1992-07-13	2001-02-06	Nika Health Products, Limited	Applications of lysozyme dimer
DZ1964A1 (fr) *	1995-01-13	2002-10-15	Nika Health Products Ltd	Nouvelle applications d'un dimère de lysozyme.
GB2304048A (en) *	1995-08-12	1997-03-12	John William Carson	Medicament containing saliva extract
US6123937A (en) *	1997-03-14	2000-09-26	Nika Health Products, Limited	Applications of lysozyme dimer
RU2157206C1 (ru) *	1999-03-10	2000-10-10	Оренбургская государственная медицинская академия	Бактерицидный отогель
RU2172179C2 (ru) *	1999-06-24	2001-08-20	Сельков Сергей Алексеевич	Шарики "биосан" для лечения кольпитов различного генеза и способ лечения кольпитов различного генеза
RU2191576C2 (ru) *	1999-07-27	2002-10-27	Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии	Способ лечения субклинической формы генитальной герпесвирусной инфекции у женщин
RU2200550C2 (ru) *	1999-10-29	2003-03-20	Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством	Новые лекарственные формы димоцифона в терапии лепры, зудящих и аллергодерматозов, герпетиформного дерматита дюринга
RU2163119C1 (ru) *	2000-04-26	2001-02-20	Свистов Виталий Владимирович	Антисептическое средство
RU2180593C1 (ru) *	2000-11-08	2002-03-20	Айламазян Эдуард Карпович	Фармацевтическая композиция для лечения и профилактики генитального герпеса, хронической папилломы вирусной инфекции и профилактики рака шейки матки (варианты)
US6716813B2 (en) *	2000-11-28	2004-04-06	House Ear Institute	Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
US7338936B2 (en) *	2000-11-28	2008-03-04	House Ear Institute	Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
RU2177781C1 (ru) *	2000-12-06	2002-01-10	Научный Центр Здоровья детей РАМН	Суппозитории ректальные, содержащие витаминный комплекс
JP2002187853A (ja) *	2000-12-21	2002-07-05	Shinei Ferumentekku:Kk	動物の乳頭除菌剤および菌環境改善方法
RU2195927C1 (ru) *	2001-07-13	2003-01-10	ООО "Тенториум"	Абиес-свеча "канделла-два"
DE10210285A1 (de) *	2002-03-08	2003-11-13	Medigene Ag	Reversibles Toxin und seine Verwendung
JP2008505853A (ja)	2004-04-13	2008-02-28	クインテセンスバイオサイエンシーズインコーポレーティッド	細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
US20050244402A1 (en) *	2004-04-30	2005-11-03	Villanueva Julie M	Absorption of pain-causing agents
US7348301B2 (en) *	2006-02-16	2008-03-25	Buckman Laboratories International, Inc.	Lysozyme-based method and composition to control the growth of microorganisms in aqueous systems
US8840882B2 (en) *	2006-06-23	2014-09-23	Quintessence Biosciences, Inc.	Modified ribonucleases
WO2008010991A2 (en)	2006-07-17	2008-01-24	Quintessence Biosciences, Inc.	Methods and compositions for the treatment of cancer
RU2009136424A (ru) *	2007-03-02	2011-04-10	СЕНТ СИМЕОН ЭлДиЭй (US)	Композиция и способ лечения папилломавируса и саркоидов лошадей
US20100317677A1 (en) *	2007-09-11	2010-12-16	Hassel Bret A	Methods of Treating a Microbial Infection by Modulating RNase-L Expression and/or Activity
WO2009048909A1 (en) *	2007-10-08	2009-04-16	Quintessence Biosciences, Inc.	Compositions and methods for ribonuclease-based therapies
BRPI0920743A2 (pt)	2008-10-01	2016-09-20	Quintessence Biosciences Inc	ribonucleases terapeuticas
US20100215707A1 (en) *	2009-02-25	2010-08-26	Mcdonald Thomas	Activated creatinine and precursors thereof as antibacterial agents, compositions and products containing such agents and uses thereof
NZ600269A (en)	2009-05-20	2014-02-28	Dec Int Nz Ltd	Delivery device for treatment of mastitis
EP2457576B1 (en)	2010-11-29	2020-07-08	Eurochit Danuta Kruszewska	Lactobacillus reuteri strain for use in the medical and veterinary prophylaxis and treatment of metabolic syndrome or infections
RU2548803C2 (ru) *	2011-11-28	2015-04-20	Общество с ограниченной ответственностью " Фарматренд"	ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ ГЛАЗНЫХ ИНФЕКЦИЙ P. Aeruginosa, СОДЕРЖАЩАЯ РЕКОМБИНАНТНЫЙ ЛИЗОЦИМ
RU2509801C2 (ru) *	2012-03-22	2014-03-20	Борис Михайлович Куриненко	СПОСОБ ИСПОЛЬЗОВАНИЯ РИБОНУКЛЕАЗЫ Bacillus intermedius
EP2674162A1 (en)	2012-05-29	2013-12-18	Danuta Kruszewska	Nanoproduct comprising lactobacillus reuteri dan080 useful in prophylaxis and medicine, both human and veterinary and medical use of the same
CN104684565A (zh)	2012-05-29	2015-06-03	达努塔·克鲁谢夫斯卡	在人类和兽医的预防和医疗中有用的、包含罗伊氏乳杆菌dan080的纳米产品及其医疗用途
RU2504397C1 (ru) *	2012-10-25	2014-01-20	Леонид Леонидович Клопотенко	Фармацевтическая композиция, содержащая фермент рибонуклеазу и глицирризиновую кислоту или ее соли: глицирризинат аммония, или дикалия, или тринатрия
WO2014152678A1 (en)	2013-03-15	2014-09-25	University Of Massachusetts	Compositions and methods for delivering agents to the central nervous system
US9573980B2 (en)	2013-03-15	2017-02-21	Spogen Biotech Inc.	Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots
EP3108894B1 (en)	2014-02-21	2022-01-26	Kewpie Corporation	Non-therapeutic method of deactivating norovirus, use of lysozyme component for non-therapeutic norovirus deactivation, and lysozyme component for use in the prevention or treatment of norovirus infection
EP3175713A4 (en) *	2014-07-31	2018-04-18	Kewpie Corporation	Water-containing fluid composition, method for producing same, processed lysozyme and/or salt thereof, and method for producing same
IL315468A (en)	2014-09-17	2024-11-01	Spogen Biotech Inc	Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
LV15071B (lv) *	2015-07-14	2016-02-20	Rīgas Stradiņa Universitāte	Kompozīcija subklīniska mastīta ārstēšanai govīm
RU2634264C1 (ru) *	2016-09-19	2017-10-24	Александр Ливиевич Ураков	Крем-молочко для лечения опоясывающего лишая
CN110088650B (zh)	2016-12-28	2021-09-07	Dic株式会社	分散体和使用其的喷墨用油墨组合物、光转换层、和液晶显示元件
AR113123A1 (es)	2017-09-20	2020-01-29	Spogen Biotech Inc	Proteínas de fusión, bacterias recombinantes y fragmentos del exosporio para promover la salud de las plantas
WO2021021765A1 (en) *	2019-07-26	2021-02-04	Evolve Biosystems, Inc.	Nutritive compositions with bioactive proteins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1268M (fr) *	1961-06-29	1962-04-24	Puiseux	Médicament antimitotique et antiviral.
FR4020M (cs) *	1965-01-29	1966-03-21
DE1517751C3 (de) *	1965-07-08	1975-02-27	Eisai Co., Ltd., Tokio	Verfahren zum Verhindern der Bildung von flockigen Lysozym- und/oder Lysozymsalzniederschlägen in wässrigen Lösungen, die Lysozym und/oder Lysozymsalze enthalten
DE1545644A1 (de) *	1965-12-06	1969-08-07	Boehringer Sohn Ingelheim	Verfahren zur Herstellung von neuen quaternaeren Scopolammoniumsalzen
GB1110504A (en) *	1966-03-18	1968-04-18	Prodotti Antibiotici Spa	Pharmaceutical compositions
US4221794A (en) *	1979-06-21	1980-09-09	Newport Pharmaceuticals International, Inc.	Method of imparting immunomodulating and antiviral activity
US4510144A (en) *	1981-08-26	1985-04-09	Newport Pharmaceuticals International	Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives
CA1263378A (en) *	1985-01-08	1989-11-28	Robert James Alaimo	Imidazo¬4,5-f\|quinolines useful as immunomodulating agents
US4739046A (en) *	1985-08-19	1988-04-19	Luzio Nicholas R Di	Soluble phosphorylated glucan
US4744984A (en) *	1985-10-08	1988-05-17	Vetrepharm Research, Inc.	Antiviral immunotherapeutic agent and preparation thereof
JPH0649659B2 (ja) *	1988-05-26	1994-06-29	ニカヘルスプロダクツ，リミテッド	抗ウイルス及び抗菌組成物並びに使用方法

1988
- 1988-05-26 JP JP63504463A patent/JPH0649659B2/ja not_active Expired - Fee Related
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- 1988-05-26 WO PCT/US1988/001785 patent/WO1989011294A1/en not_active Ceased
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- 1988-05-26 AT AT88905146T patent/ATE93143T1/de not_active IP Right Cessation
- 1988-05-26 RU SU884743095A patent/RU2092183C1/ru active
- 1988-05-26 AU AU19408/88A patent/AU624331B2/en not_active Expired
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1989
- 1989-04-20 CA CA000597341A patent/CA1335425C/en not_active Expired - Fee Related
- 1989-04-27 IL IL9009289A patent/IL90092A/en not_active IP Right Cessation
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- 1989-05-23 PH PH38684A patent/PH26284A/en unknown
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- 1989-05-26 YU YU01092/89A patent/YU109289A/xx unknown
- 1989-05-26 CS CS893180A patent/CS277030B6/cs not_active IP Right Cessation
1990
- 1990-01-22 MW MW3/90A patent/MW390A1/xx unknown
- 1990-01-22 DK DK199000168A patent/DK173078B1/da not_active IP Right Cessation
- 1990-01-26 OA OA59731A patent/OA09785A/en unknown
- 1990-02-22 BG BG91270A patent/BG60544B1/bg unknown
1992
- 1992-04-08 US US07/865,002 patent/US5466449A/en not_active Expired - Lifetime
- 1992-12-28 LV LVP-92-508A patent/LV10054B/en unknown
1994
- 1994-05-05 HK HK42394A patent/HK42394A/en not_active IP Right Cessation
1995
- 1995-06-07 US US08/474,663 patent/US6099835A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6099835A (en)	2000-08-08
HK42394A (en)	1994-05-13
DK16890A (da)	1990-01-22
HUT54060A (en)	1991-01-28
FI900412A0 (fi)	1990-01-25
WO1989011294A1 (en)	1989-11-30
CS277030B6 (en)	1992-11-18
IL90092A (en)	1995-03-30
HU883981D0 (en)	1990-12-28
AU1940888A (en)	1989-12-12
EP0380484A1 (en)	1990-08-08
ATE93143T1 (de)	1993-09-15
ZA893382B (en)	1991-01-30
MW390A1 (en)	1990-11-14
CS318089A3 (en)	1992-05-13
BG91270A (bg)	1993-12-24
BG60544B1 (en)	1995-08-28
EP0380484B1 (en)	1993-08-18
CA1335425C (en)	1995-05-02
HU204710B (en)	1992-02-28
YU109289A (en)	1991-08-31
MA21560A1 (fr)	1989-12-31
JPH03504121A (ja)	1991-09-12
AU624331B2 (en)	1992-06-11
OA09785A (en)	1994-04-15
ES2011577A6 (es)	1990-01-16
LV10054B (en)	1995-02-20
DK173078B1 (da)	1999-12-20
JPH0649659B2 (ja)	1994-06-29
LV10054A (lv)	1994-05-10
FI900412A7 (fi)	1990-01-25
DK16890D0 (da)	1990-01-22
RU2092183C1 (ru)	1997-10-10
US5466449A (en)	1995-11-14
US5200182A (en)	1993-04-06

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US5200182A (en)	1993-04-06	Antiviral or antibacterial composition and method of use
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US6132715A (en)	2000-10-17	Method of inhibiting biosynthesis of tumor necrosis factor
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EP0548558A2 (en)	1993-06-30	Compositions containing surfactants as potentiating agents for the treatment of mammalian diseases
KR930004599B1 (ko)	1993-06-01	항바이러스성 또는 항균성 조성물
US7704976B2 (en)	2010-04-27	Use of N-acetyl-D-glucosamine for preparing medicines for urogenital tract infection's treatment and prevention
Ochs	1950	Treatment of external otitis; a simple and effective technic
DE3883392T2 (de)	1994-02-24	Verwendung eines Lysozymdimeren und/oder Ribonucleasedimeren zur Herstellung eines antiviralen oder antibakteriellen Arzneimittels.
RO110037B1 (ro)	1995-09-29	Compoziții antivirale sau antibacteriene și metodă de tratare a infecțiilor, cu acestea
Iyengar et al.	1966	Plumbago zeylanica L.(Chitrak) a gastrointestinal flora normaliser
Powell, SJ & MacLeod	1966	Ambilhar, a nitrothiazole derivative, in urinary tract bilharzia
CN100577200C (zh)	2010-01-06	治疗奶牛乳房炎的药物制剂及其制备方法及用途
JOHNSON	1948	Dermatologic evaluation of yeast, tyrothricin, chlorophyll and nitrofurazone
MXPA97005246A (en)	1998-07-03	New applications of dimero de lisoz