PH27365A - Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase - Google Patents

Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Info

Publication number: PH27365A
Authority: PH; Philippines
Prior art keywords: squalene; tetra; inhibitors; fluoro analogs; epoxidase
Prior art date: 1990-03-30

Application number

PH27365A

Other languages

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-30

Filing date

1993-06-21

Publication date

1993-06-21

1993-06-21 Application filed filed Critical

1993-06-21 Publication of PH27365A publication Critical patent/PH27365A/en

Links

YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 title abstract 2
102000005782 Squalene Monooxygenase Human genes 0.000 title abstract 2
108020003891 Squalene monooxygenase Proteins 0.000 title abstract 2
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 title abstract 2
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 title abstract 2
229940031439 squalene Drugs 0.000 title abstract 2
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C21/00—Acyclic unsaturated compounds containing halogen atoms
- C07C21/02—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds
- C07C21/215—Halogenated polyenes with more than two carbon-to-carbon double bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Steroid Compounds (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Pyrrole Compounds (AREA)

PH27365A 1990-03-30 1993-06-21 Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase PH27365A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/502,203 US5011859A (en)	1990-03-30	1990-03-30	Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Publications (1)

Publication Number	Publication Date
PH27365A true PH27365A (en)	1993-06-21

Family

ID=23996803

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH27365A PH27365A (en)	1990-03-30	1993-06-21	Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Country Status (19)

Country	Link
US (1)	US5011859A (no)
EP (1)	EP0448934B1 (no)
JP (1)	JP2911239B2 (no)
KR (1)	KR0162659B1 (no)
CN (1)	CN1055172A (no)
AT (1)	ATE118756T1 (no)
AU (1)	AU629726B2 (no)
CA (1)	CA2034612C (no)
DE (1)	DE69107488T2 (no)
ES (1)	ES2071131T3 (no)
FI (1)	FI910425L (no)
HU (1)	HU208103B (no)
IE (1)	IE910181A1 (no)
IL (1)	IL97356A0 (no)
NO (1)	NO910263L (no)
NZ (1)	NZ236800A (no)
PH (1)	PH27365A (no)
PT (1)	PT96654A (no)
ZA (1)	ZA91392B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995004025A1 (en) *	1993-07-29	1995-02-09	Chugai Seiyaku Kabushiki Kaisha	Tricarboxylic acid derivative having squalene synthetase inhibitor activity
DE19754795A1 (de) *	1997-12-10	1999-06-17	Boehringer Ingelheim Pharma	Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US6103733A (en) *	1998-09-09	2000-08-15	Bachmann; Kenneth A.	Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
AR063275A1 (es) *	2006-10-12	2009-01-14	Epix Delaware Inc	Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
WO2009076404A1 (en) *	2007-12-10	2009-06-18	Epix Delaware, Inc.	Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
BRPI0820701A2 (pt)	2007-12-11	2015-06-16	Cytopathfinder Inc	Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
US20130072519A1 (en)	2010-05-21	2013-03-21	Edward Lee Conn	2-phenyl benzoylamides
EP2680874A2 (en)	2011-03-04	2014-01-08	Pfizer Inc	Edn3-like peptides and uses thereof
EP2986599A1 (en)	2013-04-17	2016-02-24	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso
CN112678833B (zh) *	2020-11-17	2023-08-04	广西中烟工业有限责任公司	纳米二氧化硅改性角鲨烯有机硅颗粒及其制备和使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3876672A (en) *	1972-02-21	1975-04-08	Du Pont	Hydroformylation of olefins
DE2913677C2 (de) *	1979-04-05	1983-03-03	Union Rheinische Braunkohlen Kraftstoff AG, 5000 Köln	Verfahren zur Herstellung von Acetaldehyddimethylacetal
US4455441A (en) *	1982-09-24	1984-06-19	Research Foundation Of State University Of New York	Attractant termiticidal compounds, compositions and methods of use therefor
DE3618115A1 (de) *	1986-05-30	1987-12-03	Bayer Ag	Halogenolefine
US4876295A (en) *	1987-03-11	1989-10-24	The Dow Chemical Company	Flexible thermoplastic epoxy resin and coatings prepared therefrom

1990
- 1990-03-30 US US07/502,203 patent/US5011859A/en not_active Expired - Fee Related
1991
- 1991-01-17 NZ NZ236800A patent/NZ236800A/xx unknown
- 1991-01-18 AU AU69468/91A patent/AU629726B2/en not_active Ceased
- 1991-01-18 IE IE018191A patent/IE910181A1/en unknown
- 1991-01-18 ZA ZA91392A patent/ZA91392B/xx unknown
- 1991-01-18 HU HU91174A patent/HU208103B/hu not_active IP Right Cessation
- 1991-01-21 CA CA002034612A patent/CA2034612C/en not_active Expired - Fee Related
- 1991-01-23 NO NO91910263A patent/NO910263L/no unknown
- 1991-01-28 DE DE69107488T patent/DE69107488T2/de not_active Expired - Fee Related
- 1991-01-28 AT AT91101057T patent/ATE118756T1/de not_active IP Right Cessation
- 1991-01-28 ES ES91101057T patent/ES2071131T3/es not_active Expired - Lifetime
- 1991-01-28 EP EP91101057A patent/EP0448934B1/en not_active Expired - Lifetime
- 1991-01-29 FI FI910425A patent/FI910425L/fi unknown
- 1991-01-30 KR KR1019910001556A patent/KR0162659B1/ko not_active Expired - Fee Related
- 1991-02-01 PT PT96654A patent/PT96654A/pt unknown
- 1991-02-08 JP JP3037724A patent/JP2911239B2/ja not_active Expired - Fee Related
- 1991-02-25 IL IL97356A patent/IL97356A0/xx unknown
- 1991-03-25 CN CN91101860A patent/CN1055172A/zh active Pending
1993
- 1993-06-21 PH PH27365A patent/PH27365A/en unknown

Also Published As

Publication number	Publication date
FI910425A0 (fi)	1991-01-29
HUT56533A (en)	1991-09-30
AU6946891A (en)	1991-10-03
HU910174D0 (en)	1991-08-28
DE69107488T2 (de)	1995-06-14
FI910425A7 (fi)	1991-10-01
PT96654A (pt)	1991-10-31
DE69107488D1 (de)	1995-03-30
EP0448934A2 (en)	1991-10-02
CA2034612A1 (en)	1991-10-01
HU208103B (en)	1993-08-30
AU629726B2 (en)	1992-10-08
EP0448934A3 (en)	1991-11-27
ES2071131T3 (es)	1995-06-16
US5011859A (en)	1991-04-30
JP2911239B2 (ja)	1999-06-23
IL97356A0 (en)	1992-05-25
NZ236800A (en)	1993-05-26
CN1055172A (zh)	1991-10-09
NO910263D0 (no)	1991-01-23
KR910016660A (ko)	1991-11-05
ZA91392B (en)	1991-10-30
ATE118756T1 (de)	1995-03-15
CA2034612C (en)	2001-05-15
NO910263L (no)	1991-10-01
JPH04221327A (ja)	1992-08-11
KR0162659B1 (ko)	1999-01-15
FI910425L (fi)	1991-10-01
EP0448934B1 (en)	1995-02-22
IE910181A1 (en)	1991-10-09

Publication	Publication Date	Title
EP0448934A3 (en)	1991-11-27	Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase
UA26213C2 (uk)	1999-07-19	Засіб для профілактики та лікуваhhя остеопорозу та фармацевтичhа композиція hа їх осhові
MY111201A (en)	1999-09-30	New imidazopyridines
ATE161013T1 (de)	1997-12-15	Verfahren zum reinigen von 20 cs)-camptothecin
ZA906250B (en)	1991-10-30	Process for the treatment of ores containing rare earths
IL102428A0 (en)	1993-01-14	Inhibitors of hiv protease useful for the treatment of aids
EP0522709A3 (en)	1993-05-05	Polymerization inhibitors for acrylic acids and esters
PH21102A (en)	1987-07-16	Improvements in or relating to benzothiophene derivatives as antiastmatic agents
PL316656A1 (en)	1997-02-03	Free halophantrin base for use in treating marsh-fever and compositions containing same
MD960168A (ro)	1998-04-30	Metodă şi compuşi pentru tratamentul infecţiilor virale
EP0521103A4 (en)	1993-03-10	Novel cyclopropyl squalene derivatives and their use as inhibitors of cholesterol synthesis
HU9403300D0 (en)	1995-01-30	Melatonin derivatives for treaing insomnia
ZA915745B (en)	1992-08-26	Gas treatment or separation apparatus
EP0520273A3 (en)	1993-07-07	Process for the preparation of bis(ethoxycarbonylamino) toluols and their use in the preparation of diisocyanato toluols
ZA906487B (en)	1991-09-25	Process for the treatment of ores containing rare earths
HU8905409D0 (en)	1990-01-28	Process for the preparation of compositions containing ace inhibitor suitable for the treatment of postischaemic cardiac disturbances
PL302250A1 (en)	1994-08-22	Purified form of streptogramines, method of obtaining same and pharmaceutical agents containing it
GB9303815D0 (en)	1993-04-14	Use of fabric treatment compositions
EP0291776A3 (en)	1989-06-21	Stabilization of amine alanes
PL303822A1 (en)	1995-01-09	Therapeutic compositions containing ipsapyrone and method of obtaining them
GB2246128B (en)	1994-03-09	Process for extraction and purification of plaunotol
GB2250217B (en)	1994-08-31	Treatment of gas
GB2279082B (en)	1996-08-28	Autoclave apparatus for dry-steam decatizing of fabric
FI942603L (fi)	1994-08-02	Eskaraasia sisältävä proteolyyttinen seos ja menetelmä eskaraasin eristämiseksi
RU1833734C (ru)	1993-08-15	Cпocoб лeчehия tяжeлыx фopm эkзemы