PH27464A - 2,4,8-Trisubstituted-3H-6H-1,4-5A,8A-Tetraazaacenaphthylene-3,5-(4H)-diones and "?$,8-Trisubstituted-4,5-Dihydro-5-Thioxo-3H,6H-1,4,5A,8A-Tetraazacenaphthylene-3-ones - Google Patents

2,4,8-Trisubstituted-3H-6H-1,4-5A,8A-Tetraazaacenaphthylene-3,5-(4H)-diones and "?$,8-Trisubstituted-4,5-Dihydro-5-Thioxo-3H,6H-1,4,5A,8A-Tetraazacenaphthylene-3-ones

Info

Publication number: PH27464A
Authority: PH; Philippines
Prior art keywords: trisubstituted; alkyl; tetraazacenaphthylene; tetraazaacenaphthylene; diones
Prior art date: 1990-02-21

Application number

PH42023A

Other languages

English (en)

Inventor

Shin Shyong Tseng

Joseph William Epstein

Jeremy Ian Levin

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-21

Filing date

1991-02-19

Publication date

1993-07-09

1991-02-19 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1993-07-09 Publication of PH27464A publication Critical patent/PH27464A/en

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
-1 carboxamidomethyl Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
239000011630 iodine Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Photoreceptors In Electrophotography (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

PH42023A 1990-02-21 1991-02-19 2,4,8-Trisubstituted-3H-6H-1,4-5A,8A-Tetraazaacenaphthylene-3,5-(4H)-diones and "?$,8-Trisubstituted-4,5-Dihydro-5-Thioxo-3H,6H-1,4,5A,8A-Tetraazacenaphthylene-3-ones PH27464A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/482,568 US5013737A (en)	1988-02-22	1990-02-21	2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones

Publications (1)

Publication Number	Publication Date
PH27464A true PH27464A (en)	1993-07-09

Family

ID=23916572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH42023A PH27464A (en)	1990-02-21	1991-02-19	2,4,8-Trisubstituted-3H-6H-1,4-5A,8A-Tetraazaacenaphthylene-3,5-(4H)-diones and "?$,8-Trisubstituted-4,5-Dihydro-5-Thioxo-3H,6H-1,4,5A,8A-Tetraazacenaphthylene-3-ones

Country Status (24)

Country	Link
US (1)	US5013737A (cs)
EP (1)	EP0443312B1 (cs)
JP (1)	JP3046851B2 (cs)
KR (1)	KR0183395B1 (cs)
AT (1)	ATE152723T1 (cs)
AU (1)	AU640202B2 (cs)
CA (1)	CA2036589A1 (cs)
CZ (1)	CZ285584B6 (cs)
DE (1)	DE69125962T2 (cs)
DK (1)	DK0443312T3 (cs)
ES (1)	ES2102371T3 (cs)
FI (1)	FI93963C (cs)
GR (1)	GR3024063T3 (cs)
HU (1)	HUT60500A (cs)
IE (1)	IE910575A1 (cs)
IL (1)	IL97289A (cs)
NO (1)	NO177749C (cs)
NZ (1)	NZ237123A (cs)
PH (1)	PH27464A (cs)
PL (1)	PL166100B1 (cs)
PT (1)	PT96805B (cs)
SG (1)	SG47638A1 (cs)
SK (1)	SK279997B6 (cs)
ZA (1)	ZA911260B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1129091T3 (da) *	1998-11-12	2002-11-04	Neurocrine Biosciences Inc	Antagonister for CRF-receptorer og fremgangsmåder med relation dertil
CA2349904A1 (en) *	1998-11-12	2000-05-18	Neurocrine Biosciences, Inc.	Crf receptor antagonists and methods relating thereto
US20070219186A1 (en) *	2006-03-17	2007-09-20	Wyeth	Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof
US20070219183A1 (en) *	2006-03-17	2007-09-20	Wyeth	Dihydropyrazolo[1,5-A]pyrimidine and dihydroimidazo[1,5-A]pyrimidine derivatives and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4178449A (en) *	1978-04-17	1979-12-11	American Cyanamid Company	Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) *	1979-07-02	1980-11-25	American Cyanamid Company	Imidazo[1,5-a]pyrimidines
US4281000A (en) *	1979-07-09	1981-07-28	American Cyanamid Company	Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4713383A (en) *	1984-10-01	1987-12-15	Ciba-Geigy Corporation	Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
US4614732A (en) *	1984-10-26	1986-09-30	Warner-Lambert Company	N6 -acenaphthyl adenosines and analogs thereof
DE68911951T2 (de) *	1988-02-22	1994-06-01	American Cyanamid Co	5-(Substituierte Amino)-8-(phenyl oder substituierte phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one.

1990
- 1990-02-21 US US07/482,568 patent/US5013737A/en not_active Expired - Lifetime
1991
- 1991-01-08 DK DK91100189.9T patent/DK0443312T3/da active
- 1991-01-08 SG SG1996003303A patent/SG47638A1/en unknown
- 1991-01-08 ES ES91100189T patent/ES2102371T3/es not_active Expired - Lifetime
- 1991-01-08 EP EP91100189A patent/EP0443312B1/en not_active Expired - Lifetime
- 1991-01-08 DE DE69125962T patent/DE69125962T2/de not_active Expired - Fee Related
- 1991-01-08 AT AT91100189T patent/ATE152723T1/de not_active IP Right Cessation
- 1991-02-14 NZ NZ23712391A patent/NZ237123A/en unknown
- 1991-02-19 PH PH42023A patent/PH27464A/en unknown
- 1991-02-19 CZ CS91419A patent/CZ285584B6/cs not_active IP Right Cessation
- 1991-02-19 SK SK419-91A patent/SK279997B6/sk unknown
- 1991-02-19 JP JP3045452A patent/JP3046851B2/ja not_active Expired - Lifetime
- 1991-02-19 PT PT96805A patent/PT96805B/pt not_active IP Right Cessation
- 1991-02-19 CA CA002036589A patent/CA2036589A1/en not_active Abandoned
- 1991-02-20 KR KR1019910002713A patent/KR0183395B1/ko not_active Expired - Fee Related
- 1991-02-20 ZA ZA911260A patent/ZA911260B/xx unknown
- 1991-02-20 AU AU71225/91A patent/AU640202B2/en not_active Ceased
- 1991-02-20 IL IL9728991A patent/IL97289A/en not_active IP Right Cessation
- 1991-02-20 FI FI910816A patent/FI93963C/fi active
- 1991-02-20 NO NO910686A patent/NO177749C/no not_active IP Right Cessation
- 1991-02-20 IE IE057591A patent/IE910575A1/en not_active Application Discontinuation
- 1991-02-21 HU HU91584A patent/HUT60500A/hu unknown
- 1991-02-21 PL PL91289157A patent/PL166100B1/pl unknown
1997
- 1997-07-09 GR GR970401719T patent/GR3024063T3/el unknown

Also Published As

Publication number	Publication date
HU910584D0 (en)	1991-09-30
EP0443312B1 (en)	1997-05-07
NO177749B (no)	1995-08-07
US5013737A (en)	1991-05-07
ATE152723T1 (de)	1997-05-15
CS41991A3 (en)	1991-09-15
KR0183395B1 (ko)	1999-05-01
PL166100B1 (pl)	1995-03-31
ES2102371T3 (es)	1997-08-01
FI910816L (fi)	1991-08-22
GR3024063T3 (en)	1997-10-31
DK0443312T3 (da)	1997-11-17
AU7122591A (en)	1991-08-22
NZ237123A (en)	1994-07-26
CZ285584B6 (cs)	1999-09-15
PT96805B (pt)	1998-07-31
JPH04211086A (ja)	1992-08-03
IL97289A0 (en)	1992-05-25
DE69125962D1 (de)	1997-06-12
EP0443312A2 (en)	1991-08-28
ZA911260B (en)	1992-10-28
FI93963C (fi)	1995-06-26
JP3046851B2 (ja)	2000-05-29
DE69125962T2 (de)	1997-10-16
AU640202B2 (en)	1993-08-19
IL97289A (en)	1995-06-29
PT96805A (pt)	1991-10-31
NO177749C (no)	1995-11-15
FI93963B (fi)	1995-03-15
CA2036589A1 (en)	1991-08-22
NO910686L (no)	1991-08-22
HUT60500A (en)	1992-09-28
SG47638A1 (en)	1998-04-17
PL289157A1 (en)	1992-06-26
SK279997B6 (sk)	1999-06-11
IE910575A1 (en)	1991-08-28
FI910816A0 (fi)	1991-02-20
EP0443312A3 (en)	1992-02-19
NO910686D0 (no)	1991-02-20

Publication	Publication Date	Title
IL83364A0 (en)	1987-12-31	Substituted 5-amino-1-phenylpyrazoles
YU48303B (sh)	1998-05-15	Novi 2-(2'3', 4' - trisupstituisani benzoil)-1,3-cikloheksandionii
DE3767778D1 (de)	1991-03-07	Entzuendung verhindernde und allergie heilende mittel.
GR3003776T3 (cs)	1993-03-16
DE68916315D1 (de)	1994-07-28	Pyrimidinon-Derivate.
SE8503415D0 (sv)	1985-07-09	Novel isoindolinyl-alkyl-piperazines
ZA911260B (en)	1992-10-28	2,4,8-trisubstituted-3h,6h-1,4,5a,8a-tetraazaacenaphthylene-3,5-(4h)-diones
NO974588D0 (no)	1997-10-03	Triazol-antifungaltmiddel
SE8203877D0 (sv)	1982-06-22	Aminosulfonylbensoesyraderivat
IT1186784B (it)	1987-12-16	Azoliderivati ad attivita' antufungina
ES2077697T3 (es)	1995-12-01	Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.