PH30120A - Stable pharmaceutical composition of fumagillol derivatives - Google Patents

Stable pharmaceutical composition of fumagillol derivatives

Info

Publication number: PH30120A
Authority: PH; Philippines
Prior art keywords: pharmaceutical composition; stable pharmaceutical; fumagillol derivatives; fumagillol; derivatives
Prior art date: 1992-12-16

Application number

PH47449A

Other languages

English (en)

Inventor

Shigeo Yanai

Kazuhiro Saito

Hiroaki Okada

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-16

Filing date

1993-12-15

Publication date

1996-12-27

1993-12-15 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1996-12-27 Publication of PH30120A publication Critical patent/PH30120A/en

Links

150000002284 fumagillol derivatives Chemical group 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
230000033115 angiogenesis Effects 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
-1 fatty acid ester Chemical class 0.000 abstract 1
235000011187 glycerol Nutrition 0.000 abstract 1
206010073071 hepatocellular carcinoma Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

PH47449A 1992-12-16 1993-12-15 Stable pharmaceutical composition of fumagillol derivatives PH30120A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP33582892		1992-12-16

Publications (1)

Publication Number	Publication Date
PH30120A true PH30120A (en)	1996-12-27

Family

ID=18292862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH47449A PH30120A (en)	1992-12-16	1993-12-15	Stable pharmaceutical composition of fumagillol derivatives

Country Status (8)

Country	Link
US (1)	US5422363A (2)
EP (1)	EP0602586B1 (2)
KR (1)	KR940013499A (2)
CN (1)	CN1093901A (2)
AT (1)	ATE153854T1 (2)
CA (1)	CA2111560A1 (2)
DE (1)	DE69311278T2 (2)
PH (1)	PH30120A (2)

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US20010025046A1 (en) *	1999-06-24	2001-09-27	Rong(Ron) Liu	Self-emulsifying systems containing anticancer medicament
ES2286998T3 (es)	1999-02-26	2007-12-16	Sanofi-Aventis	Formulacion estable que contiene fumagillina.
US6673843B2 (en) *	1999-06-30	2004-01-06	Emory University	Curcumin and curcuminoid inhibition of angiogenesis
US6919307B2 (en) *	2000-11-01	2005-07-19	Praecis Pharmaceuticals, Inc.	Therapeutic agents and methods of use thereof for the modulation of angiogenesis
US7105482B2 (en)	2000-11-01	2006-09-12	Praecis Pharmaceuticals, Inc.	Methionine aminopeptidase-2 inhibitors and methods of use thereof
US6548477B1 (en) *	2000-11-01	2003-04-15	Praecis Pharmaceuticals Inc.	Therapeutic agents and methods of use thereof for the modulation of angiogenesis
BR0115109A (pt) *	2000-11-01	2005-10-18	Praecis Pharm Inc	Agentes terapêuticos e métodos de uso dos mesmos para a modulação da angiogênese
US7001603B2 (en) *	2001-02-28	2006-02-21	Color Access, Inc.	Gelled two phase cosmetic compositions
KR100451485B1 (ko) *	2002-03-28	2004-10-06	주식회사종근당	푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물
WO2005066197A2 (en) *	2003-12-29	2005-07-21	Praecis Pharmaceuticals, Inc.	Inhibitors of methionine aminopeptidase-2 and uses thereof
EP2217283A2 (en) *	2007-11-28	2010-08-18	Mersana Therapeutics, Inc.	Biocompatible biodegradable fumagillin analog conjugates
US8865746B2 (en)	2008-07-18	2014-10-21	Zafgen, Inc.	Methods of treating an overweight or obese subject
WO2013055385A2 (en)	2011-10-03	2013-04-18	Zafgen Corporation	Methods of treating age related disorders
US8642650B2 (en)	2008-12-04	2014-02-04	Zafgen, Inc.	Methods of treating an overweight or obese subject
WO2010065877A2 (en)	2008-12-04	2010-06-10	Zafgen Corporation	Methods of treating an overweight or obese subject
CA2777108A1 (en)	2009-10-09	2011-04-14	Zafgen Corporation	Sulphone compounds and methods of making and using same
US8815309B2 (en)	2010-01-08	2014-08-26	Zafgen, Inc.	Methods of treating a subject with benign prostate hyperplasia
BR112012016793A2 (pt)	2010-01-08	2018-07-31	Zafgen Corp	compostos tipo fumagilol e métodos de fazer e usar os mesmos
WO2011088055A2 (en)	2010-01-12	2011-07-21	Zafgen Corporation	Methods and compositions for treating cardiovascular disorders
WO2011127304A2 (en)	2010-04-07	2011-10-13	Zafgen Corporation	Methods of treating an overweight subject
CN103249735B (zh)	2010-07-22	2016-04-06	扎夫根股份有限公司	三环化合物及其制备和使用方法
PH12013500934A1 (en)	2010-11-09	2022-10-24	Zafgen Inc	Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012064928A1 (en)	2010-11-10	2012-05-18	Zafgen Corporation	Methods and compositions for treating thyroid hormone related disorders
WO2012074968A1 (en)	2010-11-29	2012-06-07	Zafgen Corporation	Methods of reducing risk of hepatobiliary dysfunction during rapid weight loss with metap-2 inhibitors
US9173865B2 (en)	2010-11-29	2015-11-03	Zafgen, Inc.	Treatment of obesity using non-daily administration of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol
US9189078B2 (en)	2010-12-20	2015-11-17	Apple Inc.	Enhancing keycap legend visibility with optical components
MX344238B (es)	2011-01-26	2016-12-07	Zafgen Inc	Compuestos de tetrazol y métodos para preparar y usar los mismos.
EP2683706B1 (en)	2011-03-08	2018-02-21	Zafgen, Inc.	Oxaspiro [2.5]octane derivatives and analogs
EP2705036B1 (en)	2011-05-06	2015-08-12	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
CN103764641B (zh)	2011-05-06	2016-10-26	扎夫根股份有限公司	部分饱和的三环化合物及其制备和使用方法
BR112013028666A2 (pt)	2011-05-06	2017-08-08	Zafgen Inc	compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
JP2015509102A (ja)	2012-01-18	2015-03-26	ザフゲン，インコーポレイテッド	三環式スルホン化合物並びにその作製および使用方法
MX2014008706A (es)	2012-01-18	2015-03-05	Zafgen Inc	Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
BR112014027808A2 (pt)	2012-05-07	2017-06-27	Zafgen Inc	sal polimórfico do sal de oxalato de 6-o-(4-dimetilaminoetoxi) cinaroil fumagilol e métodos de produção e utilização do mesmo
MX2014013599A (es)	2012-05-08	2015-05-11	Zafgen Inc	Tratamiento de la obesidad hipotalamica con inhibidores de metap2.
BR112014027981A2 (pt)	2012-05-09	2017-06-27	Zafgen Inc	compostos do tipo fumagilol e métodos de produção e utilização dos mesmos
MX2015005733A (es)	2012-11-05	2016-02-10	Zafgen Inc	Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.
AU2013337282A1 (en)	2012-11-05	2015-05-21	Zafgen, Inc.	Tricyclic compounds and methods of making and using same
NZ707773A (en)	2012-11-05	2019-05-31	Zafgen Inc	Methods of treating liver diseases
CN105228610A (zh)	2013-03-14	2016-01-06	扎夫根股份有限公司	治疗肾疾病和其它病症的方法
CN106432255A (zh)	2015-08-11	2017-02-22	扎夫根公司	烟曲霉素醇螺环化合物和制备和使用其的方法
AR105671A1 (es)	2015-08-11	2017-10-25	Zafgen Inc	Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
IL300825A (en)	2017-03-15	2023-04-01	Cerecin Inc	Pharmaceutical preparations with a high drug load of medium-length triglyceride chains and methods related thereto
BE1027390B1 (nl)	2019-06-21	2021-02-02	Nutrition Sciences Nv	Mfca-samenstelling voor gebruik in de aquacultuur van schaaldieren

Family Cites Families (11)

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Publication number	Priority date	Publication date	Assignee	Title
JPH0784462B2 (ja) *	1986-07-25	1995-09-13	日清製粉株式会社	ベンゾイミダゾ−ル誘導体
CA1333363C (en) *	1988-01-19	1994-12-06	Judah Folkman	Angiogenesis inhibitor comprising fumagillin
US4954496A (en) *	1988-08-12	1990-09-04	Fujisawa Pharmaceutical Company, Ltd.	Cyclohexane derivatives and pharmaceutical compositions
PH26256A (en) *	1988-08-12	1992-04-01	Fujisawa Pharmaceutical Co	Oxaspiro [2,5] octane derivative
KR0138530B1 (ko) *	1988-09-01	1998-05-15	우메모또 요시마사	푸마길롤 유도체
ES2053890T3 (es) *	1988-09-01	1994-08-01	Takeda Chemical Industries Ltd	Agente inhibidor de la angiogenesis.
DE69001187T2 (de) *	1989-03-06	1993-07-08	Takeda Chemical Industries Ltd	6-epifumagillole, ihre herstellung und ihre verwendung.
EP0386667B1 (en) *	1989-03-06	1993-11-18	Takeda Chemical Industries, Ltd.	6-Amino-6-desoxyfumagillols, production and use thereof
EP0415294A3 (en) *	1989-08-31	1991-06-12	Takeda Chemical Industries, Ltd.	Cyclohexanol derivatives, production and use thereof
TW282399B (2) *	1990-05-25	1996-08-01	Takeda Pharm Industry Co Ltd
ATE130517T1 (de) *	1990-08-08	1995-12-15	Takeda Chemical Industries Ltd	Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.

1993
- 1993-12-14 EP EP93120104A patent/EP0602586B1/en not_active Expired - Lifetime
- 1993-12-14 DE DE69311278T patent/DE69311278T2/de not_active Expired - Fee Related
- 1993-12-14 AT AT93120104T patent/ATE153854T1/de not_active IP Right Cessation
- 1993-12-15 CA CA002111560A patent/CA2111560A1/en not_active Abandoned
- 1993-12-15 US US08/167,479 patent/US5422363A/en not_active Expired - Lifetime
- 1993-12-15 PH PH47449A patent/PH30120A/en unknown
- 1993-12-16 KR KR1019930028037A patent/KR940013499A/ko not_active Withdrawn
- 1993-12-16 CN CN93120125A patent/CN1093901A/zh active Pending

Also Published As

Publication number	Publication date
EP0602586A3 (2)	1994-08-31
CA2111560A1 (en)	1994-06-17
DE69311278T2 (de)	1997-10-30
KR940013499A (ko)	1994-07-15
EP0602586A2 (en)	1994-06-22
US5422363A (en)	1995-06-06
ATE153854T1 (de)	1997-06-15
CN1093901A (zh)	1994-10-26
EP0602586B1 (en)	1997-06-04
DE69311278D1 (de)	1997-07-10

Publication	Publication Date	Title
PH30120A (en)	1996-12-27	Stable pharmaceutical composition of fumagillol derivatives
CA2156288A1 (en)	1994-09-01	Glycerol derivative, device and pharmaceutical composition
MA22733A1 (fr)	1993-07-01	Esters citrates acyles en tant que precurseurs de peracides.
NO934499D0 (no)	1993-12-09	Ikke-klorfluorcarbonaerosolformuleringer
NO911591D0 (no)	1991-04-22	Fremgangsmaate for fremstilling av sukrose-6-ester.
PL309812A1 (en)	1996-02-05	Derivatives of 2-(2-amino- 1,6-dihydro-6-oxopurin-9-ylo) - methoxy-1,3-propanodiole, method of obtaining them and pharmaceutical composition containing such derivatives
ITRM920761A1 (it)	1994-04-20	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
NO176082C (no)	1995-02-01	Fremgangsmåte for fremstilling av et farmasöytisk preparat inneholdende bunazosin, for perkutan tilförsel
MY114765A (en)	2003-01-31	Preparation for epidermis
FI905748A0 (fi)	1990-11-21	Foerfarande foer framstaellning av 4-o -fosfater av dopamin och dopaminderivat.
EP0666865A4 (en)	1996-08-21	PLANT FATTY ACID SYNTHASES.
DK0563112T3 (da)	1995-04-10	Probucol-holdigt lægemiddel med forøget biotilgængelighed
DE3877508D1 (de)	1993-02-25	Aliphatische ester 1,3,2-oxazaphospholidinen.
ATE120730T1 (de)	1995-04-15	3.3'-dithiobis (propionsäuren) und estern davon.
MY106615A (en)	1995-06-30	Stabilized leukocyte-interferons.
OA06792A (fr)	1982-12-31	Procédé de préparation de dérivés esters d'acides cyclopropane-carboxylique.
GR3006732T3 (2)	1993-06-30
NO171912C (no)	1993-05-19	Fremgangsmaate for fremstilling av 5-klor-3-klorsulfonyl-2-tiofenkarboksylsyreestere
FR2687667B1 (fr)	1996-03-22	Esters d'acides carboxyliques d'hydroxyphenylalcanols comme stabilisants.
EP0643054A3 (en)	1995-05-03	Process for the preparation of carbonic acid ester derivatives and intermediates.
FI905930A7 (fi)	1992-05-31	Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi
BE895712A (fr)	1983-05-16	Derives de benzo-1,3-thiazine-1,1-dixoyde, leur preparation et leur utilisation
SE8104657L (sv)	1982-02-05	Injicerbara farmaceutiska kompositioner
OA06793A (fr)	1982-12-31	Procédé de préparation de dérivés esters d'acides cyclopropane-carboxyliques.
BE894245A (fr)	1983-02-28	Derives d'esters de n-arylsulfinyl-n-phosphonomethylglycinates