PL140477B1 - Method of obtaining calcium gluconate - Google Patents
Method of obtaining calcium gluconate Download PDFInfo
- Publication number
- PL140477B1 PL140477B1 PL24525383A PL24525383A PL140477B1 PL 140477 B1 PL140477 B1 PL 140477B1 PL 24525383 A PL24525383 A PL 24525383A PL 24525383 A PL24525383 A PL 24525383A PL 140477 B1 PL140477 B1 PL 140477B1
- Authority
- PL
- Poland
- Prior art keywords
- oxidation
- iodine
- calcium
- calcium gluconate
- glucose solution
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 15
- 239000004227 calcium gluconate Substances 0.000 title claims description 7
- 235000013927 calcium gluconate Nutrition 0.000 title claims description 7
- 229960004494 calcium gluconate Drugs 0.000 title claims description 7
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 title claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- 230000003647 oxidation Effects 0.000 claims description 8
- 238000007254 oxidation reaction Methods 0.000 claims description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 7
- 229910052740 iodine Inorganic materials 0.000 claims description 7
- 239000011630 iodine Substances 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 claims description 4
- 229940046413 calcium iodide Drugs 0.000 claims description 4
- 229910001640 calcium iodide Inorganic materials 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 238000006056 electrooxidation reaction Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- PRXLCSIMRQFQMX-UHFFFAOYSA-N [O].[I] Chemical class [O].[I] PRXLCSIMRQFQMX-UHFFFAOYSA-N 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001649 bromium compounds Chemical class 0.000 description 1
- 229910001622 calcium bromide Inorganic materials 0.000 description 1
- WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
Landscapes
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Przedmiotem wynalazku jest sposób otrzymywania glikonianu wapniowego* Dotychczas glukonian wapniowy otrzymuje sie przez utlenianie glukozy przy pomocy wolnego bromu lub tez utlenienie na innej drodze np. elektrochemiczne lub nadtlenkiem wodoru w obec¬ nosci bromu lub bromków, zwlaszcza bromku wapniowego jako katalizatorów, proces ten prowadzi sie naogól przy pH ponizej 7 w temperaturze okolo 303 Kprzy stezeniu glukozy 15-20% wagowo.Sposoby te posiadaja niedogodnosci, z których najistotniejsza to powstawanie podczas procesu par bardzo lotnego, trujacego bromu.Celem wynalazku jest unikniecie wyzej wymienionych niedogodnosci. Cel ten osiagnieto po¬ przez opracowanie sposobu otrzymywania glukonianu wapniowego na drodze elektrochemicznego utleniania roztworu glukozy lub utleniani a roztworu glukozy przy pomocy nadtlenku wodoru w obecnosci weglanu wapniowego, którego istota polega na tym, ze jako katalizator w procesie utleniania dodaje sie jod w postaci jodku wapniowego, wolnego jodu lub soli wapniowych tle¬ nowych kwasów jodu o stezeniu 0,2-5% wagowo, a proces prowadzi sie w temperaturze 30-60°C przy pH w zakresie 5-12.Przyklad. 1 dur roztworu zawierajacego 180 g glukozy, 15 g jodku wapniowego oraz 80 g CaC07 w postaci zawiesiny o temperaturze 323 Kpoddano elektrolizie w elektrolizerze z mieszadlem mechanicznym i elektrodami grafitowymi przy gestosci anodowej 1 A/dm • Po prze¬ plynieciu ladunku 53 Ah proces przerwano i skorygowac pH do okolo 7 za pomoca mleka wapien¬ nego. Po odfiltrowaniu i krystalizacji uzyskano glukonian wapniowy z wydajnoscia 52% w wy¬ dajnosci teoretycznej.2 HO 477 Zastrzezenie patentowe Sposób otrzymywania glukonianu wapniowego na drodze elektrochemicznego utleniania roztworu glukozy lub utleniania roztworu glukozy przy pomocy nadtlenku wodoru w obecnosci weglanu wa¬ pniowego, znamienny tym, ze jako katalizator w procesie utleniania dodaje sie jod w postaci jodku wapniowego, wolnego jodu lub soli wapniowych tlenowych kwasów jodu o stezeniu 0,2-5# wagowo, a proces prowadzi sie w temperaturze 30-60°C przy pH w zakresie 5-12• Pracownia Poligraficzna UP PRL. Naklad 100 egz Cena 220 zl PLThe subject of the invention is a method of obtaining calcium gluconate. So far, calcium gluconate is obtained by oxidation of glucose with free bromine or by oxidation in some other way, e.g. electrochemically or with hydrogen peroxide in the presence of bromine or bromides, especially calcium bromide as catalysts, the process is carried out by in general, at a pH below 7 at a temperature of about 303 K with a glucose concentration of 15-20% by weight. These methods have disadvantages, the most important of which is the formation of very volatile, poisonous bromine vapor during the process. The aim of the invention is to avoid the above-mentioned disadvantages. This goal was achieved by developing a method of obtaining calcium gluconate by electrochemical oxidation of a glucose solution or oxidation of a glucose solution with hydrogen peroxide in the presence of calcium carbonate, the essence of which is that iodine in the form of calcium iodide is added as a catalyst in the oxidation process. , free iodine or calcium salts of iodine oxygen acids at a concentration of 0.2-5% by weight, and the process is carried out at a temperature of 30-60 ° C with a pH in the range of 5-12. 1 tart of a solution containing 180 g of glucose, 15 g of calcium iodide and 80 g of CaC07 in the form of a suspension at a temperature of 323 K was electrolysed in an electrolyser with a mechanical stirrer and graphite electrodes at an anode density of 1 A / dm. • After a charge flow of 53 Ah, the process was stopped and adjust the pH to around 7 with milk of lime. After filtration and crystallization, calcium gluconate was obtained with a theoretical yield of 52%. 2 HO 477 Patent claim A method of obtaining calcium gluconate by electrochemical oxidation of a glucose solution or oxidation of a glucose solution with hydrogen peroxide in the presence of calcium carbonate, characterized by: that iodine in the form of calcium iodide, free iodine or calcium salts of oxygen iodine acids with a concentration of 0.2-5% by weight is added as a catalyst in the oxidation process, and the process is carried out at a temperature of 30-60 ° C with a pH in the range of 5-12 • Printing workshop of the UP PRL. Mintage 100 copies Price PLN 220 PL
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL24525383A PL140477B1 (en) | 1983-12-20 | 1983-12-20 | Method of obtaining calcium gluconate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL24525383A PL140477B1 (en) | 1983-12-20 | 1983-12-20 | Method of obtaining calcium gluconate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL245253A1 PL245253A1 (en) | 1985-07-02 |
| PL140477B1 true PL140477B1 (en) | 1987-04-30 |
Family
ID=20019747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL24525383A PL140477B1 (en) | 1983-12-20 | 1983-12-20 | Method of obtaining calcium gluconate |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL140477B1 (en) |
-
1983
- 1983-12-20 PL PL24525383A patent/PL140477B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL245253A1 (en) | 1985-07-02 |
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