PL141641B1 - Agent for fighting against and/or preventing paralyzing effects of microorganisms and method of obtaining new derivatives of n-/2-nitrophenylo/-4-aminopyrimidiines - Google Patents

Agent for fighting against and/or preventing paralyzing effects of microorganisms and method of obtaining new derivatives of n-/2-nitrophenylo/-4-aminopyrimidiines Download PDF

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Publication number
PL141641B1
PL141641B1 PL1984247096A PL24709684A PL141641B1 PL 141641 B1 PL141641 B1 PL 141641B1 PL 1984247096 A PL1984247096 A PL 1984247096A PL 24709684 A PL24709684 A PL 24709684A PL 141641 B1 PL141641 B1 PL 141641B1
Authority
PL
Poland
Prior art keywords
halogen
carbon atoms
group
agent
nitrophenylo
Prior art date
Application number
PL1984247096A
Other languages
English (en)
Other versions
PL247096A1 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PL247096A1 publication Critical patent/PL247096A1/xx
Publication of PL141641B1 publication Critical patent/PL141641B1/pl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58Two sulfur atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

Przedmiotem wynalazkujest srodek do zwalczania lub zapobiegania porazeniu przez mikro¬ organizmy, zwierajacy znane nosniki i/lub substancje pomocnicze oraz substancje czynna, a takze sposób wytwarzania nowych pochodnych N-/2-nitrofenylo/-4-aminopirymidyny.Srodek wedlug wynalazku zawiera jako substancje czynna co najmniej jedna nowa pochodna N-/2-nitrofenylo/-4-aminopirymidyny o ogólnym wzorze 1, w którym Ri oznacza grupe nitrowa lub grupe trójfluorometylowa, R2 oznacza grupe nitrowa lub grupe trójfluorometylowa, R3 ozna¬ cza atom wodoru lub chlorowca, R4 oznacza atom wodoru lub grupe -C/O/R7, przy czym R7 stanowi ewentualnie podstawiony chlorowcem, grupa alkoksylowa o 1-3 atomach wegla lub grupa alkilotio o 1-3 atomach wegla rodnik alkilowy o 1-4 atomach wegla, R5 i Re niezaleznie od siebie oznaczaja atom chlorowca, podstawiony chlorowcem lub grupa alkoksylowa o 1-3 atomach wegla rodnik alkilowy o 1-6 atomach wegla, ewentualnie podstawiona chlorowcem lub rodnikiem alkoksylowym o 1-3 atomach wegla grupe alkoksylowa o 1-6 atomach wegla, ewentualnie podsta¬ wiona chlorowcem lub rodnikiem alkoksylowym o 1-3 atomach wegla grupe alkilotio o 1-6 atomach wegla, grupe cykloalkoksylowa o 3-6 atomach wegla, grupe cykloalkilotio o 3-6 atomach wegla, grupe alkenyloksylowa o 3-6 atomach wegla, grupe alkenylotio o 3-6 atomach wegla, grupe alkinyloksylowa o 3-6 atomach wegla, grupe alkilosulfoksylowa o 1-6 atomach wegla, grupe alkilosulfonylowa o 1-6 atomach wegla, grupe alkilosulfonylowa o 1-6 atomach wegla, grupe alkenylosulfoksylowa o 3-6 atomach wegla, grupe alkenylosulfonylowa o 3-6 atomach wegla, grupe cykloalkilosulfoksylowa o 3-6 atomach wegla lub grupe cykloalkilosulfonylowa o 3-6 atomach wegla.Pod okresleniem rodnika alkilowego samego lub jako skladnika innych podstawników nalezy w zaleznosci od liczby podanych atomów wegla rozumiec nastepujace rodniki: metylowy, etylowy, propylowy, butylowy, pentylowy, heksylowy, itp., oraz ich izomery, takie jak rodnik izopropy¬ lowy, izobutylowy, Ill-rz. -butylowy, izopentylowy itd. Rodnik alkenylowy oznacza np. rodnik winylowy, propenyl-/l/-owy, alliiowy.butenyl-/l/-owy, butenyl-/2/-owy, butenyl-/3/-owy itd.. oraz rodniki z lancuchami o kilku wiazaniach podwójnych. Rodnik alkinylowy oznacza np. rodnik2 141641 pr PL PL PL PL PL PL PL PL

Claims (1)

1.
PL1984247096A 1983-04-08 1984-04-06 Agent for fighting against and/or preventing paralyzing effects of microorganisms and method of obtaining new derivatives of n-/2-nitrophenylo/-4-aminopyrimidiines PL141641B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH189983 1983-04-08

Publications (2)

Publication Number Publication Date
PL247096A1 PL247096A1 (en) 1985-03-12
PL141641B1 true PL141641B1 (en) 1987-08-31

Family

ID=4221193

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1984247096A PL141641B1 (en) 1983-04-08 1984-04-06 Agent for fighting against and/or preventing paralyzing effects of microorganisms and method of obtaining new derivatives of n-/2-nitrophenylo/-4-aminopyrimidiines

Country Status (26)

Country Link
US (1) US4705790A (pl)
EP (1) EP0126254B1 (pl)
JP (1) JPS59205368A (pl)
KR (1) KR840008413A (pl)
AT (1) ATE30721T1 (pl)
AU (1) AU572130B2 (pl)
BR (1) BR8401620A (pl)
CA (1) CA1218369A (pl)
CS (1) CS241078B2 (pl)
DD (1) DD222768A5 (pl)
DE (1) DE3467348D1 (pl)
DK (1) DK130584A (pl)
ES (1) ES531393A0 (pl)
FI (1) FI841301A7 (pl)
GB (1) GB2137991B (pl)
GR (1) GR79586B (pl)
HU (1) HU198697B (pl)
IL (1) IL71457A (pl)
MA (1) MA20083A1 (pl)
NO (1) NO841386L (pl)
NZ (1) NZ207767A (pl)
PH (1) PH20340A (pl)
PL (1) PL141641B1 (pl)
PT (1) PT78377B (pl)
TR (1) TR22056A (pl)
ZA (1) ZA842574B (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505910A (en) * 1983-06-30 1985-03-19 American Home Products Corporation Amino-pyrimidine derivatives, compositions and use
US4659363A (en) * 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
DE3581570D1 (de) * 1984-06-25 1991-03-07 Ciba Geigy Ag Pyrimidinderivate wirksam als schaedlingsbekaempfungsmittel.
DE3618353A1 (de) * 1986-05-31 1987-12-03 Hoechst Ag Schaedlingsbekaempfungsmittel auf der basis von aminopyrimidin-derivaten sowie neue aminopyrimidin-verbindungen
JPH0784445B2 (ja) * 1986-12-03 1995-09-13 クミアイ化学工業株式会社 ピリミジン誘導体および農園芸用殺菌剤
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
KR910021383A (ko) * 1990-02-27 1991-12-20 베그르 발데크 N-(2, 6-디니트로-3-클로로-4-트리플루오로메틸페닐)-4-아미노-6-플루오로피리미딘 유도체 및 그의 제조방법
DE4029648A1 (de) * 1990-09-19 1992-03-26 Hoechst Ag 4-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
US5574040A (en) * 1995-01-06 1996-11-12 Picower Institute For Medical Research Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions
US5733932A (en) * 1995-01-06 1998-03-31 The Picower Institute For Medical Research Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions
EP1871743A4 (en) * 2005-04-11 2009-12-30 Univ Murdoch PEST CONTROL COMPOUNDS
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9022984B2 (en) 2008-10-27 2015-05-05 Pursuit Vascular, Inc. Apparatus for delivery of device and antimicrobial agent into trans-dermal catheter
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
US8622995B2 (en) 2009-10-26 2014-01-07 Pursuit Vascular, Inc. Method for delivery of antimicrobial to proximal end of catheter
US8622996B2 (en) 2008-10-27 2014-01-07 Pursuit Vascular, Inc. Method for applying antimicrobial to proximal end of catheter
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
ES2797649T3 (es) 2011-07-12 2020-12-03 Icu Medical Inc Dispositivo para entrega de agente antimicrobiano en un catéter transdérmico
AU2015252808B2 (en) 2014-05-02 2019-02-21 Excelsior Medical Corporation Strip package for antiseptic cap
WO2016040521A1 (en) * 2014-09-10 2016-03-17 The Regents Of The University Of California Herbicidal and fungicidal compositions and their uses
WO2016182822A1 (en) 2015-05-08 2016-11-17 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
EP4194043A1 (en) 2016-10-14 2023-06-14 ICU Medical, Inc. Sanitizing caps for medical connectors
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US10525250B1 (en) 2018-11-07 2020-01-07 Pursuit Vascular, Inc. Infusion device with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
AU2019384564B2 (en) 2018-11-21 2023-11-23 Icu Medical, Inc. Antimicrobial device comprising a cap with ring and insert
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1388825A (en) * 1971-03-19 1975-03-26 Ici Ltd Substituted amino pyrimidine compounds and pesticidal compo sitions thereof
GB1394816A (en) * 1971-03-19 1975-05-21 Ici Ltd Substituted amino diazinyl compounds and pesticidal compositions thereof
JPS57203072A (en) * 1981-06-05 1982-12-13 Sankyo Co Ltd 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient
IT1211096B (it) * 1981-08-20 1989-09-29 Lpb Ist Farm Pirimidine e s.triazinici adattivita' ipolipidemizzante.

Also Published As

Publication number Publication date
DK130584D0 (da) 1984-02-29
PH20340A (en) 1986-12-04
GB2137991B (en) 1986-11-19
DE3467348D1 (de) 1987-12-17
AU2660484A (en) 1984-10-11
JPS59205368A (ja) 1984-11-20
GB8408407D0 (en) 1984-05-10
DD222768A5 (de) 1985-05-29
GR79586B (pl) 1984-10-30
FI841301A7 (fi) 1984-10-09
ES8505970A1 (es) 1985-06-16
PT78377B (en) 1986-08-14
TR22056A (tr) 1986-02-18
PL247096A1 (en) 1985-03-12
US4705790A (en) 1987-11-10
EP0126254A1 (de) 1984-11-28
DK130584A (da) 1984-10-09
AU572130B2 (en) 1988-05-05
EP0126254B1 (de) 1987-11-11
ES531393A0 (es) 1985-06-16
PT78377A (en) 1984-05-01
CS241078B2 (en) 1986-03-13
CA1218369A (en) 1987-02-24
HUT34455A (en) 1985-03-28
MA20083A1 (fr) 1984-12-31
KR840008413A (ko) 1984-12-15
IL71457A (en) 1988-01-31
ATE30721T1 (de) 1987-11-15
FI841301A0 (fi) 1984-04-02
IL71457A0 (en) 1984-07-31
BR8401620A (pt) 1984-11-13
GB2137991A (en) 1984-10-17
NZ207767A (en) 1987-07-31
NO841386L (no) 1984-10-09
HU198697B (en) 1989-11-28
ZA842574B (en) 1984-12-24

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