PL1651615T3 - Pirydazynylo-piperazyny oraz ich zastosowanie jako ligandów receptora histaminowego H3 - Google Patents

Pirydazynylo-piperazyny oraz ich zastosowanie jako ligandów receptora histaminowego H3

Info

Publication number: PL1651615T3
Authority: PL; Poland
Prior art keywords: histamine; compounds; receptor; piperazines; pyridazinyl
Prior art date: 2003-07-29

Application number

PL04738980T

Other languages

English (en)

Inventor

Rolf Hohlweg

Original Assignee

High Point Pharmaceuticals Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-29

Filing date

2004-07-06

Publication date

2010-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34105630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1651615(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-07-06 Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc

2010-08-31 Publication of PL1651615T3 publication Critical patent/PL1651615T3/pl

Links

102000004384 Histamine H3 receptors Human genes 0.000 title abstract 4
108090000981 Histamine H3 receptors Proteins 0.000 title abstract 4
MIPXOMNITKFHDA-UHFFFAOYSA-N 3-piperazin-1-ylpyridazine Chemical class C1CNCCN1C1=CC=CN=N1 MIPXOMNITKFHDA-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
230000001270 agonistic effect Effects 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
230000003042 antagnostic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000004885 piperazines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Obesity (AREA)
Immunology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL04738980T 2003-07-29 2004-07-06 Pirydazynylo-piperazyny oraz ich zastosowanie jako ligandów receptora histaminowego H3 PL1651615T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DKPA200301107		2003-07-29
US49269303P	2003-08-05	2003-08-05
PCT/DK2004/000483 WO2005009976A1 (en)	2003-07-29	2004-07-06	Pyridazinyl- piperazines and their use as histamine h3 receptor ligands
EP04738980A EP1651615B1 (en)	2003-07-29	2004-07-06	Pyridazinyl- piperazines and their use as histamine h3 receptor ligands

Publications (1)

Publication Number	Publication Date
PL1651615T3 true PL1651615T3 (pl)	2010-08-31

Family

ID=34105630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04738980T PL1651615T3 (pl)	2003-07-29	2004-07-06	Pirydazynylo-piperazyny oraz ich zastosowanie jako ligandów receptora histaminowego H3

Country Status (19)

Country	Link
US (1)	US7294626B2 (pl)
EP (1)	EP1651615B1 (pl)
JP (1)	JP4680903B2 (pl)
KR (1)	KR20060054392A (pl)
CN (1)	CN100584831C (pl)
AT (1)	ATE461178T1 (pl)
AU (1)	AU2004259263B2 (pl)
BR (1)	BRPI0413048A (pl)
CA (1)	CA2532236C (pl)
DE (1)	DE602004026068D1 (pl)
DK (1)	DK1651615T3 (pl)
ES (1)	ES2342605T3 (pl)
IL (1)	IL173161A0 (pl)
MX (1)	MXPA06001053A (pl)
NO (1)	NO20061003L (pl)
PL (1)	PL1651615T3 (pl)
PT (1)	PT1651615E (pl)
RU (1)	RU2006101452A (pl)
WO (1)	WO2005009976A1 (pl)

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WO2006050359A2 (en)	2004-11-02	2006-05-11	Northwestern University	Pyridazine compounds and methods
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BRPI0611187A2 (pt)	2005-06-03	2010-08-24	Xenon Pharmaceuticals Inc	derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
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BRPI0710938A2 (pt)	2006-04-28	2012-06-26	Univ Northwestern	formulações contendo compostos de piridazina para o tratamento de doenças neuroinflamatórias
WO2007127474A2 (en) *	2006-04-28	2007-11-08	Northwestern University	Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
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EP2079732B9 (en) *	2006-05-29	2012-03-21	High Point Pharmaceuticals, LLC	3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
KR101372941B1 (ko)	2006-05-30	2014-03-14	얀센 파마슈티카 엔.브이.	히스타민 ｈ３ 수용체 조절제로서의 치환된 피리딜 아미드 화합물
US9108948B2 (en)	2006-06-23	2015-08-18	Abbvie Inc.	Cyclopropyl amine derivatives
CA2655604C (en)	2006-06-23	2016-08-09	Abbott Laboratories	Cyclopropyl amine derivatives
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en)	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
WO2008128996A1 (en)	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
JP5431305B2 (ja)	2007-04-23	2014-03-05	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
WO2008145681A2 (en) *	2007-05-31	2008-12-04	Boehringer Ingelheim International Gmbh	Ccr2 receptor antagonists and uses thereof
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EP2014656A3 (en)	2007-06-11	2011-08-24	High Point Pharmaceuticals, LLC	New heteocyclic h3 antagonists
BRPI0820481A2 (pt)	2007-11-20	2015-06-16	Janssen Pharmaceutica Nv	Composotos cicloalquilóxi e heterocicloalquilóxi piridina como moduladores do receptor de h3 de histamina
EP2310374B1 (en)	2008-07-03	2012-10-31	Janssen Pharmaceutica N.V.	Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists
EP2307374B1 (en)	2008-07-31	2017-01-25	Janssen Pharmaceutica NV	Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
DK2379525T3 (en)	2008-12-19	2015-10-19	Boehringer Ingelheim Int	Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
US9186353B2 (en)	2009-04-27	2015-11-17	Abbvie Inc.	Treatment of osteoarthritis pain
WO2011073154A1 (en)	2009-12-17	2011-06-23	Boehringer Ingelheim International Gmbh	New ccr2 receptor antagonists and uses thereof
EP2569295B1 (en)	2010-05-12	2014-11-19	Boehringer Ingelheim International GmbH	New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8877745B2 (en)	2010-05-12	2014-11-04	Boehringer Ingelheim International Gmbh	CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en)	2010-05-17	2014-09-23	Boehringer Ingelheim International Gmbh	CCR2 antagonists and uses thereof
US9018212B2 (en) *	2010-05-25	2015-04-28	Boehringer Ingelheim International Gmbh	Pyridazine carboxamides as CCR2 receptor antagonists
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2004
- 2004-07-06 CA CA2532236A patent/CA2532236C/en not_active Expired - Fee Related
- 2004-07-06 DE DE602004026068T patent/DE602004026068D1/de not_active Expired - Lifetime
- 2004-07-06 BR BRPI0413048-0A patent/BRPI0413048A/pt not_active IP Right Cessation
- 2004-07-06 MX MXPA06001053A patent/MXPA06001053A/es active IP Right Grant
- 2004-07-06 ES ES04738980T patent/ES2342605T3/es not_active Expired - Lifetime
- 2004-07-06 AT AT04738980T patent/ATE461178T1/de active
- 2004-07-06 KR KR1020067002114A patent/KR20060054392A/ko not_active Ceased
- 2004-07-06 AU AU2004259263A patent/AU2004259263B2/en not_active Ceased
- 2004-07-06 RU RU2006101452/04A patent/RU2006101452A/ru not_active Application Discontinuation
- 2004-07-06 PT PT04738980T patent/PT1651615E/pt unknown
- 2004-07-06 DK DK04738980.4T patent/DK1651615T3/da active
- 2004-07-06 EP EP04738980A patent/EP1651615B1/en not_active Expired - Lifetime
- 2004-07-06 WO PCT/DK2004/000483 patent/WO2005009976A1/en not_active Ceased
- 2004-07-06 CN CN200480021891A patent/CN100584831C/zh not_active Expired - Fee Related
- 2004-07-06 PL PL04738980T patent/PL1651615T3/pl unknown
- 2004-07-06 JP JP2006521396A patent/JP4680903B2/ja not_active Expired - Fee Related
2006
- 2006-01-16 IL IL173161A patent/IL173161A0/en unknown
- 2006-01-18 US US11/334,207 patent/US7294626B2/en not_active Expired - Fee Related
- 2006-02-28 NO NO20061003A patent/NO20061003L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK1651615T3 (da)	2010-05-25
ES2342605T3 (es)	2010-07-09
AU2004259263B2 (en)	2010-12-16
WO2005009976A1 (en)	2005-02-03
JP4680903B2 (ja)	2011-05-11
EP1651615A1 (en)	2006-05-03
KR20060054392A (ko)	2006-05-22
EP1651615B1 (en)	2010-03-17
NO20061003L (no)	2006-04-26
CA2532236C (en)	2011-08-23
CA2532236A1 (en)	2005-02-03
BRPI0413048A (pt)	2006-10-17
CN100584831C (zh)	2010-01-27
IL173161A0 (en)	2006-06-11
MXPA06001053A (es)	2006-04-11
ATE461178T1 (de)	2010-04-15
PT1651615E (pt)	2010-04-29
US7294626B2 (en)	2007-11-13
US20060173012A1 (en)	2006-08-03
CN1829699A (zh)	2006-09-06
JP2007500135A (ja)	2007-01-11
DE602004026068D1 (de)	2010-04-29
AU2004259263A1 (en)	2005-02-03
RU2006101452A (ru)	2006-06-27

Publication	Publication Date	Title
IL173161A0 (en)	2006-06-11	Pyridazinyl-piperazines and their use as histamine h3 receptor ligands
DE60237528D1 (de)	2010-10-14	Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative
WO2003066604A3 (en)	2003-12-04	Novel aryl- and heteroarylpiperazines
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GB0222495D0 (en)	2002-11-06	Compounds
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