PL1651618T3 - 2-Podstawione pirymidyny - Google Patents

2-Podstawione pirymidyny

Info

Publication number
PL1651618T3
PL1651618T3 PL04741053T PL04741053T PL1651618T3 PL 1651618 T3 PL1651618 T3 PL 1651618T3 PL 04741053 T PL04741053 T PL 04741053T PL 04741053 T PL04741053 T PL 04741053T PL 1651618 T3 PL1651618 T3 PL 1651618T3
Authority
PL
Poland
Prior art keywords
substituted pyrimidines
pyrimidines
substituted
Prior art date
Application number
PL04741053T
Other languages
English (en)
Inventor
Anja Schwögler
Markus Gewehr
Bernd Müller
Thomas Grote
Wassilios Grammenos
I Blasco Jordi Tormo
Andreas Gypser
Joachim Rheinheimer
Carsten Blettner
Peter Schäfer
Frank Schieweck
Oliver Wagner
Reinhard Stierl
Ulrich Schöfl
Siegfried Strathmann
Maria Scherer
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of PL1651618T3 publication Critical patent/PL1651618T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL04741053T 2003-07-24 2004-07-15 2-Podstawione pirymidyny PL1651618T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10333857 2003-07-24
DE10357714 2003-12-09
EP04741053A EP1651618B1 (de) 2003-07-24 2004-07-15 2-substituierte pyrimidine
PCT/EP2004/007877 WO2005012261A1 (de) 2003-07-24 2004-07-15 2-substituierte pyrimidine

Publications (1)

Publication Number Publication Date
PL1651618T3 true PL1651618T3 (pl) 2007-05-31

Family

ID=34117367

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04741053T PL1651618T3 (pl) 2003-07-24 2004-07-15 2-Podstawione pirymidyny

Country Status (30)

Country Link
US (1) US7375108B2 (pl)
EP (1) EP1651618B1 (pl)
JP (1) JP2006528603A (pl)
KR (1) KR20060052857A (pl)
AP (1) AP2157A (pl)
AR (1) AR045100A1 (pl)
AT (1) ATE350370T1 (pl)
AU (1) AU2004261373B8 (pl)
BR (1) BRPI0412891A (pl)
CA (1) CA2532718A1 (pl)
CO (1) CO5660292A2 (pl)
CR (1) CR8184A (pl)
CY (1) CY1106391T1 (pl)
DE (1) DE502004002570D1 (pl)
DK (1) DK1651618T3 (pl)
EA (1) EA010566B1 (pl)
EC (1) ECSP066278A (pl)
ES (1) ES2279395T3 (pl)
HR (1) HRP20070057T3 (pl)
IL (1) IL172848A0 (pl)
MA (1) MA27949A1 (pl)
MX (1) MXPA06000038A (pl)
NZ (1) NZ545103A (pl)
PE (1) PE20050882A1 (pl)
PL (1) PL1651618T3 (pl)
PT (1) PT1651618E (pl)
SI (1) SI1651618T1 (pl)
TW (1) TW200516075A (pl)
UY (1) UY28436A1 (pl)
WO (1) WO2005012261A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0513211A (pt) * 2004-07-14 2008-04-29 Basf Ag composto, agente pesticida, combinação, e, processos para combater fungos nocivos fitopatogênicos, e pestes animais em agricultura
CL2007002231A1 (es) * 2006-08-02 2008-04-11 Basf Ag Uso de compuestos derivados de 5-(het) arilpirimidina para combatir hongos daninos; compuestos derivados de 5-(het) arilpirimidina; agente fungicida; y agente farmaceutico.
NZ610225A (en) * 2010-11-16 2015-08-28 Acetylon Pharmaceuticals Inc Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2015054099A1 (en) 2013-10-08 2015-04-16 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and either her2 inhibitors or pi3k inhibitors
EP3055299B1 (en) 2013-10-10 2021-01-06 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
EP3060217B1 (en) 2013-10-24 2022-06-08 Mayo Foundation for Medical Education and Research Treatment of polycystic diseases with an hdac6 inhibitor
EP3076973B1 (en) 2013-12-03 2020-04-29 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and immunomodulatory drugs
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
CN107205988A (zh) 2014-07-07 2017-09-26 埃斯泰隆制药公司 利用组蛋白脱乙酰酶抑制剂治疗白血病
CN107438436A (zh) 2014-12-05 2017-12-05 摩德纳和雷焦艾米利亚大学 用于治疗淋巴瘤的组蛋白脱乙酰酶抑制剂和苯达莫司汀的组合
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
US11813261B2 (en) 2016-04-19 2023-11-14 Acetylon Pharmaceuticals, Inc. HDAC inhibitors, alone or in combination with BTK inhibitors, for treating chronic lymphocytic leukemia
WO2018016596A1 (ja) * 2016-07-20 2018-01-25 国立大学法人東北大学 PPARαアゴニストを含有する、肺高血圧症の予防又は治療剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL362551A1 (pl) 2000-06-13 2004-11-02 Basf Aktiengesellschaft Grzybobójcze 5-fenylo-podstawione 2-(cyjanoamino)-pirymidyny
SK11422003A3 (sk) * 2001-03-15 2004-04-06 Basf Aktiengesellschaft 5-Fenylpyrimidíny, spôsoby a medziprodukty na ich prípravu a ich použitie pri ničení škodlivých húb
JP4450625B2 (ja) 2001-11-19 2010-04-14 ビーエーエスエフ ソシエタス・ヨーロピア 5−フェニルピリミジン類、その製造方法、これらを含む組成物及びこれらの使用

Also Published As

Publication number Publication date
DK1651618T3 (da) 2007-05-14
EA200600212A1 (ru) 2006-08-25
KR20060052857A (ko) 2006-05-19
PT1651618E (pt) 2007-03-30
PE20050882A1 (es) 2005-12-01
WO2005012261A1 (de) 2005-02-10
CO5660292A2 (es) 2006-07-31
ES2279395T3 (es) 2007-08-16
BRPI0412891A (pt) 2006-10-03
IL172848A0 (en) 2006-06-11
ECSP066278A (es) 2006-07-28
MXPA06000038A (es) 2006-03-21
DE502004002570D1 (de) 2007-02-15
SI1651618T1 (sl) 2007-06-30
US20070105873A1 (en) 2007-05-10
EP1651618B1 (de) 2007-01-03
EA010566B1 (ru) 2008-10-30
US7375108B2 (en) 2008-05-20
CA2532718A1 (en) 2005-02-10
JP2006528603A (ja) 2006-12-21
EP1651618A1 (de) 2006-05-03
HRP20070057T3 (hr) 2007-07-31
CY1106391T1 (el) 2011-10-12
CR8184A (es) 2006-10-06
AU2004261373B8 (en) 2010-11-04
AU2004261373A1 (en) 2005-02-10
TW200516075A (en) 2005-05-16
AR045100A1 (es) 2005-10-12
NZ545103A (en) 2008-06-30
AU2004261373B2 (en) 2010-08-19
MA27949A1 (fr) 2006-06-01
UY28436A1 (es) 2005-02-28
AP2157A (en) 2010-09-13
ATE350370T1 (de) 2007-01-15
AP2006003497A0 (en) 2006-02-28

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