PL1675956T3 - Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek - Google Patents

Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek

Info

Publication number
PL1675956T3
PL1675956T3 PL04791263T PL04791263T PL1675956T3 PL 1675956 T3 PL1675956 T3 PL 1675956T3 PL 04791263 T PL04791263 T PL 04791263T PL 04791263 T PL04791263 T PL 04791263T PL 1675956 T3 PL1675956 T3 PL 1675956T3
Authority
PL
Poland
Prior art keywords
dna sequence
protein expression
chromatin insulator
minimal dna
sequence acting
Prior art date
Application number
PL04791263T
Other languages
English (en)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of PL1675956T3 publication Critical patent/PL1675956T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL04791263T 2003-10-21 2004-10-20 Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek PL1675956T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103890 2003-10-21
PCT/EP2004/052591 WO2005040384A1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression
EP04791263A EP1675956B1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression

Publications (1)

Publication Number Publication Date
PL1675956T3 true PL1675956T3 (pl) 2011-06-30

Family

ID=34486337

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04791263T PL1675956T3 (pl) 2003-10-21 2004-10-20 Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek

Country Status (17)

Country Link
US (1) US8133699B2 (pl)
EP (1) EP1675956B1 (pl)
JP (1) JP4745972B2 (pl)
AT (1) ATE484591T1 (pl)
AU (1) AU2004284243B2 (pl)
CA (1) CA2541523A1 (pl)
CY (1) CY1110868T1 (pl)
DE (1) DE602004029598D1 (pl)
DK (1) DK1675956T3 (pl)
ES (1) ES2354160T3 (pl)
HR (1) HRP20100560T1 (pl)
IL (1) IL175021A (pl)
NO (1) NO338767B1 (pl)
PL (1) PL1675956T3 (pl)
PT (1) PT1675956E (pl)
SI (1) SI1675956T1 (pl)
WO (1) WO2005040384A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1395669B1 (en) 2001-01-26 2009-07-22 Selexis S.A. Matrix attachment regions and methods for use thereof
ATE399872T1 (de) * 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
DK1622939T3 (da) * 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
PL1959011T3 (pl) 2003-10-24 2012-07-31 Selexis Sa Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy
ES2285543T3 (es) * 2003-11-05 2007-11-16 Ares Trading S.A. Procedimiento para la purificacion de la proteina de union a il-18.
DE602005002829T2 (de) * 2004-03-01 2008-07-10 Ares Trading S.A. Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
ES2385639T3 (es) * 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
AU2006256763B2 (en) * 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
FR2919616A1 (fr) * 2007-08-02 2009-02-06 Ecole Norm Superieure Lyon Polynucleotides insulateurs derives de l'element d4z4 et leurs utilisations en transgenese
EP2697375B1 (en) 2011-04-13 2017-10-18 National Research Council of Canada Expression system with scaffold attachment region (sar) element from interferon 2
CA2857755A1 (en) * 2011-12-21 2013-06-27 Danisco Us Inc. Improving fungal gene expression using insulator dna sequences
KR102055438B1 (ko) 2012-07-31 2019-12-19 에이지엑스 쎄라퓨틱스, 인크. Hla g-변형된 세포 및 방법
KR101591823B1 (ko) * 2013-12-27 2016-02-04 재단법인 목암생명공학연구소 증가된 유전자 발현능을 갖는 발현벡터
US11246896B2 (en) 2015-10-28 2022-02-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
CN115141836B (zh) * 2015-10-28 2024-08-27 桑格摩生物治疗股份有限公司 肝特异性构建体、因子viii表达盒及其使用方法
AU2017290389B2 (en) 2016-07-01 2024-09-26 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
CN106754817B (zh) * 2016-11-03 2021-02-05 山西省生物研究院有限公司 一种重组自分泌运动因子的表达方法
US10947295B2 (en) 2017-08-22 2021-03-16 Sanabio, Llc Heterodimers of soluble interferon receptors and uses thereof
CA3100946A1 (en) 2018-05-22 2019-11-28 The Brigham And Women's Hospital, Inc. Gene therapy for alzheimer's disease
EP3829650A4 (en) 2018-08-03 2022-05-04 Sangamo Therapeutics, Inc. IMPROVED CLINICAL PARAMETERS BY EXPRESSION OF FACTOR VIII
EP3976637A4 (en) 2019-05-24 2023-07-12 The Brigham and Women's Hospital, Inc. GENE THERAPY FOR ALZHEIMER'S DISEASE
KR20220108096A (ko) * 2019-11-29 2022-08-02 파로스 바이오, 인코포레이티드 신경퇴행성 질환에 대한 유전자 요법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US6432700B1 (en) * 1997-03-03 2002-08-13 Cell Genesys, Inc. Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same
US6194152B1 (en) * 1997-08-20 2001-02-27 Dendreon Corporation Prostate tumor polynucleotide compositions and methods of detection thereof
AU1128400A (en) * 1998-10-22 2000-05-08 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
JP2003504016A (ja) 1999-06-30 2003-02-04 アメリカ合衆国 遺伝子発現の制御のための特異的エンハンサー遮断活性を有する絶縁体としてのｄｎａ結合タンパク質および配列
ATE399872T1 (de) 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
DK1622939T3 (da) 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
ES2285543T3 (es) 2003-11-05 2007-11-16 Ares Trading S.A. Procedimiento para la purificacion de la proteina de union a il-18.
DE602005002829T2 (de) 2004-03-01 2008-07-10 Ares Trading S.A. Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
AU2005259269B2 (en) 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
ES2385639T3 (es) 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein

Also Published As

Publication number Publication date
NO338767B1 (no) 2016-10-17
US8133699B2 (en) 2012-03-13
WO2005040384A1 (en) 2005-05-06
NO20062315L (no) 2006-07-18
CY1110868T1 (el) 2015-06-10
DK1675956T3 (da) 2010-11-22
EP1675956B1 (en) 2010-10-13
JP2007508833A (ja) 2007-04-12
US20070134761A1 (en) 2007-06-14
AU2004284243A1 (en) 2005-05-06
PT1675956E (pt) 2010-11-04
EP1675956A1 (en) 2006-07-05
SI1675956T1 (sl) 2010-12-31
CA2541523A1 (en) 2005-05-06
ATE484591T1 (de) 2010-10-15
IL175021A0 (en) 2006-08-20
DE602004029598D1 (de) 2010-11-25
AU2004284243B2 (en) 2010-11-04
JP4745972B2 (ja) 2011-08-10
IL175021A (en) 2011-07-31
HRP20100560T1 (hr) 2010-11-30
ES2354160T3 (es) 2011-03-10

Similar Documents

Publication Publication Date Title
SI1675956T1 (sl) Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov
WO2005121331A8 (en) Truncated galnact2 polypeptides and nucleic acids
DE502004005166D1 (de) Expressionsvektor zur antibiotikafreien expression
WO2004099370A3 (en) NOVEL BACILLUS mHKcel CELLULASE
WO2002086144A3 (en) Compositions and methods for recombinational cloning of nucleic acid molecules
CA2315274A1 (en) Polypeptides having aminopeptidase activity and nucleic acids encoding same
AU7381098A (en) Polypeptides having prolyl pipeptidyl aminopeptidase activity and nucleic acids encoding same
ATE331034T1 (de) Samenstrenung resistenz
AU2003222717A8 (en) Streptavidin-binding peptide
DE60325611D1 (de) Benzoat- und antranilatinduzierbare promotoren
AU3802595A (en) Tripeptidyl aminopeptidase
TW200512292A (en) Fungal immunomodulatory protein (FIP) prepared by microorganisms and uses thereof
WO2002059315A3 (en) Human nucleic acids and polypeptides and methods of use thereof
EP2392655A3 (en) Coagulation factor VII polypeptides
AU7489098A (en) Polypeptides having aminopeptidase activity and nucleic acids encoding same
WO2002036627A3 (en) Interferons, uses and compositions related thereto
DE60118359D1 (de) Humanische pellino-polypeptide
ATE532861T1 (de) Expressionsvektor
WO2005024006A3 (en) Coagulation factor vii polypeptides
WO2001040313A3 (en) Feline immunoregulatory proteins, nucleic acid molecules, and uses thereof
WO2004053092A3 (en) Human pellino polypeptides
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
DE69619808D1 (de) Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
SG161106A1 (en) Inhibitor proteins of a protease and use thereof
WO2005007803A3 (en) Selection free growth of host cells containing multiple integrating vectors