PL1682528T3 - Pochodne benzo[b][1,4]dioksepiny - Google Patents

Pochodne benzo[b][1,4]dioksepiny

Info

Publication number: PL1682528T3
Authority: PL; Poland
Prior art keywords: benzo; compounds; dioxepine; derivatives; dioxepine derivatives
Prior art date: 2003-11-07

Application number

PL04790968T

Other languages

English (en)

Inventor

Luca Claudio Gobbi

Marcel Gubler

Werner Neidhart

Matthias Heinrich Nettekoven

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-07

Filing date

2004-10-28

Publication date

2008-01-31

2004-10-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-01-31 Publication of PL1682528T3 publication Critical patent/PL1682528T3/pl

Links

YCRGMNXARTVRLB-UHFFFAOYSA-N 2h-1,5-benzodioxepine Chemical class O1C=CCOC2=CC=CC=C21 YCRGMNXARTVRLB-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
102100021641 Acetyl-CoA carboxylase 2 Human genes 0.000 abstract 1
101000677540 Homo sapiens Acetyl-CoA carboxylase 2 Proteins 0.000 abstract 1
230000006806 disease prevention Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Resins (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

PL04790968T 2003-11-07 2004-10-28 Pochodne benzo[b][1,4]dioksepiny PL1682528T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03104117		2003-11-07
PCT/EP2004/012198 WO2005044814A1 (en)	2003-11-07	2004-10-28	BENZO [b][1,4] DIOXEPINE DERIVATIVES
EP04790968A EP1682528B1 (en)	2003-11-07	2004-10-28	BENZO [b][1,4] DIOXEPINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
PL1682528T3 true PL1682528T3 (pl)	2008-01-31

Family

ID=34560205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04790968T PL1682528T3 (pl)	2003-11-07	2004-10-28	Pochodne benzo[b][1,4]dioksepiny

Country Status (15)

Country	Link
US (1)	US7459480B2 (pl)
EP (1)	EP1682528B1 (pl)
JP (1)	JP2007509997A (pl)
KR (1)	KR100794856B1 (pl)
CN (1)	CN100439357C (pl)
AT (1)	ATE372995T1 (pl)
AU (1)	AU2004287573A1 (pl)
BR (1)	BRPI0416287A (pl)
CA (1)	CA2551056A1 (pl)
DE (1)	DE602004008959T2 (pl)
ES (1)	ES2291951T3 (pl)
MX (1)	MXPA06004545A (pl)
PL (1)	PL1682528T3 (pl)
RU (1)	RU2350610C2 (pl)
WO (1)	WO2005044814A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0614502A2 (pt)	2005-07-30	2011-03-29	Astrazeneca Ab	Composto, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto
JP2010500300A (ja)	2006-08-08	2010-01-07	サノフィ−アベンティス	アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
JP2008063360A (ja) *	2006-09-04	2008-03-21	Kyoto Univ	ポリフェニルアセチレン系ポリマーおよびその製造方法、並びにフェニルアセチレン誘導体
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2010003624A2 (en)	2008-07-09	2010-01-14	Sanofi-Aventis	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
US20100113473A1 (en) *	2008-10-30	2010-05-06	Player Mark R	Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
SG178880A1 (en)	2009-08-26	2012-04-27	Sanofi Sa	Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2683698B1 (de)	2011-03-08	2017-10-04	Sanofi	Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8809324B2 (en)	2011-03-08	2014-08-19	Sanofi	Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8846666B2 (en)	2011-03-08	2014-09-30	Sanofi	Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683703B1 (de)	2011-03-08	2015-05-27	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120055A1 (de)	2011-03-08	2012-09-13	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de)	2011-03-08	2012-09-13	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de)	2011-03-08	2014-12-17	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012138776A1 (en) *	2011-04-05	2012-10-11	Amgen Inc.	Benzodioxepine and benzodioxine compounds that interact with glucokinase regulatory protein for the treatment of diabetes
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9073943B2 (en)	2012-02-10	2015-07-07	Lupin Limited	Antiviral compounds with a dibenzooxaheterocycle moiety
CN104059049A (zh) *	2013-03-21	2014-09-24	华东师范大学	具有光学活性的苯并二氧杂环衍生物及其制备方法和应用
BR112021002207A2 (pt)	2018-08-10	2021-05-04	Diapin Therapeutics, Llc	tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios
WO2025124544A1 (zh) *	2023-12-14	2025-06-19	华润医药研究院（深圳）有限公司	3,4-二氢-2H-苯并[b][1,4]二氧杂环庚烷类化合物及其制备方法和医药用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU626881B2 (en) *	1988-07-14	1992-08-13	F. Hoffmann-La Roche Ag	Benzofused heterocyclics used as pharmaceuticals
JPH05310678A (ja) *	1990-01-22	1993-11-22	Mitsubishi Kasei Corp	１−フェニルアルキル−３−フェニル尿素誘導体
CZ397498A3 (cs) *	1996-06-07	1999-03-17	F. Hoffmann-La Roche Ag	Dibenzooxazepinové a -dioxepinové deriváty a jejich použití jako protinádorových prostředků
AR013084A1 (es) *	1997-06-19	2000-12-13	Astrazeneca Ab	Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
US6555584B1 (en) *	2000-06-29	2003-04-29	Ajinomoto Co., Inc.	Acylsulfonamide derivative
PL339660A1 (en) *	1997-10-02	2001-01-02	Sankyo Co	Derivatives of amidocarboxylic acids
WO2002049632A1 (en) *	2000-12-18	2002-06-27	Institute Of Medicinal Molecular Design. Inc.	Inhibitors against the production and release of inflammatory cytokines
WO2003072197A1 (en) *	2002-02-27	2003-09-04	Pfizer Products Inc.	Acc inhibitors

2004
- 2004-10-28 AT AT04790968T patent/ATE372995T1/de not_active IP Right Cessation
- 2004-10-28 CA CA002551056A patent/CA2551056A1/en not_active Abandoned
- 2004-10-28 MX MXPA06004545A patent/MXPA06004545A/es active IP Right Grant
- 2004-10-28 RU RU2006119776/04A patent/RU2350610C2/ru not_active IP Right Cessation
- 2004-10-28 CN CNB2004800325633A patent/CN100439357C/zh not_active Expired - Fee Related
- 2004-10-28 ES ES04790968T patent/ES2291951T3/es not_active Expired - Lifetime
- 2004-10-28 KR KR1020067008771A patent/KR100794856B1/ko not_active Expired - Fee Related
- 2004-10-28 BR BRPI0416287-0A patent/BRPI0416287A/pt not_active IP Right Cessation
- 2004-10-28 WO PCT/EP2004/012198 patent/WO2005044814A1/en not_active Ceased
- 2004-10-28 AU AU2004287573A patent/AU2004287573A1/en not_active Abandoned
- 2004-10-28 EP EP04790968A patent/EP1682528B1/en not_active Expired - Lifetime
- 2004-10-28 JP JP2006538706A patent/JP2007509997A/ja active Pending
- 2004-10-28 PL PL04790968T patent/PL1682528T3/pl unknown
- 2004-10-28 DE DE602004008959T patent/DE602004008959T2/de not_active Expired - Lifetime
- 2004-10-29 US US10/977,028 patent/US7459480B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2007509997A (ja)	2007-04-19
CA2551056A1 (en)	2005-05-19
DE602004008959T2 (de)	2008-06-19
KR100794856B1 (ko)	2008-01-14
KR20060083225A (ko)	2006-07-20
CN100439357C (zh)	2008-12-03
ES2291951T3 (es)	2008-03-01
RU2350610C2 (ru)	2009-03-27
US20050113374A1 (en)	2005-05-26
BRPI0416287A (pt)	2007-01-23
DE602004008959D1 (de)	2007-10-25
RU2006119776A (ru)	2007-12-27
WO2005044814A1 (en)	2005-05-19
CN1875015A (zh)	2006-12-06
EP1682528A1 (en)	2006-07-26
EP1682528B1 (en)	2007-09-12
US7459480B2 (en)	2008-12-02
ATE372995T1 (de)	2007-09-15
AU2004287573A1 (en)	2005-05-19
MXPA06004545A (es)	2006-06-23

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